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Inflammation jolts “sleeping” cancer cells awake, enabling them to multiply again

MIT Latest News - Thu, 09/18/2025 - 3:40pm

Cancer cells have one relentless goal: to grow and divide. While most stick together within the original tumor, some rogue cells break away to traverse to distant organs. There, they can lie dormant — undetectable and not dividing — for years, like landmines waiting to go off.

This migration of cancer cells, called metastasis, is especially common in breast cancer. For many patients, the disease can return months — or even decades — after initial treatment, this time in an entirely different organ.

Robert Weinberg, the Daniel K. Ludwig Professor for Cancer Research at MIT and a Whitehead Institute for Biomedical Research founding member, has spent decades unraveling the complex biology of metastasis and pursuing research that could improve survival rates among patients with metastatic breast cancer — or prevent metastasis altogether.

In his latest study, Weinberg, postdoc Jingwei Zhang, and colleagues ask a critical question: What causes these dormant cancer cells to erupt into a frenzy of growth and division? The group’s findings, published Sept. 1 in The Proceedings of the National Academy of Sciences (PNAS), point to a unique culprit.

This awakening of dormant cancer cells, they’ve discovered, isn’t a spontaneous process. Instead, the wake-up call comes from the inflamed tissue surrounding the cells. One trigger for this inflammation is bleomycin, a common chemotherapy drug that can scar and thicken lung tissue.

“The inflammation jolts the dormant cancer cells awake,” Weinberg says. “Once awakened, they start multiplying again, seeding new life-threatening tumors in the body.”

Decoding metastasis

There’s a lot that scientists still don’t know about metastasis, but this much is clear: Cancer cells must undergo a long and arduous journey to achieve it. The first step is to break away from their neighbors within the original tumor.

Normally, cells stick to one another using surface proteins that act as molecular “velcro,” but some cancer cells can acquire genetic changes that disrupt the production of these proteins and make them more mobile and invasive, allowing them to detach from the parent tumor. 

Once detached, they can penetrate blood vessels and lymphatic channels, which act as highways to distant organs.

While most cancer cells die at some point during this journey, a few persist. These cells exit the bloodstream and invade different tissues—lungs, liver, bone, and even the brain — to give birth to new, often more-aggressive tumors.

“Almost 90 percent of cancer-related deaths occur not from the original tumor, but when cancer cells spread to other parts of the body,” says Weinberg. “This is why it’s so important to understand how these ‘sleeping’ cancer cells can wake up and start growing again.”

Setting up shop in new tissue comes with changes in surroundings — the “tumor microenvironment” — to which the cancer cells may not be well-suited. These cells face constant threats, including detection and attack by the immune system. 

To survive, they often enter a protective state of dormancy that puts a pause on growth and division. This dormant state also makes them resistant to conventional cancer treatments, which often target rapidly dividing cells.

To investigate what makes this dormancy reversible months or years down the line, researchers in the Weinberg Lab injected human breast cancer cells into mice. These cancer cells were modified to produce a fluorescent protein, allowing the scientists to track their behavior in the body.

The group then focused on cancer cells that had lodged themselves in the lung tissue. By examining them for specific proteins — Ki67, ITGB4, and p63 — that act as markers of cell activity and state, the researchers were able to confirm that these cells were in a non-dividing, dormant state.

Previous work from the Weinberg Lab had shown that inflammation in organ tissue can provoke dormant breast cancer cells to start growing again. In this study, the team tested bleomycin — a chemotherapy drug known to cause lung inflammation — that can be given to patients after surgery to lower the risk of cancer recurrence.

The researchers found that lung inflammation from bleomycin was sufficient to trigger the growth of large lung cancer colonies in treated mice — and to shift the character of these once-dormant cells to those that are more invasive and mobile.

Zeroing in on the tumor microenvironment, the team identified a type of immune cells, called M2 macrophages, as drivers of this process. These macrophages release molecules called epidermal growth factor receptor (EGFR) ligands, which bind to receptors on the surface of dormant cancer cells. This activates a cascade of signals that provoke dormant cancer cells to start multiplying rapidly. 

But EGFR signaling is only the initial spark that ignites the fire. “We found that once dormant cancer cells are awakened, they retain what we call an ‘awakening memory,’” Zhang says. “They no longer require ongoing inflammatory signals from the microenvironment to stay active [growing and multiplying] — they remember the awakened state.”

While signals related to inflammation are necessary to awaken dormant cancer cells, exactly how much signaling is needed remains unclear. “This aspect of cancer biology is particularly challenging, because multiple signals contribute to the state change in these dormant cells,” Zhang says.

The team has already identified one key player in the awakening process, but understanding the full set of signals and how each contributes is far more complex — a question they are continuing to investigate in their new work. 

Studying these pivotal changes in the lives of cancer cells — such as their transition from dormancy to active growth — will deepen our scientific understanding of metastasis and, as researchers in the Weinberg Lab hope, lead to more effective treatments for patients with metastatic cancers.

Biogen groundbreaking stirs optimism in Kendall Square

MIT Latest News - Thu, 09/18/2025 - 1:30pm

Nearly 300 people gathered Tuesday to mark the ceremonial groundbreaking for Biogen’s new state-of-the-art facility in Kendall Square. The project is the first building to be constructed at MIT’s Kendall Common on the former Volpe federal site, and will serve as a consolidated headquarters for the pioneering biotechnology company which has called Cambridge home for more than 40 years.

In marking the start of construction, Massachusetts Governor Maura Healey addressed the enthusiastic crowd, saying, “Massachusetts science saves lives — saves lives here, saves lives around the world. We celebrate that in Biogen today, we celebrate that in Kendall Common, and we celebrate that in this incredible ecosystem that extends all across our great state. Today, Biogen is not just building a new facility, they are building the future of medicine and innovation.”

Emceed by Kirk Taylor, president and CEO of the Massachusetts Life Sciences Center, the event featured a specially created Lego model of the new building and a historic timeline of Biogen’s origin story overlaid on Kendall Square’s transformation. The program’s theme — “Making breakthroughs happen in Kendall Square” — seemed to elicit a palpable sense of pride among the Biogen and MIT employees, business leaders, and public officials in attendance.

MIT President Sally Kornbluth reflected on the vibrancy of the local innovation ecosystem: “I sometimes say that Kendall Square’s motto might as well be ‘talent in proximity.’ By following that essential recipe, Biogen’s latest decision to intensify its presence here promises great things for the whole region.” Kornbluth described Biogen’s move as “a very important signal to the world right now.”

Biogen’s March 2025 announcement that it will centralize operations at 75 Broadway was lauded as a show of strength for the historic company and the life sciences sector. The 580,000-square-foot research and development headquarters, designed by Elkus Manfredi Architects, will optimize Biogen’s scientific discovery and clinical processes. The new facility is scheduled to open in 2028.

CEO Chris Veihbacher shared his thoughts on Biogen’s decision: “I am proud to stand here with so many individuals who have shaped our past and who are dedicated to our future in Kendall Square. … We decided to invest in the next chapter of Kendall Square because of what this community represents: talent, energy, ingenuity, and collaboration.” Biogen was founded in 1978 by Nobel laureates Phillip Sharp (an MIT Institute Professor and professor of biology emeritus) and Wally Gilbert, both of whom were not only present, but received an impromptu standing ovation, led by Viehbacher.

Kendall Common is being developed by MIT’s Investment Management Company (MITIMCo) and will ultimately include four commercial buildings, four residential buildings (including affordable housing), open space, retail, entertainment, and a community center. MITIMCo’s joint venture partner for the Biogen project is BioMed Realty, a Blackstone Real Estate portfolio company.

Senior Vice President Patrick Rowe, who oversees MITIMCo’s real estate group, says, “Biogen is such a critical anchor for the area. I’m excited for the impact that this project will have on Kendall Square, and for the way that the Kendall Common development can help to further advance our innovation ecosystem.”

Time-of-Check Time-of-Use Attacks Against LLMs

Schneier on Security - Thu, 09/18/2025 - 7:06am

This is a nice piece of research: “Mind the Gap: Time-of-Check to Time-of-Use Vulnerabilities in LLM-Enabled Agents“.:

Abstract: Large Language Model (LLM)-enabled agents are rapidly emerging across a wide range of applications, but their deployment introduces vulnerabilities with security implications. While prior work has examined prompt-based attacks (e.g., prompt injection) and data-oriented threats (e.g., data exfiltration), time-of-check to time-of-use (TOCTOU) remain largely unexplored in this context. TOCTOU arises when an agent validates external state (e.g., a file or API response) that is later modified before use, enabling practical attacks such as malicious configuration swaps or payload injection. In this work, we present the first study of TOCTOU vulnerabilities in LLM-enabled agents. We introduce TOCTOU-Bench, a benchmark with 66 realistic user tasks designed to evaluate this class of vulnerabilities. As countermeasures, we adapt detection and mitigation techniques from systems security to this setting and propose prompt rewriting, state integrity monitoring, and tool-fusing. Our study highlights challenges unique to agentic workflows, where we achieve up to 25% detection accuracy using automated detection methods, a 3% decrease in vulnerable plan generation, and a 95% reduction in the attack window. When combining all three approaches, we reduce the TOCTOU vulnerabilities from an executed trajectory from 12% to 8%. Our findings open a new research direction at the intersection of AI safety and systems security...

National Academies backstops endangerment finding, risking feud with Trump

ClimateWire News - Thu, 09/18/2025 - 6:30am
The science panel reaffirmed greenhouse gases as a threat to human health in the face of administration efforts to downplay climate risks.

Democrats line up to back the endangerment finding

ClimateWire News - Thu, 09/18/2025 - 6:29am
One senator called for "an unprecedented response" to defend federal action against climate change.

N.J. Republican makes the case for Trump’s anti-wind crusade

ClimateWire News - Thu, 09/18/2025 - 6:28am
Rep. Jeff Van Drew, a prominent wind critic, says offshore wind developers gambled — and lost — when they chose to invest in the U.S.

Meet the New England anti-wind group aligning with Trump

ClimateWire News - Thu, 09/18/2025 - 6:26am
Green Oceans says its mission is environmental protection, but the group's critics say it's promoting fossil energy.

Blue states ask court to order restart of Revolution Wind

ClimateWire News - Thu, 09/18/2025 - 6:25am
“We have no time to waste in getting Revolution Wind back online,” Rhode Island's attorney general said in a statement Wednesday.

Charleston walks away from lawsuit against fossil fuel companies

ClimateWire News - Thu, 09/18/2025 - 6:24am
The coastal city’s lawsuit was dismissed last month. Charleston won't appeal the decision.

Top Indiana Republican slams ‘disgraceful’ wind, solar restrictions

ClimateWire News - Thu, 09/18/2025 - 6:23am
The state energy secretary said "patriotic communities" are supporting President Donald Trump's artificial intelligence agenda by adding clean electricity to the grid.

Al Gore calls Trump’s energy policies a ‘tragedy’ for the US

ClimateWire News - Thu, 09/18/2025 - 6:22am
China’s green-energy supremacy — and the U.S. retreat from clean tech — brings geopolitical ramifications, the former vice president said.

Drought forces PGA to move tour opener from Maui

ClimateWire News - Thu, 09/18/2025 - 6:21am
Kapalua Resort has been dealing with drought that's affected the island's 140,000 residents.

Drier, warmer climate boosts interest in low-water landscaping

ClimateWire News - Thu, 09/18/2025 - 6:20am
As climate change makes the world hotter and triggers more extreme weather, including drought, thirsty expanses of groomed emerald grass are taxing freshwater supplies that are already under stress.

Most corporate climate transition plans aren’t credible, study finds

ClimateWire News - Thu, 09/18/2025 - 6:20am
The report found that many companies aren’t putting enough capital toward decarbonization, and some rely too much on unproven technologies.

Could a primordial black hole’s last burst explain a mysteriously energetic neutrino?

MIT Latest News - Thu, 09/18/2025 - 12:00am

The last gasp of a primordial black hole may be the source of the highest-energy “ghost particle” detected to date, a new MIT study proposes.

In a paper appearing today in Physical Review Letters, MIT physicists put forth a strong theoretical case that a recently observed, highly energetic neutrino may have been the product of a primordial black hole exploding outside our solar system.

Neutrinos are sometimes referred to as ghost particles, for their invisible yet pervasive nature: They are the most abundant particle type in the universe, yet they leave barely a trace. Scientists recently identified signs of a neutrino with the highest energy ever recorded, but the source of such an unusually powerful particle has yet to be confirmed.

The MIT researchers propose that the mysterious neutrino may have come from the inevitable explosion of a primordial black hole. Primordial black holes (PBHs) are hypothetical black holes that are microscopic versions of the much more massive black holes that lie at the center of most galaxies. PBHs are theorized to have formed in the first moments following the Big Bang. Some scientists believe that primordial black holes could constitute most or all of the dark matter in the universe today.

Like their more massive counterparts, PBHs should leak energy and shrink over their lifetimes, in a process known as Hawking radiation, which was predicted by the physicist Stephen Hawking. The more a black hole radiates, the hotter it gets and the more high-energy particles it releases. This is a runaway process that should produce an incredibly violent explosion of the most energetic particles just before a black hole evaporates away.

The MIT physicists calculate that, if PBHs make up most of the dark matter in the universe, then a small subpopulation of them would be undergoing their final explosions today throughout the Milky Way galaxy. And, there should be a statistically significant possibility that such an explosion could have occurred relatively close to our solar system. The explosion would have released a burst of high-energy particles, including neutrinos, one of which could have had a good chance of hitting a detector on Earth.

If such a scenario had indeed occurred, the recent detection of the highest-energy neutrino would represent the first observation of Hawking radiation, which has long been assumed, but has never been directly observed from any black hole. What’s more, the event might indicate that primordial black holes exist and that they make up most of dark matter — a mysterious substance that comprises 85 percent of the total matter in the universe, the nature of which remains unknown.

“It turns out there’s this scenario where everything seems to line up, and not only can we show that most of the dark matter [in this scenario] is made of primordial black holes, but we can also produce these high-energy neutrinos from a fluke nearby PBH explosion,” says study lead author Alexandra Klipfel, a graduate student in MIT’s Department of Physics. “It’s something we can now try to look for and confirm with various experiments.”

The study’s other co-author is David Kaiser, professor of physics and the Germeshausen Professor of the History of Science at MIT.

High-energy tension

In February, scientists at the Cubic Kilometer Neutrino Telescope, or KM3NeT, reported the detection of the highest-energy neutrino recorded to date. KM3NeT is a large-scale underwater neutrino detector located at the bottom of the Mediterranean Sea, where the environment is meant to mute the effects of any particles other than neutrinos.

The scientists operating the detector picked up signatures of a passing neutrino with an energy of over 100 peta-electron-volts. One peta-electron volt is equivalent to the energy of 1 quadrillion electron volts.

“This is an incredibly high energy, far beyond anything humans are capable of accelerating particles up to,” Klipfel says. “There’s not much consensus on the origin of such high-energy particles.”

Similarly high-energy neutrinos, though not as high as what KM3NeT observed, have been detected by the IceCube Observatory — a neutrino detector embedded deep in the ice at the South Pole. IceCube has detected about half a dozen such neutrinos, whose unusually high energies have also eluded explanation. Whatever their source, the IceCube observations enable scientists to work out a plausible rate at which neutrinos of those energies typically hit Earth. If this rate were correct, however, it would be extremely unlikely to have seen the ultra-high-energy neutrino that KM3NeT recently detected. The two detectors’ discoveries, then, seemed to be what scientists call “in tension.”

Kaiser and Klipfel, who had been working on a separate project involving primordial black holes, wondered: Could a PBH have produced both the KM3NeT neutrino and the handful of IceCube neutrinos, under conditions in which PBHs comprise most of the dark matter in the galaxy? If they could show a chance existed, it would raise an even more exciting possibility — that both observatories observed not only high-energy neutrinos but also the remnants of Hawking radiation.

“Our best chance”

The first step the scientists took in their theoretical analysis was to calculate how many particles would be emitted by an exploding black hole. All black holes should slowly radiate over time. The larger a black hole, the colder it is, and the lower-energy particles it emits as it slowly evaporates. Thus, any particles that are emitted as Hawking radiation from heavy stellar-mass black holes would be near impossible to detect. By the same token, however, much smaller primordial black holes would be very hot and emit high-energy particles in a process that accelerates the closer the black hole gets to disappearing entirely.

“We don’t have any hope of detecting Hawking radiation from astrophysical black holes,” Klipfel says. “So if we ever want to see it, the smallest primordial black holes are our best chance.”

The researchers calculated the number and energies of particles that a black hole should emit, given its temperature and shrinking mass. In its final nanosecond, they estimate that once a black hole is smaller than an atom, it should emit a final burst of particles, including about 1020 neutrinos, or about a sextillion of the particles, with energies of about 100 peta-electron-volts (around the energy that KM3NeT observed).

They used this result to calculate the number of PBH explosions that would have to occur in a galaxy in order to explain the reported IceCube results. They found that, in our region of the Milky Way galaxy, about 1,000 primordial black holes should be exploding per cubic parsec per year. (A parsec is a unit of distance equal to about 3 light years, which is more than 10 trillion kilometers.)

They then calculated the distance at which one such explosion in the Milky Way could have occurred, such that just a handful of the high-energy neutrinos could have reached Earth and produced the recent KM3NeT event. They find that a PBH would have to explode relatively close to our solar system — at a distance about 2,000 times further than the distance between the Earth and our sun.

The particles emitted from such a nearby explosion would radiate in all directions. However, the team found there is a small, 8 percent chance that an explosion can happen close enough to the solar system, once every 14 years, such that enough ultra-high-energy neutrinos hit the Earth.

“An 8 percent chance is not terribly high, but it’s well within the range for which we should take such chances seriously — all the more so because so far, no other explanation has been found that can account for both the unexplained very-high-energy neutrinos and the even more surprising ultra-high-energy neutrino event,” Kaiser says.

The team’s scenario seems to hold up, at least in theory. To confirm their idea will require many more detections of particles, including neutrinos at “insanely high energies.” Then, scientists can build up better statistics regarding such rare events.

“In that case, we could use all of our combined experience and instrumentation, to try to measure still-hypothetical Hawking radiation,” Kaiser says. “That would provide the first-of-its-kind evidence for one of the pillars of our understanding of black holes — and could account for these otherwise anomalous high-energy neutrino events as well. That’s a very exciting prospect!”

In tandem, other efforts to detect nearby PBHs could further bolster the hypothesis that these unusual objects make up most or all of the dark matter.

This work was supported, in part, by the National Science Foundation, MIT’s Center for Theoretical Physics – A Leinweber Institute, and the U.S. Department of Energy.

Future of climate–city research

Nature Climate Change - Thu, 09/18/2025 - 12:00am

Nature Climate Change, Published online: 18 September 2025; doi:10.1038/s41558-025-02451-6

Cities will face increasing risk along with intensified climate shocks but can also act as key agents for mitigation and adaptation. We hope to see more research that could lead to enhanced climate action by providing comprehensive, equitable and practical solutions.

Rising cost of disturbances for forestry in Europe under climate change

Nature Climate Change - Thu, 09/18/2025 - 12:00am

Nature Climate Change, Published online: 18 September 2025; doi:10.1038/s41558-025-02408-9

Climate change will raise the severity and frequency of forest disturbance, damaging the economic value of timber. Researchers show Europe’s timber-based forestry could lose up to €247 billion, yet in some regions the increase in forest productivity could offset these shocks.

Appeals Court: Abandoned Phones Don’t Equal Abandoned Privacy Rights

EFF: Updates - Wed, 09/17/2025 - 1:46pm

This posted was drafted by EFF legal intern Alexandra Halbeck

The Court of Appeals for the Ninth Circuit, which covers California and most of the Western U.S., just delivered good news for digital privacy: abandoning a phone doesn’t abandon your Fourth Amendment rights in the phone’s contents. In United States v. Hunt, the court made clear that no longer having control of a device is not the same thing as surrendering the privacy of the information it contains. As a result, courts must separately analyze whether someone intended to abandon a physical phone and whether they intended to abandon the data stored within it. Given how much personal information our phones contain, it will be unlikely for courts to find that someone truly intended to give up their privacy rights in that data.

This approach mirrors what EFF urged in the amicus brief we filed in Hunt, joined by the ACLU, ACLU of Oregon, EPIC, and NACDL. We argued that a person may be separated from—or even discard—a device, yet still retain a robust privacy interest in the information it holds. Treating phones like wallets or backpacks ignores the reality of technology. Smartphones are comprehensive archives of our lives, containing years of messages, photos, location history, health data, browsing habits, and countless other intimate details. As the Supreme Court recognized in Riley v. California, our phones hold “the privacies of life,” and accessing those digital contents generally requires a warrant. This is an issue EFF has worked on across the country, and it is gratifying to see such an unambiguous ruling from an influential appellate court.

The facts of Hunt underscore why the court’s distinction between a device and its contents matters. In 2017, Dontae Hunt was shot multiple times and dropped an iPhone while fleeing for medical help. Police collected the phone from the crime scene and kept it as evidence. Nearly three years later—during an unrelated drug investigation—federal agents obtained a warrant and searched the phone’s contents. Hunt challenged both the warrantless seizure and the later search, arguing he never intended to abandon either the device or its data.

The court rejected the government’s sweeping abandonment theory and drew a crucial line for the digital age: even if police have legal possession of hardware, they do not have green light to rummage through its contents. The panel emphasized that courts must treat the device and the data as separate questions under a Fourth Amendment analysis.

In this specific case, because the government ultimately obtained a warrant before searching the device, that aspect of the case survived constitutional scrutiny—but crucially, only on that basis. The court also found that police acted reasonably in initially seizing the phone during the shooting investigation and keeping it as unclaimed property until a warrant could be obtained to search it.

Under Hunt, if officers find a phone that’s been misplaced, dropped during an emergency, or otherwise separated from its owner, they cannot leap from custody of the glass-and-metal shell to unfettered access to the comprehensive digital record inside. This decision ensures that constitutional protections don’t evaporate just because someone abandons their device, and that warrants still matter in the digital age. Our constitutional rights should follow our digital lives—no matter where our devices may end up.

ICE 🤝 Cyber Mercenaries | EFFector 37.12

EFF: Updates - Wed, 09/17/2025 - 1:19pm

It's easy to keep up with the fight for digital privacy and free expression. Our EFFector newsletter delivers bite-sized updates, stories, and actions you can take to stay informed and help out.

In this latest issue, we show how libraries and schools can safeguard their computers with Privacy Badger; highlight the dangers of unaccountable corporations and billionaires buying surveillance tech for police; and share news that EFF’s Executive Director, Cindy Cohn, will be stepping down in mid-2026 after more than two decades of leadership.

EFFector isn’t just for reading—you can listen, too! In our audio companion, EFF Senior Staff Technologist Cooper Quintin explains why ICE’s contract with Paragon Solutions is so dangerous. Catch the conversation on YouTube or the Internet Archive.

LISTEN TO EFFECTOR

EFFECTOR 37.12 - ICE 🤝 Cyber Mercenaries

Since 1990 EFF has published EFFector to help keep readers on the bleeding edge of their digital rights. We know that the intersection of technology, civil liberties, human rights, and the law can be complicated, so EFFector is a great way to stay on top of things. The newsletter is chock full of links to updates, announcements, blog posts, and other stories to help keep readers—and listeners—up to date on the movement to protect online privacy and free expression. 

Thank you to the supporters around the world who make our work possible! If you're not a member yet, join EFF today to help us fight for a brighter digital future.

When Knowing Someone at Meta Is the Only Way to Break Out of “Content Jail”

EFF: Updates - Wed, 09/17/2025 - 11:50am

This is the second instalment in a ten-part blog series documenting EFF's findings from the Stop Censoring Abortion campaign. You can read additional posts here. 

During our Stop Censoring Abortion campaign, we set out to collect and spotlight the growing number of stories from people and organizations that have had abortion-related content removed, suppressed, or flagged by dominant social media platforms. Our survey submissions have revealed some alarming trends, including: if you don’t have a personal or second-degree connection at Meta, your chances of restoring your content or account are likely to drop significantly. 

Through the survey, we heard from activists, clinics, and researchers whose accounts were suspended or permanently removed for allegedly violating Meta’s policies on promoting or selling “restricted goods,” even when their posts were purely educational or informational. What the submissions also showed is a pattern of overenforcement, lack of transparency, and arbitrary moderation decisions that have specifically affected reproductive health and reproductive justice advocates. 

When accounts are taken down, appeals can take days, weeks, or even months (if they're even resolved at all, or if users are even given the option to appeal). For organizations and providers, this means losing access to vital communication tools and being cut off from the communities they serve. This is highly damaging since so much of that interaction happens on Meta’s platforms. Yet we saw a disturbing pattern emerge in our survey: on several occasions, accounts are swiftly restored once someone with a connection to Meta intervenes.

The Case Studies: An Abortion Clinic

The Red River Women's Clinic is an abortion clinic in Moorhead, MN. It was originally located in Fargo, North Dakota, and for many years was the only abortion clinic in North Dakota. In early January, the clinic’s director heard from a patient that she thought they only offered procedural/surgical abortions and not medication abortion. To clarify for other patients, they posted on the clinic’s page that they offered both procedural and medication abortions—attaching an image of a box of mifepristone. When they tried to boost the post, the ad was flagged and their account was suspended.

They appealed the decision and initially got the ad approved, yet the page was suspended again shortly after. But this time, multiple appeals and direct emails went unanswered, until they reached out to a digital rights organization that was able to connect with staff at Meta that stepped in. Only then was their page restored, with Meta noting that their post did not violate the policies but warning that future violations could lead to permanent removal.

While this may have been a glitch in Meta’s systems or a misapplication of policy, the suspension of the clinic’s Facebook account was detrimental for them. “We were unable to update our followers about dates/times we were closed, we were unable to share important information and news about abortion that would have kept our followers up to date, there was a legislative session happening and we were unable to share events and timely asks for reaching out to legislators about issues,” shared Tammi Kromenaker, Director of Red River Women's Clinic. The clinic was also prevented from starting an Instagram page due to the suspension. “Facebook has a certain audience and Instagram has another audience,” said Kromenaker, “we are trying to cater to all of our supporters so the loss of FB and the inability to access and start an Instagram account were really troubling to us.” 

The Case Studies: RISE at Emory University

RISE, a reproductive health research center at Emory University, launched an Instagram account to share community-centered research and combat misinformation related to reproductive health. In January of this year, they posted educational content about mifepristone on their instagram. “Let's talk about Mifepristone + its uses + the importance of access”, read the post. Two months later, their account was suddenly suspended, flagging the account under its policy against selling illegal drugs. Their appeal was denied, which led to the account being permanently deleted. 

Screenshot submitted by RISE to EFF

“As a team, this was a hit to our morale” shared Sara Redd, Director of Research Translation at RISE. “We pour countless hours of person-power, creativity, and passion into creating the content we have on our page, and having it vanish virtually overnight took a toll on our team.” For many organizational users like RISE, their social media accounts are a repository for resources and metrics that may not be stored elsewhere. “We spent a significant amount of already-constrained team capacity attempting to recover all of the content we’d created for Instagram that was potentially going to be permanently lost. [...] We also spent a significant amount of time and energy trying to understand what options we might have available from Meta to appeal our case and/or recover our account; their support options are not easily accessible, and the time it took to navigate this issue distracted from our existing work.”  

Meta restored the account only after RISE was able to connect with someone there. Once RISE logged back in, they confirmed that the flagged post was the one about mifepristone. The post never sold or directed people where to buy pills, it simply provided accurate information about the use and efficacy of the drug. 

This Shouldn’t Be How Content Moderation Works

Meta spokespersons have admitted to instances of “overenforcement” in various press statements, noting that content is sometimes incorrectly removed or blurred even when it doesn’t actually violate policy. Meta has insisted to the public that they care about free speech, as a spokesperson mentioned to The New York Times: “We want our platforms to be a place where people can access reliable information about health services, advertisers can promote health services and everyone can discuss and debate public policies in this space [...] That’s why we allow posts and ads about, discussing and debating abortion.” In fact, their platform policies directly mention this

Note that advertisers don’t need authorization to run ads that only:

  • Educate, advocate or give public service announcements related to prescription drugs

Additionally

Note: Debating or advocating for the legality or discussing scientific or medical merits of prescription drugs is allowed. This includes news and public service announcements. 

Meta also has policies specific to “Health and Wellness,” where they state: 

When targeting people 18 years or older, advertisers can run ads that:

  • Promote sexual and reproductive health and wellness products or services, as long as the focus is on health and the medical efficacy of the product or the service and not on the sexual pleasure or enhancement. And these ads must target people 18 years or older. This includes ads for: [...]
  • Family planning methods, such as:
    • Family planning clinics
    • In Vitro Fertilization (IVF) or any other artificial insemination procedures
    • Fertility awareness
    • Abortion medical consultation and related services

But these public commitments don’t always match users’ experiences. 

Take the widely covered case of Aid Access, a group that provides medication abortion by mail. This year, several of their Instagram posts were blurred and removed on Instagram, including one with tips for feeling safe and supported at home after taking abortion medication. But only after multiple national media outlets contacted Meta for comment on the story were the posts and account restored.

So the question becomes: If Meta admits its enforcement isn’t perfect, why does it still take knowing someone, or having the media involved, to get a fair review? When companies like Meta claim to uphold commitments to free speech, those commitments should materialize in clear policies that are enforced equally, not only when it is escalated through leveraging relationships with Meta personnel.

“Facebook Jail” Reform

There is no question that the enforcement of these content moderation policies on Meta platforms and the length of time people are spending in “content jail” or “Facebook/Instagram jail” has created a chilling effect

“I think that I am more cautious and aware that the 6.1K followers we have built up over time could be taken away at any time based on the whims of Meta,” Tammi from Red River Women’s Clinic told us. 

RISE sees it in a slightly different light, sharing that “[w]hile this experience has not affected our fundamental values and commitment to sharing our work and rigorous science, it has highlighted for us that no information posted on a third-party platform is entirely one’s own, and thus can be dismantled at any moment.”

At the end of the day, clinics are left afraid to post basic information, patients are left confused or misinformed, and researchers lose access to their audiences. But unless your issue catches the attention of a journalist or you know someone at Meta, you might never regain access to your account.

These case studies highlight the urgent need for transparent, equitable, and timely enforcement that is not dependent on insider connections, as well as accountability from platforms that claim to support open dialogue and free speech. Meta’s admitted overenforcement should, at minimum, be coupled with efficient and well-staffed review processes and policies that are transparent and easily understandable. 

It’s time for Meta and other social media platforms to implement the reforms they claim to support, and for them to prove that protecting access to vital health information doesn’t hinge on who you know.

This is the second post in our blog series documenting the findings from our Stop Censoring Abortion campaign. Read more in the series: https://www.eff.org/pages/stop-censoring-abortion   

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