Music technology took center stage at MIT during “FUTURE PHASES,” an evening of works for string orchestra and electronics, presented by the MIT Music Technology and Computation Graduate Program as part of the 2025 International Computer Music Conference (ICMC). 

The well-attended event was held last month in the Thomas Tull Concert Hall within the new Edward and Joyce Linde Music Building. Produced in collaboration with the MIT Media Lab’s Opera of the Future Group and Boston’s self-conducted chamber orchestra A Far Cry, “FUTURE PHASES” was the first event to be presented by the MIT Music Technology and Computation Graduate Program in MIT Music’s new space.

“FUTURE PHASES” offerings included two new works by MIT composers: the world premiere of “EV6,” by MIT Music’s Kenan Sahin Distinguished Professor Evan Ziporyn and professor of the practice Eran Egozy; and the U.S. premiere of “FLOW Symphony,” by the MIT Media Lab’s Muriel R. Cooper Professor of Music and Media Tod Machover. Three additional works were selected by a jury from an open call for works: “The Wind Will Carry Us Away,” by Ali Balighi; “A Blank Page,” by Celeste Betancur Gutiérrez and Luna Valentin; and “Coastal Portrait: Cycles and Thresholds,” by Peter Lane. Each work was performed by Boston’s own multi-Grammy-nominated string orchestra, A Far Cry.

“The ICMC is all about presenting the latest research, compositions, and performances in electronic music,” says Egozy, director of the new Music Technology and Computation Graduate Program at MIT. When approached to be a part of this year’s conference, “it seemed the perfect opportunity to showcase MIT’s commitment to music technology, and in particular the exciting new areas being developed right now: a new master’s program in music technology and computation, the new Edward and Joyce Linde Music Building with its enhanced music technology facilities, and new faculty arriving at MIT with joint appointments between MIT Music and Theater Arts (MTA) and the Department of Electrical Engineering and Computer Science (EECS).” These recently hired professors include Anna Huang, a keynote speaker for the conference and creator of the machine learning model Coconet that powered Google’s first AI Doodle, the Bach Doodle.

Egozy emphasizes the uniqueness of this occasion: “You have to understand that this is a very special situation. Having a full 18-member string orchestra [A Far Cry] perform new works that include electronics does not happen very often. In most cases, ICMC performances consist either entirely of electronics and computer-generated music, or perhaps a small ensemble of two-to-four musicians. So the opportunity we could present to the larger community of music technology was particularly exciting.”

To take advantage of this exciting opportunity, an open call was put out internationally to select the other pieces that would accompany Ziporyn and Egozy’s “EV6” and Machover’s “FLOW Symphony.” Three pieces were selected from a total of 46 entries to be a part of the evening’s program by a panel of judges that included Egozy, Machover, and other distinguished composers and technologists.

“We received a huge variety of works from this call,” says Egozy. “We saw all kinds of musical styles and ways that electronics would be used. No two pieces were very similar to each other, and I think because of that, our audience got a sense of how varied and interesting a concert can be for this format. A Far Cry was really the unifying presence. They played all pieces with great passion and nuance. They have a way of really drawing audiences into the music. And, of course, with the Thomas Tull Concert Hall being in the round, the audience felt even more connected to the music.”

Egozy continues, “we took advantage of the technology built into the Thomas Tull Concert Hall, which has 24 built-in speakers for surround sound allowing us to broadcast unique, amplified sound to every seat in the house. Chances are that every person might have experienced the sound slightly differently, but there was always some sense of a multidimensional evolution of sound and music as the pieces unfolded.”

The five works of the evening employed a range of technological components that included playing synthesized, prerecorded, or electronically manipulated sounds; attaching microphones to instruments for use in real-time signal processing algorithms; broadcasting custom-generated musical notation to the musicians; utilizing generative AI to process live sound and play it back in interesting and unpredictable ways; and audience participation, where spectators use their cellphones as musical instruments to become a part of the ensemble.

Ziporyn and Egozy’s piece, “EV6,” took particular advantage of this last innovation: “Evan and I had previously collaborated on a system called Tutti, which means ‘together’ in Italian. Tutti gives an audience the ability to use their smartphones as musical instruments so that we can all play together.” Egozy developed the technology, which was first used in the MIT Campaign for a Better World in 2017. The original application involved a three-minute piece for cellphones only. “But for this concert,” Egozy explains, “Evan had the idea that we could use the same technology to write a new piece — this time, for audience phones and a live string orchestra as well.”

To explain the piece’s title, Ziporyn says, “I drive an EV6; it’s my first electric car, and when I first got it, it felt like I was driving an iPhone. But of course it’s still just a car: it’s got wheels and an engine, and it gets me from one place to another. It seemed like a good metaphor for this piece, in which a lot of the sound is literally played on cellphones, but still has to work like any other piece of music. It’s also a bit of an homage to David Bowie’s song ‘TVC 15,’ which is about falling in love with a robot.”

Egozy adds, “We wanted audience members to feel what it is like to play together in an orchestra. Through this technology, each audience member becomes a part of an orchestral section (winds, brass, strings, etc.). As they play together, they can hear their whole section playing similar music while also hearing other sections in different parts of the hall play different music. This allows an audience to feel a responsibility to their section, hear how music can move between different sections of an orchestra, and experience the thrill of live performance. In ‘EV6,’ this experience was even more electrifying because everyone in the audience got to play with a live string orchestra — perhaps for the first time in recorded history.”

After the concert, guests were treated to six music technology demonstrations that showcased the research of undergraduate and graduate students from both the MIT Music program and the MIT Media Lab. These included a gamified interface for harnessing just intonation systems (Antonis Christou); insights from a human-AI co-created concert (Lancelot Blanchard and Perry Naseck); a system for analyzing piano playing data across campus (Ayyub Abdulrezak ’24, MEng ’25); capturing music features from audio using latent frequency-masked autoencoders (Mason Wang); a device that turns any surface into a drum machine (Matthew Caren ’25); and a play-along interface for learning traditional Senegalese rhythms (Mariano Salcedo ’25). This last example led to the creation of Senegroove, a drumming-based application specifically designed for an upcoming edX online course taught by ethnomusicologist and MIT associate professor in music Patricia Tang, and world-renowned Senegalese drummer and MIT lecturer in music Lamine Touré, who provided performance videos of the foundational rhythms used in the system.

Ultimately, Egozy muses, “'FUTURE PHASES' showed how having the right space — in this case, the new Edward and Joyce Linde Music Building — really can be a driving force for new ways of thinking, new projects, and new ways of collaborating. My hope is that everyone in the MIT community, the Boston area, and beyond soon discovers what a truly amazing place and space we have built, and are still building here, for music and music technology at MIT.”

Researchers from MIT and elsewhere have designed a novel transmitter chip that significantly improves the energy efficiency of wireless communications, which could boost the range and battery life of a connected device.

Their approach employs a unique modulation scheme to encode digital data into a wireless signal, which reduces the amount of error in the transmission and leads to more reliable communications.

The compact, flexible system could be incorporated into existing internet-of-things devices to provide immediate gains, while also meeting the more stringent efficiency requirements of future 6G technologies.

The versatility of the chip could make it well-suited for a range of applications that require careful management of energy for communications, such as industrial sensors that continuously monitor factory conditions and smart appliances that provide real-time notifications.

“By thinking outside the box, we created a more efficient, intelligent circuit for next-generation devices that is also even better than the state-of-the-art for legacy architectures. This is just one example of how adopting a modular approach to allow for adaptability can drive innovation at every level,” says Muriel Médard, the School of Science NEC Professor of Software Science and Engineering, a professor in the MIT Department of Electrical Engineering and Computer Science (EECS), and co-author of a paper on the new transmitter.

Médard’s co-authors include Timur Zirtiloglu, the lead author and a graduate student at Boston University; Arman Tan, a graduate student at BU; Basak Ozaydin, an MIT graduate student in EECS; Ken Duffy, a professor at Northeastern University; and Rabia Tugce Yazicigil, associate professor of electrical and computer engineering at BU. The research was recently presented at the IEEE Radio Frequency Circuits Symposium.

Optimizing transmissions

In wireless devices, a transmitter converts digital data into an electromagnetic signal that is sent over the airwaves to a receiver. The transmitter does this by mapping digital bits to symbols that represent the amplitude and phase of the electromagnetic signal, which is a process called modulation.

Traditional systems transmit signals that are evenly spaced by creating a uniform pattern of symbols, which helps avoid interference. But this uniform structure lacks adaptability and can be inefficient, since wireless channel conditions are dynamic and often change rapidly.

As an alternative, optimal modulation schemes follow a non-uniform pattern that can adapt to changing channel conditions, maximizing the amount of data transmitted while minimizing energy usage.

But while optimal modulation can be more energy efficient, it is also more susceptible to errors, especially in crowded wireless environments. When the signals aren’t uniform in length, it can be harder for the receiver to distinguish between symbols and noise that squeezed into the transmission.

To overcome this problem, the MIT transmitter adds a small amount of padding, in the form of extra bits between symbols, so that every transmission is the same length.

This helps the receiver identify the beginning and end of each transmission, preventing misinterpretation of the message. However, the device enjoys the energy efficiency gains of using a non-uniform, optimal modulation scheme.

This approach works because of a technique the researchers previously developed known as GRAND, which is a universal decoding algorithm that crack any code by guessing the noise that affected the transmission.

Here, they employ a GRAND-inspired algorithm to adjust the length of the received transmission by guessing the extra bits that have been added. In this way, the receiver can effectively reconstruct the original message.

“Now, thanks to GRAND, we can have a transmitter that is capable of doing these more efficient transmissions with non-uniform constellations of data, and we can see the gains,” Médard says.

A flexible circuit

The new chip, which has a compact architecture that allows the researchers to integrate additional efficiency-boosting methods, enabled transmissions with only about one-quarter the amount of signal error of methods that use optimal modulation.

Surprisingly, the device also achieved significantly lower error rates than transmitters that use traditional modulation.

“The traditional approach has become so ingrained that it was challenging to not get lured back to the status quo, especially since we were changing things that we often take for granted and concepts we’ve been teaching for decades,” Médard says.

This innovative architecture could be used to improve the energy efficiency and reliability of current wireless communication devices, while also offering the flexibility to be incorporated into future devices that employ optimal modulation.

Next, the researchers want to adapt their approach to leverage additional techniques that could boost efficiency and reduce the error rates in wireless transmissions.

“This optimal modulation transmitter radio frequency integrated circuit is a game-changing innovation over the traditional RF signal modulation. It’s set to play a major role for the next generation of wireless connectivity such as 6G and Wi-Fi,” says Rocco Tam, NXP Fellow for Wireless Connectivity SoC Research and Development at NXP Semiconductors, who was not involved with this research.

This work is supported, in part, by the U.S. Defense Advanced Research Projects Agency (DARPA), the National Science Foundation (NSF), and the Texas Analog Center for Excellence. 

A lot of attention has been paid to how climate change can drive biodiversity loss. Now, MIT researchers have shown the reverse is also true: Reductions in biodiversity can jeopardize one of Earth’s most powerful levers for mitigating climate change.

In a paper published in PNAS, the researchers showed that following deforestation, naturally-regrowing tropical forests, with healthy populations of seed-dispersing animals, can absorb up to four times more carbon than similar forests with fewer seed-dispersing animals.

Because tropical forests are currently Earth’s largest land-based carbon sink, the findings improve our understanding of a potent tool to fight climate change.

“The results underscore the importance of animals in maintaining healthy, carbon-rich tropical forests,” says Evan Fricke, a research scientist in the MIT Department of Civil and Environmental Engineering and the lead author of the new study. “When seed-dispersing animals decline, we risk weakening the climate-mitigating power of tropical forests.”

Fricke’s co-authors on the paper include César Terrer, the Tianfu Career Development Associate Professor at MIT; Charles Harvey, an MIT professor of civil and environmental engineering; and Susan Cook-Patton of The Nature Conservancy.

The study combines a wide array of data on animal biodiversity, movement, and seed dispersal across thousands of animal species, along with carbon accumulation data from thousands of tropical forest sites.

The researchers say the results are the clearest evidence yet that seed-dispersing animals play an important role in forests’ ability to absorb carbon, and that the findings underscore the need to address biodiversity loss and climate change as connected parts of a delicate ecosystem rather as separate problems in isolation.

“It’s been clear that climate change threatens biodiversity, and now this study shows how biodiversity losses can exacerbate climate change,” Fricke says. “Understanding that two-way street helps us understand the connections between these challenges, and how we can address them. These are challenges we need to tackle in tandem, and the contribution of animals to tropical forest carbon shows that there are win-wins possible when supporting biodiversity and fighting climate change at the same time.”

Putting the pieces together

The next time you see a video of a monkey or bird enjoying a piece of fruit, consider that the animals are actually playing an important role in their ecosystems. Research has shown that by digesting the seeds and defecating somewhere else, animals can help with the germination, growth, and long-term survival of the plant.

Fricke has been studying animals that disperse seeds for nearly 15 years. His previous research has shown that without animal seed dispersal, trees have lower survival rates and a harder time keeping up with environmental changes.

“We’re now thinking more about the roles that animals might play in affecting the climate through seed dispersal,” Fricke says. “We know that in tropical forests, where more than three-quarters of trees rely on animals for seed dispersal, the decline of seed dispersal could affect not just the biodiversity of forests, but how they bounce back from deforestation. We also know that all around the world, animal populations are declining.”

Regrowing forests is an often-cited way to mitigate the effects of climate change, but the influence of biodiversity on forests’ ability to absorb carbon has not been fully quantified, especially at larger scales.

For their study, the researchers combined data from thousands of separate studies and used new tools for quantifying disparate but interconnected ecological processes. After analyzing data from more than 17,000 vegetation plots, the researchers decided to focus on tropical regions, looking at data on where seed-dispersing animals live, how many seeds each animal disperses, and how they affect germination.

The researchers then incorporated data showing how human activity impacts different seed-dispersing animals’ presence and movement. They found, for example, that animals move less when they consume seeds in areas with a bigger human footprint.

Combining all that data, the researchers created an index of seed-dispersal disruption that revealed a link between human activities and declines in animal seed dispersal. They then analyzed the relationship between that index and records of carbon accumulation in naturally regrowing tropical forests over time, controlling for factors like drought conditions, the prevalence of fires, and the presence of grazing livestock.

“It was a big task to bring data from thousands of field studies together into a map of the disruption of seed dispersal,” Fricke says. “But it lets us go beyond just asking what animals are there to actually quantifying the ecological roles those animals are playing and understanding how human pressures affect them.”

The researchers acknowledged that the quality of animal biodiversity data could be improved and introduces uncertainty into their findings. They also note that other processes, such as pollination, seed predation, and competition influence seed dispersal and can constrain forest regrowth. Still, the findings were in line with recent estimates.

“What’s particularly new about this study is we’re actually getting the numbers around these effects,” Fricke says. “Finding that seed dispersal disruption explains a fourfold difference in carbon absorption across the thousands of tropical regrowth sites included in the study points to seed dispersers as a major lever on tropical forest carbon.”

Quantifying lost carbon

In forests identified as potential regrowth sites, the researchers found seed-dispersal declines were linked to reductions in carbon absorption each year averaging 1.8 metric tons per hectare, equal to a reduction in regrowth of 57 percent.

The researchers say the results show natural regrowth projects will be more impactful in landscapes where seed-dispersing animals have been less disrupted, including areas that were recently deforested, are near high-integrity forests, or have higher tree cover.

“In the discussion around planting trees versus allowing trees to regrow naturally, regrowth is basically free, whereas planting trees costs money, and it also leads to less diverse forests,” Terrer says. “With these results, now we can understand where natural regrowth can happen effectively because there are animals planting the seeds for free, and we also can identify areas where, because animals are affected, natural regrowth is not going to happen, and therefore planting trees actively is necessary.”

To support seed-dispersing animals, the researchers encourage interventions that protect or improve their habitats and that reduce pressures on species, ranging from wildlife corridors to restrictions on wildlife trade. Restoring the ecological roles of seed dispersers is also possible by reintroducing seed-dispersing species where they’ve been lost or planting certain trees that attract those animals.

The findings could also make modeling the climate impact of naturally regrowing forests more accurate.

“Overlooking the impact of seed-dispersal disruption may overestimate natural regrowth potential in many areas and underestimate it in others,” the authors write.

The researchers believe the findings open up new avenues of inquiry for the field.

“Forests provide a huge climate subsidy by sequestering about a third of all human carbon emissions,” Terrer says. “Tropical forests are by far the most important carbon sink globally, but in the last few decades, their ability to sequester carbon has been declining. We will next explore how much of that decline is due to an increase in extreme droughts or fires versus declines in animal seed dispersal.”

Overall, the researchers hope the study helps improves our understanding of the planet’s complex ecological processes.

“When we lose our animals, we’re losing the ecological infrastructure that keeps our tropical forests healthy and resilient,” Fricke says.

The research was supported by the MIT Climate and Sustainability Consortium, the Government of Portugal, and the Bezos Earth Fund.

On Thursday, June 5, 11 individuals and four teams were awarded MIT Excellence Awards — the highest awards for staff at the Institute. Cheers from colleagues holding brightly colored signs and pompoms rang out in Kresge Auditorium in celebration of the honorees. In addition to the Excellence Awards, staff members received the Collier Medal, the Staff Award for Distinction in Service, and the Gordon Y. Billard Award.  

The Collier Medal honors the memory of Officer Sean Collier, who gave his life protecting and serving MIT. The medal recognizes an individual or group whose actions demonstrate the importance of community, and whose contributions exceed the boundaries of their profession. The Staff Award for Distinction in Service is presented to an individual whose service results in a positive, lasting impact on the MIT community. The Gordon Y. Billard Award is given to staff or faculty members, or MIT-affiliated individuals, who provide "special service of outstanding merit performed for the Institute."

The 2025 MIT Excellence Award recipients and their award categories are:

Bringing Out the Best

• Timothy Collard
• Whitney Cornforth
• Roger Khazan

Embracing Inclusion

• Denise Phillips

Innovative Solutions

• Ari Jacobovits
• Stephanie Tran
• MIT Health Rebranding Team, Office of the Executive Vice President and Treasurer: Ann Adelsberger, Amy Ciarametaro, Kimberly Schive, Emily Wade

Outstanding Contributor

• Sharon Clarke
• Charles "Chip" Coldwell
• Jeremy Mineweaser
• Christopher "Petey" Peterson
• MIT Health Accreditation Team, Office of the Executive Vice President and Treasurer: Christianne Garcia, David Podradchik, Janis Puibello, Kristen Raymond
• MIT Museum Visitor Experience Supervisor Team, Associate Provost for the Arts: Mariah Crowley, Brianna Vega

Serving Our Community

• Nada Miqdadi El-Alami
• MIT International Scholars Office, Office of the Vice President for Research: Portia Brummitt-Vachon, Amanda Doran, Brianna L. Drakos, Fumiko Futai, Bay Heidrich, Benjamin Hull, Penny Rosser, Henry Rotchford, Patricia Toledo, Makiko Wada
• Building 68 Kitchen Staff, Department of Biology, School of Science: Brikti Abera, AnnMarie Budhai, Nicholas Budhai, Daniel Honiker, Janet Katin, Umme Khan, Shuming Lin, Kelly McKinnon, Karen O'Leary

The 2025 Collier Medal recipient was Kathleen Monagle, associate dean and director of disability and access services, student support, and wellbeing in the Division of Student Life. Monagle oversees a team that supports almost 600 undergraduate, graduate, and MITx students with more than 4,000 accommodations. She works with faculty to ensure those students have the best possible learning experience — both in MIT’s classrooms and online.

This year’s recipient of the 2025 Staff Award for Distinction in Service was Stu Schmill, dean of admissions and student financial services in the Office of the Vice Chancellor. Schmill graduated from MIT in 1986 and has since served the Institute in a variety of roles. His colleagues admire his passion for sharing knowledge; his insight and integrity; and his deep love for MIT’s culture, values, and people.

Three community members were honored with a 2025 Gordon Y. Billard Award. 

• William "Bill" Cormier, project technician, Department of Mechanical Engineering, School of Engineering

• John E. Fernández, professor, Department of Architecture, School of Architecture and Planning; and director of MIT Environmental Solutions Initiative, Office of the Vice President for Research

• Tony Lee, coach, MIT Women's Volleyball Club, Student Organizations, Leadership, and Engagement, Division of Student Life

Presenters included President Sally Kornbluth; MIT Chief of Police John DiFava and Deputy Chief Steven DeMarco; Dean of the School of Science Nergis Mavalvala; Vice President for Human Resources Ramona Allen; Executive Vice President and Treasurer Glen Shor; Lincoln Laboratory Assistant Director Justin Brooke; Chancellor Melissa Nobles; and Provost Anantha Chandrakasan.

Visit the MIT Human Resources website for more information about the award recipients, categories, and to view photos and video of the event. 

Scientists often seek new materials derived from polymers. Rather than starting a polymer search from scratch, they save time and money by blending existing polymers to achieve desired properties.

But identifying the best blend is a thorny problem. Not only is there a practically limitless number of potential combinations, but polymers interact in complex ways, so the properties of a new blend are challenging to predict.

To accelerate the discovery of new materials, MIT researchers developed a fully autonomous experimental platform that can efficiently identify optimal polymer blends.

The closed-loop workflow uses a powerful algorithm to explore a wide range of potential polymer blends, feeding a selection of combinations to a robotic system that mixes chemicals and tests each blend.

Based on the results, the algorithm decides which experiments to conduct next, continuing the process until the new polymer meets the user’s goals.

During experiments, the system autonomously identified hundreds of blends that outperformed their constituent polymers. Interestingly, the researchers found that the best-performing blends did not necessarily use the best individual components.

“I found that to be good confirmation of the value of using an optimization algorithm that considers the full design space at the same time,” says Connor Coley, the Class of 1957 Career Development Assistant Professor in the MIT departments of Chemical Engineering and Electrical Engineering and Computer Science, and senior author of a paper on this new approach. “If you consider the full formulation space, you can potentially find new or better properties. Using a different approach, you could easily overlook the underperforming components that happen to be the important parts of the best blend.”

This workflow could someday facilitate the discovery of polymer blend materials that lead to advancements like improved battery electrolytes, more cost-effective solar panels, or tailored nanoparticles for safer drug delivery.

Coley is joined on the paper by lead author Guangqi Wu, a former MIT postdoc who is now a Marie Skłodowska-Curie Postdoctoral Fellow at Oxford University; Tianyi Jin, an MIT graduate student; and Alfredo Alexander-Katz, the Michael and Sonja Koerner Professor in the MIT Department of Materials Science and Engineering. The work appears today in Matter.

Building better blends

When scientists design new polymer blends, they are faced with a nearly endless number of possible polymers to start with. Once they select a few to mix, they still must choose the composition of each polymer and the concentration of polymers in the blend.

“Having that large of a design space necessitates algorithmic solutions and higher-throughput workflows because you simply couldn’t test all the combinations using brute force,” Coley adds.

While researchers have studied autonomous workflows for single polymers, less work has focused on polymer blends because of the dramatically larger design space.

In this study, the MIT researchers sought new random heteropolymer blends, made by mixing two or more polymers with different structural features. These versatile polymers have shown particularly promising relevance to high-temperature enzymatic catalysis, a process that increases the rate of chemical reactions.

Their closed-loop workflow begins with an algorithm that, based on the user’s desired properties, autonomously identifies a handful of promising polymer blends.

The researchers originally tried a machine-learning model to predict the performance of new blends, but it was difficult to make accurate predictions across the astronomically large space of possibilities. Instead, they utilized a genetic algorithm, which uses biologically inspired operations like selection and mutation to find an optimal solution.

Their system encodes the composition of a polymer blend into what is effectively a digital chromosome, which the genetic algorithm iteratively improves to identify the most promising combinations.

“This algorithm is not new, but we had to modify the algorithm to fit into our system. For instance, we had to limit the number of polymers that could be in one material to make discovery more efficient,” Wu adds.

In addition, because the search space is so large, they tuned the algorithm to balance its choice of exploration (searching for random polymers) versus exploitation (optimizing the best polymers from the last experiment).

The algorithm sends 96 polymer blends at a time to the autonomous robotic platform, which mixes the chemicals and measures the properties of each.

The experiments were focused on improving the thermal stability of enzymes by optimizing the retained enzymatic activity (REA), a measure of how stable an enzyme is after mixing with the polymer blends and being exposed to high temperatures.

These results are sent back to the algorithm, which uses them to generate a new set of polymers until the system finds the optimal blend.

Accelerating discovery

Building the robotic system involved numerous challenges, such as developing a technique to evenly heat polymers and optimizing the speed at which the pipette tip moves up and down.

“In autonomous discovery platforms, we emphasize algorithmic innovations, but there are many detailed and subtle aspects of the procedure you have to validate before you can trust the information coming out of it,” Coley says.

When tested, the optimal blends their system identified often outperformed the polymers that formed them. The best overall blend performed 18 percent better than any of its individual components, achieving an REA of 73 percent.

“This indicates that, instead of developing new polymers, we could sometimes blend existing polymers to design new materials that perform even better than individual polymers do,” Wu says.

Moreover, their autonomous platform can generate and test 700 new polymer blends per day and only requires human intervention for refilling and replacing chemicals.

While this research focused on polymers for protein stabilization, their platform could be modified for other uses, like the development or new plastics or battery electrolytes.

In addition to exploring additional polymer properties, the researchers want to use experimental data to improve the efficiency of their algorithm and develop new algorithms to streamline the operations of the autonomous liquid handler.

“Technologically, there are urgent needs to enhance thermal stability of proteins and enzymes. The results demonstrated here are quite impressive. Being a platform technology and given the rapid advancement in machine learning and AI for material science, one can envision the possibility for this team to further enhance random heteropolymer performances or to optimize design based on end needs and usages,” says Ting Xu, an associate professor at the University of California at Berkeley, who was not involved with this work.

This work is funded, in part, by the U.S. Department of Energy, the National Science Foundation, and the Class of 1947 Career Development Chair.