Keeril Makan has been appointed vice provost for the arts at MIT, effective Feb. 1. In this role, Makan, who is the Michael (1949) and Sonja Koerner Music Composition Professor at MIT, will provide leadership and strategic direction for the arts across the Institute.

Provost Anantha Chandrakasan announced Makan’s appointment in an email to the MIT community today.

“Keeril’s record of accomplishment both as an artist and an administrative leader makes him exceedingly qualified to take on this important role,” Chandrakasan wrote, noting that Makan “has repeatedly taken on new leadership assignments with skill and enthusiasm.”

Makan’s appointment follows the publication last September of the final report of the Future of the Arts at MIT Committee. At MIT, the report noted, “the arts thrive as a constellation of recognized disciplines while penetrating and illuminating countless aspects of the Institute’s scientific and technological enterprise.” Makan will build on this foundation as MIT continues to strengthen the role of the arts in research, education, and community life.

As vice provost for the arts, Makan will provide Institute-wide leadership and strategic direction for the arts, working in close partnership with academic leaders, arts units, and administrative colleagues across MIT, including the Office of the Arts; the MIT Center for Art, Science and Technology; the MIT Museum; the List Visual Arts Center; and the Council for the Arts at MIT. His role will focus on strengthening connections between artistic practice, research, education, and community life, and on supporting public engagement and interdisciplinary collaboration.

“At MIT, the arts are a vital way of thinking, making, and convening,” Makan says. “As vice provost, my priority is to support and strengthen the extraordinary artistic work already happening across the Institute, while listening carefully to faculty, students, and staff as we shape what comes next. I’m excited to build on MIT’s distinctive, only-at-MIT approach to the arts and to help ensure that artistic practice remains central to MIT’s intellectual and community life.”

Makan says he will begin his new role with a period of listening and learning across MIT’s arts ecosystem, informed by the Future of the Arts at MIT report. His initial focus will be on understanding how artistic practice intersects with research, education, and community life, and on identifying opportunities to strengthen connections, visibility, and coordination across MIT’s many arts activities.

Over time, Makan says he will work with the arts community to advance MIT’s long-standing commitment to artistic excellence and experimentation, while supporting student participation and public engagement in the arts. He said his approach will “emphasize collaboration, clarity, and sustainability, reflecting MIT’s distinctive integration of the arts with science and technology.”

Makan came to MIT in 2006 as an assistant professor of music. From 2018 to 2024, he served as head of the Music and Theater Arts (MTA) Section in the School of Humanities, Arts, and Social Sciences (SHASS). In 2023, he was appointed associate dean for strategic initiatives in SHASS, where he helped guide the school’s response to recent fiscal pressures and led Institute-wide strategic initiatives.

With colleagues from MTA and the School of Engineering, Makan helped launch a new, multidisciplinary graduate program in music technology and computation. He was intimately involved in the project to develop the new Edward and Joyce Linde Music Building (Building 18), a state-of-the-art facility that opened in 2025. 

Makan was a member of the Future of the Arts at MIT Committee and chaired a working group on the creation of a center for the humanities, which ultimately became the MIT Human Insight Collaborative (MITHIC), one of the Institute’s strategic initiatives. Since last year, he has served as MITHIC’s faculty lead. Under his leadership, MITHIC has awarded $4.7 million in funding to 56 projects across 28 units at MIT, supporting interdisciplinary, human-centered research and teaching.

Trained initially as a violinist, Makan earned undergraduate degrees in music composition and religion from Oberlin and a PhD in music composition from the University of California at Berkeley.

A critically-acclaimed composer, Makan is the recipient of a Guggenheim Fellowship and the Luciano Berio Rome Prize from the American Academy in Rome. His music has been recorded by the Kronos Quartet, the Boston Modern Orchestra Project, and the International Contemporary Ensemble, and performed at Carnegie Hall, the Lincoln Center for the Performing Arts, and Tanglewood. His opera, “Persona,” premiered at National Sawdust and was performed at the Isabella Stewart Gardner Museum in Boston and by the Los Angeles Opera. The Los Angeles Times described the music from “Persona” as “brilliant.”

Makan succeeds Philip Khoury, the Ford International Professor of History, who served as vice provost for the arts from 2006 before stepping down in 2025. Khoury will return to the MIT faculty following a sabbatical.

In its first moments, the infant universe was a trillion-degree-hot soup of quarks and gluons. These elementary particles zinged around at light speed, creating a “quark-gluon plasma” that lasted for only a few millionths of a second. The primordial goo then quickly cooled, and its individual quarks and gluons fused to form the protons, neutrons, and other fundamental particles that exist today.

Physicists at CERN’s Large Hadron Collider in Switzerland are recreating quark-gluon plasma (QGP) to better understand the universe’s starting ingredients. By smashing together heavy ions at close to light speeds, scientists can briefly dislodge quarks and gluons to create and study the same material that existed during the first microseconds of the early universe.

Now, a team at CERN led by MIT physicists has observed clear signs that quarks create wakes as they speed through the plasma, similar to a duck trailing ripples through water. The findings are the first direct evidence that quark-gluon plasma reacts to speeding particles as a single fluid, sloshing and splashing in response, rather than scattering randomly like individual particles.

“It has been a long debate in our field, on whether the plasma should respond to a quark,” says Yen-Jie Lee, professor of physics at MIT. “Now we see the plasma is incredibly dense, such that it is able to slow down a quark, and produces splashes and swirls like a liquid. So quark-gluon plasma really is a primordial soup.”

To see a quark’s wake effects, Lee and his colleagues developed a new technique that they report in the study. They plan to apply the approach to more particle-collision data to zero in on other quark wakes. Measuring the size, speed, and extent of these wakes, and how long it takes for them to ebb and dissipate, can give scientists an idea of the properties of the plasma itself, and how quark-gluon plasma might have behaved in the universe’s first microseconds.

“Studying how quark wakes bounce back and forth will give us new insights on the quark-gluon plasma’s properties,” Lee says. “With this experiment, we are taking a snapshot of this primordial quark soup.”

The study’s co-authors are members of the CMS Collaboration — a team of particle physicists from around the world who work together to carry out and analyze data from the Compact Muon Solenoid (CMS) experiment, which is one of the general-purpose particle detectors at CERN’s Large Hadron Collider. The CMS experiment was used to detect signs of quark wake effects for this study. The open-access study appears in the journal Physics Letters B.

Quark shadows

Quark-gluon plasma is the first liquid to have ever existed in the universe. It is also the hottest liquid ever, as scientists estimate that during its brief existence, the QGP was around a few trillion degrees Celsius. This boiling stew is also thought to have been a near-“perfect” liquid, meaning that the individual quarks and gluons in the plasma flowed together as a smooth, frictionless fluid.

This picture of the QGP is based on many independent experiments and theoretical models. One such model, derived by Krishna Rajagopal, the William A. M. Burden Professor of Physics at MIT, and his collaborators, predicts that the quark-gluon plasma should respond like a fluid to any particles speeding through it. His theory, known as the hybrid model, suggests that when a jet of quarks is zinging through the QGP, it should produce a wake behind it, inducing the plasma to ripple and splash in response.

Physicists have looked for such wake effects in experiments at the Large Hadron Collider and other high-energy particle accelerators. These experiments whip up heavy ions such as lead, to close to the speed of light, at which point they can collide and produce a short-lived droplet of primordial soup, typically lasting for less than a quadrillionth of a second. Scientists essentially take a snapshot of the moment to try and identify characteristics of the QGP.

To identify quark wakes, physicists have looked for pairs of quarks and “antiquarks” — particles that are identical to their quark counterparts, except that certain properties are equal in magnitude but opposite in sign. For instance, when a quark is speeding through plasma, there is likely an antiquark that is traveling at exactly the same speed, but in the opposite direction.

For this reason, physicists have looked for quark/antiquark pairs in the QGP produced in heavy-ion collisions, assuming that the particles might produce identical, detectable wakes through the plasma.

“When you have two quarks produced, the problem is that, when the two quarks go in opposite directions, the one quark overshadows the wake of the second quark,” Lee says.

He and his colleagues realized that looking for the wake of the first quark would be easier if there were no second quark obscuring its effects.

“We have figured out a new technique that allows us to see the effects of a single quark in the QGP, through a different pair of particles,” Lee says.

A wake tag

Rather than search for pairs of quarks and antiquarks in the aftermath of lead ion collisions, Lee’s team instead looked for events with only one quark moving through the plasma, essentially back-to-back with a “Z boson.” A Z boson is a neutral, electrically weak elementary particle that has virtually no effect on the surrounding environment. However, because they exist at a very specific energy, Z bosons are relatively straightforward to detect.

“In this soup of quark-gluon plasma, there are numerous quarks and gluons passing by and colliding with each other,” Lee explains. “Sometimes when we are lucky, one of these collisions creates a Z boson and a quark, with high momentum.”

In such a collision, the two particles should hit each other and fly off in exact opposite directions. While the quark could leave a wake, the Z boson should have no effect on the surrounding plasma. Whatever ripples are observed in the droplet of primordial soup would have been made entirely by the single quark zipping through it.

The team, in collaboration with Professor Yi Chen’s group at Vanderbilt University, reasoned that they could use Z bosons as a “tag” to locate and trace the wake effects of single quarks. For their new study, the researchers looked through data from the Large Hadron Collider’s heavy-ion collision experiments. From 13 billion collisions, they identified about 2,000 events that produced a Z boson. For each of these events, they mapped the energies throughout the short-lived quark-gluon plasma, and consistently observed a fluid-like pattern of splashes in swirls — a wake effect — in the opposite direction of the Z bosons, which the team could directly attribute to the effect of single quarks zooming through the plasma.

What’s more, the physicists found that the wake effects they observed in the data were consistent with what Rajagopal’s hybrid model predicts. In other words, quark-gluon plasma does in fact flow and ripple like a fluid when particles speed through it.

“This is something that many of us have argued must be there for a good many years, and that many experiments have looked for,” says Rajagopal, who was not directly involved with the new study.

“What Yen-Jie and CMS have done is to devise and execute a measurement that has brought them and us the first clean, clear, unambiguous, evidence for this foundational phenomenon,” says Daniel Pablos, professor of physics at Oviedo University in Spain and a collaborator of Rajagopal’s who was not involved in the current study.

“We’ve gained the first direct evidence that the quark indeed drags more plasma with it as it travels,” Lee adds. “This will enable us to study the properties and behavior of this exotic fluid in unprecedented detail.”

This work was supported, in part, by the U.S. Department of Energy.

The Pappalardo Apprentice program pushes the boundaries of the traditional lab experience, inviting a selected group of juniors and seniors to advance their fabrication skills while also providing mentor training and peer-to-peer mentoring opportunities in an environment fueled by creativity, safety, and fun.

“This apprenticeship was largely born of my need for additional lab help during our larger sophomore-level design course, and the desire of third- and fourth-year students to advance their fabrication knowledge and skills,” says Daniel Braunstein, senior lecturer in mechanical engineering (MechE) and director of the Pappalardo Undergraduate Teaching Laboratories. “Though these needs and wants were nothing particularly new, it had not occurred to me that we could combine these interests into a manageable and meaningful program.”

Apprentices serve as undergraduate lab assistants for class 2.007 (Design and Manufacturing I), joining lab sessions and assisting 2.007 students with various aspects of the learning experience including machining, hand-tool use, brainstorming, and peer support. Apprentices also participate in a series of seminars and clinics designed to further their fabrication knowledge and hands-on skills, including advancing understanding of mill and lathe use, computer-aided design and manufacturing (CAD/CAM) and pattern-making.

Putting this learning into practice, junior apprentices fabricate Stirling engines (a closed-cycle heat engine that converts thermal energy into mechanical work), while returning senior apprentices take on more ambitious group projects involving casting. Previous years’ projects included an early 20th-century single-cylinder marine engine and a 19th-century torpedo boat steam engine, on permanent exhibit at the MIT Museum. This spring will focus on copper alloys and fabrication of a replica of an 1899 anchor windlass from the Herreshoff Manufacturing Co., used on the famous New York 70 class sloops.

The sloops, designed by MIT Class of 1870 alumnus Nathanael Greene Herreshoff for wealthy New York Yacht Club members, were a short-lived, single-design racing vessels meant for exclusive competition. The historic racing yachts used robust manual windlasses — mechanical devices used to haul large loads — to manage their substantial anchors.

“The more we got into casting, I was modestly surprised that [the students’] exposure to metals was very limited. So that really launched not just a project, but also a more specific curriculum around metallurgy,” says Braunstein.

Metallurgy is not a traditional part of the curriculum. “I think [the project] really opened up my eyes to how much material choice is an important thing for engineering in general,” says apprentice Jade Durham.

In casting the windlasses, students are working from century-old drawings. “[Looking at these old drawings,] we don't know how they made [the parts],” says Braunstein. “So, there is an element of the discovery of what they may or may not have done. It’s like technical archaeology.”

“You’re really just relying on your knowledge of the windlass system, how it’s meant to work, which surfaces are really critical, and kind of just applying your intuition,” says apprentice Saechow Yap. “I learned a lot about applying my art skills and my ability to judge and shape aesthetic.”

Learning by doing is an important hallmark of an MIT MechE education. The Pappalardo Apprentice Program, which celebrated its 10th year last spring, is housed in the Pappalardo Lab. The lab, established through a gift from Neil Pappalardo ’64, is the self-proclaimed “most wicked labs on campus” — “wicked,” for readers outside of Greater Boston, is slang used in a variety of ways, but generally meaning something is pretty awesome.

“Pappalardo is my favorite place on campus, I had never set foot in any sort of like makerspace or lab before I came to MIT,” says apprentice Wilhem Hector. “I did not just learn how to make things. I got empowered ... [to] make anything.”

Braunstein developed the Pappalardo Apprentice program to reinforce the learning of the older students while building community. In a 2023 interview, he said he called the seminar an apprenticeship to emphasize MIT’s relationship with the art — and industrial character — of engineering.

“I did want to borrow from the language of the trades,” Braunstein said. “MIT has a strong heritage in industrial work; that’s why we were founded. It was not a science institution; it was about the mechanical arts. And I think the blend of the industrial, plus the academic, is what makes this lab particularly meaningful.”

Today, he says the most enjoyable part of the program, for him, is watching relationships develop. “They come in, bright-eyed, bushy-tailed, and then to see them go to people who are capable of pouring iron, tramming mills, teaching other people how to do it and having this tight group of friends … that's fun to watch.”

Collaborators from across the Commonwealth of Massachusetts came together in December for a daylong summit of the Massachusetts Prison Education Consortium (MPEC), hosted by the Educational Justice Institute (TEJI) at MIT. Held at MIT’s Walker Memorial, the summit aimed to expand access to high-quality education for incarcerated learners and featured presentations by leaders alongside strategy sessions designed to turn ideas into concrete plans to improve equitable access to higher education and reduce recidivism in local communities.

In addition to a keynote address by author and resilience expert Shaka Senghor, speakers such as Molly Lasagna, senior strategy officer in the Ascendium Education Group, and Stefan LoBuglio, former director of the National Institute of Corrections, discussed the roles of learning, healing, and community support in building a more just system for justice-impacted individuals.

The MPEC summit, “Building Integrated Systems Together: Massachusetts Community Colleges and County Corrections 2.0,” addressed three key issues surrounding equitable education: the integration of Massachusetts community college education with county corrections to provide incarcerated individuals with access to higher education; the integration of carceral education with industry to expand work and credentialing opportunities; and the goal of better serving women who experience unique challenges within the criminal legal system.

Created by TEJI, MPEC is a statewide network of Massachusetts colleges, organizations and correctional partners working together to expand access to high-quality, credit-bearing education in Massachusetts prisons and jails. The consortium works on all levels of the pipeline, from academic programming, faculty support, research, reentry pathways, and more, drawing from the research and success of the MIT Prison Education Initiative and the recent restoration of Pell Grant eligibility for incarcerated learners.

The summit was hosted by TEJI co-directors Lee Perlman and Carole Cafferty. Perlman founded the MIT Prison Initiative after years of teaching in MIT’s Experimental Study Group (ESG) and in correctional classrooms. He has been recognized for his work in bringing humanities education to prison settings with three Irwin Sizer Awards and MIT’s Martin Luther King Jr. Leadership Award.

Cafferty jointly co-founded TEJI after more than 30 years’ experience with corrections, including working as superintendent of the Middlesex Jail and House of Correction. She now guides the institute with the knowledge she gained from building integrative and therapeutic educational programs that have since been replicated nationally.

“TEJI serves two populations, incarcerated learners and the MIT community. All of our classes involve MIT students, either learning alongside the incarcerated students or as TAs [teaching assistants],” emphasizes Perlman. In discussing the unification of TEJI with the roles and experiences MIT students take, Perlman further notes: “Our humanities classes, which we call our philosophical life skills curriculum, give MIT students the opportunity to discuss how we want to live our lives with incarcerated students with very different backgrounds.”

These courses, offered through ESG, are subjects with a unique focus that often differ from the traditional focus of a more academic course, often prioritizing hands-on learning and innovative teaching methods. Perlman’s courses are almost always taught in a carceral setting, and he notes that these courses can be highly impactful on the MIT community: “In courses like Philosophy of Love; Non-violence as a Way of Life; and Authenticity and Emotional Intelligence for Teams, the discussions are rich and personal. Many MIT students have described their experience in these classes as life-changing.”

Throughout morning addresses and afternoon strategy sessions, summit attendees developed concrete plans for scaling classroom capacity, aligning curricula with regional labor markets, and strengthening academic and reentry supports that help students remain on the right path after release. Panels explored practical issues, such as how to coordinate registration and credit transfer when a student moves between facilities and how to staff hybrid classrooms that combine in-person and remote instruction, as well as how to measure program outcomes beyond enrollment.

Co-directors Perlman and Cafferty highlighted that the average length of stay within these programs in county facilities is only six months, and that inspired a particular focus on making sure these programs are high-impact even when community members are only able to participate for a short period of time.

Speakers repeatedly emphasized that these logistical challenges often sit atop deeper, more human challenges. In his keynote, Shaka Senghor traced his own journey from trauma to transformation, stressing the power of reading, mentorship, and completing something of one’s own. “What else can you do with your mind?” he asked, describing the moment he realized that the act of reading and writing could change the trajectory of his life.

The line became a refrain throughout the day, a question that caused all to reflect on how prison education could not only function as a workforce pathway, but as a catalyst for dignity and hope after reentry. Senghor also directly confronted the stigma that returning citizens face. “They said I’d be back in prison in six months,” he recalled, using the remark from a corrections officer from the day he was released on parole as a reminder of the structural and social barriers encountered after release.

The summit also brought together funders and implementers who are shaping the field’s future. Molly Lasagna of Ascendium Education Group described the organization’s strategy of “Expand, Support, Connect,” which funds the creation of new educational programs, strengthens basic needs and advising infrastructure, and ensures that individuals leaving prison can transition into high-quality employment opportunities. “How is this education program putting somebody on a pathway to opportunity?” she asked, noting that true change requires aligning education, reentry, and workforce systems.

Participants also heard from Stefan LoBuglio, former director of the National Institute of Corrections and a national thought leader in corrections and reentry, who lauded Massachusetts as a leader while cautioning that staffing shortages, limited program space, and uneven access to technology continue to constrain progress. “We have a crisis in staffing in corrections that does affect our educational programs,” he noted, calling for attention to staff wellness and institutional support as essential components of sustainability.

Throughout the day, TEJI and MPEC leaders highlighted emerging pilots and partnerships, including a new “Prisons to Pathways” initiative aimed at building stackable, transferable credentials aligned with regional industry needs. Additional collaborations with the American Institutes for Research will support new implementation guides and technical assistance resources designed by practitioners in the field.

The summit concluded with a commitment to sustain collaboration. As Senghor reminded participants, the work is both practical and moral. The question he posed, “What else can you do with your mind?,” serves as a reminder to Massachusetts educators, corrections partners, funders, and community organizations to ensure that learning inside prison becomes a foundation for opportunity outside it.
 

On his desk, Bryan Bryson ’07, PhD ’13 still has the notes he used for the talk he gave at MIT when he interviewed for a faculty position in biological engineering. On that sheet, he outlined the main question he wanted to address in his lab: How do immune cells kill bacteria?

Since starting his lab in 2018, Bryson has continued to pursue that question, which he sees as critical for finding new ways to target infectious diseases that have plagued humanity for centuries, especially tuberculosis. To make significant progress against TB, researchers need to understand how immune cells respond to the disease, he says.

“Here is a pathogen that has probably killed more people in human history than any other pathogen, so you want to learn how to kill it,” says Bryson, now an associate professor at MIT. “That has really been the core of our scientific mission since I started my lab. How does the immune system see this bacterium and how does the immune system kill the bacterium? If we can unlock that, then we can unlock new therapies and unlock new vaccines.”

The only TB vaccine now available, the BCG vaccine, is a weakened version of a bacterium that causes TB in cows. This vaccine is widely administered in some parts of the world, but it poorly protects adults against pulmonary TB. Although some treatments are available, tuberculosis still kills more than a million people every year.

“To me, making a better TB vaccine comes down to a question of measurement, and so we have really tried to tackle that problem head-on. The mission of my lab is to develop new measurement modalities and concepts that can help us accelerate a better TB vaccine,” says Bryson, who is also a member of the Ragon Institute of Mass General Brigham, MIT, and Harvard.

From engineering to immunology

Engineering has deep roots in Bryson’s family: His great-grandfather was an engineer who worked on the Panama Canal, and his grandmother loved to build things and would likely have become an engineer if she had had the educational opportunity, Bryson says.

The oldest of four sons, Bryson was raised primarily by his mother and grandparents, who encouraged his interest in science. When he was three years old, his family moved from Worcester, Massachusetts, to Miami, Florida, where he began tinkering with engineering himself, building robots out of Styrofoam cups and light bulbs. After moving to Houston, Texas, at the beginning of seventh grade, Bryson joined his school’s math team.

As a high school student, Bryson had his heart set on studying biomedical engineering in college. However, MIT, one of his top choices, didn’t have a biomedical engineering program, and biological engineering wasn’t yet offered as an undergraduate major. After he was accepted to MIT, his family urged him to attend and then figure out what he would study.

Throughout his first year, Bryson deliberated over his decision, with electrical engineering and computer science (EECS) and aeronautics and astronautics both leading contenders. As he recalls, he thought he might study aero/astro with a minor in biomedical engineering and work on spacesuit design.

However, during an internship the summer after his first year, his mentor gave him a valuable piece of advice: “You should study something that will let you have a lot of options, because you don’t know how the world is going to change.”

When he came back to MIT for his sophomore year, Bryson switched his major to mechanical engineering, with a bioengineering track. He also started looking for undergraduate research positions. A poster in the hallway grabbed his attention, and he ended up with working with the professor whose work was featured: Linda Griffith, a professor of biological engineering and mechanical engineering.

Bryson’s experience in the lab “changed the trajectory of my life,” he says. There, he worked on building microfluidic devices that could be used to grow liver tissue from hepatocytes. He enjoyed the engineering aspects of the project, but he realized that he also wanted to learn more about the cells and why they behaved the way they did. He ended up staying at MIT to earn a PhD in biological engineering, working with Forest White.

In White’s lab, Bryson studied cell signaling processes and how they are altered in diseases such as cancer and diabetes. While doing his PhD research, he also became interested in studying infectious diseases. After earning his degree, he went to work with a professor of immunology at the Harvard School of Public Health, Sarah Fortune.

Fortune studies tuberculosis, and in her lab, Bryson began investigating how Mycobacterium tuberculosis interacts with host cells. During that time, Fortune instilled in him a desire to seek solutions to tuberculosis that could be transformative — not just identifying a new antibiotic, for example, but finding a way to dramatically reduce the incidence of the disease. This, he thought, could be done by vaccination, and in order to do that, he needed to understand how immune cells response to the disease. 

“That postdoc really taught me how to think bravely about what you could do if you were not limited by the measurements you could make today,” Bryson says. “What are the problems we really need to solve? There are so many things you could think about with TB, but what’s the thing that’s going to change history?”

Pursuing vaccine targets

Since joining the MIT faculty eight years ago, Bryson and his students have developed new ways to answer the question he posed in his faculty interviews: How does the immune system kill bacteria?

One key step in this process is that immune cells must be able to recognize bacterial proteins that are displayed on the surfaces of infected cells. Mycobacterium tuberculosis produces more than 4,000 proteins, but only a small subset of those end up displayed by infected cells. Those proteins would likely make the best candidates for a new TB vaccine, Bryson says.

Bryson’s lab has developed ways to identify those proteins, and so far, their studies have revealed that many of the TB antigens displayed to the immune system belong to a class of proteins known as type 7 secretion system substrates. Mycobacterium tuberculosis expresses about 100 of these proteins, but which of these 100 are displayed by infected cells varies from person to person, depending on their genetic background.

By studying blood samples from people of different genetic backgrounds, Bryson’s lab has identified the TB proteins displayed by infected cells in about 50 percent of the human population. He is now working on the remaining 50 percent and believes that once those studies are finished, he’ll have a very good idea of which proteins could be used to make a TB vaccine that would work for nearly everyone.

Once those proteins are chosen, his team can work on designing the vaccine and then testing it in animals, with hopes of being ready for clinical trials in about six years.

In spite of the challenges ahead, Bryson remains optimistic about the possibility of success, and credits his mother for instilling a positive attitude in him while he was growing up.

“My mom decided to raise all four of her children by herself, and she made it look so flawless,” Bryson says. “She instilled a sense of ‘you can do what you want to do,’ and a sense of optimism. There are so many ways that you can say that something will fail, but why don’t we look to find the reasons to continue?”

One of the things he loves about MIT is that he has found a similar can-do attitude across the Institute.

“The engineer ethos of MIT is that yes, this is possible, and what we’re trying to find is the way to make this possible,” he says. “I think engineering and infectious disease go really hand-in-hand, because engineers love a problem, and tuberculosis is a really hard problem.”

When not tackling hard problems, Bryson likes to lighten things up with ice cream study breaks at Simmons Hall, where he is an associate head of house. Using an ice cream machine he has had since 2009, Bryson makes gallons of ice cream for dorm residents several times a year. Nontraditional flavors such as passion fruit or jalapeno strawberry have proven especially popular.

“Recently I did flavors of fall, so I did a cinnamon ice cream, I did a pear sorbet,” he says. “Toasted marshmallow was a huge hit, but that really destroyed my kitchen.”

Pablo Jarillo-Herrero, the Cecil and Ida Green Professor of Physics at MIT, has won the 2025 BBVA Foundation Frontiers of Knowledge Award in Basic Sciences for “discoveries concerning the ‘magic angle’ that allows the behavior of new materials to be transformed and controlled.”

He shares the 400,000-euro award with Allan MacDonald of the University of Texas at Austin. According to the BBVA Foundation, “the pioneering work of the two physicists has achieved both the theoretical foundation and experimental validation of a new field where superconductivity, magnetism, and other properties can be obtained by rotating new two-dimensional materials like graphene.” Graphene is a single layer of carbon atoms arranged in hexagons resembling a honeycomb structure.

Theoretical foundation, experimental validation

In a theoretical model published in 2011, MacDonald predicted that on twisting two graphene layers at a given angle, of around 1 degree, the interaction of electrons would produce new emerging properties.
 
In 2018, Jarillo-Herrero delivered the experimental confirmation of this “magic angle” by rotating two graphene sheets in a way that transformed the material’s behavior, giving rise to new properties like superconductivity.

The physicists’ work “has opened up new frontiers in physics by demonstrating that rotating matter to a given angle allows us to control its behavior, obtaining properties that could have a major industrial impact,” explained award committee member María José García Borge, a research professor at the Institute for the Structure of Matter. “Superconductivity, for example, could bring about far more sustainable electricity transmission, with virtually no energy loss.”

Almost science fiction

MacDonald’s initial discovery had little immediate impact. It was not until some years later, when it was confirmed in the laboratory by Jarillo-Herrero, that its true importance was revealed. 

“The community would never have been so interested in my subject, if there hadn’t been an experimental program that realized that original vision,” observes MacDonald, who refers to his co-laureate’s achievement as “almost science fiction.”

Jarillo-Herrero had been intrigued by the possible effects of placing two graphene sheets on top of each other with a precise rotational alignment, because “it was uncharted territory, beyond the reach of the physics of the past, so was bound to produce some interesting results.”

But the scientist was still unsure of how to make it work in the lab. For years, he had been stacking together layers of the super-thin material, but without being able to specify the angle between them. Finally, he devised a way to do so, making the angle smaller and smaller until he got to the “magic” angle of 1.1 degrees at which the graphene revealed some extraordinary behavior.

“It was a big surprise, because the technique we used, though conceptually straightforward, was hard to pull off in the lab,” says Jarillo-Herrero, who is also affiliated with the Materials Research Laboratory.

Since 2009, the BBVA has given Frontiers of Knowledge Awards to more than a dozen MIT faculty members. The Frontiers of Knowledge Awards, spanning eight prize categories, recognize world-class research and cultural creation and aim to celebrate and promote the value of knowledge as a global public good. The BBVA Foundation works to support scientific research and cultural creation, disseminate knowledge and culture, and recognize talent and innovation. 

Researchers in Class of 1942 Professor of Chemistry Matthew D. Shoulders’ lab have uncovered a sinister hidden mechanism that can allow cancer cells to survive (and, in some cases, thrive) even when hit with powerful drugs. The secret lies in a cellular “safety net” that gives cancer the freedom to develop aggressive mutations.

This fascinating intersection between molecular biology and evolutionary dynamics, published Jan. 22 on the cover of Molecular Cell, focuses on the most famous anti-cancer gene in the human body, TP53 (tumor protein 53, known as p53), and suggests that cancer cells don’t just mutate by accident — they create a specialized environment that makes dangerous mutations possible. 

The guardian under attack

Tasked with the job of stopping damaged cells from dividing, the p53 protein has been known for decades as the “guardian of the genome” and is the most mutated gene in cancer. Some of the most perilous of these mutations are known as “dominant-negative” variants. Not only do they stop working, but they actually prevent any healthy p53 in the cell from doing its job, essentially disarming the body’s primary defense system.

To function, p53 and most other proteins must fold into specific 3D shapes, much like precise cellular origami. Typically, if a mutation occurs that ruins this shape, the protein becomes a tangled mess, and the cell destroys it.

A specialized network of proteins, called cellular chaperones, help proteins fold into their correct shape, collectively known as the proteostasis network. 

“Many chaperone networks are known to be upregulated in cancer cells, for reasons that are not totally clear,” says Stephanie Halim, a graduate student in the Shoulders Group and co-first author of the study, along with Rebecca Sebastian PhD ’22. “We hypothesized that increasing the activities of these helpful protein folding networks can allow cancer cells to tolerate more mutations than a regular cell.”

The research team investigated a “helper” system in the cell called the proteostasis network. This network involves many proteins known as chaperones that help other proteins fold correctly. A master regulator called Heat Shock Factor 1 (HSF1) controls the composition of the proteostasis network, with HSF1 activity upregulating the network to create supportive protein folding environments in response to stress. In healthy cells, HSF1 stays dormant until heat or toxins appear. In cancer, HSF1 is often permanently in action mode.

To see how this works in real-time, the team created a specialized cancer cell line that let them chemically “turn up” the activity of HSF1 on demand. They then used a cutting-edge technique to express every possible singly mutated version of a p53 protein — testing thousands of different genetic “typos” at once.

The results were clear: When HSF1 was amplified, the cancer cells became much better at handling “bad” mutations. Normally, these specific mutations are so physically disruptive that they would cause the protein to collapse and fail. However, with HSF1 providing extra folding help, these unstable, cancer-driving proteins were able to stay intact and keep the cancer growing.

“These findings show that chaperone networks can reshape the fundamental mutational tolerance of the most mutated gene in cancer, linking proteostasis network activity directly to cancer development,” said Halim. “This work also puts us one step closer to understanding how tinkering with cellular protein folding pathways can help with cancer treatment.”

Unravelling cancer’s safety net

The study revealed that HSF1 activity specifically protects normally disruptive amino acid substitutions located deep inside the protein’s core — the most sensitive areas. Without this extra folding help, these substitutions would likely cause degradation of these proteins. With it, the cancer cell can keep these broken proteins around to help it grow.

This discovery helps explain why cancer is so resilient, and why previous attempts to treat cancer by blocking chaperone proteins (like HSP90, an abundant cellular chaperone) have been so complex. By understanding how cancer “buffers” its own bad mutations, doctors may one day be able to break that safety net, forcing the cancer’s own mutations to become its downfall.

The research was conducted in collaboration with the labs of professors Yu-Shan Lin of Tufts University; Francisco J. Sánchez-Rivera of the MIT Department of Biology; William C. Hahn, institute member of the Broad Institute of MIT and Harvard and professor of medicine in the Department of Medical Oncology at the Dana-Farber Cancer Institute and Harvard Medical School; and Marc L. Mendillo of Northwestern University.

MIT Professor Emeritus Richard O. Hynes PhD ’71, a cancer biologist whose discoveries reshaped modern understandings of how cells interact with each other and their environment, passed away on Jan. 6. He was 81.

Hynes is best known for his discovery of integrins, a family of cell-surface receptors essential to cell–cell and cell–matrix adhesion. He played a critical role in establishing the field of cell adhesion biology, and his continuing research revealed mechanisms central to embryonic development, tissue integrity, and diseases including cancer, fibrosis, thrombosis, and immune disorders.

Hynes was the Daniel K. Ludwig Professor for Cancer Research, Emeritus, an emeritus professor of biology, and a member of the Koch Institute for Integrated Cancer Research at MIT and the Broad Institute of MIT and Harvard. During his more than 50 years on the faculty at MIT, he was deeply respected for his academic leadership at the Institute and internationally, as well as his intellectual rigor and contributions as an educator and mentor.

“Richard had an enormous impact in his career. He was a visionary leader of the MIT Cancer Center, what is now the Koch Institute, during a time when the progress in understanding cancer was just starting to be translated into new therapies,” reflects Matthew Vander Heiden, director of the Koch Institute and the Lester Wolfe (1919) Professor of Molecular Biology. “The research from his laboratory launched an entirely new field by defining the molecules that mediate interactions between cells and between cells and their environment. This laid the groundwork for better understanding the immune system and metastasis.”

Pond skipper

Born in Kenya, Hynes grew up during the 1950s in Liverpool, in the United Kingdom. While he sometimes recounted stories of being schoolmates with two of the Beatles, and in the same Boy Scouts troop as Paul McCartney, his academic interests were quite different, and he specialized in the sciences at a young age. Both of his parents were scientists: His father was a freshwater ecologist, and his mother a physics teacher. Hynes and all three of his siblings followed their parents into scientific fields.

"We talked science at home, and if we asked questions, we got questions back, not answers. So that conditioned me into being a scientist, for sure," Hynes said of his youth.

He described his time as an undergraduate and master’s student at Cambridge University during the 1960s as “just fantastic,” noting that it was shortly after two 1962 Nobel Prizes were awarded to Cambridge researchers — one to Francis Crick and James Watson for the structure of DNA, the other to John Kendrew and Max Perutz for the structures of proteins — and Cambridge was “the place to be” to study biology.

Newly married, Hynes and his wife traded Cambridge, U.K. for Cambridge, Massachusetts, so that he could conduct doctoral work at MIT under the direction of Paul Gross. He tried (and by his own assessment, failed) to differentiate maternal messages among the three germ layers of sea urchin embryos. However, he did make early successful attempts to isolate the globular protein tubulin, a building block for essential cellular structures, from sea urchins.

Inspired by a course he had taken with Watson in the United States, Hynes began work during his postdoc at the Institute of Cancer Research in the U.K. on the early steps of oncogenic transformation and the role of cell migration and adhesion; it was here that he made his earliest discovery and characterizations of the fibronectin protein.

Recruited back to MIT by Salvador Luria, founding director of the MIT Center for Cancer Research, whom he had met during a summer at Woods Hole Oceanographic Institute on Cape Cod, Hynes returned to the Institute in 1975 as a founding faculty member of the center and an assistant professor in the Department of Biology.

Big questions about tiny cells

To his own research, Hynes brought the same spirit of inquiry that had characterized his upbringing, asking fundamental questions: How do cells interact with each other? How do they stick together to form tissues?

His research focused on proteins that allow cells to adhere to each other and to the extracellular matrix — a mesh-like network that surrounds cells, providing structural support, as well as biochemical and mechanical cues from the local microenvironment. These proteins include integrins, a type of cell surface receptor, and fibronectins, a family of extracellular adhesive proteins. Integrins are the major adhesion receptors connecting the extracellular matrix to the intracellular cytoskeleton, or main architectural support within the cell.

Hynes began his career as a developmental biologist, studying how cells move to the correct locations during embryonic development. During this stage of development, proper modulation of cell adhesion is critical for cells to move to the correct locations in the embryo.

Hynes’ work also revealed that dysregulation of cell-to-matrix contact plays an important role in cancer cells’ ability to detach from a tumor and spread to other parts of the body, key steps in metastasis.

As a postdoc, Hynes had begun studying the differences in the surface landscapes of healthy cells and tumor cells. It was this work that led to the discovery of fibronectin, which is often lost when cells become cancerous.

He and others found that fibronectin is an important part of the extracellular matrix. When fibronectin is lost, cancer cells can more easily free themselves from their original location and metastasize to other sites in the body. By studying how fibronectin normally interacts with cells, Hynes and others discovered a family of cell surface receptors known as integrins, which function as important physical links with the extracellular matrix. In humans, 24 integrin proteins have been identified. These proteins help give tissues their structure, enable blood to clot, and are essential for embryonic development.

“Richard’s discoveries, along with others’, of cell surface integrins led to the development of a number of life-altering treatments. Among these are treatment of autoimmune diseases such as multiple sclerosis,” notes longtime colleague Phillip Sharp, MIT Institute professor emeritus.

As research technologies advanced, including proteomic and extracellular matrix isolation methods developed directly in Hynes’ laboratory, he and his group were able to uncover increasingly detailed information about specific cell adhesion proteins, the biological mechanisms by which they operate, and the roles they play in normal biology and disease.

In cancer, their work helped to uncover how cell adhesion (and the loss thereof) and the extracellular matrix contribute not only to fundamental early steps in the metastatic process, but also tumor progression, therapeutic response, and patient prognosis. This included studies that mapped matrix protein signatures associated with cancer and non-cancer cells and tissues, followed by investigations into how differentially expressed matrix proteins can promote or suppress cancer progression. 

Hynes and his colleagues also demonstrated how extracellular matrix composition can influence immunotherapy, such as the importance of a family of cell adhesion proteins called selectins for recruiting natural killer cells to tumors. Further, Hynes revealed links between fibronectin, integrins, and other matrix proteins with tumor angiogenesis, or blood vessel development, and also showed how interaction with platelets can stimulate tumor cells to remodel the extracellular matrix to support invasion and metastasis. In pursuing these insights into the oncogenic mechanisms of matrix proteins, Hynes and members of his laboratory have identified useful diagnostic and prognostic biomarkers, as well as therapeutic targets.

Along the way, Hynes shaped not only the research field, but also the careers of generations of trainees.

“There was much to emulate in Richard’s gentle, patient, and generous approach to mentorship. He centered the goals and interests of his trainees, fostered an inclusive and intellectually rigorous environment, and cared deeply about the well-being of his lab members. Richard was a role model for integrity in both personal and professional interactions and set high expectations for intellectual excellence,” recalls Noor Jailkhani, a former Hynes Lab postdoc.

Jailkhani is CEO and co-founder, with Hynes, of Matrisome Bio, a biotech company developing first-in-class targeted therapies for cancer and fibrosis by leveraging the extracellular matrix. “The impact of his long and distinguished scientific career was magnified through the generations of trainees he mentored, whose influence spans academia and the biotechnology industry worldwide. I believe that his dedication to mentorship stands among his most far-reaching and enduring contributions,” she says.

A guiding light

Widely sought for his guidance, Hynes served in a number of key roles at MIT and in the broader scientific community. As head of MIT’s Department of Biology from 1989 to 1991, then a decade as director of the MIT Center for Cancer Research, his leadership has helped shape the Institute’s programs in both areas.

“Words can’t capture what a fabulous human being Richard was. I left every interaction with him with new insights and the warm glow that comes from a good conversation,” says Amy Keating, the Jay A. Stein (1968) Professor, professor of biology and biological engineering, and head of the Department of Biology. “Richard was happy to share stories, perspectives, and advice, always with a twinkle in his eye that conveyed his infinite interest in and delight with science, scientists, and life itself. The calm support that he offered me, during my years as department head, meant a lot and helped me do my job with confidence.”

Hynes served as director of the MIT Center for Cancer Research from 1991 until 2001, positioning the center’s distinguished cancer biology program for expansion into its current, interdisciplinary research model as MIT’s Koch Institute for Integrative Cancer Research. “He recruited and strongly supported Tyler Jacks to the faculty, who subsequently became director and headed efforts to establish the Koch Institute,” recalls Sharp.

Jacks, a David H. Koch (1962) Professor of Biology and founding director of the Koch Institute, remembers Hynes as a thoughtful, caring, and highly effective leader in the Center for Cancer Research, or CCR, and in the Department of Biology. “I was fortunate to be able to lean on him when I took over as CCR director. He encouraged me to drop in — unannounced — with questions and concerns, which I did regularly. I learned a great deal from Richard, at every level,” he says.

Hynes’ leadership and recognition extended well beyond MIT to national and international contexts, helping to shape policy and strengthen connections between MIT researchers and the wider field. He served as a scientific governor of the Wellcome Trust, a global health research and advocacy foundation based in the United Kingdom, and co-chaired U.S. National Academy committees establishing guidelines for stem cell and genome editing research.

“Richard was an esteemed scientist, a stimulating colleague, a beloved mentor, a role model, and to me a partner in many endeavors both within and beyond MIT,” notes H. Robert Horvitz, a David H. Koch (1962) Professor of Biology. He was a wonderful human being, and a good friend. I am sad beyond words at his passing.”

Awarded Howard Hughes medical investigator status in 1988, Hynes’ research and leadership have since been recognized with a number of other notable honors. Most recently, he received the 2022 Albert Lasker Basic Medical Research Award, which he shared with Erkki Ruoslahti of Sanford Burnham Prebys and Timothy Springer of Harvard University, for his discovery of integrins and pioneering work in cell adhesion.

His other awards include the Canada Gairdner International Award, the Distinguished Investigator Award from the International Society for Matrix Biology, the Robert and Claire Pasarow Medical Research Award, the E.B. Wilson Medal from the American Society for Cell Biology, the David Rall Medal from the National Academy of Medicine and the Paget-Ewing Award from the Metastasis Research Society. Hynes was a member of the National Academy of Sciences, the National Academy of Medicine, the Royal Society of London, the American Association for the Advancement of Science, and the American Academy of Arts and Sciences.

Easily recognized by a commanding stature that belied his soft-spoken nature, Hynes was known around MIT’s campus not only for his acuity, integrity, and wise counsel, but also for his community spirit and service. From serving food at community socials to moderating events and meetings or recognizing the success of colleagues and trainees, his willingness to help spanned roles of every size.

“Richard was a phenomenal friend and colleague. He approached complex problems with a thoughtfulness and clarity that few can achieve,” notes Vander Heiden. “He was also so generous in his willingness to provide help and advice, and did so with a genuine kindness that was appreciated by everyone.”

Hynes is survived by his wife Fleur, their sons Hugh and Colin and their partners, and four grandchildren.