Michele David has had a long and varied career in medicine. But, she says, it took coming to MIT nine years ago to find “a job that fully engages all of who I am.”

David, a highly accomplished physician, currently serves as chief of clinical quality and patient safety at MIT Health, the Institute’s multispecialty group practice and health resource serving the MIT community — including students, faculty, and staff, as well as affiliated families and retirees. While she began her MIT tenure as a primary care provider in 2015, David now focuses on quality improvement projects for the organization. In particular, she developed and now leads the ambulatory safety net team, which is tasked with creating protocols and workflows for completing health screenings of a variety of disorders and diseases, and for managing abnormal test results.

Much of who David is was shaped by the strong women she looked up to during her childhood in Haiti. Her father died when David was just 6 months old, leaving her mother, a young schoolteacher, with four children, the oldest just 5. Despite having many suitors, she never remarried. In Haiti’s patriarchal society, she later told David, marrying again would have yielded all the power in the household to a man, something she did not want her three young daughters to experience. David’s maternal aunt, who graduated from medical school in Haiti in 1956, completed her residency in the United States, and eventually became chief of pathology at the West Side VA Medical Center in Chicago. She was another role model for David, who nudged her toward a career in medicine. The death of her infant godson from an easily curable diarrheal illness due to the local hospital’s lack of basic medical supplies further strengthened the then-teenage David’s resolve to become someone who could make a difference.

David’s passion for public health and health equity grew as she earned her medical degree from the University of Chicago School of Medicine and completed her residency at the New York-Presbyterian/Columbia University Irving Medical Center in Manhattan. The hospital where she trained was divided into sections for patients who could pay for their care and those who were uninsured. It was also the beginning of the AIDS epidemic, and David saw firsthand how fear of the disease led to bias and discrimination against members of already-marginalized communities. At the time, David was not allowed to donate blood alongside other residents, because she was Haitian.

Her subsequent career included training and working in pulmonary critical care medicine, teaching medical students, researching health disparities among populations of Caribbean and African American women, and caring for patients, with a focus on women’s health. David also contributes her knowledge and energy to causes close to her heart. She is chair of the board for Health Equity International; an advisor to the Resilient Sisterhood Project; and a member of the Massachusetts Public Health Council.

By 2015, disillusioned by what she describes as a combination of “the glass ceiling” and “corporate medicine,” David began planning an early retirement. That’s when a member of the leadership team from MIT Health heard about her plans and gave her a call. “I told him all the reasons I wanted to quit medicine. He said, ‘It won’t be like that at MIT Health. Please come join us.’”

At MIT Health, David started as a primary care provider before gradually assuming additional administrative responsibilities for clinical quality and patient safety. While still seeing patients, she wrote and received a grant to develop an “ambulatory safety net” for the organization, a system of check-ins and procedures to help ensure that patients receive care that maximizes positive health outcomes. David started by assembling a team to create a safety net for colorectal cancer screening, which identified and contacted patients who were overdue for screenings or at high risk. Within the first year of the project, scheduled or completed colonoscopies among MIT Health patients in these groups increased from 29 to 97 percent.

Last spring, David transitioned to a full-time administrative role at MIT Health. Her team recently launched additional safety nets for breast cancer screening and behavioral health and is developing safety nets for prostate cancer and lung cancer.

And as for that early retirement? “I don’t have another 20 years left in me,” David says. “But I’d like to stay at MIT for as long as I can.”

Soundbytes

Q: How did you make the decision to assume your current, full-time role as chief of clinical quality and patient safety?

A: It was a role I already had, but I was doing it part time. I was also caring for a very complex panel of patients. When Chief Health Officer Cecilia Stuopis asked me if I would consider doing it full time, I was somewhat ambivalent, because I’ve always enjoyed taking care of patients. I thought about it and realized that it was another way of doing the same thing.

Q: What do you like about working at MIT?

A: Working at MIT Health feels like the first time I’ve been able to use my entire skill set to do my job. I wear my policy and public health hats when I’m working on ambulatory safety nets. I’m able to mentor and advise students, and I collaborate with my colleagues on patient care. I also feel fully supported by MIT Health’s leadership team. They are truly invested in me, and I feel that my work matters — not only to me and to them, but also to my co-workers and direct reports. Because of this, I am able to bring my best self to work.

Q: Have you been able to keep up with your many outside projects while working at MIT?

A: Yes. I lecture regularly on medical racism and health-care disparities at conferences and at other institutions. I continue to create and exhibit fine art quilts. Last year, in my role with the Resilient Sisterhood Project and in conjunction with “Call and Response,” an exhibition at Harvard University’s Hutchins Center for African and African American Research, I was able to bring a film and panel discussion to campus. The event focused on the “mothers of gynecology,” three enslaved women — Anarcha, Betsey, and Lucy — who were forced to undergo numerous experimental surgeries without anesthesia by J. Marion Sims, the South Carolina doctor long recognized as the “father of gynecology.” This is one of the stories I started telling my medical students in the late 1990s, after one student asked me why African American patients are often so distrustful of health care. This history was not in medical textbooks at that time.

Q: What are you proudest of so far in your time at MIT?

A: Even though I’m no longer seeing my own patients in person, I’m making systemic changes that are improving health outcomes for the entire panel of patients at MIT Health.

For the fifth time in the history of the annual William Lowell Putnam Mathematical Competition, and for the fifth year in a row, MIT swept all five of the contest’s top spots.

The top five scorers each year are named Putnam Fellows. Senior Brian Liu and juniors Papon Lapate and Luke Robitaille are now three-time Putnam Fellows, sophomore Jiangqi Dai earned his second win, and first-year Qiao Sun earned his first. Each receives a $2,500 award. This is also the fifth time that any school has had all five Putnam Fellows.

MIT’s team also came in first. The team was made up of Lapate, Robitaille, and Sun (in alphabetical order); Lapate and Robitaille were also on last year’s winning team. This is MIT’s ninth first-place win in the past 11 competitions. Teams consist of the three top scorers from each institution. The institution with the first-place team receives a $25,000 award, and each team member receives $1,000.  

First-year Jessica Wan was the top-scoring woman, finishing in the top 25, which earned her the $1,000 Elizabeth Lowell Putnam Prize. She is the eighth MIT student to receive this honor since the award was created in 1992. This is the sixth year in a row that an MIT woman has won the prize.

In total, 69 MIT students scored within the top 100. Beyond the top five scorers, MIT took nine of the next 11 spots (each receiving a $1,000 award), and seven of the next nine spots (earning $250 awards). Of the 75 receiving honorable mentions, 48 were from MIT. A total of 3,988 students took the exam in December, including 222 MIT students.

This exam is considered to be the most prestigious university-level mathematics competition in the United States and Canada. 

The Putnam is known for its difficulty: While a perfect score is 120, this year’s top score was 90, and the median was just 2. While many MIT students scored well, the Department of Mathematics is proud of everyone who just took the exam, says Professor Michel Goemans, head of the Department of Mathematics. 

“Year after year, I am so impressed by the sheer number of students at MIT that participate in the Putnam competition,” Goemans says. “In no other college or university in the world can one find hundreds of students who get a kick out of thinking about math problems. So refreshing!” 

Adds Professor Bjorn Poonen, who helped MIT students prepare for the exam this year, “The incredible competition performance is just one manifestation of MIT’s vibrant community of students who love doing math and discussing math with each other, students who through their hard work in this environment excel in ways beyond competitions, too.”

While the annual Putnam Competition is administered to thousands of undergraduate mathematics students across the United States and Canada, in recent years around 70 of its top 100 performers have been MIT students. Since 2000, MIT has placed among the top five teams 23 times.  

MIT’s success in the Putnam exam isn’t surprising. MIT’s recent Putnam coaches are four-time Putnam Fellow Bjorn Poonen and three-time Putnam Fellow Yufei Zhao ’10, PhD ’15. 

MIT is also a top destination for medalists participating in the International Mathematics Olympiad (IMO) for high school students. Indeed, over the last decade MIT has enrolled almost every American IMO medalist, and more international IMO gold medalists than the universities of any other single country, according to forthcoming research from the Global Talent Fund (GTF), which offers scholarship and training programs for math Olympiad students and coaches.

IMO participation is a strong predictor of future achievement. According to the International Mathematics Olympiad Foundation, about half of Fields Medal winners are IMO alums — but it’s not the only ingredient.

“Recruiting the most talented students is only the beginning. A top-tier university education — with excellent professors, supportive mentors, and an engaging peer community — is key to unlocking their full potential," says GTF President Ruchir Agarwal. "MIT’s sustained Putnam success shows how the right conditions deliver spectacular results. The catalytic reaction of MIT’s concentration of math talent and the nurturing environment of Building 2 should accelerate advancements in fundamental science for years and decades to come.”

Many MIT mathletes see competitions not only as a way to hone their mathematical aptitude, but also as a way to create a strong sense of community, to help inspire and educate the next generation. 

Chris Peterson SM ’13, director of communications and special projects at MIT Admissions and Student Financial Services, points out that many MIT students with competition math experience volunteer to help run programs for K-12 students including HMMT and Math Prize for Girls, and mentor research projects through the Program for Research in Mathematics, Engineering and Science (PRIMES).

Many of the top scorers are also alumni of the PRIMES high school outreach program. Two of this year’s Putnam Fellows, Liu and Robitaille, are PRIMES alumni, as are four of the next top 11, and six out of the next nine winners, along with many of the students receiving honorable mentions. Pavel Etingof, a math professor who is also PRIMES’ chief research advisor, states that among the 25 top winners, 12 (48 percent) are PRIMES alumni.

“We at PRIMES are very proud of our alumnae’s fantastic showing at the Putnam Competition,” says PRIMES director Slava Gerovitch PhD ’99. “PRIMES serves as a pipeline of mathematical excellence from high school through undergraduate studies, and beyond.”

Along the same lines, a collaboration between the MIT Department of Mathematics and MISTI-Africa has sent MIT students with Olympiad experience abroad during the Independent Activities Period (IAP) to coach high school students who hope to compete for their national teams. 

First-years at MIT also take class 18.A34 (Mathematical Problem Solving), known informally as the Putnam Seminar, not only to hone their Putnam exam skills, but also to make new friends. 

“Many people think of math competitions as primarily a way to identify and recognize talent, which of course they are,” says Peterson. “But the community convened by and through these competitions generates educational externalities that collectively exceed the sum of individual accomplishment.”  

Math Community and Outreach Officer Michael King also notes the camaraderie that forms around the test. 

“My favorite time of the Putnam day is right after the problem session, when the students all jump up, run over to their friends, and begin talking animatedly,” says King, who also took the exam as an undergraduate student. “They cheer each other’s successes, debate problem solutions, commiserate over missed answers, and share funny stories. It’s always amazing to work with the best math students in the world, but the most rewarding aspect is seeing the friendships that develop.”   

A full list of the winners can be found on the Putnam website.

Rohit Karnik, the Tata Professor in the MIT Department of Mechanical Engineering, has been named the new director of the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS), effective March 1. Karnik, who has served as associate director of J-WAFS since 2023, succeeds founding director John H. Lienhard V, Abdul Latif Jameel Professor of Water and Mechanical Engineering.

Karnik assumes the role of director at a pivotal time for J-WAFS, as it celebrates its 10th anniversary. Announcing the appointment today in a letter to the J-WAFS research community, Vice President for Research Ian A. Waitz noted Karnik’s deep involvement with the lab’s research efforts and programming, as well as his accolades as a researcher, teacher, leader, and mentor. “I am delighted that Rohit will bring his talent and vision to bear on the J-WAFS mission, ensuring the program sustains its direct support of research on campus and its important impact around the world,” Waitz wrote.

J-WAFS is the only program at MIT focused exclusively on water and food research. Since 2015, the lab has made grants totaling approximately $25M to researchers across the Institute, including from all five schools and 40 departments, labs, and centers. It has supported 300 faculty, research staff, and students combined. Furthermore, the J-WAFS Solutions Program, which supports efforts to commercialize innovative water and food technologies, has spun out 12 companies and two open-sourced products. 

“We launched J-WAFS with the aim of building a community of water and food researchers at MIT, taking advantage of MIT’s strengths in so many disciplines that contribute to these most essential human needs,” writes Lienhard, who will retire this June. “After a decade’s work, that community is strong and visible. I am delighted that Rohit has agreed to take the reins. He will bring the program to the next level.” 

Lienhard has served as director since founding J-WAFS in 2014, along with executive director Renee J. Robins ’83, who last fall shared her intent to retire as well. 

“It’s a big change for a program to turn over both the director and executive director roles at the same time,” says Robins. “Having worked alongside Rohit as our associate director for the past couple of years, I am greatly assured that J-WAFS will be in good hands with a new and steady leadership team.”

Karnik became associate director of J-WAFS in July 2023, a move that coincided with the start of a sabbatical for Lienhard. Before that time, Karnik was already well engaged with J-WAFS as a grant recipient, reviewer, and community member. As associate director, Rohit has been integral to J-WAFS operations, planning, and grant management, including the proposal selection process. He was instrumental in planning the second J-WAFS Grand Challenge grant and led workshops at which researchers brainstormed proposal topics and formed teams. Karnik also engaged with J-WAFS’ corporate partners, helped plan lectures and events, and offered project oversight. 

“The experience gave me broad exposure to the amazing ideas and research at MIT in the water and food space, and the collaborations and synergies across departments and schools that enable excellence in research,” says Karnik. “The strengths of J-WAFS lie in being able to support principal investigators in pursuing research to address humanity’s water and food needs; in creating a community of students though the fellowship program and support of student clubs; and in bringing people together at seminars, workshops, and other events. All of this is made possible by the endowment and a dedicated team with close involvement in the projects after the grants are awarded.”

J-WAFS was established through a generous gift from Community Jameel, an independent, global organization advancing science to help communities thrive in a rapidly changing world. The lab was named in honor of the late Abdul Latif Jameel, the founder of the Abdul Latif Jameel company and father of MIT alumnus Mohammed Jameel ’78, who founded and chairs Community Jameel. 

J-WAFS’ operations are carried out by a small but passionate team of people at MIT who are dedicated to the mission of securing water and food systems. That mission is more important than ever, as climate change, urbanization, and a growing global population are putting tremendous stress on the world’s water and food supplies. These challenges drive J-WAFS’ efforts to mobilize the research, innovation, and technology that can sustainably secure humankind’s most vital resources. 

As director, Karnik will help shape the research agenda and key priorities for J-WAFS and usher the program into its second decade.

Karnik originally joined MIT as a postdoc in the departments of Mechanical and Chemical Engineering in October 2006. In September 2007, he became an assistant professor of mechanical engineering at MIT, before being promoted to associate professor in 2012. His research group focuses on the physics of micro- and nanofluidic flows and applying that to the design of micro- and nanofluidic systems for applications in water, healthcare, energy, and the environment. Past projects include ones on membranes for water filtration and chemical separations, sensors for water, and water filters from waste wood. Karnik has served as associate department head and interim co-department head in the Department of Mechanical Engineering. He also serves as faculty director of the New Engineering Education Transformation (NEET) program in the School of Engineering.

Before coming to MIT, Karnik received a bachelor’s degree from the Indian Institute of Technology in Bombay, and a master’s and PhD from the University of California at Berkeley, all in mechanical engineering. He has authored numerous publications, is co-inventor on several patents, and has received awards and honors including the National Science Foundation CAREER Award, the U.S. Department of Energy Early Career Award, the MIT Office of Graduate Education’s Committed to Caring award, and election to the National Academy of Inventors as a senior member. 

Lienhard, J-WAFS’ outgoing director, has served on the MIT faculty since 1988. His research and educational efforts have focused on heat and mass transfer, water purification and desalination, thermodynamics, and separation processes. Lienhard has directly supervised more than 90 PhD and master’s theses, and he is the author of over 300 peer-reviewed papers and three textbooks. He holds more than 40 U.S. patents, most commercialized through startup companies with his students. One of these, the water treatment company Gradiant Corporation, is now valued over $1 billion and employs more than 1,200 people. Lienhard has received many awards, including the 2024 Lifetime Achievement Award of the International Desalination and Reuse Association.

Since 1998, Renee Robins has worked on the conception, launch, and development of a number of large interdisciplinary, international, and partnership-based research and education collaborations at MIT and elsewhere. She served in roles for the Cambridge MIT Institute, the MIT Portugal Program, the Mexico City Program, the Program on Emerging Technologies, and the Technology and Policy Program. She holds two undergraduate degrees from MIT, in biology and humanities/anthropology, and a master’s degree in public policy from Carnegie Mellon University. She has overseen significant growth in J-WAFS’ activities, funding, staffing, and collaborations over the past decade. In 2021, she was awarded an Infinite Mile Award in the area of the Offices of the Provost and Vice President for Research, in recognition of her contributions within her role at J-WAFS to help the Institute carry out its mission.

“John and Renee have done a remarkable job in establishing J-WAFS and bringing it up to its present form,” says Karnik. “I’m committed to making sure that the key aspects of J-WAFS that bring so much value to the MIT community, the nation, and the world continue to function well. MIT researchers and alumni in the J-WAFS community are already having an impact on addressing humanity’s water and food needs, and I believe that there is potential for MIT to have an even greater positive impact on securing humanity’s vital resources in the future.”

The following is a joint announcement from the MIT Microsystems Technology Laboratories and GlobalFoundries. 

MIT and GlobalFoundries (GF), a leading manufacturer of essential semiconductors, have announced a new research agreement to jointly pursue advancements and innovations for enhancing the performance and efficiency of critical semiconductor technologies. The collaboration will be led by MIT’s Microsystems Technology Laboratories (MTL) and GF’s research and development team, GF Labs.

With an initial research focus on artificial intelligence and other applications, the first projects are expected to leverage GF’s differentiated silicon photonics technology, which monolithically integrates radio frequency silicon-on-insulator (RF SOI), CMOS (complementary metal-oxide semiconductor), and optical features on a single chip to realize power efficiencies for data centers, and GF’s 22FDX platform, which delivers ultra-low power consumption for intelligent devices at the edge.

“The collaboration between MIT MTL and GF exemplifies the power of academia-industry cooperation in tackling the most pressing challenges in semiconductor research,” says Tomás Palacios, MTL director and the Clarence J. LeBel Professor of Electrical Engineering and Computer Science. Palacios will serve as the MIT faculty lead for this research initiative.

“By bringing together MIT's world-renowned capabilities with GF's leading semiconductor platforms, we are positioned to drive significant research advancements in GF’s essential chip technologies for AI,” says Gregg Bartlett, chief technology officer at GF. “This collaboration underscores our commitment to innovation and highlights our dedication to developing the next generation of talent in the semiconductor industry. Together, we will research transformative solutions in the industry.”

“Integrated circuit technologies are the core driving a broad spectrum of applications ranging from mobile computing and communication devices to automotive, energy, and cloud computing,” says Anantha P. Chandrakasan, dean of MIT's School of Engineering, chief innovation and strategy officer, and the Vannevar Bush Professor of Electrical Engineering and Computer Science. “This collaboration allows MIT’s exceptional research community to leverage GlobalFoundries’ wide range of industry domain experts and advanced process technologies to drive exciting innovations in microelectronics across domains — while preparing our students to take on leading roles in the workforce of the future.”

The new research agreement was formalized at a signing ceremony on campus at MIT. It builds upon GF’s successful past and ongoing engagements with the university. GF serves on MTL’s Microsystems Industrial Group, which brings together industry and academia to engage in research. MIT faculty are active participants in GF’s University Partnership Program focused on joint semiconductor research and prototyping. Additionally, GF and MIT collaborate on several workforce development initiatives, including through the Northeast Microelectronics Coalition, a U.S. Department of Defense Microelectronics Commons Hub.

A fossil fuel advocacy group says liability litigation against oil and gas companies is the “biggest risk” to President Donald Trump’s energy agenda.

Renewable energy broke records last year, but so did gas generation. That's a climate problem.

As smoke billowed over the Pacific Ocean, scientists working offshore sprang into action.

The Climate Change Center provided technical assistance that helped state and local governments bring in $13 billion from the bipartisan infrastructure law.

Lawmakers are escalating their protests following news EPA wants to undo a finding allowing the agency to regulate greenhouse gas emissions.

The Trump EPA has homed in on the electric school bus manufacturer as alleged evidence of the Biden administration’s mismanagement of grant funds.

The notice comes after the Office of Administrative Law rejected changes to the low-carbon fuel standard.

Finland’s Neste blames the airlines for not keeping their promise to guarantee voluntary demand for sustainable aviation fuel.

A report said the country can reach the net-zero goal by 2050 while spending as little as 0.2 percent of its gross domestic product.

High-temperature superconducting magnets made from REBCO, an acronym for rare earth barium copper oxide, make it possible to create an intense magnetic field that can confine the extremely hot plasma needed for fusion reactions, which combine two hydrogen atoms to form an atom of helium, releasing a neutron in the process.

But some early tests suggested that neutron irradiation inside a fusion power plant might instantaneously suppress the superconducting magnets’ ability to carry current without resistance (called critical current), potentially causing a reduction in the fusion power output.

Now, a series of experiments has clearly demonstrated that this instantaneous effect of neutron bombardment, known as the “beam on effect,” should not be an issue during reactor operation, thus clearing the path for projects such as the ARC fusion system being developed by MIT spinoff company Commonwealth Fusion Systems.

The findings were reported in the journal Superconducting Science and Technology, in a paper by MIT graduate student Alexis Devitre and professors Michael Short, Dennis Whyte, and Zachary Hartwig, along with six others.

“Nobody really knew if it would be a concern,” Short explains. He recalls looking at these early findings: “Our group thought, man, somebody should really look into this. But now, luckily, the result of the paper is: It’s conclusively not a concern.”

The possible issue first arose during some initial tests of the REBCO tapes planned for use in the ARC system. “I can remember the night when we first tried the experiment,” Devitre recalls. “We were all down in the accelerator lab, in the basement. It was a big shocker because suddenly the measurement we were looking at, the critical current, just went down by 30 percent” when it was measured under radiation conditions (approximating those of the fusion system), as opposed to when it was only measured after irradiation.

Before that, researchers had irradiated the REBCO tapes and then tested them afterward, Short says. “We had the idea to measure while irradiating, the way it would be when the reactor’s really on,” he says. “And then we observed this giant difference, and we thought, oh, this is a big deal. It’s a margin you’d want to know about if you’re designing a reactor.”

After a series of carefully calibrated tests, it turned out the drop in critical current was not caused by the irradiation at all, but was just an effect of temperature changes brought on by the proton beam used for the irradiation experiments. This is something that would not be a factor in an actual fusion plant, Short says.

“We repeated experiments ‘oh so many times’ and collected about a thousand data points,” Devitre says. They then went through a detailed statistical analysis to show that the effects were exactly the same, under conditions where the material was just heated as when it was both heated and irradiated.

This excluded the possibility that the instantaneous suppression of the critical current had anything to do with the “beam on effect,” at least within the sensitivity of their tests. “Our experiments are quite sensitive,” Short says. “We can never say there’s no effect, but we can say that there’s no important effect.”

To carry out these tests required building a special facility for the purpose. Only a few such facilities exist in the world. “They’re all custom builds, and without this, we wouldn’t have been able to find out the answer,” he says.

The finding that this specific issue is not a concern for the design of fusion plants “illustrates the power of negative results. If you can conclusively prove that something doesn’t happen, you can stop scientists from wasting their time hunting for something that doesn’t exist.” And in this case, Short says, “You can tell the fusion companies: ‘You might have thought this effect would be real, but we’ve proven that it’s not, and you can ignore it in your designs.’ So that’s one more risk retired.”

That could be a relief to not only Commonwealth Fusion Systems but also several other companies that are also pursuing fusion plant designs, Devitre says. “There’s a bunch. And it’s not just fusion companies,” he adds. There remains the important issue of longer-term degradation of the REBCO that would occur over years or decades, which the group is presently investigating. Others are pursuing the use of these magnets for satellite thrusters and particle accelerators to study subatomic physics, where the effect could also have been a concern. For all these uses, “this is now one less thing to be concerned about,” Devitre says.

The research team also included David Fischer, Kevin Woller, Maxwell Rae, Lauryn Kortman, and Zoe Fisher at MIT, and N. Riva at Proxima Fusion in Germany. This research was supported by Eni S.p.A. through the MIT Energy Initiative.

Nature Climate Change, Published online: 28 February 2025; doi:10.1038/s41558-025-02269-2

In 2023–2024, widespread marine heatwaves associated with record ocean temperatures impacted ocean processes, marine species, ecosystems and coastal communities, with economic consequences. Despite warnings, interventions were limited. Proactive strategies are needed for inevitable future events.

Nature Climate Change, Published online: 28 February 2025; doi:10.1038/s41558-025-02257-6

Critical methodological choices in marine heatwave detection can yield dramatically different results. We call for context-specific methods that account for regional variability to advance marine heatwave research and socio-ecological outcomes.

Nature Climate Change, Published online: 28 February 2025; doi:10.1038/s41558-025-02250-z

Governance of domestic cross-border carbon capture and storage faces great challenges, which varies across political systems, economic structures and socio-cultural backgrounds, yet is often overlooked. Overcoming these challenges requires a comprehensive and coordinated approach built on synergistic cluster governance.

A vast search of natural diversity has led scientists at MIT’s McGovern Institute for Brain Research and the Broad Institute of MIT and Harvard to uncover ancient systems with potential to expand the genome editing toolbox. 

These systems, which the researchers call TIGR (Tandem Interspaced Guide RNA) systems, use RNA to guide them to specific sites on DNA. TIGR systems can be reprogrammed to target any DNA sequence of interest, and they have distinct functional modules that can act on the targeted DNA. In addition to its modularity, TIGR is very compact compared to other RNA-guided systems, like CRISPR, which is a major advantage for delivering it in a therapeutic context.  

These findings are reported online Feb. 27 in the journal Science.

“This is a very versatile RNA-guided system with a lot of diverse functionalities,” says Feng Zhang, the James and Patricia Poitras Professor of Neuroscience at MIT, who led the research. The TIGR-associated (Tas) proteins that Zhang’s team found share a characteristic RNA-binding component that interacts with an RNA guide that directs it to a specific site in the genome. Some cut the DNA at that site, using an adjacent DNA-cutting segment of the protein. That modularity could facilitate tool development, allowing researchers to swap useful new features into natural Tas proteins.

“Nature is pretty incredible,” says Zhang, who is also an investigator at the McGovern Institute and the Howard Hughes Medical Institute, a core member of the Broad Institute, a professor of brain and cognitive sciences and biological engineering at MIT, and co-director of the K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics at MIT. “It’s got a tremendous amount of diversity, and we have been exploring that natural diversity to find new biological mechanisms and harnessing them for different applications to manipulate biological processes,” he says. Previously, Zhang’s team adapted bacterial CRISPR systems into gene editing tools that have transformed modern biology. His team has also found a variety of programmable proteins, both from CRISPR systems and beyond. 

In their new work, to find novel programmable systems, the team began by zeroing in a structural feature of the CRISPR-Cas9 protein that binds to the enzyme’s RNA guide. That is a key feature that has made Cas9 such a powerful tool: “Being RNA-guided makes it relatively easy to reprogram, because we know how RNA binds to other DNA or other RNA,” Zhang explains. His team searched hundreds of millions of biological proteins with known or predicted structures, looking for any that shared a similar domain. To find more distantly related proteins, they used an iterative process: from Cas9, they identified a protein called IS110, which had previously been shown by others to bind RNA. They then zeroed in on the structural features of IS110 that enable RNA binding and repeated their search. 

At this point, the search had turned up so many distantly related proteins that they team turned to artificial intelligence to make sense of the list. “When you are doing iterative, deep mining, the resulting hits can be so diverse that they are difficult to analyze using standard phylogenetic methods, which rely on conserved sequence,” explains Guilhem Faure, a computational biologist in Zhang’s lab. With a protein large language model, the team was able to cluster the proteins they had found into groups according to their likely evolutionary relationships. One group set apart from the rest, and its members were particularly intriguing because they were encoded by genes with regularly spaced repetitive sequences reminiscent of an essential component of CRISPR systems. These were the TIGR-Tas systems.

Zhang’s team discovered more than 20,000 different Tas proteins, mostly occurring in bacteria-infecting viruses. Sequences within each gene’s repetitive region — its TIGR arrays — encode an RNA guide that interacts with the RNA-binding part of the protein. In some, the RNA-binding region is adjacent to a DNA-cutting part of the protein. Others appear to bind to other proteins, which suggests they might help direct those proteins to DNA targets.     

Zhang and his team experimented with dozens of Tas proteins, demonstrating that some can be programmed to make targeted cuts to DNA in human cells. As they think about developing TIGR-Tas systems into programmable tools, the researchers are encouraged by features that could make those tools particularly flexible and precise.

They note that CRISPR systems can only be directed to segments of DNA that are flanked by short motifs known as PAMs (protospacer adjacent motifs). TIGR Tas proteins, in contrast, have no such requirement. “This means theoretically, any site in the genome should be targetable,” says scientific advisor Rhiannon Macrae. The team’s experiments also show that TIGR systems have what Faure calls a “dual-guide system,” interacting with both strands of the DNA double helix to home in on their target sequences, which should ensure they act only where they are directed by their RNA guide. What’s more, Tas proteins are compact — a quarter of the size Cas9, on average — making them easier to deliver, which could overcome a major obstacle to therapeutic deployment of gene editing tools.  

Excited by their discovery, Zhang’s team is now investigating the natural role of TIGR systems in viruses, as well as how they can be adapted for research or therapeutics. They have determined the molecular structure of one of the Tas proteins they found to work in human cells, and will use that information to guide their efforts to make it more efficient. Additionally, they note connections between TIGR-Tas systems and certain RNA-processing proteins in human cells. “I think there’s more there to study in terms of what some of those relationships may be, and it may help us better understand how these systems are used in humans,” Zhang says.

This work was supported by the Helen Hay Whitney Foundation, Howard Hughes Medical Institute, K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics, Broad Institute Programmable Therapeutics Gift Donors, Pershing Square Foundation, William Ackman, Neri Oxman, the Phillips family, J. and P. Poitras, and the BT Charitable Foundation. 

The U.S. Court of Appeals for the Ninth Circuit correctly held that Grindr, a popular dating app, can’t be held responsible for matching users and enabling them to exchange messages that led to real-world harm. EFF and the Woodhull Freedom Foundation filed an amicus brief in the Ninth Circuit in support of Grindr.

Grindr and other dating apps are possible thanks to strong Section 230 immunity. Without this protection, dating apps—and other platforms that host user-generated content—would have more incentive to censor people online. While real-world harms do happen when people connect online, these can be directly redressed by holding perpetrators who did the harm accountable.

The case, Doe v. Grindr, was brought by a plaintiff who was 15 years old when he signed up for Grindr but claimed to be over 18 years old to use the app. He was matched with other users and exchanged messages with them. This led to four in-person meetings that resulted in three out of four adult men being prosecuted for rape.

The plaintiff brought various state law claims against Grindr centering around the idea that the app was defectively designed, enabling him to be matched with and to communicate with the adults. The plaintiff also brought a federal civil sex trafficking claim.

Grindr invoked Section 230, the federal statute that has ensured a free and open internet for nearly 30 years. Section 230(c)(1) specifically provides that online services are generally not responsible for “publishing” harmful user-generated content. Section 230 protects users’ online speech by protecting the intermediaries we all rely on to communicate via dating apps, social media, blogs, email, and other internet platforms.

The Ninth Circuit rightly affirmed the district court’s dismissal of all of the plaintiff’s claims. The court held that Section 230 bars nearly all of plaintiff’s claims (except the sex trafficking claim, which is exempted from Section 230). The court stated:

Each of Doe’s state law claims necessarily implicates Grindr’s role as a publisher of third-party content. The theory underpinning Doe’s claims for defective design, defective manufacturing, and negligence faults Grindr for facilitating communication among users for illegal activity….

The Ninth Circuit’s holding is important because many plaintiffs have tried in recent years to plead around Section 230 by framing their cases as seeking to hold internet platforms responsible for their own “defective designs,” rather than third-party content. Yet, a closer look at a plaintiff’s allegations often reveals that the plaintiff’s harm is indeed premised on third-party content—that’s true in this case, where the plaintiff exchanged messages with the adult men. As we argued in our brief:

Plaintiff’s claim here is based not on mere access to the app, but on the actions of a third party once John Doe logged in—messages exchanged between a third party and Doe, and ultimately, on unlawful acts occurring between them because of those communications.

Additionally, courts generally have concluded that an internet platform’s features that relate to how users can engage with the app and how third-party content is displayed and organized, are also “publishing” activities protected by Section 230.

As for the federal civil sex trafficking claim, the Ninth Circuit held that the plaintiff’s allegations failed to meet the statutory requirements. The court stated:

Doe must plausibly allege that Grindr ‘knowingly’ sex trafficked a person by a list of specified means. But the [complaint] merely shows that Grindr provided a platform that facilitated sharing of messages between users.

While the facts of this case are no doubt difficult, the Ninth Circuit reached the correct conclusion. Our modern communications are mediated by private companies, and any weakening of Section 230 immunity for internet platforms would stifle everyone’s ability to communicate, as companies would be incentivized to engage in greater censorship of users to mitigate their legal exposure.

This does not leave victims without redress—they may seek to hold perpetrators responsible directly. Importantly in this case, three of the perpetrators were criminally charged. And should facts show that an online service participated in criminal conduct, Section 230 would not block a federal prosecution. The court’s ruling demonstrates that Section 230 is working as Congress intended.

Join EFF's Cindy Cohn and Eva Galperin in conversation with Ron Deibert of the University of Toronto’s Citizen Lab, to discuss Ron’s latest book: Chasing Shadows: Cyber Espionage, Subversion and the Global Fight for Democracy. Chasing Shadows provides a front-row seat to a dark underworld of digital espionage, dark PR, and subversion. The book provides a gripping account of how the Citizen Lab, the world’s foremost digital watchdog, has uncovered dozens of cyber espionage cases and protects people in countries around the world. Called “essential reading” by Margaret Atwood, it’s a chilling reminder of the invisible invasions happening on smartphones and computers around the world.

LEARN MORE

When:

Monday, March 10, 2025 
7:oo pm - 9:o0 pm (PT)

Where:

In-person:
City Lights Bookstore
261 Columbus Avenue
San Francisco, CA 94133

Virtual:
Zoom

About the Author:

Ronald J. Deibert is the founder and director of the Citizen Lab, a world-renowned digital security research center at the University of Toronto. The bestselling author of Reset: Reclaiming the Internet for Civil Society and Black Code: Surveillance, Privacy, and the Dark Side of the Internet, he has also written many landmark articles and reports on espionage operations that infiltrated government and NGO computer networks. His team’s exposés of the spyware that attacks journalists and anti-corruption advocates around the world have been featured in The New York Times, The Washington Post, Financial Times, and other media. Deibert has received multiple honors for his cutting-edge work, and in 2022 he was appointed an Officer of the Order of Canada—the country’s second-highest honor of merit.