Glioblastoma is the most common form of brain cancer in adults, and its consequences are usually quick and fatal. After receiving standard-of-care treatment (surgery followed by radiation and chemotherapy), fewer than half of patients will survive longer than 15 months. Only 5 percent of patients survive longer than five years.

Researchers have explored immune checkpoint inhibitors as an avenue for boosting glioblastoma survival rates. This type of immunotherapy, which has proven effective against a range of tumor types, turns off a molecular switch that prevents T cells from attacking cancer cells. The patient’s own immune system is then able to clear the tumor. 

However, glioblastoma is unusually resistant to attack by T cells, rendering immune checkpoint inhibitors ineffective. The culprit is a different immune cell, macrophages, which have been recruited to tumors, where they support tumor growth while suppressing the ability of T cells to infiltrate and attack tumors.

A team of researchers led by Forest White at the MIT Koch Institute for Integrative Cancer Research used sophisticated immune profiling tools to map out how macrophages evolve from a first-line defense against cancer and other pathogens into a shield that protects the glioblastoma tumor — as well as how the tumor cells themselves are transformed by the encounter.

“Looking at the co-evolution of both cell types is key,” says White, who is also the Ned C. (1949) and Janet C. (Bemis) Rice Professor in the Department of Biological Engineering. “It’s a little bit like what happens when a new family moves into a neighborhood: The family members’ lives change, but so do the social dynamics of the people around them. Whether you’re mixing people or cells, you won’t be able to predict how they will interact, even if you know both well.”

“By looking at what happens when macrophages move into the tumor, we can observe changes to both types of cells that we wouldn’t otherwise be able to see,” says Yufei Cui, a PhD candidate in the White Laboratory. “We were able to identify new targets for both glioblastoma and macrophages that could be used to develop therapies that, when delivered in combination with immune checkpoint inhibitors, more effectively treat glioblastoma.”

The study, appearing recently in Cancer Research, includes Stefani Spranger, associate professor of biology and member of the MIT Koch Institute, and Darrell Irvine, former member of the Koch Institute and now professor at the Scripps Research Institute.

As in other cancers, macrophages play a pivotal role in glioblastoma development and resistance to immune therapies. In laboratory models, inhibiting the activity of tumor-associated macrophages has been found to slow glioblastoma growth, but that success has not translated to studies of human patients. While the overall strategy of targeting glioblastoma-associated macrophages is promising, new targets — derived from models that more accurately reproduce the cell interactions in patient tumors — need to be identified.

One approach to discovering such targets is a specialty of the White lab: profiling cells’ immunopeptidomes — the repertoires of antigens presented on the surfaces of cancer cells, macrophages, and many other types of cells. Surface-presenting antigens are a window into the internal state of the cell: The antigens derive from proteins produced as the cell carries out different functions and responds to its environment. By binding to surface antigens, T cells and other immune cells can monitor cells for dysfunction and respond to them. 

The White lab has developed sophisticated methods for immunopeptidome profiling, combining methods such as liquid chromatography and mass spectrometry to isolate cell surface antigens — in this case, from glioblastoma and macrophage cells cultured in isolation and together — and quantifying changes in expression over time. The researchers identified over 800 peptides in macrophages that either increased or decreased in expression when cultured with glioblastoma cells. Peptides with the biggest gains in expression under co-cultivation derived from 33 source proteins, mostly related to cytokine signaling that promotes tumor aggression and suppresses immune response to tumors.

Antigen presentation on glioblastoma cells was also transformed by interactions with macrophages. These antigens were associated with Rho GTPase, a signaling protein that belongs to Ras, a class of proteins that is mutated in 30 percent of all cancers. Changes in Rho GTPase expression predispose cells to developing hallmark traits of cancer, such as prolonged cell longevity, abnormal growth, and metastasis. Antigen profiles of co-cultured glioblastoma cells revealed over 40 Rho GTPase-associated antigens with increased expression compared to tumor cells cultured in isolation.

Researchers compared antigen expression changes in co-cultured macrophage and glioblastoma cells to immunopeptidome profiles of mouse models and human tumor samples, finding that patterns observed in cell culture translated to animal models and, potentially, to patients.

Researchers selected six antigens showing increased expression in either glioblastoma cells or macrophages to test as therapeutic targets, developing an mRNA-based immunostimulatory therapy for each antigen. After treating mice with glioblastoma, tumors showed significantly slowed growth overall and, in a few cases, were completely eradicated. 

In future work, the team plans to use their immunopeptidome profiling techniques to characterize co-cultured dendritic cells, which retrieve proteins from cancer cells and presents them to T cells as antigens, as well as to explore antigen presentation of cells in live models of glioblastoma.

“This study demonstrates the promise of profiling cell surface antigens,” says Cui. “With quantitative accuracy and cell type resolution, our approach could be used to design improved immunotherapies against many cancer types and other diseases,” says Cui.

This work was supported, in part, by the National Cancer Institute (NCI) and the MIT Center for Precision Cancer Medicine. 

Antibody treatments for cancer and other diseases are typically delivered intravenously, because of the large volumes that are needed per dose. This means the patient has to go to a hospital for every treatment, where they may spend hours receiving the infusion.

MIT engineers have now taken a major step toward reformulating antibodies so that they can be injected using a standard syringe. The researchers found a way to create solid particles of highly concentrated antibodies, suspended in a solution. These particles carry enough antibodies that only about 2 milliliters of solution would be needed per dose.

This advance could make it much easier for patients to receive antibody treatments, and could make treatment more accessible for patients who have difficulty coming into a hospital, including older people.

“As the global population ages, making the treatment process more convenient and accessible for those populations is something that needs to be addressed,” says Talia Zheng, an MIT graduate student who is the lead author of the new study.

Patrick Doyle, the Robert T. Haslam Professor of Chemical Engineering, is the senior author of the open-access paper, which appears in Advanced Materials. MIT graduate student Lucas Attia and Janet Teng ’25 are also authors of the study.

Highly concentrated antibodies

Therapeutic antibody drugs such as rituximab, which is used to treat some cancers, consist of antibodies suspended in a water-based solution. In addition to cancers, antibodies are also used to treat infectious diseases, as well as autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.

Because the antibody solutions are formulated at low concentrations (10 to 30 milligrams of antibody per milliliter of solution), patients need to be given at least 100 milliliters per dose, which is much too large to be injected using a standard syringe. To decrease this volume to the point where it could be injected, the antibody concentration would need to be at least 300 milligrams per milliliter, but that would make the solution much too thick to be injected.

“You can’t concentrate existing formulations to these concentrations,” Doyle says. “They’ll be very viscous and will exceed the force threshold of what you can inject into a patient.”

In 2023, Doyle’s lab developed a way to generated highly concentrated antibody formulations by encapsulating them into hydrogel particles. However, that process requires centrifugation, a step that would be difficult to scale up for manufacturing.

In their new study, the researchers took a different approach that allows them to create droplets suspended in an emulsion, similar to oil and vinegar. In this case, droplets containing antibodies dissolved in a watery solution are suspended in an organic solvent called pentanol.

These droplets can then be dehydrated, leaving behind highly concentrated solid antibodies — about 360 milligrams of antibody per milliliter of solution. These particles also include a small amount of polyethylene glycol (PEG), a polymer that helps stabilize the particles.

Once these solid particles form, the organic solvent surrounding them is removed and replaced with an aqueous solution (water containing dissolved salts and small amount of stabilizing polymer), similar to the solution now used to infuse therapeutic antibodies.

This assembly process can be done rapidly using a microfluidic setup and does not require centrifugation, which should allow it to be scaled up much more easily using emulsification devices compliant with GMP (good manufacturing practice) regulations.

“Our first approach was a bit brute force, and when we were developing this new approach, we said to it’s got to be simple if it’s going to be better and scalable,” Doyle says.

Injectable particles

The researchers showed that they could control the size of the particles — from about 60 to 200 microns in diameter — by changing the flow rate of the solutions that make up the droplets.

Using particles 100 microns in diameter, they tested the injectability of the solution using a mechanical force tester. Those studies showed that the force needed to push the plunger of a syringe containing the particle solution was less than 20 newtons.

“That is less than half of the maximum acceptable force that people usually try to aim for, so it’s very injectable,” Zheng says.

Using a 2-milliliter syringe, a typical size for subcutaneous injections, more than 700 milligrams of the target antibody could be given at once — enough for most therapeutic applications. The researchers also showed that their formulations remained stable under refrigeration for at least four months.

The researchers now plan to test their antibody particles for therapeutic applications in animal models. They are also working on scaling up the manufacturing process, so they can make enough for large-scale testing.

The research was funded by the MIT Undergraduate Research Opportunities Program and the U.S. Department of Energy.

Lisa Su ’90, SM ’91, PhD ’94, a leading executive in the semiconductor industry and head of the company Advanced Micro Devices (AMD), will deliver the address at the OneMIT Commencement Ceremony on Thursday, May 28.

As chair and CEO of AMD, Su has transformed the company, which is now a global leader in high-performance and AI computing. In addition to designing industry-leading CPUs and the specialized GPUs that enable AI applications, AMD technology is the foundation of many of the world’s most advanced supercomputers and high-performance computing systems. The company continues to work on next-generation hardware and open software that will accelerate the adoption of AI, which Su has described as the most transformational technology of our time.

Su has maintained a close relationship with MIT since her days as a student. She was the speaker at the 2017 doctoral hooding ceremony, and in 2018 she established the Lisa Su Fellowship Fund. She served on the Electrical Engineering and Computer Science Visiting Committee for 10 years. In 2022, Building 12, which houses MIT.nano, was named in her honor.

“Long before she led the spectacular turnaround of AMD and lent her name to MIT’s world-class nano facility, Lisa Su was an MIT student who inspired and mentored her classmates. During her PhD studies, she created instructions that guided generations of student researchers in using some of the Institute’s most advanced equipment,” says MIT President Sally Kornbluth. “Lisa is renowned for her intellectual rigor, boldness, and originality, and we're absolutely thrilled that she has agreed to deliver the Commencement address to our graduates this year.”

“MIT has always held a special place in my life and career, and I’m thrilled to accept the invitation to speak at Commencement,” Su says. “The Class of 2026 will be graduating at an exciting time, as AI transforms our world and expands what is possible, and I look forward to celebrating them as they prepare to share their skills and ideas with the world.”

Born in Taiwan, Su grew up in Queens, New York. After earning bachelor’s, master’s, and doctoral degrees in electrical engineering from MIT, she worked at Texas Instruments, IBM, and Freescale Semiconductor, then joined AMD in 2012. In her current position, Su is a member of a small group: Only about 10 percent of Fortune 500 companies have female CEOs.

“Lisa Su has embraced MIT’s ‘mind and hand’ motto over the course of her career, first with important scientific discoveries in semiconductor design and engineering, and later as an extraordinary business executive leading the delivery of innovative products that play an essential role in the modern digital economy. We are very fortunate that she has agreed to share some of the lessons learned on her journey,” says Jim Poterba, the Mitsui Professor of Economics and chair of the Commencement Committee.

“Dr. Lisa Su is an inspiration to the MIT community for the way she combines exceptional engineering and leadership with meaningful, far-reaching impact in computing and countless other fields,” senior class president Heba Hussein says. “Her journey embodies the spirit of MIT, and the Class of 2026 is incredibly excited to welcome her at Commencement as we step into the world carrying the same MIT values!”

“I am excited to hear from someone that I know we can all learn something from. I think all MIT students respect the ‘lock-in’ that must have been required to achieve all that she has, with AMD and beyond,” says Alice Hall, president of the Undergraduate Association.

“Dr. Su is a world leader in manufacturing technologies and personifies MIT's values. As an alum, she has shared many experiences with current students, and I look forward to hearing about how these experiences shaped her successful career,” says Teddy Warner, president of the Graduate Student Council.

Su has received many honors including two named for MIT alumni: the Global Semiconductor Association’s Dr. Morris Chang Exemplary Leadership Award and the Robert N. Noyce Medal. She was named TIME’s 2024 CEO of the Year and has been recognized as one of TIME’s 100 Most Influential People and Fortune's Most Powerful People in Business. She received the 2024 Bower Award for Business Leadership and the Distinguished Leadership Award from the Committee for Economic Development (CED). Su is a member of the American Academy of Arts and Sciences and the National Academy of Engineering.

Su joins notable recent MIT Commencement speakers including science communicator Hank Green (2025); inventor and entrepreneur Noubar Afeyan (2024); YouTuber and inventor Mark Rober (2023); Director-General of the World Trade Organization Ngozi Okonjo-Iweala (2022); lawyer and social justice activist Bryan Stevenson (2021); and retired U.S. Navy four-star admiral William McRaven (2020). 

Capturing carbon dioxide from industrial plants is an important strategy in the efforts to reduce the impact of global climate change. It’s used in many industries, including the production of petrochemicals, cement, and fertilizers.

MIT chemical engineers have now discovered a simple way to make carbon capture more efficient and affordable, by adding a common chemical compound to capture solutions. The innovation could cut costs significantly and enable the technology to run on waste heat or even sunlight, instead of energy-intensive heating.

Their new approach uses a chemical called tris — short for tris(hydroxymethyl)aminomethane — to stabilize the pH of the solution used to capture CO2, allowing the system to absorb more of the gas at relatively low temperature. The system can release CO2 at just 60 degrees Celsius (140 degrees Fahrenheit) — a dramatic improvement over conventional methods, which require temperatures exceeding 120 C to release captured carbon.

“It’s something that could be implemented almost immediately in fairly standard types of equipment,” says T. Alan Hatton, the Ralph Landau Professor of Chemical Engineering Practice at MIT and the senior author of the study.

Youhong (Nancy) Guo, a recent MIT postdoc who is now an assistant professor of applied physical sciences at the University of North Carolina at Chapel Hill, is the lead author of the paper, which appears today in Nature Chemical Engineering.

More efficient capture

Using current technologies, around 0.1 percent of global carbon emissions is captured and either stored underground or converted into other products.

The most widely used carbon-capture method involves running waste gases through a solution that contains chemical compounds called amines. These solutions have a high pH, which allows them to absorb CO2, an acidic gas. In addition to traditional amines, basic compounds called carbonates, which are inexpensive and readily available, can also capture acidic CO2 gas. However, as CO2 is absorbed, the pH of the solution drops quickly, limiting the CO2 uptake capacity.

The most energy-intensive step comes once the CO2 is absorbed, because both amine and carbonate solutions must be heated to above 120 C to release the captured carbon. This regeneration step consumes enormous amounts of energy.

To make carbon capture by carbonates more efficient, the MIT team added tris into a potassium carbonate solution. This chemical, commonly used in lab experiments and found in some cosmetics and the Covid-19 mRNA vaccines, acts as a pH buffer — a solution that helps prevent the pH from changing.

When added to a carbonate solution, positively charged tris balances the negative charge of the bicarbonate ions formed when CO2 is absorbed. This stabilizes the pH, allowing the solution to absorb triple the amount of CO2.

As another advantage, tris is highly sensitive to temperature changes. When the solution full of CO2 is heated just slightly, to about 60 C, tris quickly releases protons, causing the pH to drop and the captured CO2 to bubble out.

“At room temperature, the solution can absorb more CO2, and with mild heating it can release the CO2. There is an instant pH change when we heat up the solution a little bit,” Guo says.

“Potassium carbonate is one of the holy grail solvents for carbon capture due to its high chemical stability, low cost, and negligible emissions,” says David Heldebrant, an associate professor of chemical engineering and bioengineering at Washington State University, who was not involved in the study. “I believe this electrochemical tris-promoted potassium carbonate solvent system has a lot of promise for the field of carbon capture, especially since the researchers have been able to improve on the energetics by regenerating at atmospheric pressure, as compared to vacuum-assisted regeneration, which is normally done.”

A simple swap

To demonstrate their approach, the researchers built a continuous-flow reactor for carbon capture. First, gases containing CO2 are bubbled through a reservoir containing carbonate and tris, which absorbs the CO2. That solution then is pumped into a CO2 regeneration module, which is heated to about 60 C to release a pure stream of CO2.

Once the CO2 is released, the carbonate solution is cooled and returned to the reservoir for another round of CO2 absorption and regeneration.

Because the system can operate at relatively low temperatures, there is more flexibility in where the energy could come from, such as solar panels, electricity, or waste heat already generated by industrial plants.

Swapping in carbonate-tris solutions to replace conventional amines should be straightforward for industrial facilities, the researchers say. “One of the nice things about this is its simplicity, in terms of overall design. It’s a drop-in approach that allows you to readily change over from one kind of solution to another,” Hatton says.

When carbon is captured from industrial plants, some of it can be diverted into the manufacture of other useful products, but most of it will likely end up being stored in underground geological formations, Hatton says.

“You can only use a small fraction of the captured CO2 for producing chemicals before you saturate the market,” he says.

Guo is now exploring whether other additives could make the carbon capture process even more efficient by speeding up CO2 absorption rates.

The authors acknowledge Eni S.p.A. for the fruitful discussions under the MIT–Eni research framework agreement.

MIT researchers have developed a new fabrication method that could enable the production of more energy efficient electronics by stacking multiple functional components on top of one existing circuit.

In traditional circuits, logic devices that perform computation, like transistors, and memory devices that store data are built as separate components, forcing data to travel back and forth between them, which wastes energy.

This new electronics integration platform allows scientists to fabricate transistors and memory devices in one compact stack on a semiconductor chip. This eliminates much of that wasted energy while boosting the speed of computation.

Key to this advance is a newly developed material with unique properties and a more precise fabrication approach that reduces the number of defects in the material. This allows the researchers to make extremely tiny transistors with built-in memory that can perform faster than state-of-the-art devices while consuming less electricity than similar transistors.

By improving the energy efficiency of electronic devices, this new approach could help reduce the burgeoning electricity consumption of computation, especially for demanding applications like generative AI, deep learning, and computer vision tasks.

“We have to minimize the amount of energy we use for AI and other data-centric computation in the future because it is simply not sustainable. We will need new technology like this integration platform to continue that progress,” says Yanjie Shao, an MIT postdoc and lead author of two papers on these new transistors.

The new technique is described in two papers (one invited) that were presented at the IEEE International Electron Devices Meeting. Shao is joined on the papers by senior authors Jesús del Alamo, the Donner Professor of Engineering in the MIT Department of Electrical Engineering and Computer Science (EECS); Dimitri Antoniadis, the Ray and Maria Stata Professor of Electrical Engineering and Computer Science at MIT; as well as others at MIT, the University of Waterloo, and Samsung Electronics.

Flipping the problem

Standard CMOS (complementary metal-oxide semiconductor) chips traditionally have a front end, where the active components like transistors and capacitors are fabricated, and a back end that includes wires called interconnects and other metal bonds that connect components of the chip.

But some energy is lost when data travel between these bonds, and slight misalignments can hamper performance. Stacking active components would reduce the distance data must travel and improve a chip’s energy efficiency.

Typically, it is difficult to stack silicon transistors on a CMOS chip because the high temperature required to fabricate additional devices on the front end would destroy the existing transistors underneath.

The MIT researchers turned this problem on its head, developing an integration technique to stack active components on the back end of the chip instead.

“If we can use this back-end platform to put in additional active layers of transistors, not just interconnects, that would make the integration density of the chip much higher and improve its energy efficiency,” Shao explains.

The researchers accomplished this using a new material, amorphous indium oxide, as the active channel layer of their back-end transistor. The active channel layer is where the transistor’s essential functions take place.

Due to the unique properties of indium oxide, they can “grow” an extremely thin layer of this material at a temperature of only about 150 degrees Celsius on the back end of an existing circuit without damaging the device on the front end.

Perfecting the process

They carefully optimized the fabrication process, which minimizes the number of defects in a layer of indium oxide material that is only about 2 nanometers thick.

A few defects, known as oxygen vacancies, are necessary for the transistor to switch on, but with too many defects it won’t work properly. This optimized fabrication process allows the researchers to produce an extremely tiny transistor that operates rapidly and cleanly, eliminating much of the additional energy required to switch a transistor between off and on.

Building on this approach, they also fabricated back-end transistors with integrated memory that are only about 20 nanometers in size. To do this, they added a layer of material called ferroelectric hafnium-zirconium-oxide as the memory component.

These compact memory transistors demonstrated switching speeds of only 10 nanoseconds, hitting the limit of the team’s measurement instruments. This switching also requires much lower voltage than similar devices, reducing electricity consumption.

And because the memory transistors are so tiny, the researchers can use them as a platform to study the fundamental physics of individual units of ferroelectric hafnium-zirconium-oxide.

“If we can better understand the physics, we can use this material for many new applications. The energy it uses is very minimal, and it gives us a lot of flexibility in how we can design devices. It really could open up many new avenues for the future,” Shao says.

The researchers also worked with a team at the University of Waterloo to develop a model of the performance of the back-end transistors, which is an important step before the devices can be integrated into larger circuits and electronic systems.

In the future, they want to build upon these demonstrations by integrating back-end memory transistors onto a single circuit. They also want to enhance the performance of the transistors and study how to more finely control the properties of ferroelectric hafnium-zirconium-oxide.

“Now, we can build a platform of versatile electronics on the back end of a chip that enable us to achieve high energy efficiency and many different functionalities in very small devices. We have a good device architecture and material to work with, but we need to keep innovating to uncover the ultimate performance limits,” Shao says.

This work is supported, in part, by Semiconductor Research Corporation (SRC) and Intel. Fabrication was carried out at the MIT Microsystems Technology Laboratories and MIT.nano facilities. 

On Nov. 8, the MIT Priscilla King Gray Public Service Center (MIT PKG Center) collaborated with the MIT Club of Princeton, New Jersey, and the Trenton Area Soup Kitchen (TASK) to prototype tech-driven interventions to the growing challenge of food insecurity in the Trenton, New Jersey region.  

Twelve undergraduates traveled to Trenton for a one-day social impact hackathon, working in teams with alumni active in the MIT Club of Princeton to address technical challenges posed by TASK. These included predicting the number of daily meals based on historical data for an organization serving over 12,000 meals each week, and gathering real-time feedback from hundreds of patrons with limited access to technology. 

The day culminated in a pitch session judged by MIT alumni and TASK leadership. The winning solution, developed by a cross-generational team of MIT alumni and students, addressed one of TASK’s most pressing challenges with a blend of technical ingenuity and human-centered design. Drawing on TASK datasets and external data such as weather and holidays, the team proposed a predictive dashboard that impressed judges with its practical utility, enabling the kitchen to reduce waste and distribute the appropriate number of meals to varied locations. TASK also appreciated several elements of solutions proposed to gather real-time feedback from patrons, and plans to experiment with them. 

“The last few weeks have shown how quickly the need for food can escalate in a place like Trenton, where so many people are living below or close to the federal poverty line,” says TASK CEO Amy Flynn. “The issues we are facing are complex and unprecedented, and the hackathon was an opportunity to think about our challenges, and their solutions, in modern and innovative ways. TASK is very excited to be partnering with MIT, the PKG Center for Social Impact, and the local MIT Club of Princeton for this event, particularly at this critical time.”

Students will implement the winning intervention through the PKG Center’s Social Impact Internship Program during MIT’s Independent Activities Period (IAP) in January 2026. Alumni from the MIT Club of Princeton will also serve as mentors to students during their internship. 

Alumni connections

The PKG Center recently completed a new strategic plan, and heard through the process that alumni and students passionate about making a positive impact want more opportunities to interact with and learn from each other.

“A hackathon seemed like an ideal way to connect students and alumni, generating mentoring relationships while making a tangible impact,” says Alison Badgett, associate dean and director of the PKG Center. “We’re grateful to the MIT Club of Princeton and the Trenton Area Soup Kitchen for enabling us to pilot what we hope will be a regular event.”

The idea for a regional hackathon came from the Friends of the PKG Center, the center’s alumni advisory board, which grew 25 percent this year with the addition of several young alumni. Princeton-based alumni Eberhard Wunderlich SM ’75, PhD ’78 and Shahla Wunderlich PhD ’78 offered to help make the idea a reality by connecting PKG with local partners. 

"We have been longtime friends of the PKG Center and have observed over the years that MIT students are uniquely positioned to make a real impact. We were eager to connect the PKG Center with the MIT Club of Princeton and TASK because we knew this collaboration would be meaningful not only for students, alumni, and families, but also for many people in need within our community," said the Wunderlichs. “It was a wonderful experience working with such talented students. We were happy to participate and look forward to the project enhancing the operation of TASK, which provides meals and develops skills for independence for those in need in Mercer County, New Jersey.”

A legacy of innovation and impact

The hackathon was facilitated by Lauren Tyger, the PKG Center’s assistant dean for social innovation, who leads a growing suite of social innovation and entrepreneurship programming for the PKG Center. Tyger recruited the 12 undergraduate participants from PKG’s Social Innovation Exploration first-year pre-orientation program (FPOP), an intensive five-day hackathon exploring food insecurity through the lens of sustainability at MIT and in Cambridge, Massachusetts. 

“For students, the regional alumni-student hackathon was an opportunity to implement what they learned through PKG’s FPOP to a real-world challenge with TASK,” says Tyger. “We hope students will not only be inspired to implement their winning interventions through an IAP internship, but also to explore social enterprise solutions to food insecurity through our IDEAS Social Innovation Incubator, now in its 25th year.”

With the success of this event, the PKG Center is exploring opportunities to host more alumni-student hackathons with regional MIT clubs, as a way to celebrate the 25th anniversary of the IDEAS Social Innovation Challenge, which has invested $1.3 million in nearly 300 social enterprises since its inception in 2001. 

“Getting to work with TASK was amazing because it allowed me to put the skills I learned in PKG’s SIE FPOP to a real-world application that could help people,” says Vivian Dinh, a student who participated in the hackathon. “It was a great feeling to put together things that we learned in SIE like ideation strategies, interviewing skills, and prototyping into a product, and then see that TASK truly believed in our ideas. Overall, it was a very empowering experience, knowing that my skills and ideas could help a community.”

In the vision disorder amblyopia (commonly known as “lazy eye”), impaired vision in one eye during development causes neural connections in the brain’s visual system to shift toward supporting the other eye, leaving the amblyopic eye less capable even after the original impairment is corrected. Current interventions are only effective during infancy and early childhood, while the neural connections are still being formed. 

Now a study in mice by neuroscientists in The Picower Institute for Learning and Memory at MIT shows that if the retina of the amblyopic eye is temporarily and reversibly anesthetized just for a couple of days, the brain’s visual response to the eye can be restored, even in adulthood.

The open-access findings, published Nov. 25 in Cell Reports, may improve the clinical potential of the idea of temporarily anesthetizing a retina to restore the strength of the amblyopic eye’s neural connections. 

In 2021, the lab of Picower Professor Mark Bear and collaborators showed that anesthetizing the non-amblyopic eye could improve vision in the amblyopic one — an approach analogous in that way to the treatment used in childhood of patching the unimpaired eye. Those 2021 findings have now been replicated in adults of multiple species. But the new evidence on how inactivation works suggests that the proposed treatment also could be effective when applied directly to the amblyopic eye, Bear says, though a key next step will be to again show that it works in additional species and, ultimately, people.

“If it does, it’s a pretty substantial step forward, because it would be reassuring to know that vision in the good eye would not have to be interrupted by treatment,” says Bear, a faculty member in MIT’s Department of Brain and Cognitive Sciences. “The amblyopic eye, which is not doing much, could be inactivated and ‘brought back to life’ instead. Still, I think that especially with any invasive treatment, it’s extremely important to confirm the results in higher species with visual systems closer to our own.”

Madison Echavarri-Leet PhD ’25, whose doctoral thesis included this research, is the lead author of the study, which also demonstrates the underlying process in the brain that makes the potential treatment work.

A beneficial burst

Bear’s lab has been studying the science underlying amblyopia for decades, for instance by working to understand the molecular mechanisms that enable neural circuits to change their connections in response to visual experience or deprivation. The research has produced ideas about how to address amblyopia in adulthood. In a 2016 study with collaborators at Dalhousie University, they showed that temporarily anesthetizing both retinas could restore vision loss in amblyopia. Then, five years later, they published the study showing that anesthetizing just the non-amblyopic eye produced visual recovery for the amblyopic eye.

Throughout that time, the lab weighed multiple hypotheses to explain how retinal inactivation works its magic. Lingering in the lab’s archive of results, Bear says, was an unexplored finding in the lateral geniculate nucleus (LGN) that relays information from the eyes to the visual cortex, where vision is processed: back in 2008, they had found that blocking inputs from a retina to neurons in the LGN caused those neurons to fire synchronous “bursts” of electrical signals to downstream neurons in the visual cortex. Similar patterns of activity occur in the visual system before birth and guide early synaptic development.

The new study tested whether those bursts might have a role in the potential amblyopia treatments the lab was reporting. To get started, Leet and Bear’s team used a single injection of tetrodotoxin (TTX) to anesthetize retinas in the lab animals. They found that the bursting occurred not only in LGN neurons that received input from the anesthetized eye, but also in LGN neurons that received input from the unaffected eye.

From there, they showed that the bursting response depended on a particular “T-type” channel for calcium in the LGN neurons. This was important, because knowing this gave the scientists a way to turn it off. Once they gained that ability, then they could test whether doing so prevented TTX from having a therapeutic effect in mice with amblyopia.

Sure enough, when the researchers genetically knocked out the channels and disrupted the bursting, they found that anesthetizing the non-amblyopic eye could no longer help amblyopic mice. That showed the bursting is necessary for the treatment to work.

Aiding amblyopia

Given their finding that bursting occurs when either retina is anesthetized, the scientists hypothesized it might be enough to just do it in the amblyopic eye. To test this, they ran an experiment in which some mice modeling amblyopia received TTX in their amblyopic eye and some did not. The injection took the retina offline for two days. After a week, the scientists then measured activity in neurons in the visual cortex to calculate a ratio of input from each eye. They found that the ratio was much more even in mice that received the treatment versus those left untreated, indicating that after the amblyopic eye was anesthetized, its input in the brain rose to be at parity with input from the non-amblyopic one.

Further testing is needed, Bear notes, but the team wrote in the study that the results were encouraging.

“We are cautiously optimistic that these findings may lead to a new treatment approach for human amblyopia, particularly given the discovery that silencing the amblyopic eye is effective,” the scientists wrote.

In addition to Leet and Bear, the paper’s authors are Tushar Chauhan, Teresa Cramer, and Ming-fai Fong.

The National Institutes of Health, the Swiss National Science Foundation, the Severin Hacker Vision Research Fund, and the Freedom Together Foundation supported the study.

In the horticultural world, some vines are especially grabby. As they grow, the woody tendrils can wrap around obstacles with enough force to pull down entire fences and trees.

Inspired by vines’ twisty tenacity, engineers at MIT and Stanford University have developed a robotic gripper that can snake around and lift a variety of objects, including a glass vase and a watermelon, offering a gentler approach compared to conventional gripper designs. A larger version of the robo-tendrils can also safely lift a human out of bed.

The new bot consists of a pressurized box, positioned near the target object, from which long, vine-like tubes inflate and grow, like socks being turned inside out. As they extend, the vines twist and coil around the object before continuing back toward the box, where they are automatically clamped in place and mechanically wound back up to gently lift the object in a soft, sling-like grasp.

The researchers demonstrated that the vine robot can safely and stably lift a variety of heavy and fragile objects. The robot can also squeeze through tight quarters and push through clutter to reach and grasp a desired object.

The team envisions that this type of robot gripper could be used in a wide range of scenarios, from agricultural harvesting to loading and unloading heavy cargo. In the near term, the group is exploring applications in eldercare settings, where soft inflatable robotic vines could help to gently lift a person out of bed.

“Transferring a person out of bed is one of the most physically strenuous tasks that a caregiver carries out,” says Kentaro Barhydt, a PhD candidate in MIT’s Department of Mechanical Engineering. “This kind of robot can help relieve the caretaker, and can be gentler and more comfortable for the patient.”

Barhydt, along with his co-first author from Stanford, O. Godson Osele, and their colleagues, present the new robotic design today in the journal Science Advances. The study’s co-authors are Harry Asada, the Ford Professor of Engineering at MIT, and Allison Okamura, the Richard W. Weiland Professor of Engineering at Stanford University, along with Sreela Kodali and Cosmia du Pasquier at Stanford University, and former MIT graduate student Chase Hartquist, now at the University of Florida, Gainesville.

Open and closed

The team’s Stanford collaborators, led by Okamura, pioneered the development of soft, vine-inspired robots that grow outward from their tips. These designs are largely built from thin yet sturdy pneumatic tubes that grow and inflate with controlled air pressure. As they grow, the tubes can twist, bend, and snake their way through the environment, and squeeze through tight and cluttered spaces.

Researchers have mostly explored vine robots for use in safety inspections and search and rescue operations. But at MIT, Barhydt and Asada, whose group has developed robotic aides for the elderly, wondered whether such vine-inspired robots could address certain challenges in eldercare — specifically, the challenge of safely lifting a person out of bed. Often in nursing and rehabilitation settings, this transfer process is done with a patient lift, operated by a caretaker who must first physically move a patient onto their side, then back onto a hammock-like sheet. The caretaker straps the sheet around the patient and hooks it onto the mechanical lift, which then can gently hoist the patient out of bed, similar to suspending a hammock or sling.

The MIT and Stanford team imagined that as an alternative, a vine-like robot could gently snake under and around a patient to create its own sort of sling, without a caretaker having to physically maneuver the patient. But in order to lift the sling, the researchers realized they would have to add an element that was missing in existing vine robot designs: Essentially, they would have to close the loop.

Most vine-inspired robots are designed as “open-loop” systems, meaning they act as open-ended strings that can extend and bend in different configurations, but they are not designed to secure themselves to anything to form a closed loop. If a vine robot could be made to transform from an open loop to a closed loop, Barhydt surmised that it could make itself into a sling around the object and pull itself up, along with whatever, or whomever, it might hold.

For their new study, Barhydt, Osele, and their colleagues outline the design for a new vine-inspired robotic gripper that combines both open- and closed-loop actions. In an open-loop configuration, a robotic vine can grow and twist around an object to create a firm grasp. It can even burrow under a human lying on a bed. Once a grasp is made, the vine can continue to grow back toward and attach to its source, creating a closed loop that can then be retracted to retrieve the object.

“People might assume that in order to grab something, you just reach out and grab it,” Barhydt says. “But there are different stages, such as positioning and holding. By transforming between open and closed loops, we can achieve new levels of performance by leveraging the advantages of both forms for their respective stages.”

Gentle suspension

As a demonstration of their new open- and closed-loop concept, the team built a large-scale robotic system designed to safely lift a person up from a bed. The system comprises a set of pressurized boxes attached on either end of an overhead bar. An air pump inside the boxes slowly inflates and unfurls thin vine-like tubes that extend down toward the head and foot of a bed. The air pressure can be controlled to gently work the tubes under and around a person, before stretching back up to their respective boxes. The vines then thread through a clamping mechanism that secures the vines to each box. A winch winds the vines back up toward the boxes, gently lifting the person up in the process.

“Heavy but fragile objects, such as a human body, are difficult to grasp with the robotic hands that are available today,” Asada says. “We have developed a vine-like, growing robot gripper that can wrap around an object and suspend it gently and securely.”

"There’s an entire design space we hope this work inspires our colleagues to continue to explore,” says co-lead author Osele. “I especially look forward to the implications for patient transfer applications in health care.”

“I am very excited about future work to use robots like these for physically assisting people with mobility challenges,” adds co-author Okamura. “Soft robots can be relatively safe, low-cost, and optimally designed for specific human needs, in contrast to other approaches like humanoid robots.”

While the team’s design was motivated by challenges in eldercare, the researchers realized the new design could also be adapted to perform other grasping tasks. In addition to their large-scale system, they have built a smaller version that can attach to a commercial robotic arm. With this version, the team has shown that the vine robot can grasp and lift a variety of heavy and fragile objects, including a watermelon, a glass vase, a kettle bell, a stack of metal rods, and a playground ball. The vines can also snake through a cluttered bin to pull out a desired object.

“We think this kind of robot design can be adapted to many applications,” Barhydt says. “We are also thinking about applying this to heavy industry, and things like automating the operation of cranes at ports and warehouses.”

This work was supported, in part, by the National Science Foundation and the Ford Foundation.

In everyday conversation, it’s critical to understand not just the words that are spoken, but the context in which they are said. If it’s pouring rain and someone remarks on the “lovely weather,” you won’t understand their meaning unless you realize that they’re being sarcastic.

Making inferences about what someone really means when it doesn’t match the literal meaning of their words is a skill known as pragmatic language ability. This includes not only interpreting sarcasm but also understanding metaphors and white lies, among many other conversational subtleties.

“Pragmatics is trying to reason about why somebody might say something, and what is the message they’re trying to convey given that they put it in this particular way,” says Evelina Fedorenko, an MIT associate professor of brain and cognitive sciences and a member of MIT’s McGovern Institute for Brain Research.

New research from Fedorenko and her colleagues has revealed that these abilities can be grouped together based on what types of inferences they require. In a study of 800 people, the researchers identified three clusters of pragmatic skills that are based on the same kinds of inferences and may have similar underlying neural processes.

One of these clusters includes inferences that are based on our knowledge of social conventions and rules. Another depends on knowledge of how the physical world works, while the last requires the ability to interpret differences in tone, which can indicate emphasis or emotion.

Fedorenko and Edward Gibson, an MIT professor of brain and cognitive sciences, are the senior authors of the study, which appears today in the Proceedings of the National Academy of Sciences. The paper’s lead authors are Sammy Floyd, a former MIT postdoc who is now an assistant professor of psychology at Sarah Lawrence College, and Olessia Jouravlev, a former MIT postdoc who is now an associate professor of cognitive science at Carleton University.

The importance of context

Much past research on how people understand language has focused on processing the literal meanings of words and how they fit together. To really understand what someone is saying, however, we need to interpret those meanings based on context.

“Language is about getting meanings across, and that often requires taking into account many different kinds of information — such as the social context, the visual context, or the present topic of the conversation,” Fedorenko says.

As one example, the phrase “people are leaving” can mean different things depending on the context, Gibson points out. If it’s late at night and someone asks you how a party is going, you may say “people are leaving,” to convey that the party is ending and everyone’s going home.

“However, if it’s early, and I say ‘people are leaving,’ then the implication is that the party isn’t very good,” Gibson says. “When you say a sentence, there’s a literal meaning to it, but how you interpret that literal meaning depends on the context.”

About 10 years ago, with support from the Simons Center for the Social Brain at MIT, Fedorenko and Gibson decided to explore whether it might be possible to precisely distinguish the types of processing that go into pragmatic language skills.

One way that neuroscientists can approach a question like this is to use functional magnetic resonance imaging (fMRI) to scan the brains of participants as they perform different tasks. This allows them to link brain activity in different locations to different functions. However, the tasks that the researchers designed for this study didn’t easily lend themselves to being performed in a scanner, so they took an alternative approach.

This approach, known as “individual differences,” involves studying a large number of people as they perform a variety of tasks. This technique allows researchers to determine whether the same underlying brain processes may be responsible for performance on different tasks.

To do this, the researchers evaluate whether each participant tends to perform similarly on certain groups of tasks. For example, some people might perform well on tasks that require an understanding of social conventions, such as interpreting indirect requests and irony. The same people might do only so-so on tasks that require understanding how the physical world works, and poorly on tasks that require distinguishing meanings based on changes in intonation — the melody of speech. This would suggest that separate brain processes are being recruited for each set of tasks.

The first phase of the study was led by Jouravlev, who assembled existing tasks that require pragmatic skills and created many more, for a total of 20. These included tasks that require people to understand humor and sarcasm, as well as tasks where changes in intonation can affect the meaning of a sentence. For example, someone who says “I wanted blue and black socks,” with emphasis on the word “black,” is implying that the black socks were forgotten.

“People really find ways to communicate creatively and indirectly and non-literally, and this battery of tasks captures that,” Floyd says.

Components of pragmatic ability

The researchers recruited study participants from an online crowdsourcing platform to perform the tasks, which took about eight hours to complete. From this first set of 400 participants, the researchers found that the tasks formed three clusters, related to social context, general knowledge of the world, and intonation. To test the robustness of the findings, the researchers continued the study with another set of 400 participants, with this second half run by Floyd after Jouravlev had left MIT.

With the second set of participants, the researchers found that tasks clustered into the same three groups. They also confirmed that differences in general intelligence, or in auditory processing ability (which is important for the processing of intonation), did not affect the outcomes that they observed.

In future work, the researchers hope to use brain imaging to explore whether the pragmatic components they identified are correlated with activity in different brain regions. Previous work has found that brain imaging often mirrors the distinctions identified in individual difference studies, but can also help link the relevant abilities to specific neural systems, such as the core language system or the theory of mind system.

This set of tests could also be used to study people with autism, who sometimes have difficulty understanding certain social cues. Such studies could determine more precisely the nature and extent of these difficulties. Another possibility could be studying people who were raised in different cultures, which may have different norms around speaking directly or indirectly.

“In Russian, which happens to be my native language, people are more direct. So perhaps there might be some differences in how native speakers of Russian process indirect requests compared to speakers of English,” Jouravlev says.

The research was funded by the Simons Center for the Social Brain at MIT, the National Institutes of Health, and the National Science Foundation. 

MIT has long bolstered U.S. manufacturing by developing key innovations and production technologies, and training entrepreneurs. This fall, the Institute introduced a new tool for U.S. manufacturing: an education program for workers, held at collaborating institutions, which teaches core principles of production, helping employees and firms alike.

The new effort, the Technologist Advanced Manufacturing Program, or TechAMP, developed with U.S. Department of Defense funding, features a mix of in-person lab instruction at participating institutions, online lectures by MIT faculty and staff, and interactive simulations. There are also capstone projects, in which employees study manufacturing issues with the aim of saving their firms money.

Ultimately, TechAMP is a 12-month certificate program aimed at making the concept of the accredited “technologist” a vital part of the manufacturing enterprise. That could help workers advance in their careers. And it could help firms develop a more skilled workforce.

“We think there’s a gap between the traditional worker categories of engineer and technician, and this technologist training fills it,” says John Liu, a principal research scientist in MIT’s Department of Mechanical Engineering and co-principal investigator of the TechAMP program. “We’re very interested in creating new career pathways and allowing the manufacturing workforce to have a different kind of perspective. We want to formalize the path to becoming a technologist.”

Liu, who is also the principal investigator of the MIT Learning Engineering and Practice Group (LEAP), adds that the MIT program “is a pathway to leadership. No longer should a technician just think about one piece of equipment. They can think about the whole system, the whole operation, and help with decision-making.”

TechAMP launched this fall, in collaboration with multiple institutions, including the University of Massachusetts at Lowell, Cape Cod Community College, Ohio State University, the Community College of Rhode Island, the Connecticut Center for Advanced Technology, and the Berkshire Innovation Center in Pittsfield, Massachusetts. More than 70 people are in the initial cohort of students.

“MIT has embraced the idea that we’re reaching this new type of learner,” says Julie Diop, executive director of MIT’s Initiative for New Manufacturing (INM). TechAMP forms a key part of the education arm of that initiative, a campus-wide effort to reinvigorate U.S. manufacturing that was announced in May 2025. INM also collaborates with several industry firms embracing innovative approaches to manufacturing.

“Through TechAMP and other programs, we’re excited to reach beyond MIT’s traditional realm of manufacturing education and collaborate with companies of all sizes alongside our community college partners,” says John Hart, the Class of 1922 Professor of Mechanical Engineering, head of the Department of Mechanical Engineering at MIT, and faculty co-director of INM. “We hope that the program equips manufacturing technologists to be innovators and problem-solvers in their organizations, and to effectively deploy new technologies that can improve manufacturing productivity.”

INM is one of the key Institute-wide initiatives prioritized by MIT President Sally A. Kornbluth.

“Helping America build a future of new manufacturing is a perfect job for MIT,” Kornbluth said at the INM launch event in May. She continued: “I’m convinced that there is no more important work we can do to meet the moment and serve the nation now.”

A “confidence booster” for workers

TechAMP has been supported by two Department of Defense grants enabling the program’s development. MIT scholars collaborated with colleagues at Clemson University and Ohio State University to develop a number of the interactive simulations used in the course.

The course work is based around a “hub-and-spoke” model that includes segments on core principles of manufacturing — that’s the hub — as well as six areas, or spokes, where companies have advised MIT that workers need more training.

The four parts of the hub comprise manufacturing process controls and their statistical analysis; understanding manufacturing systems, including workflow and efficiency; leadership skills; and operations management, from factory analysis to supply chain issues. These are also the core issues studied in MIT’s online micromaster’s certificate in manufacturing.

The six spokes may change or expand over time but currently consist of mechatronics, automation programming, robotics, machining, digital manufacturing, and design and manufacturing fundamentals.

Having the TechAMP curriculum revolve around concepts common to all manufacturing industries helps technologists-in-training better understand how their companies are trying to function and how their own work relates to those principles.

“The hub concepts are what defines manufacturing,” Liu says. “We need to teach this undervalued set of principles to the workforce, including people without university degrees. If we do that, it means they have a timeless set of ideas. We can adapt ourselves to add industries like biomanufacturing, but we’re starting with the fundamentals.”

Students say they are enjoying the program.

“It’s been a confidence booster,” says Nicole Swan, an employee at the manufacturing firm Proterial, who is taking the TechAMP class at the Community College of Rhode Island campus in Westerly, Rhode Island. “This has really shown me so many different opportunities [for] what I could do in the future, and different avenues that are available.”

Direct value capture possible for firms

The TechAMP certificate program also involves a capstone project, in which the students try to analyze issues or challenges within their own firms. Ideally, if those projects lead to savings or add value, that could make it well worthwhile for manufacturing companies to pay for their students to attend the TechAMP program — which is about 10 to 14 hours of work per week, for the year.

“That could be a form of impact — direct value capture for the firm,” Diop says.

Some firms are already pleased with the development of TechAMP.

“There are so many manufacturing jobs that don’t need a four-year degree, but do require a very high skill level and good communications skills,” says Michael Trotta, CEO of Crystal Engineering, a versatile, 45-employee manufacturer in Newburyport, Massachusetts, whose products range from medical devices to aerospace and defense items. “I see TechAMP as a next logical step in developing a sustainable workforce."

Trotta and three of his employees worked with MIT on the TechAMP project last spring, studying the curriculum material and providing feedback about it to the program leaders, in an effort to make the coursework as useful as possible.

"What we want workers to do is progress to a point where they become that technologist making not $20 an hour, but $40 or $50 an hour, because they have that skill set to run a lot more than just one piece of the process,” Trotta explains. “They’re able to communicate effectively with the engineers, with operations, to identify strengths and weaknesses, to help the firm drive success."

And while the position of “technologist” may not yet be in every manufacturer’s vocabulary yet, the MIT program leaders think it makes eminent sense, as a way of further equipping workers who are currently regarded as technicians or machinists.

By analogy, Diop observes, “The role of nurse practitioner bridges the gap between nurse and doctor, and has changed how medicine is delivered.” Manufacturing, she adds, “has had a reputation for dead-end jobs, but if MIT can help break that image by providing a real pathway, I think that would be meaningful, especially for those without university degrees.”

Intriguingly — as shown by research from Ben Armstrong, executive director and a research scientist at MIT’s Industrial Performance Center — about 10 to 15 percent of titled engineers in manufacturing industries do not have engineering degrees, either. For that portion of the workforce as well, more formal training and credentials may prove useful over time.

TechAMP is new, evolving — and likely to be expanding soon. Diop and Liu are in talks with interested education networks in multiple manufacturing-heavy states, to see if they would like to partner with MIT. There is also new interest from more manufacturers, including some of the partners in MIT’s Initiative for New Manufacturing. Given that the initiative just launched in May, TechAMP has hit the ground running.

“There’s been a lot of excitement so far, we think,” Liu says. “And it’s coming from organizations and people who are eager to learn more.”  

“Can we make tissues that are made from you, for you?” asked Jennifer Lewis ScD ’91 at the 2025 Mildred S. Dresselhaus Lecture, organized by MIT.nano, on Nov. 3. “The grand challenge goal is to create these tissues for therapeutic use and, ultimately, at the whole organ scale.”

Lewis, the Hansjörg Wyss Professor of Biologically Inspired Engineering at Harvard University, is pursuing that challenge through advances in 3D printing. In her talk presented to a combined in-person and virtual audience of over 500 attendees, Lewis shared work from her lab that focuses on enhanced function in 3D printed components for use in soft electronics, robotics, and life sciences.

“How you make a material affects its structure, and it affects its properties,” said Lewis. “This perspective was a light bulb moment for me, to think about 3D printing beyond just prototyping and making shapes, but really being able to control local composition, structure, and properties across multiple scales.”

A trained materials scientist, Lewis reflected on learning to speak the language of biologists when she joined Harvard to start her own lab focused on bioprinting and biological engineering. How does one compare particles and polymers to stem cells and extracellular matrices? A key commonality, she explained, is the need for a material that can be embedded and then erased, leaving behind open channels. To meet this need, Lewis’ lab developed new 3D printing methods, sophisticated printhead designs, and viscoelastic inks — meaning the ink can go back and forth between liquid and solid form.

Displaying a video of a moving robot octopus named Octobot, Lewis showed how her group engineered two sacrificial inks that change from fluid to solid upon either warming or cooling. The concept draws inspiration from nature — plants that dynamically change in response to touch, light, heat, and hydration. For Octobot, Lewis’ team used sacrificial ink and an embedded printing process that enables free-form printing in three dimensions, rather than layer-by-layer, to create a fully soft autonomous robot. An oscillating circuit in the center guides the fuel (hydrogen peroxide), making the arms move up and down as they inflate and deflate.

From robots to whole organ engineering

“How can we leverage shape morphing in tissue engineering?” asked Lewis. “Just like our blood continuously flows through our body, we could have continuous supply of healing.”

Lewis’ lab is now working on building human tissues, primarily cardiac, kidney, and cerebral tissue, using patient-specific cells. The motivation, Lewis explained, is not only the need for human organs for people with diseases, but the fact that receiving a donated organ means taking immunosuppressants the rest of your life. If, instead, the tissue could be made from your own cells, it would be a stronger match to your own body.

“Just like we did to engineer viscoelastic matrices for embedded printing of functional and structural materials,” said Lewis, “we can take stem cells and then use our sacrificial writing method to write in perfusable vasculature.” The process uses a technique Lewis calls SWIFT — sacrificial writing into functional tissue. Sharing lab results, Lewis showed how the stem cells, differentiated into cardiac building blocks, are initially beating individually, but after being packed into a tighter space that will support SWIFT, these building blocks fuse together and become one tissue that beats synchronously. Then, her team uses a gelatin ink that solidifies or liquefies with temperature changes to print the complex design of human vessels, flushing away the ink to leave behind open lumens. The channel remains open, mimicking a blood vessel network that could have fluid actively, continuously flowing through it. “Where we’re going is to expand this not only to different tissue types, but also building in mechanisms by which we can build multi-scale vasculature,” said Lewis.

Honoring Mildred S. Dresselhaus

In closing, Lewis reflected on Dresselhaus’ positive impact on her own career. “I want to dedicate this [talk] to Millie Dresselhaus,” said Lewis. She pointed to a quote by Millie: “The best thing about having a lady professor on campus is that it tells women students that they can do it, too.” Lewis, who arrived at MIT as a materials science and engineering graduate student in the late 1980s, a time when there were very few women with engineering doctorates, noted that “just seeing someone of her stature was really an inspiration for me. I thank her very much for all that she’s done, for her amazing inspiration both as a student, as a faculty member, and even now, today.”

After the lecture, Lewis was joined by Ritu Raman, the Eugene Bell Career Development Assistant Professor of Tissue Engineering in the MIT Department of Mechanical Engineering, for a question-and-answer session. Their discussion included ideas on 3D printing hardware and software, tissue repair and regeneration, and bioprinting in space. 

“Both Mildred Dresselhaus and Jennifer Lewis have made incredible contributions to science and served as inspiring role models to many in the MIT community and beyond, including myself,” said Raman. “In my own career as a tissue engineer, the tools and techniques developed by Professor Lewis and her team have critically informed and enabled the research my lab is pursuing.”

This was the seventh Dresselhaus Lecture, named in honor of the late MIT Institute Professor Mildred Dresselhaus, known to many as the "Queen of Carbon Science.” The annual event honors a significant figure in science and engineering from anywhere in the world whose leadership and impact echo Dresselhaus’ life, accomplishments, and values. 

“Professor Lewis exemplifies, in so many ways, the spirit of Millie Dresselhaus,” said MIT.nano Director Vladimir Bulović. “Millie’s groundbreaking work, indeed, is well known; and the groundbreaking work of Professor Lewis in 3D printing and bio-inspired materials continues that legacy.”

"To really understand science policy, you have to step outside the lab and see it in action," says Jack Fletcher, an MIT PhD student in nuclear science and engineering and chair of the 15th annual Executive Visit Days (ExVD). 

Inspired by this mindset, ExVD — jointly organized by the MIT Science Policy Initiative (SPI) and the MIT Washington Office — convened a delegation of 21 MIT affiliates, including undergraduates, graduate students, and postdocs, in Washington Oct. 27-28. 

Although the government shutdown prevented the delegation’s usual visits to executive agencies, participants met with experts across the federal science and technology policy ecosystem. These discussions built connections in the nation’s capital, displayed how evidence interacts with political realities, and demonstrated how scientists, engineers, and business leaders can pursue impactful careers in public service. 

A recurring theme across meetings was that political realities and institutional constraints, not just evidence and analysis, shape policy outcomes. As Mykyta Kliapets, a PhD student at KU Leuven (Belgium) and a visiting student at the MIT Kavli Institute for Astrophysics and Space Research, reflected, “It was really helpful to hear how rarely straightforward policy environments are — sometimes, a solution that makes the most sense technically is not always politically feasible.” 

The group also heard how political forces directly impact science, from disruptions during government shutdowns to recent reductions in federal research support. Speakers underscored that effective science policy requires combined fluency in evidence, systems, and incentives.

For the first time, ExVD visited the Delegation of the European Union to the United States to meet with Francesco Maria Graziani, climate and energy counselor. He described E.U.-U.S. cooperation on energy and climate as “active and vital, but complex,” noting that the E.U. can struggle to navigate a diverse, multilevel, and variable U.S. policy landscape. “The E.U. and the U.S. share many goals, but we often operate on different timelines and with different tools,” said Graziani. He identified nuclear power, geothermal energy, and supply chain security as areas of continued E.U. and U.S. collaboration. 

Graziani also discussed ongoing collaborations like the Destination Earth project, which improves global climate models using U.S. state-level data. “As a European, hearing differences in how the U.S. navigates science policy gave me a new lens on how two advanced democracies balance innovation, regulation, and the urgency of scientific challenges,” said Sofia Karagianni, an MBA student at the MIT Sloan School of Management. 

The ExVD delegation also met with three MIT alumni at the Science and Technology Policy Institute (STPI). A federally funded research and development center, STPI provides technical and analytical support on science and technology issues to inform policy decisions by the White House Office of Science and Technology Policy (OSTP) and other federal sponsors. Recently, STPI’s research reports have focused on a number of topics including quantum computing, biotechnology, and artificial intelligence. The discussion at STPI emphasized the importance of conducting  objective analyses that have relevance for policymakers. Director Asha Balakrishnan explained how it is often useful to provide “options” in their reports, rather than “recommendations,” because policymakers benefit from understanding the advantages and disadvantages of potential policy actions.

Participants found the speakers’ reflections on career development and fellowships particularly valuable. Several speakers discussed their experiences with the AAAS Science and Technology Policy Fellowship, which places scientists and engineers in federal agencies and congressional offices for a year. 

“In speaking with former fellows, I learned just how transformative these fellowships can be for scientists seeking to apply their academic research backgrounds to a wide range of careers at the intersection of science and policy,” said Amanda Hornick, a recent doctoral graduate of the Harvard-MIT Program in Health Sciences and Technology. Eli Duggan, a graduate student in MIT's Technology and Policy Program, added that “seeing how the speakers’ work makes a real impact got me excited to apply my technical and policy background for the public good.”

The lessons from these conversations reflect the broader mission of the MIT Science Policy Initiative: to help the MIT community understand and engage with the policymaking process. SPI is a student- and postdoc-led organization dedicated to strengthening dialogue between MIT and the broader policy ecosystem. Each year, SPI organizes multiple trips to Washington, giving members the chance to meet directly with federal agencies and policymakers while exploring careers at the intersection of science, technology, and policy. These trips also spark connections and conversations that participants bring back to campus, enriching policy dialogue within the MIT community. 

SPI is grateful to the individuals and organizations who shared their time and insights at this year’s ExVD, giving participants a foundation to draw on as they explore career opportunities and the many ways technical expertise can shape public decision-making.

Students enrolled in MIT’s New Engineering Education Transformation (NEET) program recently collaborated across academic disciplines to design and construct a solar-powered charging station. Positioned in a quiet campus courtyard, the station provides the MIT community with climate-friendly power for phones, laptops, and tablets.

Its installation marked the “first time a cross-departmental team of undergraduates designed, created, and installed on campus a green technology artifact for the public good, as part of a class they took for credit,” says Amitava “Babi” Mitra, NEET founding executive director.

The project was very on-brand for the NEET program, which centers interdisciplinary, cross-departmental, and project-centric scholarship with experiential learning at its core. Launched in 2017 as an effort to reimagine undergraduate engineering education at MIT, NEET seeks to empower students to tackle complex societal challenges that straddle disciplines.

The solar-powered charging station project class is an integral part of NEET’s decarbonization-focused Climate and Sustainability Systems (CSS) “thread,” one of four pathways of study offered by the program. The class, 22.03/3.0061 (Introduction to Design Thinking and Rapid Prototyping), teaches the design and fabrication techniques used to create the station, such as laser cutting, 3D printing, computer-aided design (CAD), electronics prototyping, microcontroller programming, and composites manufacturing.

The project team included students majoring in chemical engineering, materials science and engineering, mechanical engineering, and nuclear science and engineering.

“What I really liked about this project was, at the beginning, it was really about ideation, about design, about brainstorming in ways that I haven’t seen before,” says NEET CSS student Aaron De Leon, a nuclear science and engineering major focused on clean energy development. 

During these brainstorming sessions, the team considered how their subjective design choices for the charging station would shape user experience, something De Leon, who enrolled in the class as a sophomore, says is often overlooked in engineering classes.

The team’s forest-inspired station design — complete with “tree trunks,” oyster mushroom-shaped desk space, and four solar panels curved to mimic the undulation of the forest canopy — was intended to evoke a sense of organic connectivity. The tree trunks were crafted from novel flax fiber-based composite layups the team developed through experiments designed to identify more sustainable alternatives to traditional composites.

The group also discussed how a dearth of device charging options made it difficult for students to work outside, according to NEET CSS student Celestina Pint, who enrolled in the class as a sophomore. The desk space was added to help MIT students work comfortably outdoors while also charging their devices with renewable energy.

Pint joined NEET because she wanted to “keep an open approach to climate and sustainability,” as opposed to relying on her materials science and engineering major alone, she says. “I like the interdisciplinary aspect.”

The project class presented abundant interdisciplinary learning opportunities that couldn’t be replicated in a purely theory-based curriculum, says Nathan Melenbrink, NEET lecturer, who teaches the project class and is the lead instructor for the NEET CSS thread.

For example, the team got a crash course in navigating real-world bureaucracy when they discovered that the installation of their charging station had to be approved by more than a dozen entities, including campus police, MIT’s insurance provider, and the campus facilities department.

The team also gained valuable experience with troubleshooting unanticipated design implementation challenges during the project’s fabrication phase.

“Adjustments had to be made,” Pint says. Once the station was installed, “it was interesting to see what was the same and what was different” from the team’s initial design.

This underscores a unique value of the project, according to NEET CSS student Tyler Ea, a fifth-year mechanical engineering major who joined the project team last year and is now a teaching assistant for the class.

Students “are able to take ownership of something physical, like a physical embodiment of their ideas, and something that they can point towards and say, ‘here’s something that I thought about, and this is how I went about building it, and then here’s the final result,’” he says.

While students only become eligible to join NEET in their second year, first-year students interested in the program were also able to learn from the solar-powered charging station project in the first-year discovery class SP.248 (The NEET Experience). After learning fundamental concepts in systems engineering, the class analyzed the station and suggested changes they thought would improve its design.

Melenbrink says student-built campus installations were once a hallmark of MIT’s academic culture, and he sees the NEET CSS solar-powered charging station project as an opportunity to help revive this tradition.

“What I hear from the old guard is that there was always somebody … lugging some giant, odd-looking prototype of something across campus,” Melenbrink says.

More collaborative, hands-on, student-led climate projects would also help the Institute meet its commitment to become a leading source of meaningful climate solutions, according to Elsa Olivetti, the Jerry McAfee (1940) Professor of Materials Science and Engineering and strategic advisor to the MIT Climate and Sustainability Consortium (MCSC).

“This local renewable energy project demonstrates that our campus community can learn through solution development,” she says. “Students don’t have to wait until they graduate or enter the job market to make a contribution.”

Students enrolled in this year’s Introduction to Design Thinking and Rapid Prototyping class will fabricate and install a new solar-powered charging station with a unique design. De Leon says he appreciates the latitude NEET students have to make the project their own.

“There was never the case of a professor saying, ‘We need to do it this way,’” he says. “I really liked that ability to learn as many things as you wanted to, and also have the autonomy to make your own design decisions along the way.”

“I just can’t make it tonight. You have fun without me.” Across much of the animal kingdom, when infection strikes, social contact shuts down. A new study details how the immune and central nervous systems implement this sickness behavior.

It makes perfect sense that when we’re battling an infection, we lose our desire to be around others. That protects others from getting sick and lets us get much-needed rest. What hasn’t been as clear is how this behavior change happens.

In new research published Nov. 25 in Cell, scientists at MIT’s Picower Institute for Learning and Memory and collaborators used multiple methods to demonstrate causally that when the immune system cytokine interleukin-1 beta (IL-1β) reaches the IL-1 receptor 1 (IL-1R1) on neurons in a brain region called the dorsal raphe nucleus, that activates connections with the intermediate lateral septum to shut down social behavior.

“Our findings show that social isolation following immune challenge is self-imposed and driven by an active neural process, rather than a secondary consequence of physiological symptoms of sickness, such as lethargy,” says study co-senior author Gloria Choi, associate professor in MIT’s Department of Brain and Cognitive Sciences and a member of the Picower Institute.

Jun Huh, Harvard Medical School associate professor of immunology, is the paper’s co-senior author. The lead author is Liu Yang, a research scientist in Choi’s lab.

A molecule and its receptor

Choi and Huh’s long collaboration has identified other cytokines that affect social behavior by latching on to their receptors in the brain, so in this study their team hypothesized that the same kind of dynamic might cause social withdrawal during infection. But which cytokine? And what brain circuits might be affected?

To get started, Yang and her colleagues injected 21 different cytokines into the brains of mice, one by one, to see if any triggered social withdrawal the same way that giving mice LPS (a standard way of simulating infection) did. Only IL-1β injection fully recapitulated the same social withdrawal behavior as LPS. That said, IL-1β also made the mice more sluggish.

IL-1β affects cells when it hooks up with the IL-1R1, so the team next went looking across the brain for where the receptor is expressed. They identified several regions and examined individual neurons in each. The dorsal raphe nucleus (DRN) stood out among regions, both because it is known to modulate social behavior and because it is situated next to the cerebral aqueduct, which would give it plenty of exposure to incoming cytokines in cerebrospinal fluid. The experiments identified populations of DRN neurons that express IL-1R1, including many involved in making the crucial neuromodulatory chemical serotonin.

From there, Yang and the team demonstrated that IL-1β activates those neurons, and that activating the neurons promotes social withdrawal. Moreover, they showed that inhibiting that neural activity prevented social withdrawal in mice treated with IL-1β, and they showed that shutting down the IL-1R1 in the DRN neurons also prevented social withdrawal behavior after IL-1β injection or LPS exposure. Notably, these experiments did not change the lethargy that followed IL-1β or LPS, helping to demonstrate that social withdrawal and lethargy occur through different means.

“Our findings implicate IL-1β as a primary effector driving social withdrawal during systemic immune activation,” the researchers wrote in Cell.

Tracing the circuit

With the DRN identified as the site where neurons receiving IL-1β drove social withdrawal, the next question was what circuit they effected that behavior change through. The team traced where the neurons make their circuit projections and found several regions that have a known role in social behavior. Using optogenetics, a technology that engineers cells to become controllable with flashes of light, the scientists were able to activate the DRN neurons’ connections with each downstream region. Only activating the DRN’s connections with the intermediate lateral septum caused the social withdrawal behaviors seen with IL-1β injection or LPS exposure.

In a final test, they replicated their results by exposing some mice to salmonella.

“Collectively, these results reveal a role for IL-1R1-expressing DRN neurons in mediating social withdrawal in response to IL-1β during systemic immune challenge,” the researchers wrote.

Although the study revealed the cytokine, neurons, and circuit responsible for social withdrawal in mice in detail and with demonstrations of causality, the results still inspire new questions. One is whether IL-1R1 neurons affect other sickness behaviors. Another is whether serotonin has a role in social withdrawal or other sickness behaviors.

In addition to Yang, Choi, and Huh, the paper’s other authors are Matias Andina, Mario Witkowski, Hunter King, and Ian Wickersham.

Funding for the research came from the National Institute of Mental Health, the National Research Foundation of Korea, the Denis A. and Eugene W. Chinery Fund for Neurodevelopmental Research, the Jeongho Kim Neurodevelopmental Research Fund, Perry Ha, the Simons Center for the Social Brain, the Simons Foundation Autism Research Initiative, The Picower Institute for Learning and Memory, and The Freedom Together Foundation.

Concrete was the foundation of the ancient Roman empire. It enabled Rome’s storied architectural revolution as well as the construction of buildings, bridges, and aqueducts, many of which are still used some 2,000 years after their creation.

In 2023, MIT Associate Professor Admir Masic and his collaborators published a paper describing the manufacturing process that gave Roman concrete its longevity: Lime fragments were mixed with volcanic ash and other dry ingredients before the addition of water. Once water is added to this dry mix, heat is produced. As the concrete sets, this “hot-mixing” process traps and preserves the highly reactive lime as small, white, gravel-like features. When cracks form in the concrete, the lime clasts redissolve and fill the cracks, giving the concrete self-healing properties.

There was only one problem: The process Masic’s team described was different from the one described by the famed ancient Roman architect Vitruvius. Vitruvius literally wrote the book on ancient architecture. His highly influential work, “De architectura,” written in the 1st century B.C.E., is the first known book on architectural theory. In it, Vitruvius says that Romans added water to lime to create a paste-like material before mixing it with other ingredients.

“Having a lot of respect for Vitruvius, it was difficult to suggest that his description may be inaccurate,” Masic says. “The writings of Vitruvius played a critical role in stimulating my interest in ancient Roman architecture, and the results from my research contradicted these important historical texts.”

Now, Masic and his collaborators have confirmed that hot-mixing was indeed used by the Romans, a conclusion he reached by studying a newly discovered ancient construction site in Pompeii that was exquisitely preserved by the volcanic eruption of Mount Vesuvius in the year 79 C.E. They also characterized the volcanic ash material the Romans mixed with the lime, finding a surprisingly diverse array of reactive minerals that further added to the concrete’s ability to repair itself many years after these monumental structures were built.

“There is the historic importance of this material, and then there is the scientific and technological importance of understanding it,” Masic explains. “This material can heal itself over thousands of years, it is reactive, and it is highly dynamic. It has survived earthquakes and volcanoes. It has endured under the sea and survived degradation from the elements. We don’t want to completely copy Roman concrete today. We just want to translate a few sentences from this book of knowledge into our modern construction practices.”

The findings are described today in Nature Communications. Joining Masic on the paper are first authors Ellie Vaserman ’25 and Principal Research Scientist James Weaver, along with Associate Professor Kristin Bergmann, PhD candidate Claire Hayhow, and six other Italian collaborators.

Uncovering ancient secrets

Masic has spent close to a decade studying the chemical composition of the concrete that allowed Rome’s famous structures to endure for so much longer than their modern counterparts. His 2023 paper analyzed the material’s chemical composition to deduce how it was made.

That paper used samples from a city wall in Priverno in southwest Italy, which was conquered by the Romans in the 4th century B.C.E. But there was a question as to whether this wall was representative of other concrete structures built throughout the Roman empire.

The recent discovery by archaeologists of an active ancient construction site in Pompeii (complete with raw material piles and tools) therefore offered an unprecedented opportunity.

For the study, the researchers analyzed samples from these pre-mixed dry material piles, a wall that was in the process of being built, completed buttress and structural walls, and mortar repairs in an existing wall.

“We were blessed to be able to open this time capsule of a construction site and find piles of material ready to be used for the wall,” Masic says. “With this paper, we wanted to clearly define a technology and associate it with the Roman period in the year 79 C.E.”

The site offered the clearest evidence yet that the Romans used hot-mixing in concrete production. Not only did the concrete samples contain the lime clasts described in Masic’s previous paper, but the team also discovered intact quicklime fragments pre-mixed with other ingredients in a dry raw material pile, a critical first step in the preparation of hot-mixed concrete.

Bergman, an associate professor of earth and planetary sciences, helped develop tools for differentiating the materials at the site.

“Through these stable isotope studies, we could follow these critical carbonation reactions over time, allowing us to distinguish hot-mixed lime from the slaked lime originally described by Vitruvius,” Masic says. “These results revealed that the Romans prepared their binding material by taking calcined limestone (quicklime), grinding them to a certain size, mixing it dry with volcanic ash, and then eventually adding water to create a cementing matrix.”

The researchers also analyzed the volcanic ingredients in the cement, including a type of volcanic ash called pumice. They found that the pumice particles chemically reacted with the surrounding pore solution over time, creating new mineral deposits that further strengthened the concrete.

Rewriting history

Masic says the archaeologists listed as co-authors on the paper were indispensable to the study. When Masic first entered the Pompeii site, as he inspected the perfectly preserved work area, tears came to his eyes.

“I expected to see Roman workers walking between the piles with their tools,” Masic says. “It was so vivid, you felt like you were transported in time. So yes, I got emotional looking at a pile of dirt. The archaeologists made some jokes.”

Masic notes that calcium is a key component in both ancient and modern concretes, so understanding how it reacts over time holds lessons for understanding dynamic processes in modern cement as well. Towards these efforts, Masic has also started a company, DMAT, that uses lessons from ancient Roman concrete to create long-lasting modern concretes.

“This is relevant because Roman cement is durable, it heals itself, and it’s a dynamic system,” Masic says. “The way these pores in volcanic ingredients can be filled through recrystallization is a dream process we want to translate into our modern materials. We want materials that regenerate themselves.”

As for Vitruvius, Masic guesses that he may have been misinterpreted. He points out that Vitruvius also mentions latent heat during the cement mixing process, which could suggest hot-mixing after all.

The work was supported, in part, by the MIT Research Support Commmittee (RSC) and the MIT Concrete Sustainability Hub.

When it comes to brain function, neurons get a lot of the glory. But healthy brains depend on the cooperation of many kinds of cells. The most abundant of the brain’s non-neuronal cells are astrocytes, star-shaped cells with a lot of responsibilities. Astrocytes help shape neural circuits, participate in information processing, and provide nutrient and metabolic support to neurons. Individual cells can take on new roles throughout their lifetimes, and at any given time, the astrocytes in one part of the brain will look and behave differently than the astrocytes somewhere else.

After an extensive analysis by researchers at MIT, neuroscientists now have an atlas detailing astrocytes’ dynamic diversity. Its maps depict the regional specialization of astrocytes across the brains of both mice and marmosets — two powerful models for neuroscience research — and show how their populations shift as brains develop, mature, and age. 

The open-access study, reported in the Nov. 20 issue of the journal Neuron, was led by Guoping Feng, the James W. (1963) and Patricia T. Poitras Professor of Brain and Cognitive Sciences at MIT. This work was supported by the Hock E. Tan and K. Lisa Yang Center for Autism Research, part of the Yang Tan Collective at MIT, and the National Institutes of Health’s BRAIN Initiative.

“It’s really important for us to pay attention to non-neuronal cells’ role in health and disease,” says Feng, who is also the associate director of the McGovern Institute for Brain Research and the director of the Hock E. Tan and K. Lisa Yang Center for Autism Research at MIT. And indeed, these cells — once seen as mere supporting players — have gained more of the spotlight in recent years. Astrocytes are known to play vital roles in the brain’s development and function, and their dysfunction seems to contribute to many psychiatric disorders and neurodegenerative diseases. “But compared to neurons, we know a lot less — especially during development,” Feng adds.

Probing the unknown

Feng and Margaret Schroeder, a former graduate student in his lab, thought it was important to understand astrocyte diversity across three axes: space, time, and species. They knew from earlier work in the lab, done in collaboration with Steve McCarroll’s lab at Harvard University and led by Fenna Krienen in his group, that in adult animals, different parts of the brain have distinctive sets of astrocytes.

“The natural question was, how early in development do we think this regional patterning of astrocytes starts?” Schroeder says.

To find out, she and her colleagues collected brain cells from mice and marmosets at six stages of life, spanning embryonic development to old age. For each animal, they sampled cells from four different brain regions: the prefrontal cortex, the motor cortex, the striatum, and the thalamus.

Then, working with Krienen, who is now an assistant professor at Princeton University, they analyzed the molecular contents of those cells, creating a profile of genetic activity for each one. That profile was based on the mRNA copies of genes found inside the cell, which are known collectively as the cell’s transcriptome. Determining which genes a cell is using, and how active those genes are, gives researchers insight into a cell’s function and is one way of defining its identity.

Dynamic diversity

After assessing the transcriptomes of about 1.4 million brain cells, the group focused in on the astrocytes, analyzing and comparing their patterns of gene expression. At every life stage, from before birth to old age, the team found regional specialization: astrocytes from different brain regions had similar patterns of gene expression, which were distinct from those of astrocytes in other brain regions.

This regional specialization was also apparent in the distinct shapes of astrocytes in different parts of the brain, which the team was able to see with expansion microscopy, a high-resolution imaging method developed by McGovern colleague Edward Boyden that reveals fine cellular features.

Notably, the astrocytes in each region changed as animals matured. “When we looked at our late embryonic time point, the astrocytes were already regionally patterned. But when we compare that to the adult profiles, they had completely shifted again,” Schroeder says. “So there’s something happening over postnatal development.” The most dramatic changes the team detected occurred between birth and early adolescence, a period during which brains rapidly rewire as animals begin to interact with the world and learn from their experiences.

Feng and Schroeder suspect that the changes they observed may be driven by the neural circuits that are sculpted and refined as the brain matures. “What we think they’re doing is kind of adapting to their local neuronal niche,” Schroeder says. “The types of genes that they are up-regulating and changing during development points to their interaction with neurons.” Feng adds that astrocytes may change their genetic programs in response to nearby neurons, or alternatively, they might help direct the development or function of local circuits as they adopt identities best suited to support particular neurons.

Both mouse and marmoset brains exhibited regional specialization of astrocytes and changes in those populations over time. But when the researchers looked at the specific genes whose activity defined various astrocyte populations, the data from the two species diverged. Schroeder calls this a note of caution for scientists who study astrocytes in animal models, and adds that the new atlas will help researchers assess the potential relevance of findings across species.

Beyond astrocytes

With a new understanding of astrocyte diversity, Feng says his team will pay close attention to how these cells are impacted by the disease-related genes they study and how those effects change during development. He also notes that the gene expression data in the atlas can be used to predict interactions between astrocytes and neurons. “This will really guide future experiments: how these cells’ interactions can shift with changes in the neurons or changes in the astrocytes,” he says.

The Feng lab is eager for other researchers to take advantage of the massive amounts of data they generated as they produced their atlas. Schroeder points out that the team analyzed the transcriptomes of all kinds of cells in the brain regions they studied, not just astrocytes. They are sharing their findings so researchers can use them to understand when and where specific genes are used in the brain, or dig in more deeply to further to explore the brain’s cellular diversity.

Two current MIT affiliates and seven additional alumni are among those named to the 2025 cohort of AI2050 Fellows.  

Zongyi Li, a postdoc in the MIT Computer Science and Artificial Intelligence Lab, and Tess Smidt ’12, an associate professor of electrical engineering and computer science (EECS), were both named as AI2050 Early Career Fellows. 

Seven additional MIT alumni were also honored. AI2050 Early Career Fellows include Brian Hie SM '19, PhD '21; Natasha Mary Jaques PhD '20; Martin Anton Schrimpf PhD '22; Lindsey Raymond SM '19, PhD '24, who will join the MIT faculty in EECS, the Department of Economics, and the MIT Schwarzman College of Computing in 2026; and Ellen Dee Zhong PhD ’22. AI2050 Senior Fellows include Surya Ganguli ’98, MNG ’98; and Luke Zettlemoyer SM ’03, PhD ’09. 

AI2050 Fellows are announced annually by Schmidt Sciences, a nonprofit organization founded in 2024 by Eric and Wendy Schmidt that works to accelerate scientific knowledge and breakthroughs with the most promising, advanced tools to support a thriving planet. The organization prioritizes research in areas poised for impact including AI and advanced computing, astrophysics, biosciences, climate, and space — as well as supporting researchers in a variety of disciplines through its science systems program. 

Li is postdoc in CSAIL working with associate professor of EECS Kaiming He. Li's research focuses on developing neural operator methods to accelerate scientific computing. He received his PhD in computing and mathematical sciences from Caltech, where he was advised by Anima Anandkumar and Andrew Stuart. He holds undergraduate degrees in computer science and mathematics from Washington University in St. Louis. 

Li's work has been supported by a Kortschak Scholarship, PIMCO Fellowship, Amazon AI4Science Fellowship, Nvidia Fellowship, and MIT-Novo Nordisk AI Fellowship. He has also completed three summer internships at Nvidia. Li will join the NYU Courant Institute of Mathematical Sciences as an assistant professor of mathematics and data science in fall 2026.

Smidt, associate professor of electrical engineering and computer science (EECS), is the principal investigator of the Atomic Architects group at the Research Laboratory of Electronics (RLE), where she works at the intersection of physics, geometry, and machine learning to design algorithms that aid in the understanding of physical systems under physical and geometric constraints, with applications to the design both of new materials and new molecules. She has a particular focus on symmetries present in 3D physical systems, such as rotation, translation, and reflection.

Smidt earned her BS in physics from MIT in 2012 and her PhD in physics from the University of California at Berkeley in 2018. Prior to joining the MIT EECS faculty in 2021, she was the 2018 Alvarez Postdoctoral Fellow in Computing Sciences at Lawrence Berkeley National Laboratory, and a software engineering intern on the Google Accelerated Sciences team, where she developed Euclidean symmetry equivariant neural networks that naturally handle 3D geometry and geometric tensor data. Besides the AI2050 fellowship, she has received an Air Force Office of Scientific Research Young Investigator Program award, the EECS Outstanding Educator Award, and a Transformative Research Fund award.

Conceived and co-chaired by Eric Schmidt and James Manyika, AI2050 is a philanthropic initiative aimed at helping to solve hard problems in AI. Within their research, each fellow will contend with the central motivating question of AI2050: “It’s 2050. AI has turned out to be hugely beneficial to society. What happened? What are the most important problems we solved and the opportunities and possibilities we realized to ensure this outcome?” 

Aggressive T-cell lymphoma is a rare and devastating form of blood cancer with a very low five-year survival rate. Patients often relapse after receiving initial therapy, making it especially challenging for clinicians to keep this destructive disease in check.

In a new study, researchers from MIT, in collaboration with researchers involved in the PETAL consortium at Massachusetts General Hospital, identified a practical and powerful prognostic marker that could help clinicians identify high-risk patients early, and potentially tailor treatment strategies to improve survival.

The team found that, when patients relapse within 12 months of initial therapy, their chances of survival decline dramatically. For these patients, targeted therapies might improve their chances for survival, compared to traditional chemotherapy, the researchers say.

According to their analysis, which used data collected from thousands of patients all over the world, the finding holds true across patient subgroups, regardless of the patient’s initial therapy or their score in a commonly used prognostic index.

A causal inference framework called Synthetic Survival Controls (SSC), developed as part of MIT graduate student Jessy (Xinyi) Han’s thesis, was central to this analysis. This versatile framework helps to answer “when-if” questions — to estimate how the timing of outcomes would shift under different interventions — while overcoming the limitations of inconsistent and biased data.

The identification of novel risk groups could guide clinicians as they select therapies to improve overall survival. For instance, a clinician might prioritize early-phase clinical trials over canonical therapies for this cohort of patients. The results could inform inclusion criteria for some clinical trials, according to the researchers.

The causal inference framework for survival analysis can also be applied more broadly. For instance, the MIT researchers have used it in areas like criminal justice to study how structural factors drive recidivism.

“Often we don’t only care about what will happen, but when the target event will happen. These when-if problems have remained under the radar for a long time, but they are common in a lot of domains. We’ve shown here that, to answer these questions with data, you need domain experts to provide insight and good causal inference methods to close the loop,” says Devavrat Shah, the Andrew and Erna Viterbi Professor in Electrical Engineering and Computer Science at MIT, a member of Institute for Data, Systems and Society (IDSS) and of the Laboratory for Information and Decision Systems (LIDS), and co-author of the study.

Shah is joined on the paper by many co-authors, including Han, who is co-advised by Shah and Fotini Christia, the Ford International Professor of the Social Sciences in the Department of Political Science and director of IDSS; and corresponding authors Mark N. Sorial, a clinical pharmacist and investigator at the Dana-Farber Cancer Institute, and Salvia Jain, a clinician-investigator at the Massachusetts General Hospital Cancer Center, founder of the global PETAL consortium, and an assistant professor of medicine at Harvard Medical School. The research appears today in the journal Blood.

Estimating outcomes

The MIT researchers have spent the past few years developing the Synthetic Survival Control causal inference framework, which enables them to answer complex “when-if” questions when using available data is statistically challenging. Their approach estimates when a target event happens if a certain intervention is used.

In this paper, the researchers investigated an aggressive cancer called nodal mature T-cell lymphoma, and whether a certain prognostic marker led to worse outcomes. The marker, TTR12, signifies that a patient relapsed within 12 months of initial therapy.

They applied their framework to estimate when a patient will die if they have TTR12, and how their survival trajectory would be different if they do not have this prognostic marker.

“No experiment can answer that question because we are asking about two outcomes for the same patient. We have to borrow information from other patients to estimate, counterfactually, what a patient’s survival outcome would have been,” Han explains.

Answering these types of questions is notoriously difficult due to biases in the available observational data. Plus, patient data gathered from an international cohort bring their own unique challenges. For instance, a clinical dataset often contains some historical data about a patient, but at some point the patient may stop treatment, leading to incomplete records.

In addition, if a patient receives a specific treatment, that might impact how long they will survive, adding to the complexity of the data. Plus, for each patient, the researchers only observe one outcome on how long the patient survives — limiting the amount of data available.

Such issues lead to suboptimal performance of many classical methods.

The Synthetic Survival Control framework can overcome these challenges. Even though the researchers don’t know all the details for each patient, their method stitches information from multiple other patients together in such a way that it can estimate survival outcomes.

Importantly, their method is robust to specific modeling assumptions, making it broadly applicable in practice. 

The power of prognostication

The researchers’ analysis revealed that TTR12 patients consistently had much greater risk of death within five years of initial therapy than patients without the marker. This was true no matter the initial therapy the patients received or which subgroup they fell into.

“This tells us that early relapse is a very important prognosis. This acts as a signal to clinicians so they can think about tailored therapies for these patients that can overcome resistance in second-line or third-line,” Han says.

Moving forward, the researchers are looking to expand this analysis to include high-dimensional genomics data. This information could be used to develop bespoke treatments that can avoid relapse within 12 months.

“Based on our work, there is already a risk calculation tool being used by clinicians. With more information, we can make it a richer tool that can provide more prognostic details,” Shah says.

They are also applying the framework to other domains.

For instance, in a paper recently presented at the Conference on Neural Information Processing Systems, the researchers identified a dramatic difference in the recidivism rate among prisoners of different races that begins about seven months after release. A possible explanation is the different access to long-term support by different racial groups. They are also investigating individuals’ decisions to leave insurance companies, while exploring other domains where the framework could generate actionable insights.

“Partnering with domain experts is crucial because we want to demonstrate that our methods are of value in the real world. We hope these tools can be used to positively impact individuals across society,” Han says.

This work was funded, in part, by Daiichi Sankyo, Secure Bio, Inc., Acrotech Biopharma, Kyowa Kirin, the Center for Lymphoma Research, the National Cancer Institute, Massachusetts General Hospital, the Reid Fund for Lymphoma Research, the American Cancer Society, and the Scarlet Foundation.

National Institutes of Health (NIH) Director Jay Bhattacharya visited MIT on Friday, engaging in a wide-ranging discussion about policy issues and research aims at an event also featuring Rep. Jake Auchincloss MBA ’16 of Massachusetts.

The forum consisted of a dialogue between Auchincloss and Bhattacharya, followed by a question-and-answer session with an audience that included researchers from the greater Boston area. The event was part of a daylong series of stops Bhattacharya and Auchincloss made around Boston, a world-leading hub of biomedical research.

“I was joking with Dr. Bhattacharya that when the NIH director comes to Massachusetts, he gets treated like a celebrity, because we do science, and we take science very seriously here,” Auchincloss quipped at the outset.

Bhattacharya said he was “delighted” to be visiting, and credited the thousands of scientists who participate in peer review for the NIH. “The reason why the NIH succeeds is the willingness and engagement of the scientific community,” he said.

In response to an audience question, Bhattacharya also outlined his overall vision of the NIH’s portfolio of projects.

“You both need investments in ideas that are not tested, just to see if something works. You don’t know in advance,” he said. “And at the same time, you need an ecosystem that tests those ideas rigorously and winnows those ideas to the ones that actually work, that are replicable. A successful portfolio will have both elements in it.”

MIT President Sally A. Kornbluth gave opening remarks at the event, welcoming Bhattacharya and Auchincloss to campus and noting that the Institute’s earliest known NIH grant on record dates to 1948. In recent decades, biomedical research at MIT has boomed, expanding across a wide range of frontier fields.

Indeed, Kornbluth noted, MIT’s federally funded research projects during U.S. President Trump’s first term include a method for making anesthesia safer, especially for children and the elderly; a new type of expanding heart valve for children that eliminates the need for repeated surgeries; and a noninvasive Alzheimer’s treatment using sound and light stimulation, which is currently in clinical trials.

“Today, researchers across our campus pursue pioneering science on behalf of the American people, with profoundly important results,” Kornbluth said.

“The hospitals, universities, startups, investors, and companies represented here today have made greater Boston an extraordinary magnet for talent,” Kornbluth added. “Both as a force for progress in human health and an engine of economic growth, this community of talent is a precious national asset. We look forward to working with Dr. Bhattacharya to build on its strengths.”

The discussion occurred amid uncertainty about future science funding levels and pending changes in the NIH’s grant-review processes. The NIH has announced a “unified strategy” for reviewing grant applications that may lead to more direct involvement in grant decisions by directors of the 27 NIH institutes and centers, along with other changes that could shift the types of awards being made.

Auchincloss asked multiple questions about the ongoing NIH changes; about 10 audience members from a variety of institutions also posed a range of questions to Bhattacharya, often about the new grant-review process and the aims of the changes.

“The unified funding strategy is a way to allow institute direcors to look at the full range of scoring, including scores on innovation, and pick projects that look like they are promising,” Bhattacharya said in response to one of Auchincloss’ queries.

One audience member also emphasized concerns about the long-term effects of funding uncertainties on younger scientists in the U.S.

“The future success of the American biomedical enterprise depends on us training the next generation of scientists,” Bhattacharya acknowledged.

Bhattacharya is the 18th director of the NIH, having been confirmed by the U.S. Senate in March. He has served as a faculty member at Stanford University, where he received his BA, MA, MD, and PhD, and is currently a professor emeritus. During his career, Bhattacharya’s work has often examined the economics of health care, though his research has ranged broadly across topics, in over 170 published papers. He has also served as director of the Center on the Demography and Economics of Health and Aging at Stanford University.

Auchincloss is in his third term as the U.S. Representative to Congress from the 4th district in Massachusetts, having first been elected in 2020. He is also a major in the Marine Corps Reserve, and received his MBA from the MIT Sloan School of Management.

Ian Waitz, MIT’s vice president for research, concluded the session with a note of thanks to Auchincloss and Bhattacharya for their “visit to the greater Boston ecosystem which has done so much for so many and contributed obviously to the NIH mission that you articulated.” He added: “We have such a marvelous history in this region in making such great gains for health and longevity, and we’re here to do more to partner with you.”

Many organizations are taking actions to shrink their carbon footprint, such as purchasing electricity from renewable sources or reducing air travel.

Both actions would cut greenhouse gas emissions, but which offers greater societal benefits?

In a first step toward answering that question, MIT researchers found that even if each activity reduces the same amount of carbon dioxide emissions, the broader air quality impacts can be quite different.

They used a multifaceted modeling approach to quantify the air quality impacts of each activity, using data from three organizations. Their results indicate that air travel causes about three times more damage to air quality than comparable electricity purchases.

Exposure to major air pollutants, including ground-level ozone and fine particulate matter, can lead to cardiovascular and respiratory disease, and even premature death.

In addition, air quality impacts can vary dramatically across different regions. The study shows that air quality effects differ sharply across space because each decarbonization action influences pollution at a different scale. For example, for organizations in the northeast U.S., the air quality impacts of energy use affect the region, but the impacts of air travel are felt globally. This is because associated pollutants are emitted at higher altitudes.

Ultimately, the researchers hope this work highlights how organizations can prioritize climate actions to provide the greatest near-term benefits to people’s health.

“If we are trying to get to net zero emissions, that trajectory could have very different implications for a lot of other things we care about, like air quality and health impacts. Here we’ve shown that, for the same net zero goal, you can have even more societal benefits if you figure out a smart way to structure your reductions,” says Noelle Selin, a professor in the MIT Institute for Data, Systems, and Society (IDSS) and the Department of Earth, Atmospheric and Planetary Sciences (EAPS); director of the Center for Sustainability Science and Strategy; and senior author of the study.

Selin is joined on the paper by lead author Yuang (Albert) Chen, an MIT graduate student; Florian Allroggen, a research scientist in the MIT Department of Aeronautics and Astronautics; Sebastian D. Eastham, an associate professor in the Department of Aeronautics at Imperial College of London; Evan Gibney, an MIT graduate student; and William Clark, the Harvey Brooks Research Professor of International Science at Harvard University. The research was published Friday in Environmental Research Letters.

A quantification quandary

Climate scientists often focus on the air quality benefits of national or regional policies because the aggregate impacts are more straightforward to model.

Organizations’ efforts to “go green” are much harder to quantify because they exist within larger societal systems and are impacted by these national policies.

To tackle this challenging problem, the MIT researchers used data from two universities and one company in the greater Boston area. They studied whether organizational actions that remove the same amount of CO2 from the atmosphere would have an equivalent benefit on improving air quality.

“From a climate standpoint, CO2 has a global impact because it mixes through the atmosphere, no matter where it is emitted. But air quality impacts are driven by co-pollutants that act locally, so where those emissions occur really matters,” Chen says.

For instance, burning fossil fuels leads to emissions of nitrogen oxides and sulfur dioxide along with CO2. These co-pollutants react with chemicals in the atmosphere to form fine particulate matter and ground-level ozone, which is a primary component of smog.

Different fossil fuels cause varying amounts of co-pollutant emissions. In addition, local factors like weather and existing emissions affect the formation of smog and fine particulate matter. The impacts of these pollutants also depend on the local population distribution and overall health.

“You can’t just assume that all CO2-reduction strategies will have equivalent near-term impacts on sustainability. You have to consider all the other emissions that go along with that CO2,” Selin says.

The researchers used a systems-level approach that involved connecting multiple models. They fed the organizational energy consumption and flight data into this systems-level model to examine local and regional air quality impacts.

Their approach incorporated many interconnected elements, such as power plant emissions data, statistical linkages between air quality and mortality outcomes, and aviation emissions associated with specific flight routes. They fed those data into an atmospheric chemistry transport model to calculate air quality and climate impacts for each activity.

The sheer breadth of the system created many challenges.

“We had to do multiple sensitivity analyses to make sure the overall pipeline was working,” Chen says.

Analyzing air quality

At the end, the researchers monetized air quality impacts to compare them with the climate impacts in a consistent way. Monetized climate impacts of CO2 emissions based on prior literature are about $170 per ton (expressed in 2015 dollars), representing the financial cost of damages caused by climate change.

Using the same method as used to monetize the impact of CO2, the researchers calculated that air quality damages associated with electricity purchases are an additional $88 per ton of CO2, while the damages from air travel are an additional $265 per ton.

This highlights how the air quality impacts of a ton of emitted CO2 depend strongly on where and how the emissions are produced.

“A real surprise was how much aviation impacted places that were really far from these organizations. Not only were flights more damaging, but the pattern of damage, in terms of who is harmed by air pollution from that activity, is very different than who is harmed by energy systems,” Selin says.

Most airplane emissions occur at high altitudes, where differences in atmospheric chemistry and transport can amplify their air quality impacts. These emissions are also carried across continents by atmospheric winds, affecting people thousands of miles from their source.

Nations like India and China face outsized air quality impacts from such emissions due to the higher level of existing ground-level emissions, which exacerbates the formation of fine particulate matter and smog.

The researchers also conducted a deeper analysis of short-haul flights. Their results showed that regional flights have a relatively larger impact on local air quality than longer domestic flights.

“If an organization is thinking about how to benefit the neighborhoods in their backyard, then reducing short-haul flights could be a strategy with real benefits,” Selin says.

Even in electricity purchases, the researchers found that location matters.

For instance, fine particulate matter emissions from power plants caused by one university are in a densely populated region, while emissions caused by the corporation fall over less populated areas.

Due to these population differences, the university’s emissions resulted in 16 percent more estimated premature deaths than those of the corporation, even though the climate impacts are identical.

“These results show that, if organizations want to achieve net zero emissions while promoting sustainability, which unit of CO2 gets removed first really matters a lot,” Chen says.

In the future, the researchers want to quantify the air quality and climate impacts of train travel, to see whether replacing short-haul flights with train trips could provide benefits.

They also want to explore the air quality impacts of other energy sources in the U.S., such as data centers.

This research was funded, in part, by Biogen, Inc., the Italian Ministry for Environment, Land, and Sea, and the MIT Center for Sustainability Science and Strategy.