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How should personal data be protected? What are the best uses of it? In our networked world, questions about data privacy are ubiquitous and matter for companies, policymakers, and the public.

A new study by MIT researchers adds depth to the subject by suggesting that people’s views about privacy are not firmly fixed and can shift significantly, based on different circumstances and different uses of data.

“There is no absolute value in privacy,” says Fabio Duarte, principal research scientist in MIT’s Senseable City Lab and co-author of a new paper outlining the results. “Depending on the application, people might feel use of their data is more or less invasive.”

The study is based on an experiment the researchers conducted in multiple countries using a newly developed game that elicits public valuations of data privacy relating to different topics and domains of life.

“We show that values attributed to data are combinatorial, situational, transactional, and contextual,” the researchers write.

The open-access paper, “Data Slots: tradeoffs between privacy concerns and benefits of data-driven solutions,” is published today in Nature: Humanities and Social Sciences Communications. The authors are Martina Mazzarello, a postdoc in the Senseable City Lab; Duarte; Simone Mora, a research scientist at Senseable City Lab; Cate Heine PhD ’24 of University College London; and Carlo Ratti, director of the Senseable City Lab.

The study is based around a card game with poker-type chips the researchers created to study the issue, called Data Slots. In it, players hold hands of cards with 12 types of data — such as a personal profile, health data, vehicle location information, and more — that relate to three types of domains where data are collected: home life, work, and public spaces. After exchanging cards, the players generate ideas for data uses, then assess and invest in some of those concepts. The game has been played in-person in 18 different countries, with people from another 74 countries playing it online; over 2,000 individual player-rounds were included in the study.

The point behind the game is to examine the valuations that members of the public themselves generate about data privacy. Some research on the subject involves surveys with pre-set options that respondents choose from. But in Data Slots, the players themselves generate valuations for a wide range of data-use scenarios, allowing the researchers to estimate the relative weight people place on privacy in different situations. 

 

The idea is “to let people themselves come up with their own ideas and assess the benefits and privacy concerns of their peers’ ideas, in a participatory way,” Ratti explains.

The game strongly suggests that people’s ideas about data privacy are malleable, although the results do indicate some tendencies. The data privacy card whose use players most highly valued was for personal mobility; given the opportunity in the game to keep it or exchange it, players retained it in their hands 43 percent of the time, an indicator of its value. That was followed in order by personal health data, and utility use. (With apologies to pet owners, the type of data privacy card players held on to the least, about 10 percent of the time, involved animal health.)

However, the game distinctly suggests that the value of privacy is highly contingent on specific use-cases. The game shows that people care about health data to a substantial extent but also value the use of environmental data in the workplace, for instance. And the players of Data Slots also seem less concerned about data privacy when use of data is combined with clear benefits. In combination, that suggests a deal to be cut: Using health data can help people understand the effects of the workplace on wellness.

“Even in terms of health data in work spaces, if they are used in an aggregated way to improve the workspace, for some people it’s worth combining personal health data with environmental data,” Mora says.

Mazzarello adds: “Now perhaps the company can make some interventions to improve overall health. It might be invasive, but you might get some benefits back.”

In the bigger picture, the researchers suggest, taking a more flexible, user-driven approach to understanding what people think about data privacy can help inform better data policy. Cities — the core focus on the Senseable City Lab — often face such scenarios. City governments can collect a lot of aggregate traffic data, for instance, but public input can help determine how anonymized such data should be. Understanding public opinion along with the benefits of data use can produce viable policies for local officials to pursue.

“The bottom line is that if cities disclose what they plan to do with data, and if they involve resident stakeholders to come up with their own ideas about what they could do, that would be beneficial to us,” Duarte says. “And in those scenarios, people’s privacy concerns start to decrease a lot.” 

The United States population is older than it has ever been. Today, the country’s median age is 38.9, which is nearly a decade older than it was in 1980. And the number of adults older than 65 is expected to balloon from 58 million to 82 million by 2050. The challenge of caring for the elderly, amid shortages in care workers, rising health care costs, and evolving family structures, is an increasingly urgent societal issue.

To help address the eldercare challenge, a team of MIT engineers is looking to robotics. They have built and tested the Elderly Bodily Assistance Robot, or E-BAR, a mobile robot designed to physically support the elderly and prevent them from falling as they move around their homes.

E-BAR acts as a set of robotic handlebars that follows a person from behind. A user can walk independently or lean on the robot’s arms for support. The robot can support the person’s full weight, lifting them from sitting to standing and vice versa along a natural trajectory. And the arms of the robot can them by rapidly inflating side airbags if they begin to fall.

With their design, the researchers hope to prevent falls, which today are the leading cause of injury in adults who are 65 and older. 

“Many older adults underestimate the risk of fall and refuse to use physical aids, which are cumbersome, while others overestimate the risk and may not to exercise, leading to declining mobility,” says Harry Asada, the Ford Professor of Engineering at MIT. “Our design concept is to provide older adults having balance impairment with robotic handlebars for stabilizing their body. The handlebars go anywhere and provide support anytime, whenever they need.”

In its current version, the robot is operated via remote control. In future iterations, the team plans to automate much of the bot’s functionality, enabling it to autonomously follow and physically assist a user. The researchers are also working on streamlining the device to make it slimmer and more maneuverable in small spaces.

“I think eldercare is the next great challenge,” says E-BAR designer Roberto Bolli, a graduate student in the MIT Department of Mechanical Engineering. “All the demographic trends point to a shortage of caregivers, a surplus of elderly persons, and a strong desire for elderly persons to age in place. We see it as an unexplored frontier in America, but also an intrinsically interesting challenge for robotics.”

Bolli and Asada will present a paper detailing the design of E-BAR at the IEEE Conference on Robotics and Automation (ICRA) later this month.

Asada’s group at MIT develops a variety of technologies and robotic aides to assist the elderly. In recent years, others have developed fall prediction algorithms, designed robots and automated devices including robotic walkers, wearable, self-inflating airbags, and robotic frames that secure a person with a harness and move with them as they walk.

In designing E-BAR, Asada and Bolli aimed for a robot that essentially does three tasks: providing physical support, preventing falls, and safely and unobtrusively moving with a person. What’s more, they looked to do away with any harness, to give a user more independence and mobility.

“Elderly people overwhelmingly do not like to wear harnesses or assistive devices,” Bolli says. “The idea behind the E-BAR structure is, it provides body weight support, active assistance with gait, and fall catching while also being completely unobstructed in the front. You can just get out anytime.”

The team looked to design a robot specifically for aging in place at home or helping in care facilities. Based on their interviews with older adults and their caregivers, they came up with several design requirements, including that the robot must fit through home doors, allow the user to take a full stride, and support their full weight to help with balance, posture, and transitions from sitting to standing.

The robot consists of a heavy, 220-pound base whose dimensions and structure were optimized to support the weight of an average human without tipping or slipping. Underneath the base is a set of omnidirectional wheels that allows the robot to move in any direction without pivoting, if needed. (Imagine a car’s wheels shifting to slide into a space between two other cars, without parallel parking.)

Extending out from the robot’s base is an articulated body made from 18 interconnected bars, or linkages, that can reconfigure like a foldable crane to lift a person from a sitting to standing position, and vice versa. Two arms with handlebars stretch out from the robot in a U-shape, which a person can stand between and lean against if they need additional support. Finally, each arm of the robot is embedded with airbags made from a soft yet grippable material that can inflate instantly to catch a person if they fall, without causing bruising on impact. The researchers believe that E-BAR is the first robot able to catch a falling person without wearable devices or use of a harness.

They tested the robot in the lab with an older adult who volunteered to use the robot in various household scenarios. The team found that E-BAR could actively support the person as they bent down to pick something up from the ground and stretched up to reach an object off a shelf — tasks that can be challenging to do while maintaining balance. The robot also was able to lift the person up and over the lip of a tub, simulating the task of getting out of a bathtub.

Bolli envisions a design like E-BAR would be ideal for use in the home by elderly people who still have a moderate degree of muscle strength but require assistive devices for activities of daily living.

“Seeing the technology used in real-life scenarios is really exciting,” says Bolli.

In their current paper, the researchers did not incorporate any fall-prediction capabilities in E-BAR’s airbag system. But another project in Asada’s lab, led by graduate student Emily Kamienski, has focused on developing algorithms with machine learning to control a new robot in response to the user’s real-time fall risk level.

Alongside E-BAR, Asada sees different technologies in his lab as providing different levels of assistance for people at certain phases of life or mobility.

“Eldercare conditions can change every few weeks or months,” Asada says. “We’d like to provide continuous and seamless support as a person’s disability or mobility changes with age.”

This work was supported, in part, by the National Robotics Initiative and the National Science Foundation.

Nature Climate Change, Published online: 13 May 2025; doi:10.1038/s41558-025-02335-9

Advancing science, policy and action in tipping points research

Studies by a growing number of labs have identified neurological health benefits from exposing human volunteers or animal models to light, sound, and/or tactile stimulation at the brain’s “gamma” frequency rhythm of 40Hz. In the latest such research at The Picower Institute for Learning and Memory and Alana Down Syndrome Center at MIT, scientists found that 40Hz sensory stimulation improved cognition and circuit connectivity and encouraged the growth of new neurons in mice genetically engineered to model Down syndrome.

Li-Huei Tsai, Picower Professor at MIT and senior author of the new study in PLOS ONE, says that the results are encouraging, but also cautions that much more work is needed to test whether the method, called GENUS (for gamma entrainment using sensory stimulation), could provide clinical benefits for people with Down syndrome. Her lab has begun a small study with human volunteers at MIT.

“While this work, for the first time, shows beneficial effects of GENUS on Down syndrome using an imperfect mouse model, we need to be cautious, as there is not yet data showing whether this also works in humans,” says Tsai, who directs The Picower Institute and The Alana Center, and is a member of MIT’s Department of Brain and Cognitive Sciences faculty.

Still, she says, the newly published article adds evidence that GENUS can promote a broad-based, restorative, “homeostatic” health response in the brain amid a wide variety of pathologies. Most GENUS studies have addressed Alzheimer’s disease in humans or mice, but others have found benefits from the stimulation for conditions such as “chemo brain” and stroke.

Down syndrome benefits

In the study, the research team led by postdoc Md Rezaul Islam and Brennan Jackson PhD ’23 worked with the commonly used “Ts65Dn” Down syndrome mouse model. The model recapitulates key aspects of the disorder, although it does not exactly mirror the human condition, which is caused by carrying an extra copy of chromosome 21.

In the first set of experiments in the paper, the team shows that an hour a day of 40Hz light and sound exposure for three weeks was associated with significant improvements on three standard short-term memory tests — two involving distinguishing novelty from familiarity and one involving spatial navigation. Because these kinds of memory tasks involve a brain region called the hippocampus, the researchers looked at neural activity there and measured a significant increase in activity indicators among mice that received the GENUS stimulation versus those that did not.

To better understand how stimulated mice could show improved cognition, the researchers examined whether cells in the hippocampus changed how they express their genes. To do this, the team used a technique called single cell RNA sequencing, which provided a readout of how nearly 16,000 individual neurons and other cells transcribed their DNA into RNA, a key step in gene expression. Many of the genes whose expression varied most prominently in neurons between the mice that received stimulation and those that did not were directly related to forming and organizing neural circuit connections called synapses.

To confirm the significance of that finding, the researchers directly examined the hippocampus in stimulated and control mice. They found that in a critical subregion, the dentate gyrus, stimulated mice had significantly more synapses.

Diving deeper

The team not only examined gene expression across individual cells, but also analyzed those data to assess whether there were patterns of coordination across multiple genes. Indeed, they found several such “modules” of co-expression. Some of this evidence further substantiated the idea that 40Hz-stimulated mice made important improvements in synaptic connectivity, but another key finding highlighted a role for TCF4, a key regulator of gene transcription needed for generating new neurons, or “neurogenesis.”  

The team’s analysis of genetic data suggested that TCF4 is underexpressed in Down syndrome mice, but the researchers saw improved TCF4 expression in GENUS-stimulated mice. When the researchers went to the lab bench to determine whether the mice also exhibited a difference in neurogenesis, they found direct evidence that stimulated mice exhibited more than unstimulated mice in the dentate gyrus. These increases in TCF4 expression and neurogenesis are only correlational, the researchers noted, but they hypothesize that the increase in new neurons likely helps explain at least some of the increase in new synapses and improved short-term memory function.

“The increased putative functional synapses in the dentate gyrus is likely related to the increased adult neurogenesis observed in the Down syndrome mice following GENUS treatment,” Islam says.

This study is the first to document that GENUS is associated with increased neurogenesis.

The analysis of gene expression modules also yielded other key insights. One is that a cluster of genes whose expression typically declines with normal aging, and in Alzheimer’s disease, remained at higher expression levels among mice who received 40Hz sensory stimulation.

And the researchers also found evidence that mice that received stimulation retained more cells in the hippocampus that express Reelin. Reelin-expressing neurons are especially vulnerable in Alzheimer’s disease, but expression of the protein is associated with cognitive resilience amid Alzheimer’s disease pathology, which Ts65Dn mice develop. About 90 percent of people with Down syndrome develop Alzheimer’s disease, typically after the age of 40.

“In this study, we found that GENUS enhances the percentage of Reln+ neurons in hippocampus of a mouse model of Down syndrome, suggesting that GENUS may promote cognitive resilience,” Islam says.

Taken together with other studies, Tsai and Islam say, the new results add evidence that GENUS helps to stimulate the brain at the cellular and molecular level to mount a homeostatic response to aberrations caused by disease pathology, be it neurodegeneration in Alzheimer’s, demyelination in chemo brain, or deficits of neurogenesis in Down syndrome.

But the authors also cautioned that the study had limits. Not only is the Ts65Dn model an imperfect reflection of human Down syndrome, but also the mice used were all male. Moreover, the cognitive tests in the study only measured short-term memory. And finally, while the study was novel for extensively examining gene expression in the hippocampus amid GENUS stimulation, it did not look at changes in other cognitively critical brain regions, such as the prefrontal cortex.

In addition to Jackson, Islam, and Tsai, the paper’s other authors are Maeesha Tasnim Naomi, Brooke Schatz, Noah Tan, Mitchell Murdock, Dong Shin Park, Daniela Rodrigues Amorim, Fred Jiang, S. Sebastian Pineda, Chinnakkaruppan Adaikkan, Vanesa Fernandez, Ute Geigenmuller, Rosalind Mott Firenze, Manolis Kellis, and Ed Boyden.

Funding for the study came from the Alana Down Syndrome Center at MIT and the Alana USA Foundation, the U.S. National Science Foundation, the La Caixa Banking Foundation, a European Molecular Biology Organization long-term postdoctoral fellowship, Barbara J. Weedon, Henry E. Singleton, and the Hubolow family.

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