The SeaPerch underwater robot is a popular educational tool for students in grades 5 to 12.  Building and piloting SeaPerch, a remotely operated vehicle (ROV), involves a variety of hand fabrication processes, electronics techniques, and STEM concepts. Through the SeaPerch program, educators and students explore structures, electronics, and underwater dynamics.  

“SeaPerch has had a tremendous impact on the fields of ocean science and engineering,” says Andrew Bennett ’85, PhD ’97, MIT SeaGrant education administrator and senior lecturer in the Department of Mechanical Engineering (MechE).

The original SeaPerch project was launched by MIT Sea Grant in 2003. In the decades that followed, it quickly spread across the country and overseas, creating a vibrant community of builders. Now under the leadership of RoboNation, SeaPerch continues to thrive with competitions around the world. These competitions introduce challenging real-world problems to foster creative solutions. Some recent topics have included deep sea mining and collecting data on hydrothermal vents.

SeaPerch II, which has been in development at MIT Sea Grant since 2021, builds on the original program by adding robotics and elements of marine and climate science. It remains a “do-it-yourself” maker project with objectives that are achievable by middle and high school students. Bennett says he hopes SeaPerch II will enable an even greater impact by providing an approachable path to learning more about sensors, robotics, climate science, and more.

“What I think is most valuable about it is that it uses hardware store components that need to be cut, waterproofed, connected, soldered, or somehow processed before becoming part of the robot or controller,” says Diane Brancazio ME ’90, K-12 maker team leader for the MIT Edgerton Center, who co-leads the MIT SeaPerch initiative with Bennett. “[It’s] kind of like making a cake from scratch, instead of from a mix — you see what goes into the final product and how it all comes together.”

SeaPerch II is a family of modules that allow students and educators to create educational adventures tailored to their particular wants or requirements. Offerings include a pressure and temperature sensing module that can be used on its own; an autonomy module that the students can use to construct a closed-loop automatic depth control system for their SeaPerch; and a lesson module for soft robotic “fingers” that can be configured into grippers, distance sensors, and bump sensors.

The basic SeaPerch is a PVC pipe structure with three motors and a tether to a switch box. Through the building process, students learn about buoyancy, structural design, hand fabrication, and electric circuits. SeaPerch II leverages technologies that are more advanced, less expensive, and more accessible than they were when SeaPerch was first conceived. Bennett says SeaPerch II is meant to extend the original SeaPerch program without invalidating any of the existing system.

Teagan Sullivan, a third-year student in mechanical engineering, first became involved with the project in January 2023 through an Undergraduate Research Opportunities Program project with MIT Sea Grant. Initially, she continued development of the soft robotics portion of the project, before switching to a more general focus where she worked on frame design for SeaPerch II, making sure components could fit and that stability could be maintained. Later she helped run outreach programs, taking feedback from the students she worked with to help modify designs and make them “more robust and kid-friendly.”

“I have been able to see the impact of SeaPerch II on a small scale by working directly with students,” Sullivan says. “I have seen how it encourages creativity, and how it has taught kids that collaboration is the best road to success. SeaPerch II teaches the basics of electronics, coding, and manufacturing, but its best strength is the ability to challenge the way people think and encourage critical thinking.”

The team’s vision is to create opportunities for young people to engage in authentic science investigations and engineering challenges, developing a passion for engineering, science, and the aquatic environment. MIT Sea Grant is continuing to develop new SeaPerch II modules, including incorporating land-water communication, salinity and dissolved oxygen sensors, and fluorometers.

Sullivan says she hopes the program will reach more students and inspire them to take an interest in engineering while teaching the skills they need to be the next generation of problem-solvers. Brancazio says she hopes this project inspires and prepares young people to work on climate change issues.

“Robots are supposed to help people do things they couldn’t otherwise do,” Brancazio says. “SeaPerch is a robot with a mission.”

Nuclear physicist and MIT Professor Emeritus Lee Grodzins died on March 6 at his home in the Maplewood Senior Living Community at Weston, Massachusetts. He was 98.   

Grodzins was a pioneer in nuclear physics research. He was perhaps best known for the highly influential experiment determining the helicity of the neutrino, which led to a key understanding of what's known as the weak interaction. He was also the founder of Niton Corp. and the nonprofit Cornerstones of Science, and was a co-founder of the Union of Concerned Scientists.

He retired in 1999 after serving as an MIT physics faculty member for 40 years. As a member of the Laboratory for Nuclear Science (LNS), he initiated the relativistic heavy-ion physics program. He published over 170 scientific papers and held 64 U.S. patents.

“Lee was a very good experimental physicist, especially with his hands making gadgets,” says Heavy Ion Group and Francis L. Friedman Professor Emeritus Wit Busza PhD ’64. “His enthusiasm for physics spilled into his enthusiasm for how physics was taught in our department.”

Industrious son of immigrants

Grodzins was born July 10, 1926, in Lowell, Massachusetts, the middle child of Eastern European Jewish immigrants David and Taube Grodzins. He grew up in Manchester, New Hampshire. His two sisters were Ethel Grodzins Romm, journalist, author, and businesswoman who later ran his company, Niton Corp.; and Anne Lipow, who became a librarian and library science expert.

His father, who ran a gas station and a used-tire business, died when Lee was 15. To help support his family, Lee sold newspapers, a business he grew into the second-largest newspaper distributor in Manchester.

At 17, Grodzins attended the University of New Hampshire, graduating in less than three years with a degree in mechanical engineering.  However, he decided to be a physicist after disagreeing with a textbook that used the word “never.”

“I was pretty good in math and was undecided about my future,” Grodzins said in a 1958 New York Daily News article. “It wasn’t until my senior year that I unexpectedly realized I wanted to be a physicist. I was reading a physics text one day when suddenly this sentence hit me: ‘We will never be able to see the atom.’ I said to myself that that was as stupid a statement as I’d ever read. What did he mean ‘never!’ I got so annoyed that I started devouring other writers to see what they had to say and all at once I found myself in the midst of modern physics.”

He wrote his senior thesis on “Atomic Theory.”

After graduating in 1946, he approached potential employers by saying, “I have a degree in mechanical engineering, but I don’t want to be one. I’d like to be a physicist, and I’ll take anything in that line at whatever you will pay me.”

He accepted an offer from General Electric’s Research Laboratory in Schenectady, New York, where he worked in fundamental nuclear research building cosmic ray detectors, while also pursuing his master’s degree at Union College. “I had a ball,” he recalled. “I stayed in the lab 12 hours a day. They had to kick me out at night.”

Brookhaven

After earning his PhD from Purdue University in 1954, he spent a year as a lecturer there, before becoming a researcher at Brookhaven National Laboratory (BNL) with Maurice Goldhaber’s nuclear physics group, probing the properties of the nuclei of atoms.

In 1957, he, with Goldhaber and Andy Sunyar, used a simple table-top experiment to measure the helicity of the neutrino. Helicity characterizes the alignment of a particle’s intrinsic spin vector with that particle’s direction of motion. 

The research provided new support for the idea that the principle of conservation of parity — which had been accepted for 30 years as a basic law of nature before being disproven the year before, leading to the 1957 Nobel Prize in Physics — was not as inviolable as the scientists thought it was, and did not apply to the behavior of some subatomic particles.

The experiment took about 10 days to complete, followed by a month of checks and rechecks. They submitted a letter on “Helicity of Neutrinos” to Physical Review on Dec. 11, 1957, and a week later, Goldhaber told a Stanford University audience that the neutrino is left-handed, meaning that the weak interaction was probably one force. This work proved crucial to our understanding of the weak interaction, the force that governs nuclear beta decay.

“It was a real upheaval in our understanding of physics,” says Grodzins’ longtime colleague Stephen Steadman. The breakthrough was commemorated in 2008, with a conference at BNL on “Neutrino Helicity at 50.” 

Steadman also recalls Grodzins’ story about one night at Brookhaven, where he was working on an experiment that involved a radioactive source inside a chamber. Lee noticed that a vacuum pump wasn’t working, so he tinkered with it a while before heading home. Later that night, he gets a call from the lab. “They said, ‘Don't go anywhere!’” recalls Steadman. It turns out the radiation source in the lab had exploded, and the pump filled the lab with radiation. “They were actually able to trace his radioactive footprints from the lab to his home,” says Steadman. “He kind of shrugged it off.”

The MIT years       

Grodzins joined the faculty of MIT in 1959, where he taught physics for four decades. He inherited Robley Evans’ Radiation Laboratory, which used radioactive sources to study properties of nuclei, and led the Relativistic Heavy Ion Group, which was affiliated with the LNS.

In 1972, he launched a program at BNL using the then-new Tandem Van de Graaff accelerator to study interactions of heavy ions with nuclei. “As the BNL tandem was getting commissioned, we started a program, together with Doug Cline at the University of Rochester, tandem to investigate Coulomb-nuclear interference,” says Steadman, a senior research scientist at LNS. “The experimental results were decisive but somewhat controversial at the time. We clearly detected the interference effect.” The experimental work was published in Physical Review Letters.

Grodzins’ team looked for super-heavy elements using the Lawrence Berkeley National Laboratory Super-Hilac, investigated heavy-ion fission and other heavy-ion reactions, and explored heavy-ion transfer reactions. The latter research showed with precise detail the underlying statistical behavior of the transfer of nucleons between the heavy-ion projectile and target, using a theoretical statistical model of Surprisal Analysis developed by Rafi Levine and his graduate student. Recalls Steadman, “these results were both outstanding in their precision and initially controversial in interpretation.”

In 1985, he carried out the first computer axial tomographic experiment using synchrotron radiation, and in 1987, his group was involved in the first run of Experiment 802, a collaborative experiment with about 50 scientists from around the world that studied relativistic heavy ion collisions at Brookhaven. The MIT responsibility was to build the drift chambers and design the bending magnet for the experiment.

“He made significant contributions to the initial design and construction phases, where his broad expertise and knowledge of small area companies with unique capabilities was invaluable,” says George Stephans, physics senior lecturer and senior research scientist at MIT.

Professor emeritus of physics Rainer Weiss ’55, PhD ’62 recalls working on a Mossbauer experiment to establish if photons changed frequency as they traveled through bright regions. “It was an idea held by some to explain the ‘apparent’ red shift with distance in our universe,” says Weiss. “We became great friends in the process, and of course, amateur cosmologists.”

“Lee was great for developing good ideas,” Steadman says. “He would get started on one idea, but then get distracted with another great idea. So, it was essential that the team would carry these experiments to their conclusion: they would get the papers published.”

MIT mentor

Before retiring in 1999, Lee supervised 21 doctoral dissertations and was an early proponent of women graduate students in physics. He also oversaw the undergraduate thesis of Sidney Altman, who decades later won the Nobel Prize in Chemistry. For many years, he helped teach the Junior Lab required of all undergraduate physics majors. He got his favorite student evaluation, however, for a different course, billed as offering a “superficial overview” of nuclear physics. The comment read: “This physics course was not superficial enough for me.”

“He really liked to work with students,” says Steadman. “They could always go into his office anytime. He was a very supportive mentor.”

“He was a wonderful mentor, avuncular and supportive of all of us,” agrees Karl van Bibber ’72, PhD ’76, now at the University of California at Berkeley. He recalls handing his first paper to Grodzins for comments. “I was sitting at my desk expecting a pat on the head. Quite to the contrary, he scowled, threw the manuscript on my desk and scolded, ‘Don't even pick up a pencil again until you've read a Hemingway novel!’ … The next version of the paper had an average sentence length of about six words; we submitted it, and it was immediately accepted by Physical Review Letters.”

Van Bibber has since taught the “Grodzins Method” in his graduate seminars on professional orientation for scientists and engineers, including passing around a few anthologies of Hemingway short stories. “I gave a copy of one of the dog-eared anthologies to Lee at his 90th birthday lecture, which elicited tears of laughter.”

Early in George Stephans’ MIT career as a research scientist, he worked with Grodzins’ newly formed Relativistic Heavy Ion Group. “Despite his wide range of interests, he paid close attention to what was going on and was always very supportive of us, especially the students. He was a very encouraging and helpful mentor to me, as well as being always pleasant and engaging to work with. He actively pushed to get me promoted to principal research scientist relatively early, in recognition of my contributions.”

“He always seemed to know a lot about everything, but never acted condescending,” says Stephans. “He seemed happiest when he was deeply engaged digging into the nitty-gritty details of whatever unique and unusual work one of these companies was doing for us.”

Al Lazzarini ’74, PhD ’78 recalls Grodzins’ investigations using proton-induced X-ray emission (PIXE) as a sensitive tool to measure trace elemental amounts. “Lee was a superb physicist,” says Lazzarini. “He gave an enthralling seminar on an investigation he had carried out on a lock of Napoleon’s hair, looking for evidence of arsenic poisoning.”

Robert Ledoux ’78, PhD ’81, a former professor of physics at MIT who is now program director of the U.S. Advanced Research Projects Agency with the Department of Energy, worked with Grodzins as both a student and colleague. “He was a ‘nuclear physicist’s physicist’ — a superb experimentalist who truly loved building and performing experiments in many areas of nuclear physics. His passion for discovery was matched only by his generosity in sharing knowledge.”

The research funding crisis starting in 1969 led Grodzins to become concerned that his graduate students would not find careers in the field. He helped form the Economic Concerns Committee of the American Physical Society, for which he produced a major report on the “Manpower Crisis in Physics” (1971), and presented his results before the American Association for the Advancement of Science, and at the Karlsruhe National Lab in Germany.   

Grodzins played a significant role in bringing the first Chinese graduate students to MIT in the 1970s and 1980s.

One of the students he welcomed was Huan Huang PhD ’90. “I am forever grateful to him for changing my trajectory,” says Huang, now at the University of California at Los Angeles. “His unwavering support and ‘go do it’ attitude inspired us to explore physics at the beginning of a new research field of high energy heavy ion collisions in the 1980s. I have been trying to be a ‘nice professor’ like Lee all my academic career.”

Even after he left MIT, Grodzins remained available for his former students. “Many tell me how much my lifestyle has influenced them, which is gratifying,” Huang says. “They’ve been a central part of my life. My biography would be grossly incomplete without them.”

Niton Corp. and post-MIT work

Grodzins liked what he called “tabletop experiments,” like the one used in his 1957 neutrino experiment, which involved a few people building a device that could fit on a tabletop. “He didn’t enjoy working in large collaborations, which nuclear physics embraced.” says Steadman. “I think that’s why he ultimately left MIT.”

In the 1980s, he launched what amounted to a new career in detection technology. In 1987, after developing a scanning proton-induced X-ray microspectrometer for use measuring elemental concentrations in air, he founded the Niton Corp., which developed, manufactured, and marketed test kits and instruments to measure radon gas in buildings, lead-based paint detection, and other nondestructive testing applications. (“Niton” is an obsolete term for radon.)

“At the time, there was a big scare about radon in New England, and he thought he could develop a radon detector that was inexpensive and easy to use,” says Steadman. “His radon detector became a big business.”

He later developed devices to detect explosives, drugs, and other contraband in luggage and cargo containers. Handheld devices used X-ray fluorescence to determine the composition of metal alloys and to detect other materials. The handheld XL Spectrum Analyzer could detect buried and surface lead on painted surfaces, to protect children living in older homes. Three Niton X-ray fluorescence analyzers earned R&D 100 awards.

“Lee was very technically gifted,” says Steadman.

In 1999, Grodzins retired from MIT and devoted his energies to industry, including directing the R&D group at Niton.

His sister Ethel Grodzins Romm was the president and CEO of Niton, followed by his son Hal. Many of Niton’s employees were MIT graduates. In 2005, he and his family sold Niton to Thermo Fisher Scientific, where Lee remained as a principal scientist until 2010.

In the 1990s, he was vice president of American Science and Engineering, and between the ages of 70 and 90, he was awarded three patents a year. 

“Curiosity and creativity don’t stop after a certain age,” Grodzins said to UNH Today. “You decide you know certain things, and you don’t want to change that thinking. But thinking outside the box really means thinking outside your box.”

“I miss his enthusiasm,” says Steadman. “I saw him about a couple of years ago and he was still on the move, always ready to launch a new effort, and he was always trying to pull you into those efforts.”

A better world

In the 1950s, Grodzins and other Brookhaven scientists joined the American delegation at the Second United Nations International Conference on the Peaceful Uses of Atomic Energy in Geneva.

Early on, he joined several Manhattan Project alums at MIT in their concern about the consequences of nuclear bombs. In Vietnam-era 1969, Grodzins co-founded the Union of Concerned Scientists, which calls for scientific research to be directed away from military technologies and toward solving pressing environmental and social problems. He served as its chair in 1970 and 1972. He also chaired committees for the American Physical Society and the National Research Council.

As vice president for advanced products at American Science and Engineering, which made homeland security equipment, he became a consultant on airport security, especially following the 9/11 attacks. As an expert witness, he testified at the celebrated trial to determine whether Pan Am was negligent for the bombing of Flight 103 over Lockerbie, Scotland, and he took part in a weapons inspection trip on the Black Sea. He also was frequently called as an expert witness on patent cases.

In 1999, Grodzins founded the nonprofit Cornerstones in Science, a public library initiative to improve public engagement with science. Based originally at the Curtis Memorial Library in Brunswick, Maine, Cornerstones now partners with libraries in Maine, Arizona, Texas, Massachusetts, North Carolina, and California. Among their initiatives was one that has helped supply telescopes to libraries and astronomy clubs around the country.

“He had a strong sense of wanting to do good for mankind,” says Steadman.

Awards

Grodzins authored more than 170 technical papers and holds more than 60 U.S. patents. His numerous accolades included being named a Guggenheim Fellow in 1964 and 1971, and a senior von Humboldt fellow in 1980. He was a fellow of the American Physical Society and the American Academy of Arts and Sciences, and received an honorary doctor of science degree from Purdue University in 1998.

In 2021, the Denver X-Ray Conference gave Grodzins the Birks Award in X-Florescence Spectrometry, for having introduced “a handheld XRF unit which expanded analysis to in-field applications such as environmental studies, archeological exploration, mining, and more.”

Personal life

One evening in 1955, shortly after starting his work at Brookhaven, Grodzins decided to take a walk and explore the BNL campus. He found just one building that had lights on and was open, so he went in. Inside, a group was rehearsing a play. He was immediately smitten with one of the actors, Lulu Anderson, a young biologist. “I joined the acting company, and a year-and-a-half later, Lulu and I were married,” Grodzins had recalled. They were happily married for 62 years, until Lulu’s death in 2019.

They raised two sons, Dean, now of Cambridge, Massachusetts, and Hal Grodzins, who lives in Maitland, Florida. Lee and Lulu owned a succession of beloved huskies, most of them named after physicists.

After living in Arlington, Massachusetts, the Grodzins family moved to Lexington, Massachusetts, in 1972 and bought a second home a few years later in Brunswick, Maine. Starting around 1990, Lee and Lulu spent every weekend, year-round, in Brunswick. In both places, they were avid supporters of their local libraries, museums, theaters, symphonies, botanical gardens, public radio, and TV stations.

Grodzins took his family along to conferences, fellowships, and other invitations. They all lived in Denmark for two sabbaticals, in 1964-65 and 1971-72, while Lee worked at the Neils Bohr Institute. They also traveled together to China for a month in 1975, and for two months in 1980. As part of the latter trip, they were among the first American visitors to Tibet since the 1940s. Lee and Lulu also traveled the world, from Antarctica to the Galapagos Islands to Greece.

His homes had basement workshops well-stocked with tools. His sons enjoyed a playroom he built for them in their Arlington home. He also once constructed his own high-fidelity record player, patched his old Volvo with fiberglass, changed his own oil, and put on the winter tires and chains himself. He was an early adopter of the home computer.

“His work in science and technology was part of a general love of gadgets and of fixing and making things,” his son, Dean, wrote in a Facebook post.

Lee is survived by Dean, his wife, Nora Nykiel Grodzins, and their daughter, Lily; and by Hal and his wife Cathy Salmons. 

A remembrance and celebration for Lee Grodzins is planned for this summer. Donations in his name may be made to Cornerstones of Science.

To help find solutions to the planet’s climate crisis, MIT Associate Professor Daniel Suess is looking to Earth’s ancient past.

Early in the evolution of life, cells gained the ability to perform reactions such as transferring electrons from one atom to another. These reactions, which help cells to build carbon-containing or nitrogen-containing compounds, rely on specialized enzymes with clusters of metal atoms.

By learning more about how those enzymes work, Suess hopes to eventually devise new ways to perform fundamental chemical reactions that could help capture carbon from the atmosphere or enable the development of alternative fuels.

“We have to find some way of rewiring society so that we are not just relying on vast reserves of reduced carbon, fossil fuels, and burning them using oxygen,” he says. “What we’re doing is we’re looking backward, up to a billion years before oxygen and photosynthesis came along, to see if we can identify the chemical principles that underlie processes that aren’t reliant on burning carbon.”

His work could also shed light on other important cellular reactions such as the conversion of nitrogen gas to ammonia, which is also the key step in the production of synthetic fertilizer.

Exploring chemistry

Suess, who grew up in Spokane, Washington, became interested in math at a young age, but ended up majoring in chemistry and English at Williams College, which he chose based on its appealing selection of courses.

“I was interested in schools that were more focused on the liberal arts model, Williams being one of those. And I just thought they had the right combination of really interesting courses and freedom to take classes that you wanted,” he says. “I went in not expecting to major in chemistry, but then I really enjoyed my chemistry classes and chemistry teachers.”

In his classes, he explored all aspects of chemistry and found them all appealing.

“I liked organic chemistry, because there’s an emphasis on making things. And I liked physical chemistry because there was an attempt to have at least a semiquantitative way of understanding the world. Physical chemistry describes some of the most important developments in science in the 20th century, including quantum mechanics and its application to atoms and molecules,” he says.

After college, Suess came to MIT for graduate school and began working with chemistry professor Jonas Peters, who had recently arrived from Caltech. A couple of years later, Peters ended up moving back to Caltech, and Suess followed, continuing his PhD thesis research on new ways to synthesize inorganic molecules.

His project focused on molecules that consist of a metal such as iron or cobalt bound to a nonmetallic group known as a ligand. Within these molecules, the metal atom typically pulls in electrons from the ligand. However, the molecules Suess worked on were designed so that the metal would give up its own electrons to the ligand. Such molecules can be used to speed up difficult reactions that require breaking very strong bonds, like the nitrogen-nitrogen triple bond in N2.

During a postdoc at the University of California at Davis, Suess switched gears and began working on biomolecules — specifically, metalloproteins. These are protein enzymes that have metals tucked into their active sites, where they help to catalyze reactions.

Suess studied how cells synthesize the metal-containing active sites in these proteins, focusing on an enzyme called iron-iron hydrogenase. This enzyme, found mainly in anaerobic bacteria, including some that live in the human digestive tract, catalyzes reactions involving the transfer of protons and electrons. Specifically, it can combine two protons and two electrons to make H2, or can perform the reverse reaction, breaking H2 into protons and electrons.

“That enzyme is really important because a lot of cellular metabolic processes either generate excess electrons or require excess electrons. If you generate excess electrons, they have to go somewhere, and one solution is to put them on protons to make H2,” Suess says.

Global scale reactions

Since joining the MIT faculty in 2017, Suess has continued his investigations of metalloproteins and the reactions that they catalyze.

“We’re interested in global-scale chemical reactions, meaning they’re occurring on the microscopic scale but happening on a huge scale,” he says. “They impact the planet and have determined what the molecular composition of the biosphere is and what it’s going to be.”

Photosynthesis, which emerged around 2.4 billion years ago, has had the biggest impact on the atmosphere, filling it with oxygen, but Suess focuses on reactions that cells began using even earlier, when the atmosphere lacked oxygen and cell metabolism could not be driven by respiration.

Many of these ancient reactions, which are still used by cells today, involve a class of metalloproteins called iron-sulfur proteins. These enzymes, which are found in all kingdoms of life, are involved in catalyzing many of the most difficult reactions that occur in cells, such as forming carbon radicals and converting nitrogen to ammonia.

To study the metalloenzymes that catalyze these reactions, Suess’s lab takes two different approaches. In one, they create synthetic versions of the proteins that may contain fewer metal atoms, which allows for greater control over the composition and shape of the protein, making them easier to study.

In another approach, they use the natural version of the protein but substitute one of the metal atoms with an isotope that makes it easier to use spectroscopic techniques to analyze the protein’s structure.

“That allows us to study both the bonding in the resting state of an enzyme, as well as the bonding and structures of reaction intermediates that you can only characterize spectroscopically,” Suess says.

Understanding how enzymes perform these reactions could help researchers find new ways to remove carbon dioxide from the atmosphere by combining it with other molecules to create larger compounds. Finding alternative ways to convert nitrogen gas to ammonia could also have a big impact on greenhouse gas emissions, as the Haber Bosch process now used to synthesize fertilizer produces requires huge amounts of energy.

“Our primary focus is on understanding the natural world, but I think that as we’re looking at different ways to wire biological catalysts to do efficient reactions that impact society, we need to know how that wiring works. And so that is what we’re trying to figure out,” he says.

As director of the MIT BioMicro Center (BMC), Stuart Levine ’97 wholeheartedly embraces the variety of challenges he tackles each day. One of over 50 core facilities providing shared resources across the Institute, the BMC supplies integrated high-throughput genomics, single-cell and spatial transcriptomic analysis, bioinformatics support, and data management to researchers across MIT.

“Every day is a different day,” Levine says, “there are always new problems, new challenges, and the technology is continuing to move at an incredible pace.” After more than 15 years in the role, Levine is grateful that the breadth of his work allows him to seek solutions for so many scientific problems.

By combining bioinformatics expertise with biotech relationships and a focus on maximizing the impact of the center’s work, Levine brings the broad range of skills required to match the diversity of questions asked by researchers in MIT’s Department of Biology.

Expansive expertise

Biology first appealed to Levine as an MIT undergraduate taking class 7.012 (Introduction to Biology), thanks to the charisma of instructors Professor Eric Lander and Amgen Professor Emerita Nancy Hopkins. After earning his PhD in biochemistry from Harvard University and Massachusetts General Hospital, Levine returned to MIT for postdoctoral work with Professor Richard Young, core member at the Whitehead Institute for Biomedical Research.

In the Young Lab, Levine found his calling as an informaticist and ultimately decided to stay at MIT. Here, his work has a wide-ranging impact: the BMC serves over 100 labs annually, from the the Computer Science and Artificial Intelligence Laboratory and the departments of Brain and Cognitive Sciences; Earth, Atmospheric and Planetary Sciences; Chemical Engineering; Mechanical Engineering; and, of course, Biology.

“It’s a fun way to think about science,” Levine says, noting that he applies his knowledge and streamlines workflows across these many disciplines by “truly and deeply understanding the instrumentation complexities.”

This depth of understanding and experience allows Levine to lead what longtime colleague Professor Laurie Boyer describes as “a state-of-the-art core that has served so many faculty and provides key training opportunities for all.” He and his team work with cutting-edge, finely tuned scientific instruments that generate vast amounts of bioinformatics data, then use powerful computational tools to store, organize, and visualize the data collected, contributing to research on topics ranging from host-parasite interactions to proposed tools for NASA’s planetary protection policy.

Staying ahead of the curve

With a scientist directing the core, the BMC aims to enable researchers to “take the best advantage of systems biology methods,” says Levine. These methods use advanced research technologies to do things like prepare large sets of DNA and RNA for sequencing, read DNA and RNA sequences from single cells, and localize gene expression to specific tissues.

Levine presents a lightweight, clear rectangle about the width of a cell phone and the length of a VHS cassette.

“This is a flow cell that can do 20 human genomes to clinical significance in two days — 8 billion reads,” he says. “There are newer instruments with several times that capacity available as well.”

The vast majority of research labs do not need that kind of power, but the Institute, and its researchers as a whole, certainly do. Levine emphasizes that “the ROI [return on investment] for supporting shared resources is extremely high because whatever support we receive impacts not just one lab, but all of the labs we support. Keeping MIT’s shared resources at the bleeding edge of science is critical to our ability to make a difference in the world.”

To stay at the edge of research technology, Levine maintains company relationships, while his scientific understanding allows him to educate researchers on what is possible in the space of modern systems biology. Altogether, these attributes enable Levine to help his researcher clients “push the limits of what is achievable.”

The man behind the machines

Each core facility operates like a small business, offering specialized services to a diverse client base across academic and industry research, according to Amy Keating, Jay A. Stein (1968) Professor of Biology and head of the Department of Biology. She explains that “the PhD-level education and scientific and technological expertise of MIT’s core directors are critical to the success of life science research at MIT and beyond.” 

While Levine clearly has the education and expertise, the success of the BMC “business” is also in part due to his tenacity and focus on results for the core’s users.

He was recognized by the Institute with the MIT Infinite Mile Award in 2015 and the MIT Excellence Award in 2017, for which one nominator wrote, “What makes Stuart’s leadership of the BMC truly invaluable to the MIT community is his unwavering dedication to producing high-quality data and his steadfast persistence in tackling any type of troubleshooting needed for a project. These attributes, fostered by Stuart, permeate the entire culture of the BMC.”      

“He puts researchers and their research first, whether providing education, technical services, general tech support, or networking to collaborators outside of MIT,” says Noelani Kamelamela, lab manager of the BMC. “It’s all in service to users and their projects.”

Tucked into the far back corner of the BMC lab space, Levine’s office is a fitting symbol of his humility. While his guidance and knowledge sit at the center of what elevates the BMC beyond technical support, he himself sits away from the spotlight, resolutely supporting others to advance science.

“Stuart has always been the person, often behind the scenes, that pushes great science, ideas, and people forward,” Boyer says. “His knowledge and advice have truly allowed us to be at the leading edge in our work.”

Wildfires set acres ablaze. Earthquakes decimate towns into rubble. People go missing in mountains and bodies of water. Coronavirus cases surge globally.

When disaster strikes, timely, cohesive emergency response is crucial to saving lives, reducing property and resource loss, and protecting the environment. Large-scale incidents can call into action thousands of first responders from multiple jurisdictions and agencies, national and international. To effectively manage response, relief, and recovery efforts, they must work together to collect, process, and distribute accurate information from disparate systems. This lack of interoperability can hinder coordination and ultimately result in significant failures in disaster response.

MIT Lincoln Laboratory developed the Next-Generation Incident Command System (NICS) to enable first responders across different jurisdictions, agencies, and countries to effectively coordinate during emergencies of any scale. Originally intended to help U.S. firefighters respond to wildfires, NICS has since evolved from an R&D prototype into an open-source operational platform adopted by emergency-response agencies worldwide, not only for natural disaster response but also search-and-rescue operations, health crises management, public event security, and aviation safety. The global community of users cultivated by NICS, and spinouts inspired by NICS, have maximized its impact.

At the core of the web-based NICS software tool is an incident map overlaying aggregated data from various external and internal sources such as first responders on the ground, airborne imaging sensors, weather and traffic reports, census data, and satellite-based maps; virtually any data source can be added. Emergency personnel upload the content directly on a computer or mobile app and communicate in real time through voice and chat functions. Role-based collaboration rooms are available for user-defined subsets of first responders to focus on a particular activity — such as air drop support, search and rescue, and wildlife rescue — while maintaining access to the comprehensive operational picture.

With its open-standards architecture, NICS interoperates with organizations' existing systems and allows internal data to be shared externally for enhanced visibility and awareness among users as a disaster unfolds. The modular design of NICS facilitates system customization for diverse user needs and changing mission requirements. The system archives all aspects of a created incident and can generate reports for post-incident analysis to inform future response planning. 

Partnering with first responders

As a federally funded research and development (R&D) center, Lincoln Laboratory has a long history of conducting R&D of architectures for information sharing, situational awareness, and decision-making in support of the U.S. Department of Defense and other federal entities. Recognizing that aspects of these architectures are relevant to disaster response, Lincoln Laboratory's Technology Office initiated in 2007 a study focused on wildfire response in California. A laboratory-led research team partnered with the California Department of Forestry and Fire Protection (CAL FIRE), which annually responds to thousands of wildfires in collaboration with police, medical, and other services.

"CAL FIRE provided firsthand insight into what information is critical during emergency response and how may be best to view and share this information," says NICS co-developer Gregory Hogan, now associate leader of the laboratory's Advanced Sensors and Techniques Group.

With this insight, the laboratory developed and demonstrated a prototype of NICS. Noting the utility of such a system, the U.S. Department of Homeland Security (DHS) Science and Technology Directorate (S&T) began funding the R&D of NICS in 2010. Over the next several years, the laboratory team refined NICS, soliciting input from an organically formed users' group comprising more than 450 organizations across fire, law, medical, emergency services and management, border patrol, industry, utilities, nongovernmental organizations, and tribal partners. Thousands of training exercises and real emergencies employed NICS to coordinate diverse emergency-response activities spanning disaster management, law enforcement, and special security.

In 2014, CAL FIRE — which had been using NICS to respond to wildfires, mudslides and floods — officially adopted NICS statewide. That same year, the Emergency Management Directorate of Victoria, Australia's largest state, implemented NICS (as the Victorian Information Network for Emergencies, or VINE) after a worldwide search for a system to manage large-scale crises like bush fires.

In 2015, NICS was transferred to the California Office of Emergency Services. The California Governor's Office of Emergency Services deployed NICS as the Situation Awareness and Collaboration Tool (SCOUT) for emergency responders and law enforcement officials statewide in 2016.

Creating an open-source community

NICS also spawned an initial spinout company formed by personnel from CAL FIRE, the Worldwide Incident Command Services (WICS), which received a license for the system's software code in early 2015. WICS is a California-incorporated nonprofit public benefit corporation and the official DHS S&T Technology Transition Partner created to transition the NICS R&D project to a robust operational platform, which was named Raven. Later that year, DHS S&T made NICS available worldwide at no cost to first responder and emergency management agencies through an open-source release of the software code base on Github.

Sponsorship of NICS by DHS S&T is ongoing, with contributions over the years from the U.S. Coast Guard (USCG) Research and Development Center and the NATO Science for Peace and Security (SPS) Program. In 2015, the USCG funded the development of the cross-platform mobile app Portable Handset Integrated NICS (PHINICS), which enables first responders to access NICS with or without cellular coverage.

In 2016, Lincoln Laboratory and DHS S&T launched a four-year partnership with the NATO SPS Program to extend NICS to Bosnia and Herzegovina (BiH), Croatia, North Macedonia, and Montenegro for enhanced emergency collaboration among and within these Western Balkan nations. Under this Advanced Regional Civil Emergency Coordination Pilot, NICS was demonstrated in dozens of field exercises and applied to real-life incidents, including wildfires in BiH and a 6.2-magnitude earthquake in Croatia. In 2019, North Macedonia adopted NICS as its official crisis management system. And, when Covid-19 struck, NICS entered a new application space: public health. In North Macedonia, emergency institutions used NICS to not only coordinate emergency response, but also inform residents about infection cases and health resource locations. The laboratory team worked with North Macedonia's Crisis Management Center to enable national public access to NICS. 

Increasing global impact

NICS' reach continues to grow. In 2021, the Massachusetts Department of Transportation Aeronautics Division and the U.S. Department of Transportation Volpe National Transportation Systems Center collaborated with Lincoln Laboratory using the baseline NICS system to field a new web-based tool: the Commonwealth aiRspace and Information Sharing Platform (CRISP). Integrating sensor feeds, airspace information, and resource data, CRISP enables a robust counter–small uncrewed aircraft systems mission for the safety and security of aviation and aviation-related activities throughout the Commonwealth of Massachusetts.

"The NICS project has demonstrated the power of collaborative development, in which each partner lends their expertise, resulting in a meaningful contribution to the global disaster response community," says Stephanie Foster, who was the lead developer and program manager of NICS.

In 2023, Foster co-founded the spinout company Generation NYX to increase access to NICS, renamed NYX DEFENDER, and create a community of users who work together to advance its capabilities. Generation NYX offers services to existing users established during the laboratory's R&D work, and provides a software-as-a-service solution for all new users. NYX DEFENDER improves the ability of local emergency management organizations to manage events such as parades and festivals; supports decision-making during floods and other natural disasters; and expands awareness among community stakeholders such as police, fire, and state officials. 

"NYX DEFENDER offers an innovative tool for local emergency management and public safety agencies and departments to create a common operating picture and foster interoperability, improve communications, and develop and maintain situational awareness during preplanned and no-notice events," says Clara Decerbo, director at the Providence Emergency Management Agency. "Our use of NYX DEFENDER during major City of Providence events has allowed us to integrate situational awareness between multiple public safety entities, private security, and event organizers and assisted us in ensuring our teams have the information they need to provide well-organized and coordinated public safety services to members of our community and visitors."

Generation NYX was recently subcontracted to provide support for a new three-year project that NATO SPS and DHS S&T kicked off earlier this year with the laboratory to establish NICS as the national disaster management platform in BiH. Foster has experience in this area, as she not only led the laboratory technical team who successfully adapted and deployed NICS in the Western Balkans under the 2016 SPS pilot, but also coordinated teams across the four nations. Though BiH participated in the 2016 SPS pilot, this latest effort seeks to expand NICS' adoption more broadly across the country, working within its complex multilevel government structure. NATO SPS is funding a second project, which began in October 2024, that will bring NICS to Albania and Georgia for use in search and rescue, particularly in response to chemical, biological, radiological, and nuclear events. For both projects, the laboratory team will enhance the open-source NICS code to operate on the edge (i.e., in disconnected communication scenarios) and integrate wearables for monitoring the health of first responders.

Since NICS was released open source on Github, NICS' worldwide usage has continued to grow for a wide range of applications. NICS has been used to locate missing persons in the Miljacka and Bosna Rivers in BiH; to direct ambulances to hypothermic runners at the Los Angeles Marathon; and to provide situational awareness among the National Guard for the Fourth of July celebration in Boston, Massachusetts. NICS has also proven its utility in mine and unexploded ordnance detection and clearance activities; in BiH, an estimated 80,000 explosive remnants of war pose a direct threat to the country's residents. Envisioned applications of NICS include monitoring of critical infrastructure such as utilities.

In recognition of its broader humanitarian impact, NICS was awarded a 2018 Excellence in Technology Transfer Award, Northeast Region, from the Federal Laboratory Consortium and a 2019 IEEE Innovation in Societal Infrastructure Award.

"NICS is a mature product, so what we are thinking about now is outside-the-box use cases for the technology," says the laboratory's Bioanalytics Systems and Technologies Group Leader Kajal Claypool, who is supervising the ongoing NATO SPS and DHS S&T projects. "That is where I see Lincoln Laboratory can bring innovation to bear."

A hospital that wants to use a cloud computing service to perform artificial intelligence data analysis on sensitive patient records needs a guarantee those data will remain private during computation. Homomorphic encryption is a special type of security scheme that can provide this assurance.

The technique encrypts data in a way that anyone can perform computations without decrypting the data, preventing others from learning anything about underlying patient records. However, there are only a few ways to achieve homomorphic encryption, and they are so computationally intensive that it is often infeasible to deploy them in the real world.

MIT researchers have developed a new theoretical approach to building homomorphic encryption schemes that is simple and relies on computationally lightweight cryptographic tools. Their technique combines two tools so they become more powerful than either would be on its own. The researchers leverage this to construct a “somewhat homomorphic” encryption scheme — that is, it enables users to perform a limited number of operations on encrypted data without decrypting it, as opposed to fully homomorphic encryption that can allow more complex computations.

This somewhat homomorphic technique can capture many applications, such as private database lookups and private statistical analysis.

While this scheme is still theoretical, and much work remains before it could be used in practice, its simpler mathematical structure could make it efficient enough to protect user data in a wider range of real-world scenarios.

“The dream is that you type your ChatGPT prompt, encrypt it, send the encrypted message to ChatGPT, and then it can produce outputs for you without ever seeing what you are asking it,” says Henry Corrigan-Gibbs, the Douglas Ross Career Development Professor of Software Technology in the MIT Department of Electrical Engineering and Computer Science (EECS) and a co-author of a paper on this security scheme. “We are a long way from getting there, in part because these schemes are so inefficient. In this work, we wanted to try to build homomorphic encryption schemes that don’t use the standard tools, since different approaches can often lead to more efficient, more practical constructions.”

His co-authors include Alexandra Henzinger, an EECS graduate student; Yael Kalai, an Ellen Swallow Richards (1873) Professor and professor of EECS; and Vinod Vaikuntanathan, the Ford Professor of Engineering and a principal investigator in the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL). The research will be presented at the International Conference on the Theory and Applications of Cryptographic Techniques.

Balancing security and flexibility

MIT researchers began theorizing about homomorphic encryption in the 1970s. But designing the mathematical structure needed to securely embed a message in a manner flexible enough to enable computation proved to be enormously challenging. The first homomorphic encryption scheme wasn’t designed until 2009.

“These two requirements are very much in tension. On the one hand, we need security, but on the other hand, we need this flexibility in the homomorphism. We have very few mathematical pathways to get there,” says Henzinger.

Essentially, homomorphic schemes add noise to a message to encrypt it. As algorithms and machine-learning models perform operations on that encrypted message, the noise inevitably grows. If one computes for too long, the noise can eventually overshadow the message.

“If you run a deep neural network on these encrypted data, for instance, by the time you get to the end of the computation, the noise might be a billion times larger than the message and you can’t actually figure out what the message says,” Corrigan-Gibbs explains.

There are two main ways to get around this problem. A user could keep operations to a minimum, but this restricts how the encrypted data can be used. On the other hand, a user could add extra steps to reduce noise, but these techniques require a massive amount of additional computation.

Somewhat homomorphic encryption seeks to meet users somewhere in the middle. They can use the technique to perform secure operations on encrypted data using a specific class of functions that keep the noise from growing out of hand.

These functions, known as bounded polynomials, are designed to prevent excessively complex operations. For instance, the functions allow many additions, but only a few multiplications on encrypted data to avoid generating too much extra noise.

Greater than the sum of their parts

The researchers built their scheme by combining two simple cryptographic tools. They started with a linear homomorphic encryption scheme, which can only perform additions on encrypted data, and added one theoretical assumption to it.

This cryptographic assumption “lifts” the linear scheme into a somewhat homomorphic one that can operate with a broader class of more complex functions.

“On its own, this assumption doesn’t give us much. But when we put them together, we get something much more powerful. Now, we can do additions and some bounded number of multiplications,” Henzinger says.

The process for performing homomorphic encryptions is quite simple. The researchers’ scheme encrypts each piece of data into a matrix in a way that the matrix provably hides the underlying data. Then, to perform additions or multiplications on those encrypted data, one only needs to add or multiply the corresponding matrices.

The researchers used mathematical proofs to show that their theoretical encryption scheme provides guaranteed security when operations are limited to this class of bounded polynomial functions.

Now that they have developed this theoretical approach, one next step will be making it practical for real-world applications. For that, they will need to make the encryption scheme fast enough to run certain types of computations on modern hardware.

“We haven’t spent 10 years trying to optimize this scheme yet, so we don’t know how efficient it could get,” Henzinger says.

In addition, the researchers hope to expand their technique to allow more complex operations, perhaps moving closer to developing a new approach for fully homomorphic encryption.

“The exciting thing for us is that, when we put these two simple things together, something different happened that we didn’t expect. It gives us hope. What else can we do now? If we add something else, maybe we can do something even more exciting,” Corrigan-Gibbs says.

This research was funded, in part, by Apple, Capital One, Facebook, Google, Mozilla, NASDAQ, MIT’s FinTech@CSAIL Initiative, the National Science Foundation (NSF), and a Simons Investigator Award.

David Schmittlein, an MIT professor of marketing and the MIT Sloan School of Management’s longest-serving dean and a visionary and transformational leader, died March 13, following a long illness. He was 69.

Schmittlein, the John C Head III Dean from 2007 to 2024, guided MIT Sloan through a financial crisis, a global pandemic, and numerous school-wide milestones. During those 17 years, Schmittlein led initiatives introducing several new degree programs, redesigning the academic program portfolio while maintaining the MBA as the flagship degree, and diversifying executive offerings. Under his guidance, the school enhanced alumni engagement, increased philanthropic support, expanded the faculty, oversaw numerous campus capital projects, and opened several international programs. He also championed a centennial celebration of Course 15 — MIT’s designation for management — and led a branding and marketing effort that cemented MIT Sloan’s reputation as a place for smart, open, grounded, and inventive leaders.

In all, he brought MIT Sloan’s value to managers, organizations, and the world into clear focus, positioning and preparing the school to lead in a new era of management education.

“Dave transformed the MIT Sloan School of Management from a niche player to a top five business school and, in the process, drew us closer to the Institute in ways that all of the faculty, staff, and students welcome and support,” says MIT professor of finance Andrew W. Lo. “He greatly expanded our visibility internationally [and] also expanded our footprint from a research and educational and outreach perspective. Really, it gave us the opportunity to define ourselves in ways that we weren’t doing prior to his joining.”

In a letter to the MIT community, President Sally Kornbluth wrote, “Dave helped build MIT Sloan’s reputation and impact around the globe, worked with faculty to create first-rate new management education programs, and substantially improved current students’ educational opportunities.”

Kornbluth, who was appointed MIT president in 2023, noted that she didn’t overlap with Schmittlein for very long before he stepped down in February 2024 due to his illness. But during that year, his “wise, funny, judicious counsel left a lasting impression,” Kornbluth wrote. “I knew I could always call on him as a sounding board and thought partner, and I did.”

Professor Georgia Perakis, who was appointed the John C Head III Dean (Interim) when Schmittlein left last year, says, “Dave was not only an incredible leader for MIT Sloan, but also a mentor, teacher, and friend. Under his leadership, he took MIT Sloan to new heights. I will always be grateful for his guidance and support during my time as interim dean. I know the legacy of his contributions to MIT and MIT Sloan will always stay with us.”

Before coming to MIT Sloan, Schmittlein was a professor of marketing and deputy dean at the Wharton School of the University of Pennsylvania, where he spent 27 years. Schmittlein, who grew up in Northampton, Massachusetts, viewed his appointment as the eighth dean of MIT Sloan as a homecoming in 2007.

From modest roots, and the oldest of six siblings, Schmittlein graduated from Brown University, where he earned a BA in mathematics, and Columbia University, where he was awarded both an MPhil in business and a PhD in marketing.

“Growing up in Massachusetts, MIT was always an icon for me,” Schmittlein later wrote.

“MIT picks an outsider to lead Sloan School”

As The Boston Globe headline announcing his arrival made clear, Schmittlein’s appointment as dean was unusual. He was the first to come from outside MIT since the school’s founding dean, E. Pennell Brooks, was appointed. But, in 2007, Institute leadership determined that there was a need for a fresh perspective at MIT Sloan.

“While most of Dean Schmittlein’s MIT predecessors had risen through the MIT faculty ranks, I directed the search committee to search broadly to identify a leader who could amplify the MIT Sloan School’s impact and extend its reach,” says President Emerita Susan Hockfield, who led MIT from 2004 to 2012. “David Schmittlein emerged with his unusual combination of cerebral and collaborative talents, along with his academic experience at the highest level.”

By the time Schmittlein arrived, the MIT Sloan School, which had its origins in 1914 as an undergraduate major called Engineering Administration, was at an exciting crossroads. Schmittlein’s predecessor, Richard Schmalensee, who had served as dean for nearly a decade, had secured donor funding for the construction of a new central building and established a concise mission statement that would guide the school in the coming decades. MIT’s management school was at a point of reflection and growth.

“I acknowledged head-on that I was coming from a very different school — not to change MIT, but to help it be the best version of its distinctive self,” Schmittlein wrote recently.

Schmittlein quickly identified several critical tasks. In 2007, the school had a group of 96 tenure-line faculty members, but they often left for peer schools, and the small faculty size meant that one person’s exit affected an entire department. There was no real mechanism for highlighting MIT Sloan expert faculty insights. The flagship MBA program was successful, but had challenges with selectivity and scale. And the comparatively small class size meant that the alumni community was challenged in networking, particularly in finance.

Financial crisis and MFin degree

Schmittlein collaborated with the school’s finance faculty to launch the Master of Finance degree program in 2008. Nobel laureate Robert C. Merton, who had begun his career at MIT Sloan but had decamped to Harvard University, returned to the school in 2010 to be involved in the one-year program. Today, the MFin program — known for its selectivity and rigor — offers a range of quantitative courses and features an 18-month option in addition to the original one-year curriculum.

Schmittlein’s arrival at MIT coincided with the global financial crisis of 2007–09. “The entire Institute was reeling from the meltdown,” Lo remembers. “We had to respond … and one of the most impressive things Dave did was to acknowledge the problems with the financial crisis and the financial system. But instead of de-emphasizing finance, he encouraged the finance group to do research on the crisis and to come up with a better version of finance that acknowledged these potential dangers.”

In turn, program enrollment increased, and “a number of our students ultimately went off to regulatory positions, as well as to industry, with a new knowledge of how to deal with financial crises more systematically,” Lo says.

Expansion of executive and other degree programs

In 2010, the long-standing full-time MIT Sloan Fellows MBA program attracted mid-career leaders and managers from around the world to MIT Sloan. That year, Schmittlein shepherded the launch of the 20-month part-time MIT Executive MBA program. This program opened up more opportunities for U.S.-based executives to earn a degree without having to leave their jobs for a full-time program.

Next, MIT Sloan launched the Master of Science in Management Studies program, which allowed graduates and current students from several international partner schools, including Fudan University and Tsinghua University in China, to earn a master’s degree from MIT in nine months.

Rounding out the portfolio of academic programs introduced during Schmittlein’s tenure is the MIT Sloan Master of Business Analytics program, launched in 2016. The program, which bridged MIT Sloan’s classes with MIT’s offerings in computer science, became one of the most competitive master’s degree programs at the Institute.

One distinction for MIT Sloan was “its integration with the university within which it lives,” Schmittlein said in a 2008 interview. “We are different from other schools in that regard. Most other leading schools of management wall off their teaching programs and their research programs from the rest of the university. We simply don’t do that.”

“MIT Sloan in 2025 is very much ‘the house that Dave built,’” says Professor Ezra W. Zuckerman Sivan.

“This is nothing short of astonishing, given that Dave came to Sloan from another business school with a distinct mission and culture … What’s more, Sloan was hardly broken — it had several strong deans leading up Dave’s arrival, a sterling reputation, and very proud traditions,” Zuckerman Sivan says.

Zuckerman Sivan, who served as MIT Sloan’s deputy dean and then as an associate dean for teaching and learning from 2015 to 2021, says it was a tremendous privilege to work for Schmittlein, and he notes that Schmittlein often saw potential in others before they saw it in themselves, including him.

“Personally, I hadn’t given a thought to becoming a dean … when Dave popped the question to me. I’m so glad he did, though, because I learned so much from the experience, not least from being able to consult with Dave and see how he thought about different managerial challenges,” Zuckerman Sivan says.

Faculty, capital projects, and international ties

Schmittlein invested in faculty compensation, and by 2012 the MIT Sloan faculty count had grown to 112.

“Dave recognized early on that growth was essential for Sloan to retain and recruit the very best faculty,” Zuckerman Sivan says. “And every move he made, especially with regard to the degree programs, was done in close and deliberate collaboration with faculty leaders. This was absolutely key. He got senior faculty at Sloan on board with the moves that he had recognized were essential for the school, such that now the moves seem obvious and organic.”

Schmittlein also oversaw several capital projects, some of which were already underway when he joined MIT Sloan. When Building E62 opened in 2010, for the first time in history all of MIT Sloan’s faculty members were housed under one roof. The Gold-certified LEED building also included six new classrooms and an executive education suite. Following that, the landmark historic buildings E60 and E52 were renovated and refreshed.

President Emerita Hockfield says that Schmittlein advanced the school in many dimensions. One area that resonates with her was his agility in building and maintaining relationships with international partners and donors. During Schmittlein’s tenure, the MIT Sloan Latin America Office opened in Santiago, Chile, in 2013, and the Asia School of Business was launched in Kuala Lumpur, Malaysia, in 2015. Schmittlein also helped to lay the groundwork for the launch of the MIT Sloan Office for Southeast Asian Nations, which opened in October 2024 in Bangkok.

The international collaborations increased the school’s visibility throughout the world. Hockfield notes that those international relationships benefited MIT Sloan students.

“For any leader today — being able to foster international relationships has to be a critical part of anyone’s toolkit,” she says. “And [for MIT Sloan students] to see that up close and personal, they can understand how they can make that happen as business leaders.”

Indeed, some MIT Sloan students were introduced firsthand to global business leaders under the guidance of both Hockfield and Schmittlein, who, for the past several years, co-taught an elective course, Corporations at the Crossroads, that featured guest speakers discussing management, strategy, and leadership.

“It was inspiring and just a lot of fun to teach that course with him … Dave possessed the wonderful combination of a brilliant intellect and a profound kindness. While he generously shared both, he more eagerly shared his kindness than his brilliance,” Hockfield says.

Ideas Made to Matter

During Schmittlein’s tenure, MIT Sloan launched a brand identity project with new messaging and the tagline “Ideas Made to Matter,” accompanied by a new website and logo. In the early 2000s, at Wharton, he had championed the online business journal Knowledge at Wharton, which went on to be a standout thought leadership publication. Under Schmittlein’s helm, MIT Sloan launched Ideas Made to Matter, a publication bringing practical insights from MIT Sloan’s faculty to global business leaders.

Hockfield recalls how Schmittlein deftly brought marketing insights to MIT Sloan. “He really understood organizational communications … and he was brilliant [at getting the MIT Sloan story out] with just the right tone,” she says.

Legacy: Principled, innovative leaders who improve the world

Lo says that Schmittlein embodied the example of a principled leader. “He was not only an amazing leader, but he was an amazing human being. He inspired all of us, and will continue to inspire all of us for years to come,” he says.

“Dave gave the Sloan School and MIT a great gift,” Lo continues. “We are now perfectly positioned to reach the next inflection point of changing the role of management education, not only at MIT but around the world.”

Hockfield says, “One of the things I deeply admired about Dave is that his personal ambitions were always secondary or tertiary to his ambitions for the school, the faculty, and the students. And that’s just a wonderful thing to behold. It brings out the best in people … I’m just so grateful that MIT had the benefit of his brilliance and curiosity for the time that we did. It’s a huge loss.”

“We are heartbroken,” MIT Provost Cynthia Barnhart says. “For nearly 17 years, the MIT community relied on and benefited from Dave Schmittlein’s inspiring vision, skillful leadership, and kind and collaborative nature. He worked tirelessly to advance MIT Sloan’s mission of developing principled, innovative leaders, all while strengthening the school’s ties to the rest of campus and building partnerships across the country and globe. He will be deeply missed by his friends and colleagues at MIT.”

Schmittlein continually searched for ways to invent and innovate. He often quoted Alfred P. Sloan, the original benefactor of MIT Sloan, who said in 1964, “I hope we all recognize that the Alfred P. Sloan School of Management is not finished. It never will be finished. It is only on its way. Nothing is finished in a world that is moving so rapidly forward …”

Schmittlein is survived by his wife of nearly 33 years, Barbara Bickart, and their children, Brigitte Schmittlein and Gabriel Schmittlein, as well as his siblings, in-laws, several nieces and nephews, and a host of lifelong friends and colleagues.

MIT Sloan is developing plans for a future celebration of Schmittlein’s life, with details for the community to come. To read more about his life and contributions, read his obituary online.

Ben Vinson III, president of Howard University, made a compelling call for artificial intelligence to be “developed with wisdom,” as he delivered MIT’s annual Karl Taylor Compton Lecture on campus Monday. 

The broad-ranging talk posed a series of searching questions about our human ideals and practices, and was anchored in the view that, as Vinson said, “Technological progress must serve humanity, and not the other way around.”

In the course of his remarks, Vinson offered thoughts about our self-conception as rational beings; the effects of technological revolutions on human tasks, jobs, and society; and the values and ethics we want our lives and our social fabric to reflect.   

“Philosophers like Cicero argue that the good life centers on the pursuit of virtue and wisdom,” Vinson said. “Can AI enhance our pursuit of virtue and wisdom? Does it risk automating critical aspects of human reflection? Does a world that increasingly defers to AI for decision-making and artistic creation, and even ethical deliberation, does that reflect a more advanced society? Or does it signal a quiet surrender of human agency?”

Vinson’s talk, titled “AI in an Age After Reason: A Discourse on Fundamental Human Questions,” was delivered to a large audience in MIT’s Samberg Conference Center.

He also suggested that universities can serve as an “intellectual compass” in the development of AI, bringing realism and specificity to the topic and “separating real risks from speculative fears, ensuring that AI is neither demonized nor blindly embraced but developed with wisdom, with ethical oversight, and with societal adaptation.”

The Compton lecture series was introduced in 1957, in honor of Karl Taylor Compton, who served as MIT’s ninth president, from 1930 to 1948, and as chair of the MIT Corporation from 1948 to 1954.

In introductory remarks, MIT President Sally A. Kornbluth observed that Compton “helped the Institute transform itself from an outstanding technical school for training hands-on engineers to a truly great global university. A renowned physicist, President Compton brought a new focus on fundamental scientific research, and he made science an equal partner with engineering at MIT.”

Beyond that, Kornbluth added, “through the war, he helped invent a partnership between the federal government and America’s research universities.”

Introducing Vinson, Kornbluth described him as an academic leader who projects a “wonderful sense of energy, positivity, and forward movement.”

Vinson became president of Howard University in September 2023, having previously served as provost and executive vice president of Case Western Reserve University; dean of George Washington University's Columbian College of Arts and Sciences; and vice dean for centers, interdisciplinary studies, and graduate education at Johns Hopkins University. A historian who has studied the African diaspora in Latin America, Vinson is a member of the American Academy of Arts and Sciences and a former president of the American Historical Association.

Using history as a guide, Vinson suggested that AI has potential to substantially influence society and the economy, even if it may not fully deliver all of the advances it is imagined to bring.

“It serves as a Rorschach test for society’s deepest hopes and anxieties,” Vinson said of AI. “Optimists, they see it as a productivity revolution and a leap in human evolution, while pessimists warn of mass surveillance, bias, job displacement, and even existential risk. The reality, as history suggests, will likely fall somewhere in between. AI will likely evolve through a cycle of inflated expectations, disillusionment, and eventual pragmatic inspiration.”

Still, Vinson suggested there were substantial differences between AI and some of our earlier technological leaps — the industrial revolution, the electrical revolution, and the digital revolution, among others.

“Unlike previous technologies that have extended human labor, again, AI targets cognition, creativity, decision-making, and even emotional intelligence,” Vinson said.

In all cases, Vinson said, people should be active about discussing the profound effects technological change can have upon society: “AI is not just about technological progress, it is about power, it is about justice, and the very essence of what it means to be human.”

At a few times, Vinson’s remarks looped back to the subject of education and the impact of AI. Howard, one of the nation’s leading historically Black colleges and universities, has recently achieved an R1 designation as a university with a very high level of research activity. At the same time, it has thriving programs in the humanities and social sciences that depend on individual cognition and inquiry.

But suppose, Vinson remarked, that AI eventually ends up displacing a portion of humanistic scholarship. “Does a world with fewer humanities truly represent human progress?” he asked.

All told, Vinson proposed, as AI advances, we have a responsibility to engage with the advances and potential of the field while keeping everyday human values in mind.

“Let’s guide the world through this transformative age with more wisdom, with foresight, and with an unwavering dedication to the common good,” Vinson said. “This is not just a technological moment. It is a moment that calls for a form of intellectual courage and moral imagination. Together, we can shape an AI future that honors dignity for everyone, and at the same time, advances the ideals of humanity itself.”

It’s difficult to build devices that replicate the fluid, precise motion of humans, but that might change if we could pull a few (literal) strings.

At least, that’s the idea behind “cable-driven” mechanisms in which running a string through an object generates streamlined movement across an object’s different parts. Take a robotic finger, for example: You could embed a cable through the palm to the fingertip of this object and then pull it to create a curling motion.

While cable-driven mechanisms can create real-time motion to make an object bend, twist, or fold, they can be complicated and time-consuming to assemble by hand. To automate the process, researchers from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) have developed an all-in-one 3D printing approach called “Xstrings.” Part design tool, part fabrication method, Xstrings can embed all the pieces together and produce a cable-driven device, saving time when assembling bionic robots, creating art installations, or working on dynamic fashion designs.

In a paper to be presented at the 2025 Conference on Human Factors in Computing Systems (CHI2025), the researchers used Xstrings to print a range of colorful and unique objects that included a red walking lizard robot, a purple wall sculpture that can open and close like a peacock’s tail, a white tentacle that curls around items, and a white claw that can ball up into a fist to grab objects.

To fabricate these eye-catching mechanisms, Xstrings allows users to fully customize their designs in a software program, sending them to a multi-material 3D printer to bring that creation to life. You can automatically print all the device’s parts in their desired locations in one step, including the cables running through it and the joints that enable its intended motion.

MIT CSAIL postdoc and lead author Jiaji Li says that Xstrings can save engineers time and energy, reducing 40 percent of total production time compared to doing things manually. “Our innovative method can help anyone design and fabricate cable-driven products with a desktop bi-material 3D printer,” says Li.

A new twist on cable-driven fabrication

To use the Xstrings program, users first input a design with specific dimensions, like a rectangular cube divided into smaller pieces with a hole in the middle of each one. You can then choose which way its parts move by selecting different “primitives:” bending, coiling (like a spring), twisting (like a screw), or compressing — and the angle of these motions.

For even more elaborate creations, users can incorporate multiple primitives to create intriguing combinations of motions. If you wanted to make a toy snake, you could include several twists to create a “series” combo, in which a single cord drives a sequence of motions. To create the robot claw, the team embedded multiple cables into a “parallel” combination, where several strings are embedded, to enable each finger to close up into a fist.

Beyond fine-tuning the way cable-driven mechanisms move, Xstrings also facilitates how cables are integrated into the object. Users can choose exactly how the strings are secured, in terms of where the “anchor” (endpoint), “threaded areas” (or holes within the structure that the cord passes through), and “exposed point” (where you’d pull to operate the device) are located. With a robot finger, for instance, you could choose the anchor to be located at the fingertip, with a cable running through the finger and a pull tag exposed at the other end.

Xstrings also supports diverse joint designs by automatically placing components that are elastic, compliant, or mechanical. This allows the cable to turn as needed as it completes the device’s intended motion.

Driving unique designs across robotics, art, and beyond

Once users have simulated their digital blueprint for a cable-driven item, they can bring it to life via fabrication. Xstrings can send your design to a fused deposition modeling 3D printer, where plastic is melted down into a nozzle before the filaments are poured out to build structures up layer by layer.

Xstrings uses this technique to lay out cables horizontally and build around them. To ensure their method would successfully print cable-driven mechanisms, the researchers carefully tested their materials and printing conditions.

For example, the researchers found that their strings only broke after being pulled up and down by a mechanical device more than 60,000 times. In another test, the team discovered that printing at 260 degrees Celsius with a speed of 10-20 millimeters per second was ideal for producing their many creative items.

“The Xstrings software can bring a variety of ideas to life,” says Li. “It enables you to produce a bionic robot device like a human hand, mimicking our own gripping capabilities. You can also create interactive art pieces, like a cable-driven sculpture with unique geometries, and clothes with adjustable flaps. One day, this technology could enable the rapid, one-step creation of cable-driven robots in outer space, even within highly confined environments such as space stations or extraterrestrial bases.”

The team’s approach offers plenty of flexibility and a noticeable speed boost to fabricating cable-driven objects. It creates objects that are rigid on the outside, but soft and flexible on the inside; in the future, they may look to develop objects that are soft externally but rigid internally, much like humans’ skin and bones. They’re also considering using more resilient cables, and, instead of just printing strings horizontally, embedding ones that are angled or even vertical.

Li wrote the paper with Zhejiang University master’s student Shuyue Feng; Tsinghua University master’s student Yujia Liu; Zhejiang University assistant professor and former MIT Media Lab visiting researcher Guanyun Wang; and three CSAIL members: Maxine Perroni-Scharf, an MIT PhD student in electrical engineering and computer science; Emily Guan, a visiting researcher; and senior author Stefanie Mueller, the TIBCO Career Development Associate Professor in the MIT departments of Electrical Engineering and Computer Science and Mechanical Engineering, and leader of the HCI Engineering Group.

This research was supported, in part, by a postdoctoral research fellowship from Zhejiang University, and the MIT-GIST Program.

Within the human brain, a network of regions has evolved to process language. These regions are consistently activated whenever people listen to their native language or any language in which they are proficient.

A new study by MIT researchers finds that this network also responds to languages that are completely invented, such as Esperanto, which was created in the late 1800s as a way to promote international communication, and even to languages made up for television shows such as “Star Trek” and “Game of Thrones.”

To study how the brain responds to these artificial languages, MIT neuroscientists convened nearly 50 speakers of these languages over a single weekend. Using functional magnetic resonance imaging (fMRI), the researchers found that when participants listened to a constructed language in which they were proficient, the same brain regions lit up as those activated when they processed their native language.

“We find that constructed languages very much recruit the same system as natural languages, which suggests that the key feature that is necessary to engage the system may have to do with the kinds of meanings that both kinds of languages can express,” says Evelina Fedorenko, an associate professor of neuroscience at MIT, a member of MIT’s McGovern Institute for Brain Research and the senior author of the study.

The findings help to define some of the key properties of language, the researchers say, and suggest that it’s not necessary for languages to have naturally evolved over a long period of time or to have a large number of speakers.

“It helps us narrow down this question of what a language is, and do it empirically, by testing how our brain responds to stimuli that might or might not be language-like,” says Saima Malik-Moraleda, an MIT postdoc and the lead author of the paper, which appears this week in the Proceedings of the National Academy of Sciences.

Convening the conlang community

Unlike natural languages, which evolve within communities and are shaped over time, constructed languages, or “conlangs,” are typically created by one person who decides what sounds will be used, how to label different concepts, and what the grammatical rules are.

Esperanto, the most widely spoken conlang, was created in 1887 by Ludwik Zamenhok, who intended it to be used as a universal language for international communication. Currently, it is estimated that around 60,000 people worldwide are proficient in Esperanto.

In previous work, Fedorenko and her students have found that computer programming languages, such as Python — another type of invented language — do not activate the brain network that is used to process natural language. Instead, people who read computer code rely on the so-called multiple demand network, a brain system that is often recruited for difficult cognitive tasks.

Fedorenko and others have also investigated how the brain responds to other stimuli that share features with language, including music and nonverbal communication such as gestures and facial expressions.

“We spent a lot of time looking at all these various kinds of stimuli, finding again and again that none of them engage the language-processing mechanisms,” Fedorenko says. “So then the question becomes, what is it that natural languages have that none of those other systems do?”

That led the researchers to wonder if artificial languages like Esperanto would be processed more like programming languages or more like natural languages. Similar to programming languages, constructed languages are created by an individual for a specific purpose, without natural evolution within a community. However, unlike programming languages, both conlangs and natural languages can be used to convey meanings about the state of the external world or the speaker’s internal state.

To explore how the brain processes conlangs, the researchers invited speakers of Esperanto and several other constructed languages to MIT for a weekend conference in November 2022. The other languages included Klingon (from “Star Trek”), Na’vi (from “Avatar”), and two languages from “Game of Thrones” (High Valyrian and Dothraki). For all of these languages, there are texts available for people who want to learn the language, and for Esperanto, Klingon, and High Valyrian, there is even a Duolingo app available.

“It was a really fun event where all the communities came to participate, and over a weekend, we collected all the data,” says Malik-Moraleda, who co-led the data collection effort with former MIT postbac Maya Taliaferro, now a PhD student at New York University.

During that event, which also featured talks from several of the conlang creators, the researchers used fMRI to scan 44 conlang speakers as they listened to sentences from the constructed language in which they were proficient. The creators of these languages — who are co-authors on the paper — helped construct the sentences that were presented to the participants.

While in the scanner, the participants also either listened to or read sentences in their native language, and performed some nonlinguistic tasks for comparison. The researchers found that when people listened to a conlang, the same language regions in the brain were activated as when they listened to their native language.

Common features

The findings help to identify some of the key features that are necessary to recruit the brain’s language processing areas, the researchers say. One of the main characteristics driving language responses seems to be the ability to convey meanings about the interior and exterior world — a trait that is shared by natural and constructed languages, but not programming languages.

“All of the languages, both natural and constructed, express meanings related to inner and outer worlds. They refer to objects in the world, to properties of objects, to events,” Fedorenko says. “Whereas programming languages are much more similar to math. A programming language is a symbolic generative system that allows you to express complex meanings, but it’s a self-contained system: The meanings are highly abstract and mostly relational, and not connected to the real world that we experience.”

Some other characteristics of natural languages, which are not shared by constructed languages, don’t seem to be necessary to generate a response in the language network.

“It doesn’t matter whether the language is created and shaped over time by a community of speakers, because these constructed languages are not,” Malik-Moraleda says. “It doesn’t matter how old they are, because conlangs that are just a decade old engage the same brain regions as natural languages that have been around for many hundreds of years.”

To further refine the features of language that activate the brain’s language network, Fedorenko’s lab is now planning to study how the brain responds to a conlang called Lojban, which was created by the Logical Language Group in the 1990s and was designed to prevent ambiguity of meanings and promote more efficient communication.

The research was funded by MIT’s McGovern Institute for Brain Research, Brain and Cognitive Sciences Department, the Simons Center for the Social Brain, the Frederick A. and Carole J. Middleton Career Development Professorship, and the U.S. National Institutes of Health.

Prototyping large structures with integrated electronics, like a chair that can monitor someone’s sitting posture, is typically a laborious and wasteful process.

One might need to fabricate multiple versions of the chair structure via 3D printing and laser cutting, generating a great deal of waste, before assembling the frame, grafting sensors and other fragile electronics onto it, and then wiring it up to create a working device.

If the prototype fails, the maker will likely have no choice but to discard it and go back to the drawing board.

MIT researchers have come up with a better way to iteratively design large and sturdy interactive structures. They developed a rapid development platform that utilizes reconfigurable building blocks with integrated electronics that can be assembled into complex, functional devices. Rather than building electronics into a structure, the electronics become the structure.

These lightweight three-dimensional lattice building blocks, known as voxels, have high strength and stiffness, along with integrated sensing, response, and processing abilities that enable users without mechanical or electrical engineering expertise to rapidly produce interactive electronic devices.

The voxels, which can be assembled, disassembled, and reconfigured almost infinitely into various forms, cost about 50 cents each.

The prototyping platform, called VIK (Voxel Invention Kit), includes a user-friendly design tool that enables end-to-end prototyping, allowing a user to simulate the structure’s response to mechanical loads and iterate on the design as needed.

“This is about democratizing access to functional interactive devices. With VIK, there is no 3D printing or laser cutting required. If you just have the voxel faces, you are able to produce these interactive structures anywhere you want,” says Jack Forman, an MIT graduate student in media arts and sciences and affiliate of the MIT Center for Bits and Atoms (CBA) and the MIT Media Lab, and co-lead author of a paper on VIK.

Forman is joined on the paper by co-lead author and fellow graduate student Miana Smith; graduate student Amira Abdel-Rahman; and senior author Neil Gershenfeld, an MIT professor and director of the CBA. The research will be presented at the Conference on Human Factors in Computing Systems.

Functional building blocks

VIK builds upon years of work in the CBA to develop discrete, cellular building blocks called voxels. One voxel, an aluminum cuboctahedra lattice (which has eight triangular faces and six square faces), is strong enough to support 228 kilograms, or about the weight of an upright piano.

Instead of being 3D printed, milled, or laser cut, voxels are assembled into largescale, strong, durable structures like airplane components or wind turbines that can respond to their environments.

The CBA team merged voxels other work in their lab centered on interconnected electrical components, yielding voxels with structural electronics. Assembling these functional voxels generates structures that can transmit data and power, as well as mechanical forces, without the need for wires.

They used these electromechanical building blocks to develop VIK.

“It was an interesting challenge to think about adapting a lot of our previous work, which has been about hitting hard engineering metrics, into a user-friendly system that makes sense and is fun and easy for people to work with,” Smith says.

For instance, they made the voxel design larger so the lattice structures are easier for human hands to assemble and disassemble. They also added aluminum cross-bracing to the units to improve their strength and stability.

In addition, VIK voxels have a reversible, snap-fit connection so a user can seamlessly assemble them without the need for additional tools, in contrast to some prior voxel designs that used rivets as fasteners.

“We designed the voxel faces to permit only the correct connections. That means that, if you are building with voxels, you are guaranteed to be building the correct wiring harness. Once you finish your device, you can just plug it in and it will work,” says Smith.

Wiring harnesses can add significant cost to functional systems and can often be a source of failure.

An accessible prototyping platform

To help users who have minimal engineering expertise create a wide array of interactive devices, the team developed a user-friendly interface to simulate 3D voxel structures.

The interface includes a Finite Element Analysis (FEA) simulation model that enables users to draw out a structure and simulate the forces and mechanical loads that will be applied to it. It adds colors to an animation of the user’s device to identify potential points of failure.

“We created what is essentially a ‘Minecraft’ for voxel applications. You don’t need a good sense of civil engineering or truss analysis to verify that the structure you are making is safe. Anyone can build something with VIK and have confidence in it,” Forman says.

Users can also easily integrate off-the-shelf modules, like speakers, sensors, or actuators, into their device. VIK emphasizes flexibility, enabling makers to use the types of microcontrollers they are comfortable with.

“The next evolution of electronics will be in three-dimensional space and the Voxel Invention Kit (VIK) is the stepping stone that will enable users, designers, and innovators a way to visualize and integrate electronics directly into structures,” says Victor Zaderej, manager of advanced electronics packaging technology at Molex, a manufacturer of electronic, electrical, and fiber optic connectivity systems. “Think of the VIK as the merging of a LEGO building kit and an electronics breadboard. When creative engineers and designers begin thinking about potential applications, the opportunities and unique products that will be enabled will be limitless.”

Using the design tool for feedback, a maker can rapidly change the configuration of voxels to adjust a prototype or disassemble the structure to build something new. If the user eventually wishes to discard the device, the aluminum voxels are fully recyclable.

This reconfigurability and recyclability, along with the high strength, high stiffness, light weight, and integrated electronics of the voxels, could make VIK especially well-suited for applications such as theatrical stage design, where stage managers want to support actors safely with customizable set pieces that might only exist for a few days.

And by enabling the rapid-prototyping of large, complex structures, VIK could also have future applications in areas like space fabrication or in the development of smart buildings and intelligent infrastructure for sustainable cities.

But for the researchers, perhaps the most important next step will be to get VIK out into the world to see what users come up with.

“These voxels are now so readily available that someone can use them in their day-to-day life. It will be exciting to see what they can do and create with VIK,” adds Forman.

The MIT women's track and field team won its first NCAA Division III National Championship in program history on Saturday, March 15, at the 2025 NCAA Division III Track and Field Championships, hosted by Nazareth College in Rochester, New York.

The Engineers, who entered the meet as the top-ranked team in the nation, scored the most points ever scored by an MIT women's team at a national indoor meet. They finished with 49 points, which earned them a first place finish in a field of 62. They were ahead of Washington University, with 45.5 points; the University of Wisconsin at La Crosse, with 37 points; Loras College, with 32 points; and the State University of New York at Geneseo, with 29 points.

“This was such a fun and exciting outcome, and what our team has been working toward all year,” says Julie Heyde, MIT director of track and field and head coach of cross country and track and field. “Since last year, even, the team knew they had a possibility of being national champs. We didn't gear only toward this goal; we have been very process-driven, and that's why this team win is so special. Each and every person competed for each other, representing a total team culture.” 

Field events

Senior Alexis Boykin's (Clayton, Ohio) third attempt in the shot put was the mark to beat, as the defending national champion registered a mark of 15.31 meters. Boykin also repeated as the indoor national champion in the shot put, which gave her two titles on the weekend and her seventh individual NCAA national championship. 

Senior Emily Ball (Des Moines, Iowa) set a new personal record with a mark of 14.19m (46 feet, 6-3/4 inches) to finish in sixth and earn All-American honors. Ball's second throw was the best attempt for the MIT senior, earning the Engineers three valuable points in the team standings. 

Junior Nony Otu Ugwu (Katy, Texas) finished ninth in the first flight of the triple jump and did not advance to the final. Otu Ugwu's best mark came on her second jump with a mark of 11.78m (38 feet, 7-3/4 inches).

Running events

Graduate student Gillian Roeder (Delmar, New York) finished fifth in the mile event in a hard-fought race, earning All-America honors with a time of 4:51.97.

With MIT on the verge of clinching the national title, Roeder, senior Christina Crow (Mercer Island, Washington), and juniors Rujuta Sane (Chandler, Arizona) and Kate Sanderson (West Hartford, Connecticut) took to the track in the 3,000-meter event. Sane finished 20th in 10:02.86, with Roeder taking 16th in 9:56.02. Crow and Sanderson held in the middle of the pack for most of the race before Sanderson made a late move, taking over sixth place with just a few laps remaining. Sanderson would hold the position to earn three points and clinch the national championship. Crow took 11th in 9:44.99.

Other numbers of note

Otu Ugwu was making her second appearance at indoor nationals and her third overall NCAA appearance. She was 14th in the triple jump at both the indoor and outdoor national championship last year. Roeder was running in the final in the mile for the first time since 2023 indoor nationals, where she also finished fifth. Sanderson qualified for indoor nationals in the 5,000 meters in both 2023 and 2024, but Saturday was her first All-American after finishing 16th in 2024 and 20th in 2023.

MIT will head outside in two weeks, opening the outdoor track and field season Thursday-Saturday, March 27-29, at the Raleigh Relays, hosted by North Carolina State University in Raleigh.

A version of this article first appeared on the MIT Athletics website. 

When you’re challenging a century-old assumption, you’re bound to meet a bit of resistance. That’s exactly what John Joannopoulos and his group at MIT faced in 1998, when they put forth a new theory on how materials can be made to bend light in entirely new ways.

“Because it was such a big difference in what people expected, we wrote down the theory for this, but it was very difficult to get it published,” Joannopoulos told a capacity crowd in MIT’s Huntington Hall on Friday, as he delivered MIT’s James R. Killian, Jr. Faculty Achievement Award Lecture.

Joannopoulos’ theory offered a new take on a type of material known as a one-dimensional photonic crystal. Photonic crystals are made from alternating layers of refractive structures whose arrangement can influence how incoming light is reflected or absorbed.

In 1887, the English physicist John William Strutt, better known as the Lord Rayleigh, established a theory for how light should bend through a similar structure composed of multiple refractive layers. Rayleigh predicted that such a structure could reflect light, but only if that light is coming from a very specific angle. In other words, such a structure could act as a mirror for light shining from a specific direction only.

More than a century later, Joannopoulos and his group found that, in fact, quite the opposite was true. They proved in theoretical terms that, if a one-dimensional photonic crystal were made from layers of materials with certain “refractive indices,” bending light to different degrees, then the crystal as a whole should be able to reflect light coming from any and all directions. Such an arrangement could act as a “perfect mirror.”

The idea was a huge departure from what scientists had long assumed, and as such, when Joannopoulos submitted the research for peer review, it took some time for the journal, and the community, to come around. But he and his students kept at it, ultimately verifying the theory with experiments.

That work led to a high-profile publication, which helped the group focus the idea into a device: Using the principles that they laid out, they effectively fabricated a perfect mirror and folded it into a tube to form a hollow-core fiber. When they shone light through, the inside of the fiber reflected all the light, trapping it entirely in the core as the light pinged through the fiber. In 2000, the team launched a startup to further develop the fiber into a flexible, highly precise and minimally invasive “photonics scalpel,” which has since been used in hundreds of thousands of medical procedures including a surgeries of the brain and spine.

“And get this: We have estimated more than 500,000 procedures across hospitals in the U.S. and abroad,” Joannopoulos proudly stated, to appreciative applause.

Joannopoulos is the recipient of the 2024-2025 James R. Killian, Jr. Faculty Achievement Award, and is the Francis Wright Davis Professor of Physics and director of the Institute for Soldier Nanotechnologies at MIT. In response to an audience member who asked what motivated him in the face of initial skepticism, he replied, “You have to persevere if you believe what you have is correct.”

Immeasurable impact

The Killian Award was established in 1971 to honor MIT’s 10th president, James Killian. Each year, a member of the MIT faculty is honored with the award in recognition of their extraordinary professional accomplishments.

Joannopoulos received his PhD from the University of California at Berkeley in 1974, then immediately joined MIT’s physics faculty. In introducing his lecture, Mary Fuller, professor of literature and chair of the MIT faculty, noted: “If you do the math, you’ll know he just celebrated 50 years at MIT.” Throughout that remarkable tenure, Fuller noted Joannopoulos’ profound impact on generations of MIT students.

“We recognize you as a leader, a visionary scientist, beloved mentor, and a believer in the goodness of people,” Fuller said. “Your legendary impact at MIT and the broader scientific community is immeasurable.”

Bending light

In his lecture, which he titled “Working at the Speed of Light,” Joannopoulos took the audience through the basic concepts underlying photonic crystals, and the ways in which he and others have shown that these materials can bend and twist incoming light in a controlled way.

As he described it, photonic crystals are “artificial materials” that can be designed to influence the properties of photons in a way that’s similar to how physical features in semiconductors affect the flow of electrons. In the case of semiconductors, such materials have a specific “band gap,” or a range of energies in which electrons cannot exist.

In the 1990s, Joannopoulos and others wondered whether the same effects could be realized for optical materials, to intentionally reflect, or keep out, some kinds of light while letting others through. And even more intriguing: Could a single material be designed such that incoming light pinballs away from certain regions in a material in predesigned paths?

“The answer was a resounding yes,” he said.

Joannopoulos described the excitement within the emerging field by quoting an editor from the journal Nature, who wrote at the time: “If only it were possible to make materials in which electromagnetic waves cannot propagate at certain frequencies, all kinds of almost-magical things would be possible.”

Joannopoulos and his group at MIT began in earnest to elucidate the ways in which light interacts with matter and air. The team worked first with two-dimensional photonic crystals made from a horizontal matrix-like pattern of silicon dots surrounded by air. Silicon has a high refractive index, meaning it can greatly bend or reflect light, while air has a much lower index. Joannopoulos predicted that the silicon could be patterned to ping light away, forcing it to travel through the air in predetermined paths.

In multiple works, he and his students showed through theory and experiments that they could design photonic crystals to, for instance, bend incoming light by 90 degrees and force light to circulate only at the edges of a crystal under an applied magnetic field.

“Over the years there have been quite a few examples we’ve discovered of very anomalous, strange behavior of light that cannot exist in normal objects,” he said.

In 1998, after showing that light can be reflected from all directions from a stacked, one-dimensional photonic crystal, he and his students rolled the crystal structure into a fiber, which they tested in a lab. In a video that Joannopoulos played for the audience, a student carefully aimed the end of the long, flexible fiber at a sheet of material made from the same material as the fiber’s casing. As light pumped through the multilayered photonic lining of the fiber and out the other end, the student used the light to slowly etch a smiley face design in the sheet, drawing laughter from the crowd.

As the video demonstrated, although the light was intense enough to melt the material of the fiber’s coating, it was nevertheless entirely contained within the fiber’s core, thanks to the multilayered design of its photonic lining. What’s more, the light was focused enough to make precise patterns when it shone out of the fiber.

“We had originally developed this [optical fiber] as a military device,” Joannopoulos said. “But then the obvious choice to use it for the civilian population was quite clear.”

“Believing in the goodness of people and what they can do”

He and others co-founded Omniguide in 2000, which has since grown into a medical device company that develops and commercializes minimally invasive surgical tools such as the fiber-based “photonics scalpel.” In illustrating the fiber’s impact, Joannopoulos played a news video, highlighting the fiber’s use in performing precise and effective neurosurgery. The optical scalpel has also been used to perform procedures in larynology, head and neck surgery, and gynecology, along with brain and spinal surgeries.

Omniguide is one of several startups that Joannopoulos has helped found, along with Luminus Devices, Inc., WiTricity Corporation, Typhoon HIL, Inc., and Lightelligence. He is author or co-author of over 750 refereed journal articles, four textbooks, and 126 issued U.S. patents. He has earned numerous recognitions and awards, including his election to the National Academy of Sciences and the American Academy of Arts and Sciences.

The Killian Award citation states: “Professor Joannopoulos has been a consistent role model not just in what he does, but in how he does it. … Through all these individuals he has impacted — not to mention their academic descendants — Professor Joannopoulos has had a vast influence on the development of science in recent decades.”

At the end of the talk, Yoel Fink, Joannopoulos’ former student and frequent collaborator, who is now professor of materials science, asked Joannopoulos how, particularly in current times, he has been able to “maintain such a positive and optimistic outlook, of humans and human nature.”

“It’s a matter of believing in the goodness of people and what they can do, what they accomplish, and giving an environment where they’re working in, where they feel extermely comfortable,” Joannopoulos offered. “That includes creating a sense of trust between the faculty and the students, which is key. That helps enormously.”

Olivier Blanchard PhD ’77, the Robert M. Solow Professor of Economics Emeritus, has been named a winner of the 2025 BBVA Foundation Frontiers of Knowledge Award in Economics, Finance and Management for “profoundly influencing modern macroeconomic analysis by establishing rigorous foundations for the study of business cycle fluctuations,” as described in the BBVA Foundation’s award citation.

Blanchard, who is also senior fellow at the Peterson Institute for International Economics, shares the award with MIT alumni Jordi Galí PhD ’89 of the Centre de Recerca en Economia Internacional and Pompeu Fabra University in Spain and Michael Woodford PhD ’83 of Columbia University. The three economists were instrumental in developing the New Keynesian model, now widely taught and applied in central banking policy around the world.

The framework builds on classical Keynesian models in part by introducing the role of consumer expectations to macroeconomic policy analysis — in short, using the public’s perception of the future to help inform current policy. The model’s unconventional tools, including greater transparency around monetary policy, were tested by policymakers following the burst of the dotcom bubble in the early 2000s and applied by the Federal Reserve and European Central Bank in response to the 2008 financial crisis.

Blanchard played a foundational role in the development of New Keynesian economics, beginning with a 1987 paper coauthored with Princeton University’s Nobuhiro Kiyotaki (also a Frontiers of Knowledge laureate) on the effects of monetary policy under monopolistic competition. A decade later, Woodford described optimal monetary policy within the New Keynesian framework, laying key theoretical groundwork for the model, and Galí extended and synthesized the framework, ultimately resulting in a blueprint for designing optimal monetary policy.

Blanchard, who joined the MIT faculty in 1983 and served as head of the Department of Economics from 1998 to 2003, advised and taught decades of macroeconomics students at MIT, including Galí. As chief economist of the International Monetary Fund from 2008 to 2015, Blanchard used his framework to help design policy during the Global Financial Crisis and the Euro debt crisis. Blanchard’s leadership as a scholar, student advisor, teacher, and policy advisor is at the heart of the trio’s prize-winning research.

MIT Professor Jonathan Gruber, current head of the economics department, praises Blanchard’s multifaceted contributions.

“Olivier is not only an amazing macroeconomist whose work continues to have profound influence in this time of global macroeconomic uncertainty,” says Gruber, “but also a pillar of the department. His leadership in research and enormous dedication to our program were central in carrying forward the legacy of the department’s early greats and making MIT Economics what it is today.”

Blanchard, Galí, and Woodford share the award’s 400,000-euro prize and will be formally honored at a ceremony in Bilbao, Spain, in June.

The BBVA Foundation works to support scientific research and cultural creation, disseminate knowledge and culture, and recognize talent and innovation, focusing on five strategic areas: environment, biomedicine and health, economy and society, basic sciences and technology, and culture. The Frontiers of Knowledge Awards, spanning eight prize categories, recognize world-class research and cultural creation and aim to celebrate and promote the value of knowledge as a global public good.

Since 2009, the BBVA has given awards to more than a dozen MIT faculty members, including MIT economist Daron Acemoglu, as well as to the Abdul Latif Jameel Poverty Action Lab (J-PAL), led by MIT economists Abhijit Banerjee, Esther Duflo, and Ben Olken.

We move thanks to coordination among many skeletal muscle fibers, all twitching and pulling in sync. While some muscles align in one direction, others form intricate patterns, helping parts of the body move in multiple ways.

In recent years, scientists and engineers have looked to muscles as potential actuators for “biohybrid” robots — machines powered by soft, artificially grown muscle fibers. Such bio-bots could squirm and wiggle through spaces where traditional machines cannot. For the most part, however, researchers have only been able to fabricate artificial muscle that pulls in one direction, limiting any robot’s range of motion.

Now MIT engineers have developed a method to grow artificial muscle tissue that twitches and flexes in multiple coordinated directions. As a demonstration, they grew an artificial, muscle-powered structure that pulls both concentrically and radially, much like how the iris in the human eye acts to dilate and constrict the pupil.

The researchers fabricated the artificial iris using a new “stamping” approach they developed. First, they 3D-printed a small, handheld stamp patterned with microscopic grooves, each as small as a single cell. Then they pressed the stamp into a soft hydrogel and seeded the resulting grooves with real muscle cells. The cells grew along these grooves within the hydrogel, forming fibers. When the researchers stimulated the fibers, the muscle contracted in multiple directions, following the fibers’ orientation.

“With the iris design, we believe we have demonstrated the first skeletal muscle-powered robot that generates force in more than one direction. That was uniquely enabled by this stamp approach,” says Ritu Raman, the Eugene Bell Career Development Professor of Tissue Engineering in MIT’s Department of Mechanical Engineering.

The team says the stamp can be printed using tabletop 3D printers and fitted with different patterns of microscopic grooves. The stamp can be used to grow complex patterns of muscle — and potentially other types of biological tissues, such as neurons and heart cells — that look and act like their natural counterparts.

“We want to make tissues that replicate the architectural complexity of real tissues,” Raman says. “To do that, you really need this kind of precision in your fabrication.”

She and her colleagues published their open-access results Friday in the journal Biomaterials Science. Her MIT co-authors include first author Tamara Rossy, Laura Schwendeman, Sonika Kohli, Maheera Bawa, and Pavankumar Umashankar, along with Roi Habba, Oren Tchaicheeyan, and Ayelet Lesman of Tel Aviv University in Israel.

Training space

Raman’s lab at MIT aims to engineer biological materials that mimic the sensing, activity, and responsiveness of real tissues in the body. Broadly, her group seeks to apply these bioengineered materials in areas from medicine to machines. For instance, she is looking to fabricate artificial tissue that can restore function to people with neuromuscular injury. She is also exploring artificial muscles for use in soft robotics, such as muscle-powered swimmers that move through the water with fish-like flexibility.

Raman has previously developed what could be seen as gym platforms and workout routines for lab-grown muscle cells. She and her colleagues designed a hydrogel “mat” that encourages muscle cells to grow and fuse into fibers without peeling away. She also derived a way to “exercise” the cells by genetically engineering them to twitch in response to pulses of light. And, her group has come up with ways to direct muscle cells to grow in long, parallel lines, similar to natural, striated muscles. However, it’s been a challenge, for her group and others, to design artificial muscle tissue that moves in multiple, predictable directions.

“One of the cool things about natural muscle tissues is, they don’t just point in one direction. Take for instance, the circular musculature in our iris and around our trachea. And even within our arms and legs, muscle cells don’t point straight, but at an angle,” Raman notes. “Natural muscle has multiple orientations in the tissue, but we haven’t been able to replicate that in our engineered muscles.”

Muscle blueprint

In thinking of ways to grow multidirectional muscle tissue, the team hit on a surprisingly simple idea: stamps. Inspired in part by the classic Jell-O mold, the team looked to design a stamp, with microscopic patterns that could be imprinted into a hydrogel, similar to the muscle-training mats that the group has previously developed. The patterns of the imprinted mat could then serve as a roadmap along which muscle cells might follow and grow.

“The idea is simple. But how do you make a stamp with features as small as a single cell? And how do you stamp something that’s super soft? This gel is much softer than Jell-O, and it’s something that’s really hard to cast, because it could tear really easily,” Raman says.

The team tried variations on the stamp design and eventually landed on an approach that worked surprisingly well. The researchers fabricated a small, handheld stamp using high-precision printing facilities in MIT.nano, which enabled them to print intricate patterns of grooves, each about as wide as a single muscle cell, onto the bottom of the stamp. Before pressing the stamp into a hydrogel mat, they coated the bottom with a protein that helped the stamp imprint evenly into the gel and peel away without sticking or tearing.

As a demonstration, the researchers printed a stamp with a pattern similar to the microscopic musculature in the human iris. The iris comprises a ring of muscle surrounding the pupil. This ring of muscle is made up of an inner circle of muscle fibers arranged concentrically, following a circular pattern, and an outer circle of fibers that stretch out radially, like the rays of the sun.  Together, this complex architecture acts to constrict or dilate the pupil.

Once Raman and her colleagues pressed the iris pattern into a hydrogel mat, they coated the mat with cells that they genetically engineered to respond to light. Within a day, the cells fell into the microscopic grooves and began to fuse into fibers, following the iris-like patterns and eventually growing into a whole muscle, with an architecture and size similar to a real iris.

When the team stimulated the artificial iris with pulses of light, the muscle contracted in multiple directions, similar to the iris in the human eye. Raman notes that the team’s artificial iris is fabricated with skeletal muscle cells, which are involved in voluntary motion, whereas the muscle tissue in the real human iris is made up of smooth muscle cells, which are a type of involuntary muscle tissue. They chose to pattern skeletal muscle cells in an iris-like pattern to demonstrate the ability to fabricate complex, multidirectional muscle tissue.

“In this work, we wanted to show we can use this stamp approach to make a ‘robot’ that can do things that previous muscle-powered robots can’t do,” Raman says. “We chose to work with skeletal muscle cells. But there’s nothing stopping you from doing this with any other cell type.”

She notes that while the team used precision-printing techniques, the stamp design can also be made using conventional tabletop 3D printers. Going forward, she and her colleagues plan to apply the stamping method to other cell types, as well as explore different muscle architectures and ways to activate artificial, multidirectional muscle to do useful work.

“Instead of using rigid actuators that are typical in underwater robots, if we can use soft biological robots, we can navigate and be much more energy-efficient, while also being completely biodegradable and sustainable,” Raman says. “That’s what we hope to build toward.”

This work was supported, in part, by the U.S. Office of Naval Research, the U.S. Army Research Office, the U.S. National Science Foundation, and the U.S. National Institutes of Health.

A decade after scientists in The Picower Institute for Learning and Memory at MIT first began testing whether sensory stimulation of the brain’s 40Hz “gamma” frequency rhythms could treat Alzheimer’s disease in mice, a growing evidence base supporting the idea that it can improve brain health — in humans as well as animals — has emerged from the work of labs all over the world. A new open-access review article in PLOS Biology describes the state of research so far and presents some of the fundamental and clinical questions at the forefront of the noninvasive gamma stimulation now.

“As we’ve made all our observations, many other people in the field have published results that are very consistent,” says Li-Huei Tsai, Picower professor of neuroscience at MIT, director of MIT’s Aging Brain Initiative, and senior author of the new review, with postdoc Jung Park. “People have used many different ways to induce gamma including sensory stimulation, transcranial alternating current stimulation, or transcranial magnetic stimulation, but the key is delivering stimulation at 40 hertz. They all see beneficial effects.”

A decade of discovery at MIT

Starting with a paper in Nature in 2016, a collaboration led by Tsai has produced a series of studies showing that 40Hz stimulation via light, sound, the two combined, or tactile vibration reduces hallmarks of Alzheimer’s pathology such as amyloid and tau proteins, prevents neuron death, decreases synapse loss, and sustains memory and cognition in various Alzheimer’s mouse models. The collaboration’s investigations of the underlying mechanisms that produce these benefits have so far identified specific cellular and molecular responses in many brain cell types including neurons, microglia, astrocytes, oligodendrocytes, and the brain’s blood vessels. Last year, for instance, the lab reported in Nature that 40Hz audio and visual stimulation induced interneurons in mice to increase release of the peptide VIP, prompting increased clearance of amyloid from brain tissue via the brain’s glymphatic “plumbing” system.

Meanwhile, at MIT and at the MIT spinoff company Cognito Therapeutics, phase II clinical studies have shown that people with Alzheimer’s exposed to 40Hz light and sound experienced a significant slowing of brain atrophy and improvements on some cognitive measures, compared to untreated controls. Cognito, which has also measured significant preservation of the brain’s “white matter” in volunteers, has been conducting a pivotal, nationwide phase III clinical trial of sensory gamma stimulation for more than a year.

“Neuroscientists often lament that it is a great time to have AD [Alzheimer’s disease] if you are a mouse,” Park and Tsai wrote in the review. “Our ultimate goal, therefore, is to translate GENUS discoveries into a safe, accessible, and noninvasive therapy for AD patients.” The MIT team often refers to 40Hz stimulation as “GENUS” for Gamma Entrainment Using Sensory Stimulation.

A growing field

As Tsai’s collaboration, which includes MIT colleagues Edward Boyden and Emery N. Brown, has published its results, many other labs have produced studies adding to the evidence that various methods of noninvasive gamma sensory stimulation can combat Alzheimer’s pathology. Among many examples cited in the new review, in 2024 a research team in China independently corroborated that 40Hz sensory stimulation increases glymphatic fluid flows in mice. In another example, a Harvard Medical School-based team in 2022 showed that 40Hz gamma stimulation using Transcranial Alternating Current Stimulation significantly reduced the burden of tau in three out of four human volunteers. And in another study involving more than 100 people, researchers in Scotland in 2023 used audio and visual gamma stimulation (at 37.5Hz) to improve memory recall.

Open questions

Amid the growing number of publications describing preclinical studies with mice and clinical trials with people, open questions remain, Tsai and Park acknowledge. The MIT team and others are still exploring the cellular and molecular mechanisms that underlie GENUS’s effects. Tsai says her lab is looking at other neuropeptide and neuromodulatory systems to better understand the cascade of events linking sensory stimulation to the observed cellular responses. Meanwhile, the nature of how some cells, such as microglia, respond to gamma stimulation and how that affects pathology remains unclear, Tsai adds.

Even with a national phase III clinical trial underway, it is still important to investigate these fundamental mechanisms, Tsai says, because new insights into how noninvasive gamma stimulation affects the brain could improve and expand its therapeutic potential.

“The more we understand the mechanisms, the more we will have good ideas about how to further optimize the treatment,” Tsai says. “And the more we understand its action and the circuits it affects, the more we will know beyond Alzheimer’s disease what other neurological disorders will benefit from this.”

Indeed, the review points to studies at MIT and other institutions providing at least some evidence that GENUS might be able to help with Parkinson’s disease, stroke, anxiety, epilepsy, and the cognitive side effects of chemotherapy and conditions that reduce myelin, such as multiple sclerosis. Tsai’s lab has been studying whether it can help with Down syndrome as well.

The open questions may help define the next decade of GENUS research.

It is a deep question, from deep in our history: When did human language as we know it emerge? A new survey of genomic evidence suggests our unique language capacity was present at least 135,000 years ago. Subsequently, language might have entered social use 100,000 years ago.

Our species, Homo sapiens, is about 230,000 years old. Estimates of when language originated vary widely, based on different forms of evidence, from fossils to cultural artifacts. The authors of the new analysis took a different approach. They reasoned that since all human languages likely have a common origin — as the researchers strongly think — the key question is how far back in time regional groups began spreading around the world.

“The logic is very simple,” says Shigeru Miyagawa, an MIT professor and co-author of a new paper summarizing the results. “Every population branching across the globe has human language, and all languages are related.” Based on what the genomics data indicate about the geographic divergence of early human populations, he adds, “I think we can say with a fair amount of certainty that the first split occurred about 135,000 years ago, so human language capacity must have been present by then, or before.”

The paper, “Linguistic capacity was present in the Homo sapiens population 135 thousand years ago,” appears in Frontiers in Psychology. The co-authors are Miyagawa, who is a professor emeritus of linguistics and the Kochi-Manjiro Professor of Japanese Language and Culture at MIT; Rob DeSalle, a principal investigator at the American Museum of Natural History’s Institute for Comparative Genomics; Vitor Augusto Nóbrega, a faculty member in linguistics at the University of São Paolo; Remo Nitschke, of the University of Zurich, who worked on the project while at the University of Arizona linguistics department; Mercedes Okumura of the Department of Genetics and Evolutionary Biology at the University of São Paulo; and Ian Tattersall, curator emeritus of human origins at the American Museum of Natural History.

The new paper examines 15 genetic studies of different varieties, published over the past 18 years: Three used data about the inherited Y chromosome, three examined mitochondrial DNA, and nine were whole-genome studies.

All told, the data from these studies suggest an initial regional branching of humans about 135,000 years ago. That is, after the emergence of Homo sapiens, groups of people subsequently moved apart geographically, and some resulting genetic variations have developed, over time, among the different regional subpopulations. The amount of genetic variation shown in the studies allows researchers to estimate the point in time at which Homo sapiens was still one regionally undivided group.

Miyagawa says the studies collectively provide increasingly converging evidence about when these geographic splits started taking place. The first survey of this type was performed by other scholars in 2017, but they had fewer existing genetic studies to draw upon. Now, there are much more published data available, which when considered together point to 135,000 years ago as the likely time of the first split.

The new meta-analysis was possible because “quantity-wise we have more studies, and quality-wise, it’s a narrower window [of time],” says Miyagawa, who also holds an appointment at the University of São Paolo.

Like many linguists, Miyagawa believes all human languages are demonstrably related to each other, something he has examined in his own work. For instance, in his 2010 book, “Why Agree? Why Move?” he analyzed previously unexplored similarities between English, Japanese, and some of the Bantu languages. There are more than 7,000 identified human languages around the globe.

Some scholars have proposed that language capacity dates back a couple of million years, based on the physiological characteristics of other primates. But to Miyagawa, the question is not when primates could utter certain sounds; it is when humans had the cognitive ability to develop language as we know it, combining vocabulary and grammar into a system generating an infinite amount of rules-based expression.

“Human language is qualitatively different because there are two things, words and syntax, working together to create this very complex system,” Miyagawa says. “No other animal has a parallel structure in their communication system. And that gives us the ability to generate very sophisticated thoughts and to communicate them to others.”

This conception of human language origins also holds that humans had the cognitive capacity for language for some period of time before we constructed our first languages.

“Language is both a cognitive system and a communication system,” Miyagawa says. “My guess is prior to 135,000 years ago, it did start out as a private cognitive system, but relatively quickly that turned into a communications system.”

So, how can we know when distinctively human language was first used? The archaeological record is invaluable in this regard. Roughly 100,000 years ago, the evidence shows, there was a widespread appearance of symbolic activity, from meaningful markings on objects to the use of fire to produce ochre, a decorative red color.

Like our complex, highly generative language, these symbolic activities are engaged in by people, and no other creatures. As the paper notes, “behaviors compatible with language and the consistent exercise of symbolic thinking are detectable only in the archaeological record of H. sapiens.”

Among the co-authors, Tattersall has most prominently propounded the view that language served as a kind of ignition for symbolic thinking and other organized activities.

“Language was the trigger for modern human behavior,” Miyagawa says. “Somehow it stimulated human thinking and helped create these kinds of behaviors. If we are right, people were learning from each other [due to language] and encouraging innovations of the types we saw 100,000 years ago.”

To be sure, as the authors acknowledge in the paper, other scholars believe there was a more incremental and broad-based development of new activities around 100,000 years ago, involving materials, tools, and social coordination, with language playing a role in this, but not necessarily being the central force.

For his part, Miyagawa recognizes that there is considerable room for further progress in this area of research, but thinks efforts like the current paper are at least steps toward filling out a more detailed picture of language’s emergence.

“Our approach is very empirically based, grounded in the latest genetic understanding of early homo sapiens,” Miyagawa says. “I think we are on a good research arc, and I hope this will encourage people to look more at human language and evolution.”

This research was, in part, supported by the São Paolo Excellence Chair awarded to Miyagawa by the São Paolo Research Foundation.

More than 60,000 tons of plastic makes the journey down the Amazon River to the Atlantic Ocean every year. And that doesn’t include what finds its way to the river’s banks, or the microplastics ingested by the region’s abundant and diverse wildlife.

It’s easy to demonize plastic, but it has been crucial in developing the society we live in today. Creating materials that have the benefits of plastics while reducing the harms of traditional production methods is a goal of chemical engineering and materials science labs the world over, including that of Bradley Olsen, the Alexander and I. Michael Kasser (1960) Professor of Chemical Engineering at MIT.

Olsen, a Fulbright Amazonia scholar and the faculty lead of MIT-Brazil, works with communities to develop alternative plastics solutions that can be derived from resources within their own environments.

“The word that we use for this is co-design,” says Olsen. “The idea is, instead of engineers just designing something independently, they engage and jointly design the solution with the stakeholders.”

In this case, the stakeholders were small businesses around Manaus in the Brazilian state of Amazonas curious about the feasibility of bioplastics and other alternative packaging.

“Plastics are inherent to modern life and actually perform key functions and have a really beautiful chemistry that we want to be able to continue to leverage, but we want to do it in a way that is more earth-compatible,” says Desirée Plata, MIT associate professor of civil and environmental engineering.

That’s why Plata joined Olsen in creating the course 1.096/10.496 (Design of Sustainable Polymer Systems) in 2021. Now, as a Global Classroom offering under the umbrella of MISTI since 2023, the class brings MIT students to Manaus during the three weeks of Independent Activities Period (IAP).

“In my work running the Global Teaching Labs in Brazil since 2016, MIT students collaborate closely with Brazilian undergraduates,” says Rosabelli Coelho-Keyssar, managing director of MIT-Brazil and MIT-Amazonia, who also runs MIT’s Global Teaching Labs program in Brazil. “This peer-learning model was incorporated into the Global Classroom in Manaus, ensuring that MIT and Brazilian students worked together throughout the course.”

The class leadership worked with climate scientist and MIT alumnus Carlos Nobre PhD ’83, who facilitated introductions to faculty at the Universidade Estadual de Amazonas (UAE), the state university of Amazonas. The group then scouted businesses in the Amazonas region who would be interested in partnering with the students.

“In the first year, it was Comunidade Julião, a community of people living on the edge of the Tarumã Mirim River west of Manaus,” says Olsen. “This year, we worked with Comunidade Para Maravilha, a community living in the dry land forest east of Manaus.”

A tailored solution

Plastic, by definition, is made up of many small carbon-based molecules, called monomers, linked by strong bonds into larger molecules called polymers. Linking different monomers and polymers in different ways creates different plastics — from trash bags to a swimming pool float to the dashboard of a car. Plastics are traditionally made from petroleum byproducts that are easy to link together, stable, and plentiful.

But there are ways to reduce the use of petroleum-based plastics. Packaging can be made from materials found within the local ecosystem, as was the focus of the 2024 class. Or carbon-based monomers can be extracted from high-starch plant matter through a number of techniques, the goal of the 2025 cohort. But plants that grow well in one location might not in another. And bioplastic production facilities can be tricky to install if the necessary resources aren’t immediately available.

“We can design a whole bunch of new sustainable chemical processes, use brand new top-of-the-line catalysts, but if you can’t actually implement them sustainably inside an environment, it falls short on a lot of the overall goals,” says Brian Carrick, a PhD candidate in the Olsen lab and a teaching assistant for the 2025 course offering.

So, identifying local candidates and tailoring the process is key. The 2025 MIT cohort collaborated with students from throughout the Amazonas state to explore the local flora, study its starch content in the lab, and develop a new plastic-making process — all within the three weeks of IAP.

“It’s easy when you have projects like this to get really locked into the MIT vacuum of just doing what sounds really cool, which isn’t always effective or constructive for people actually living in that environment,” says Claire Underwood, a junior chemical-biological engineering major who took the class. “That’s what really drew me into the project, being able to work with people in Brazil.”

The 31 students visited a protected area of the Amazon rainforest on Day One. They also had chances throughout IAP to visit the Amazon River, where the potential impact of their work became clear as they saw plastic waste collecting on its banks.

“That was a really cool aspect to the class, for sure, being able to actually see what we were working towards protecting and what the goal was,” says Underwood.

They interviewed stakeholders, such as farmers who could provide the feedstock and plastics manufacturers who could incorporate new techniques. Then, they got into the classroom, where massive intellectual ground was covered in a crash course on the sustainable design process, the nitty gritty of plastic production, and the Brazilian cultural context on how building such an industry would affect the community. For the final project, they separated into teams to craft preliminary designs of process and plant using a simplified model of these systems.

Connecting across boundaries

Working in another country brought to the fore how interlinked policy, culture, and technical solutions are.

“I know nothing about economics, and especially not Brazilian economics and politics,” says Underwood. But one of the Brazilian students in her group was a management and finance major. “He was super helpful when we were trying to source things and account for inflation and things like that — knowing what was feasible, and not just academically feasible.”

Before they parted at the end of IAP, each team presented their proposals to a panel of company representatives and Brazilian MIT alumni who chose first-, second-, and third-place winners. While more research is needed before comfortably implementing the ideas, the experience seemed to generate legitimate interest in creating a local bioplastics production facility.

Understanding sustainable design concepts and how to do interdisciplinary work is an important skill to learn. Even if these students don’t wind up working on bioplastics in the heart of the Amazon, being able to work with people of different perspectives — be it a different discipline or a different culture — is valuable in virtually every field.

“The exchange of knowledge across different fields and cultures is essential for developing innovative and sustainable solutions to global challenges such as climate change, waste management, and the development of eco-friendly materials,” says Taisa Sampaio, a PhD candidate in materials chemistry at UEA and a co-instructor for the course. “Programs like this are crucial in preparing professionals who are more aware and better equipped to tackle future challenges.”

Right now, Olsen and Plata are focused on harnessing the deep well of connections and resources they have around Manaus, but they hope to develop that kind of network elsewhere to expand this sustainable design exploration to other regions of the world.

“A lot of sustainability solutions are hyperlocal,” says Plata. “Understanding that not all locales are exactly the same is really powerful and important when we’re thinking about sustainability challenges. And it’s probably where we've gone wrong with the one-size-fits-all or silver-bullet solution — seeking that we’ve been doing for the past many decades.”

Collaborations for the 2026 trip are still in development but, as Olsen says, “we hope this is an experience we can continue to offer long into the future, based on how positive it has been for our students and our Brazilian partners.”

Many companies invest heavily in hiring talent to create the high-performance library code that underpins modern artificial intelligence systems. NVIDIA, for instance, developed some of the most advanced high-performance computing (HPC) libraries, creating a competitive moat that has proven difficult for others to breach.

But what if a couple of students, within a few months, could compete with state-of-the-art HPC libraries with a few hundred lines of code, instead of tens or hundreds of thousands?

That’s what researchers at MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) have shown with a new programming language called Exo 2.

Exo 2 belongs to a new category of programming languages that MIT Professor Jonathan Ragan-Kelley calls “user-schedulable languages” (USLs). Instead of hoping that an opaque compiler will auto-generate the fastest possible code, USLs put programmers in the driver's seat, allowing them to write “schedules” that explicitly control how the compiler generates code. This enables performance engineers to transform simple programs that specify what they want to compute into complex programs that do the same thing as the original specification, but much, much faster.

One of the limitations of existing USLs (like the original Exo) is their relatively fixed set of scheduling operations, which makes it difficult to reuse scheduling code across different “kernels” (the individual components in a high-performance library).

In contrast, Exo 2 enables users to define new scheduling operations externally to the compiler, facilitating the creation of reusable scheduling libraries. Lead author Yuka Ikarashi, an MIT PhD student in electrical engineering and computer science and CSAIL affiliate, says that Exo 2 can reduce total schedule code by a factor of 100 and deliver performance competitive with state-of-the-art implementations on multiple different platforms, including Basic Linear Algebra Subprograms (BLAS) that power many machine learning applications. This makes it an attractive option for engineers in HPC focused on optimizing kernels across different operations, data types, and target architectures.

“It’s a bottom-up approach to automation, rather than doing an ML/AI search over high-performance code,” says Ikarashi. “What that means is that performance engineers and hardware implementers can write their own scheduling library, which is a set of optimization techniques to apply on their hardware to reach the peak performance.”

One major advantage of Exo 2 is that it reduces the amount of coding effort needed at any one time by reusing the scheduling code across applications and hardware targets. The researchers implemented a scheduling library with roughly 2,000 lines of code in Exo 2, encapsulating reusable optimizations that are linear-algebra specific and target-specific (AVX512, AVX2, Neon, and Gemmini hardware accelerators). This library consolidates scheduling efforts across more than 80 high-performance kernels with up to a dozen lines of code each, delivering performance comparable to, or better than, MKL, OpenBLAS, BLIS, and Halide.

Exo 2 includes a novel mechanism called “Cursors” that provides what they call a “stable reference” for pointing at the object code throughout the scheduling process. Ikarashi says that a stable reference is essential for users to encapsulate schedules within a library function, as it renders the scheduling code independent of object-code transformations.

“We believe that USLs should be designed to be user-extensible, rather than having a fixed set of operations,” says Ikarashi. “In this way, a language can grow to support large projects through the implementation of libraries that accommodate diverse optimization requirements and application domains.”

Exo 2’s design allows performance engineers to focus on high-level optimization strategies while ensuring that the underlying object code remains functionally equivalent through the use of safe primitives. In the future, the team hopes to expand Exo 2’s support for different types of hardware accelerators, like GPUs. Several ongoing projects aim to improve the compiler analysis itself, in terms of correctness, compilation time, and expressivity.

Ikarashi and Ragan-Kelley co-authored the paper with graduate students Kevin Qian and Samir Droubi, Alex Reinking of Adobe, and former CSAIL postdoc Gilbert Bernstein, now a professor at the University of Washington. This research was funded, in part, by the U.S. Defense Advanced Research Projects Agency (DARPA) and the U.S. National Science Foundation, while the first author was also supported by Masason, Funai, and Quad Fellowships.

Converting one type of cell to another — for example, a skin cell to a neuron — can be done through a process that requires the skin cell to be induced into a “pluripotent” stem cell, then differentiated into a neuron. Researchers at MIT have now devised a simplified process that bypasses the stem cell stage, converting a skin cell directly into a neuron.

Working with mouse cells, the researchers developed a conversion method that is highly efficient and can produce more than 10 neurons from a single skin cell. If replicated in human cells, this approach could enable the generation of large quantities of motor neurons, which could potentially be used to treat patients with spinal cord injuries or diseases that impair mobility.

“We were able to get to yields where we could ask questions about whether these cells can be viable candidates for the cell replacement therapies, which we hope they could be. That’s where these types of reprogramming technologies can take us,” says Katie Galloway, the W. M. Keck Career Development Professor in Biomedical Engineering and Chemical Engineering.

As a first step toward developing these cells as a therapy, the researchers showed that they could generate motor neurons and engraft them into the brains of mice, where they integrated with host tissue.

Galloway is the senior author of two papers describing the new method, which appear today in Cell Systems. MIT graduate student Nathan Wang is the lead author of both papers.

From skin to neurons

Nearly 20 years ago, scientists in Japan showed that by delivering four transcription factors to skin cells, they could coax them to become induced pluripotent stem cells (iPSCs). Similar to embryonic stem cells, iPSCs can be differentiated into many other cell types. This technique works well, but it takes several weeks, and many of the cells don’t end up fully transitioning to mature cell types.

“Oftentimes, one of the challenges in reprogramming is that cells can get stuck in intermediate states,” Galloway says. “So, we’re using direct conversion, where instead of going through an iPSC intermediate, we’re going directly from a somatic cell to a motor neuron.”

Galloway’s research group and others have demonstrated this type of direct conversion before, but with very low yields — fewer than 1 percent. In Galloway’s previous work, she used a combination of six transcription factors plus two other proteins that stimulate cell proliferation. Each of those eight genes was delivered using a separate viral vector, making it difficult to ensure that each was expressed at the correct level in each cell.

In the first of the new Cell Systems papers, Galloway and her students reported a way to streamline the process so that skin cells can be converted to motor neurons using just three transcription factors, plus the two genes that drive cells into a highly proliferative state.

Using mouse cells, the researchers started with the original six transcription factors and experimented with dropping them out, one at a time, until they reached a combination of three — NGN2, ISL1, and LHX3 — that could successfully complete the conversion to neurons.

Once the number of genes was down to three, the researchers could use a single modified virus to deliver all three of them, allowing them to ensure that each cell expresses each gene at the correct levels.

Using a separate virus, the researchers also delivered genes encoding p53DD and a mutated version of HRAS. These genes drive the skin cells to divide many times before they start converting to neurons, allowing for a much higher yield of neurons, about 1,100 percent.

“If you were to express the transcription factors at really high levels in nonproliferative cells, the reprogramming rates would be really low, but hyperproliferative cells are more receptive. It’s like they’ve been potentiated for conversion, and then they become much more receptive to the levels of the transcription factors,” Galloway says.

The researchers also developed a slightly different combination of transcription factors that allowed them to perform the same direct conversion using human cells, but with a lower efficiency rate — between 10 and 30 percent, the researchers estimate. This process takes about five weeks, which is slightly faster than converting the cells to iPSCs first and then turning them into neurons.

Implanting cells

Once the researchers identified the optimal combination of genes to deliver, they began working on the best ways to deliver them, which was the focus of the second Cell Systems paper.

They tried out three different delivery viruses and found that a retrovirus achieved the most efficient rate of conversion. Reducing the density of cells grown in the dish also helped to improve the overall yield of motor neurons. This optimized process, which takes about two weeks in mouse cells, achieved a yield of more than 1,000 percent.

Working with colleagues at Boston University, the researchers then tested whether these motor neurons could be successfully engrafted into mice. They delivered the cells to a part of the brain known as the striatum, which is involved in motor control and other functions.

After two weeks, the researchers found that many of the neurons had survived and seemed to be forming connections with other brain cells. When grown in a dish, these cells showed measurable electrical activity and calcium signaling, suggesting the ability to communicate with other neurons. The researchers now hope to explore the possibility of implanting these neurons into the spinal cord.

The MIT team also hopes to increase the efficiency of this process for human cell conversion, which could allow for the generation of large quantities of neurons that could be used to treat spinal cord injuries or diseases that affect motor control, such as ALS. Clinical trials using neurons derived from iPSCs to treat ALS are now underway, but expanding the number of cells available for such treatments could make it easier to test and develop them for more widespread use in humans, Galloway says.

The research was funded by the National Institute of General Medical Sciences and the National Science Foundation Graduate Research Fellowship Program.