Peripheral nerves — the network connecting the brain, spinal cord, and central nervous system to the rest of the body — transmit sensory information, control muscle movements, and regulate automatic bodily functions. Bioelectronic devices implanted on these nerves offer remarkable potential for the treatment and rehabilitation of neurological and systemic diseases. However, because the body perceives these implants as foreign objects, they often trigger the formation of dense fibrotic tissue at bioelectronic device–tissue interfaces, which can significantly compromise device performance and longevity.

New research published in the journal Science Advances presents a robust bioadhesive strategy that establishes non-fibrotic bioelectronic interfaces on diverse peripheral nerves — including the occipital, vagus, deep peroneal, sciatic, tibial, and common peroneal nerves — for up to 12 weeks.

“We discovered that adhering the bioelectrodes to peripheral nerves can fully prevent the formation of fibrosis on the interfaces,” says Xuanhe Zhao, the Uncas and Helen Whitaker Professor, and professor of mechanical engineering and civil engineering at MIT. “We further demonstrated long-term, drug-free hypertension mitigation using non-fibrotic bioelectronics over four weeks, and ongoing.”

The approach inhibits immune cell infiltration at the device-tissue interface, thereby preventing the formation of fibrous capsules within the inflammatory microenvironment. In preclinical rodent models, the team demonstrated that the non-fibrotic, adhesive bioelectronic device maintained stable, long-term regulation of blood pressure.

“Our long-term blood pressure regulation approach was inspired by traditional acupuncture,” says Hyunmin Moon, lead author of the study and a postdoc in the Department of Mechanical Engineering. “The lower leg has long been used in hypertension treatment, and the deep peroneal nerve lies precisely at an acupuncture point. We were thrilled to see that stimulating this nerve achieved blood pressure regulation for the first time. The convergence of our non-fibrotic, adhesive bioelectronic device with this long-term regulation capability holds exciting promise for translational medicine.”

Importantly, after 12 weeks of implantation with continuous nerve stimulation, only minimal macrophage activity and limited deposition of smooth muscle actin and collagen were detected, underscoring the device’s potential to deliver long-term neuromodulation without triggering fibrosis. “The contrast between the immune response of the adhered device and that of the non-adhered control is striking,” says Bastien Aymon, a study co-author and a PhD candidate in mechanical engineering. “The fact that we can observe immunologically pristine interfaces after three months of adhesive implantation is extremely encouraging for future clinical translation.”

This work offers a broadly applicable strategy for all implantable bioelectronic systems by preventing fibrosis at the device interface, paving the way for more effective and long-lasting therapies such as hypertension mitigation.

Hypertension is a major contributor to cardiovascular diseases, the leading cause of death worldwide. Although medications are effective in many cases, more than 50 percent of patients remain hypertensive despite treatment — a condition known as resistant hypertension. Traditional carotid sinus or vagus nerve stimulation methods are often accompanied by side effects including apnea, bradycardia, cough, and paresthesia.

“In contrast, our non-fibrotic, adhesive bioelectronic device targeting the deep peroneal nerve enables long-term blood pressure regulation in resistant hypertensive patients without metabolic side effects,” says Moon.

Three of the nation’s largest carbon-free projects are being completed in a region whose progressive political leaders are shifting toward gas as electricity prices rise.

Jared Isaacman is getting another chance to lead the space agency after President Donald Trump changed his mind about the Elon Musk ally.

Save My Louisiana asserts that state policies favoring CO2 pipelines and wells are unconstitutional.

Waymo is in a standoff with the California city after residents complained of nonstop beeping at the robotaxi company's charging hub.

The Netherlands-based Climate Litigation Network said the suits are now establishing legal requirements on governments and corporations.

Nevison is a contractor working with the Advisory Committee on Immunization Practices’ hepatitis B work group.

The bloc’s goal for 2040 “is actually an acceleration, rather than a downgrade, of what we are having today,” says Wopke Hoekstra.

The nation says $7 billion is required over the next decade to hit its 2035 target.

The nation’s efforts to slash its emissions have been hampered by a slow rollout of new transmission infrastructure that can accommodate solar and wind generation.

As climate change makes it harder to grow arabica beans in Brazil, some farmers are investing in robusta, which produces a more bitter bean but can tolerate higher temperatures.

A noninvasive method for measuring blood glucose levels, developed at MIT, could save diabetes patients from having to prick their fingers several times a day.

The MIT team used Raman spectroscopy — a technique that reveals the chemical composition of tissues by shining near-infrared or visible light on them — to develop a shoebox-sized device that can measure blood glucose levels without any needles.

In tests in a healthy volunteer, the researchers found that the measurements from their device were similar to those obtained by commercial continuous glucose monitoring sensors that require a wire to be implanted under the skin. While the device presented in this study is too large to be used as a wearable sensor, the researchers have since developed a wearable version that they are now testing in a small clinical study.

“For a long time, the finger stick has been the standard method for measuring blood sugar, but nobody wants to prick their finger every day, multiple times a day. Naturally, many diabetic patients are under-testing their blood glucose levels, which can cause serious complications,” says Jeon Woong Kang, an MIT research scientist and the senior author of the study. “If we can make a noninvasive glucose monitor with high accuracy, then almost everyone with diabetes will benefit from this new technology.”

MIT postdoc Arianna Bresci is the lead author of the new study, which appears today in the journal Analytical Chemistry. Other authors include Peter So, director of the MIT Laser Biomedical Research Center (LBRC) and an MIT professor of biological engineering and mechanical engineering; and Youngkyu Kim and Miyeon Jue of Apollon Inc., a biotechnology company based in South Korea.

Noninvasive glucose measurement

While most diabetes patients measure their blood glucose levels by drawing blood and testing it with a glucometer, some use wearable monitors, which have a sensor that is inserted just under the skin. These sensors provide continuous glucose measurements from the interstitial fluid, but they can cause skin irritation and they need to be replaced every 10 to 15 days.

In hopes of creating wearable glucose monitors that would be more comfortable for patients, researchers in MIT’s LBRC have been pursuing noninvasive sensors based on Raman spectroscopy. This type of spectroscopy reveals the chemical composition of tissue or cells by analyzing how near-infrared light is scattered, or deflected, as it encounters different kinds of molecules.

In 2010, researchers at the LBRC showed that they could indirectly calculate glucose levels based on a comparison between Raman signals from the interstitial fluid that bathes skin cells and a reference measurement of blood glucose levels. While this approach produced reliable measurements, it wasn’t practical for translating to a glucose monitor.

More recently, the researchers reported a breakthrough that allowed them to directly measure glucose Raman signals from the skin. Normally, this glucose signal is too small to pick out from all of the other signals generated by molecules in tissue. The MIT team found a way to filter out much of the unwanted signal by shining near-infrared light onto the skin at a different angle from which they collected the resulting Raman signal.

The researchers obtained those measurements using equipment that was around the size of a desktop printer, and since then, they have been working on further shrinking the footprint of the device.

In their new study, they were able to create a smaller device by analyzing just three bands — spectral regions that correspond to specific molecular features — in the Raman spectrum.

Typically, a Raman spectrum may contain about 1,000 bands. However, the MIT team found that they could determine blood glucose levels by measuring just three bands — one from the glucose plus two background measurements. This approach allowed the researchers to reduce the amount and cost of equipment needed, allowing them to perform the measurement with a cost-effective device about the size of a shoebox.

“By refraining from acquiring the whole spectrum, which has a lot of redundant information, we go down to three bands selected from about 1,000,” Bresci says. “With this new approach, we can change the components commonly used in Raman-based devices, and save space, time, and cost.”

Toward a wearable sensor

In a clinical study performed at the MIT Center for Clinical Translation Research (CCTR), the researchers used the new device to take readings from a healthy volunteer over a four-hour period. As the subject rested their arm on top of the device, a near-infrared beam shone through a small glass window onto the skin to perform the measurement.

Each measurement takes a little more than 30 seconds, and the researchers took a new reading every five minutes.

During the study, the subject consumed two 75-gram glucose drinks, allowing the researchers to monitor significant changes in blood glucose concentration. They found that the Raman-based device showed accuracy levels similar to those of two commercially available, invasive glucose monitors worn by the subject.

Since finishing that study, the researchers have developed a smaller prototype, about the size of a cellphone, that they’re currently testing at the MIT CCTR as a wearable monitor in healthy and prediabetic volunteers. Next year, they plan to run a larger study working with a local hospital, which will include people with diabetes.

The researchers are also working on making the device even smaller, about the size of a watch. Additionally, they are exploring ways to ensure that the device can obtain accurate readings from people with different skin tones.

The research was funded by the National Institutes of Health, the Korean Technology and Information Promotion Agency for SMEs, and Apollon Inc.

For the first time, MIT chemists have synthesized a fungal compound known as verticillin A, which was discovered more than 50 years ago and has shown potential as an anticancer agent.

The compound has a complex structure that made it more difficult to synthesize than related compounds, even though it differed by only a couple of atoms.

“We have a much better appreciation for how those subtle structural changes can significantly increase the synthetic challenge,” says Mohammad Movassaghi, an MIT professor of chemistry. “Now we have the technology where we can not only access them for the first time, more than 50 years after they were isolated, but also we can make many designed variants, which can enable further detailed studies.”

In tests in human cancer cells, a derivative of verticillin A showed particular promise against a type of pediatric brain cancer called diffuse midline glioma. More tests will be needed to evaluate its potential for clinical use, the researchers say.

Movassaghi and Jun Qi, an associate professor of medicine at Dana-Farber Cancer Institute/Boston Children’s Cancer and Blood Disorders Center and Harvard Medical School, are the senior authors of the study, which appears today in the Journal of the American Chemical Society. Walker Knauss PhD ’24 is the lead author of the paper. Xiuqi Wang, a medicinal chemist and chemical biologist at Dana-Farber, and Mariella Filbin, research director in the Pediatric Neurology-Oncology Program at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, are also authors of the study.

A complex synthesis

Researchers first reported the isolation of verticillin A from fungi, which use it for protection against pathogens, in 1970. Verticillin A and related fungal compounds have drawn interest for their potential anticancer and antimicrobial activity, but their complexity has made them difficult to synthesize.

In 2009, Movassaghi’s lab reported the synthesis of (+)-11,11'-dideoxyverticillin A, a fungal compound similar to verticillin A. That molecule has 10 rings and eight stereogenic centers, or carbon atoms that have four different chemical groups attached to them. These groups have to be attached in a way that ensures they have the correct orientation, or stereochemistry, with respect to the rest of the molecule.

Once that synthesis was achieved, however, synthesis of verticillin A remained challenging, even though the only difference between verticillin A and (+)-11,11'-dideoxyverticillin A is the presence of two oxygen atoms.

“Those two oxygens greatly limit the window of opportunity that you have in terms of doing chemical transformations,” Movassaghi says. “It makes the compound so much more fragile, so much more sensitive, so that even though we had had years of methodological advances, the compound continued to pose a challenge for us.”

Both of the verticillin A compounds consist of two identical fragments that must be joined together to form a molecule called a dimer. To create (+)-11,11'-dideoxyverticillin A, the researchers had performed the dimerization reaction near the end of the synthesis, then added four critical carbon-sulfur bonds.

Yet when trying to synthesize verticillin A, the researchers found that waiting to add those carbon-sulfur bonds at the end did not result in the correct stereochemistry. As a result, the researchers had to rethink their approach and ended up creating a very different synthetic sequence.

“What we learned was the timing of the events is absolutely critical. We had to significantly change the order of the bond-forming events,” Movassaghi says.

The verticillin A synthesis begins with an amino acid derivative known as beta-hydroxytryptophan, and then step-by-step, the researchers add a variety of chemical functional groups, including alcohols, ketones, and amides, in a way that ensures the correct stereochemistry.

A functional group containing two carbon-sulfur bonds and a disulfide bond were introduced early on, to help control the stereochemistry of the molecule, but the sensitive disulfides had to be “masked” and protected as a pair of sulfides to prevent them from breakdown under subsequent chemical reactions. The disulfide-containing groups were then regenerated after the dimerization reaction.

“This particular dimerization really stands out in terms of the complexity of the substrates that we’re bringing together, which have such a dense array of functional groups and stereochemistry,” Movassaghi says.

The overall synthesis requires 16 steps from the beta-hydroxytryptophan starting material to verticillin A.

Killing cancer cells

Once the researchers had successfully completed the synthesis, they were also able to tweak it to generate derivates of verticillin A. Researchers at Dana-Farber then tested these compounds against several types of diffuse midline glioma (DMG), a rare brain tumor that has few treatment options.

The researchers found that the DMG cell lines most susceptible to these compounds were those that have high levels of a protein called EZHIP. This protein, which plays a role in the methylation of DNA, has been previously identified as a potential drug target for DMG.

“Identifying the potential targets of these compounds will play a critical role in further understanding their mechanism of action, and more importantly, will help optimize the compounds from the Movassaghi lab to be more target specific for novel therapy development,” Qi says.

The verticillin derivatives appear to interact with EZHIP in a way that increases DNA methylation, which induces the cancer cells to under programmed cell death. The compounds that were most successful at killing these cells were N-sulfonylated (+)-11,11'-dideoxyverticillin A and N-sulfonylated verticillin A. N-sulfonylation — the addition of a functional group containing sulfur and oxygen — makes the molecules more stable.

“The natural product itself is not the most potent, but it’s the natural product synthesis that brought us to a point where we can make these derivatives and study them,” Movassaghi says.

The Dana-Farber team is now working on further validating the mechanism of action of the verticillin derivatives, and they also hope to begin testing the compounds in animal models of pediatric brain cancers.

“Natural compounds have been valuable resources for drug discovery, and we will fully evaluate the therapeutic potential of these molecules by integrating our expertise in chemistry, chemical biology, cancer biology, and patient care. We have also profiled our lead molecules in more than 800 cancer cell lines, and will be able to understand their functions more broadly in other cancers,” Qi says.

The research was funded by the National Institute of General Medical Sciences, the Ependymoma Research Foundation, and the Curing Kids Cancer Foundation.

EFF has submitted its formal comment to the U.S. Patent and Trademark Office (USPTO) opposing a set of proposed rules that would sharply restrict the public’s ability to challenge wrongly granted patents. These rules would make inter partes review (IPR)—the main tool Congress created to fix improperly granted patents—unavailable in most of the situations where it’s needed most.

If adopted, they would give patent trolls exactly what they want: a way to keep questionable patents alive and out of reach.

If you haven’t commented yet, there’s still time. The deadline is today, December 2.

TAKE ACTION

Tell USPTO: The public has a right to challenge bad patents

Sample comment:

I oppose the USPTO’s proposed rule changes for inter partes review (IPR), Docket No. PTO-P-2025-0025. The IPR process must remain open and fair. Patent challenges should be decided on their merits, not shut out because of legal activity elsewhere. These rules would make it nearly impossible for the public to challenge bad patents, and that will harm innovation and everyday technology users.

IPR Is Already Under Siege, And These Rules Would Make It Worse

Since USPTO Director John Squires was sworn into office just over two months ago, we’ve seen the Patent Office take an increasingly aggressive stance against IPR petitions. In a series of director-level decisions, the USPTO has denied patent challengers the chance to be heard—sometimes dozens of them at a time—without explanation or reasoning. 

That reality makes this rulemaking even more troubling. The USPTO is already denying virtually every new petition challenging patents. These proposed rules would cement that closed-door approach and make it harder for challengers to be heard. 

What EFF Told the USPTO

Our comment lays out how these rules would make patent challenges nearly impossible to pursue for small businesses, nonprofits, software developers, and everyday users of technology. 

Here are the core problems we raised:

First, no one should have to give up their court defenses just to use IPR. The USPTO proposal would force defendants to choose: either use IPR and risk losing their legal defenses, or keep their defenses and lose IPR.

That’s not a real choice. Anyone being sued or threatened for patent infringement needs access to every legitimate defense. Patent litigation is devastatingly expensive, and forcing people to surrender core rights in federal court is unreasonable and unlawful.

Second, one early case should not make a bad patent immune forever. Under the proposed rules, if a patent survives any earlier validity fight—no matter how rushed, incomplete, or poorly reasoned—everyone else could be barred from filing an IPR later.

New prior art? Doesn’t matter. Better evidence? Doesn’t matter. 

Congress never intended IPR to be a one-shot shield for bad patents. 

Third, patent owners could manipulate timing to shut down petitions. The rules would let the USPTO deny IPRs simply because a district court case might move faster.

Patent trolls already game the system by filing in courts with rapid schedules. This rule would reward that behavior. It allows patent owners—not facts, not law, not the merits—to determine whether an IPR can proceed. 

IPR isn't supposed to be a race to the courthouse. It’s supposed to be a neutral review of whether the Patent Office made a mistake.

Why Patent Challenges Matter

IPR isn’t perfect, and it doesn’t apply to every patent. But compared to multimillion-dollar federal litigation, it’s one of the only viable tools available to small companies, developers, and the public. It needs to remain open. 

When an overbroad patent gets waved at hundreds or thousands of people—podcasters, app developers, small retailers—IPR is often the only mechanism that can actually fix the underlying problem: the patent itself. These rules would take that option away.

There’s Still Time To Add Your Voice

If you haven’t submitted a comment yet, now is the time. The more people speak up, the harder it becomes for these changes to slip through.

Comments don’t need to be long or technical. A few clear sentences in your own words are enough. We’ve written a short sample comment below. It’s even more powerful if you add a sentence or two describing your own experience. If you mention EFF in your comment, it helps our collective impact. 

TAKE ACTION

Sample comment: 

I oppose the USPTO’s proposed rule changes for inter partes review (IPR), Docket No. PTO-P-2025-0025. The IPR process must remain open and fair. Patent challenges should be decided on their merits, not shut out because of legal activity elsewhere. These rules would make it nearly impossible for the public to challenge bad patents, and that will harm innovation and everyday technology users.

Further reading:

• EFF Comment to USPTO, Docket No. PTO-P-2025-0025

More than 600 undergraduate students crowded into the Stratton Student Center on Oct. 28, for MIT’s first-ever Institute-wide Undergraduate Research Opportunities Program (UROP) mixer.

“At MIT, we believe in the transformative power of learning by doing, and there’s no better example than UROP,” says MIT President Sally Kornbluth, who attended the mixer with Provost Anantha Chandrakasan and Chancellor Melissa Nobles. “The energy at the inaugural UROP mixer was exhilarating, and I’m delighted that students now have this easy way to explore different paths to the frontiers of research.”

The event gave students the chance to explore internships and undergraduate research opportunities — in fields ranging from artificial intelligence to the life sciences to the arts, and beyond — all in one place, with approximately 150 researchers from labs available to discuss the projects and answer questions in real time. The offices of the Chancellor and Provost co-hosted the event, which the UROP office helped coordinate. 

First-year student Isabell Luo recently began a UROP project in the Living Matter lab led by Professor Rafael Gómez-Bombarelli, where she is benchmarking machine-learned interatomic potentials that simulate chemical reactions at the molecular level and exploring fine-tuning strategies to improve their accuracy. She’s passionate about AI and machine learning, eco-friendly design, and entrepreneurship, and was attending the UROP mixer to find more “real-world” projects to work on.

“I’m trying to dip my toes into different areas, which is why I’m at the mixer,” said Luo. “On the internet it would be so hard to find the right opportunities. It’s nice to have a physical space and speak to people from so many disciplines.”

More than nine out of every 10 members of MIT’s class of 2025 took part in a UROP before graduating. In recent years, approximately 3,200 undergraduates have participated in a UROP project each year. To meet the strong demand for UROPs, the Institute will commit up to $1 million in funding this year to create more of them. The funding will come from MIT’s schools and Office of the Provost. 

“UROPs have become an indispensable part of the MIT undergraduate education, providing hands-on experience that really helps students learn new ways to problem-solve and innovate,” says Chandrakasan. “I was thrilled to see so many students at the mixer — it was a testament to their willingness to roll up their sleeves and get to work on really tough challenges.”

Arielle Berman, a postdoc in the Raman Lab, was looking to recruit an undergraduate researcher for a project on sensor integration for muscle actuators for biohybrid robots — robots that include living parts. She spoke about how her own research experience as an undergraduate had shaped her career.

“It’s a really important event because we’re able to expose undergraduates to research,” says Berman. “I’m the first PhD in my family, so I wasn’t aware that research existed, or could be a career. Working in a research lab as an undergraduate student changed my life trajectory, and I’m happy to pass it forward and help students have experiences they wouldn’t have otherwise.”

The event drew students with interests as varied as the projects available. For first-year Nate Black, who plans to major in mechanical engineering, “I just wanted something to develop my interest in 3D printing and additive manufacturing.” First-year Akpandu Ekezie, who expects to major in Course 6-5 (Electrical Engineering with Computing), was interested in photonic circuits. “I’m looking mainly for EE-related things that are more hands-on,” he explained. “I want to get more physical experience.”

Nobles has a message for students considering a UROP project: Just go for it. “There’s a UROP for every student, regardless of experience,” she says. “Find something that excites you and give it a try.” She encourages students who weren’t able to attend the mixer, as well as those who did attend but still have questions, to get in touch with the UROP office.

First-year students Ruby Mykkanen and Aditi Deshpande attended the mixer together. Both were searching for UROP projects they could work on during Independent Activities Period in January. Deshpande also noted that the mixer was helpful for understanding “what research is being done at MIT.”

Said Mykkanen, “It’s fun to have it all in one place!”

Imagine having a continuum soft robotic arm bend around a bunch of grapes or broccoli, adjusting its grip in real time as it lifts the object. Unlike traditional rigid robots that generally aim to avoid contact with the environment as much as possible and stay far away from humans for safety reasons, this arm senses subtle forces, stretching and flexing in ways that mimic more of the compliance of a human hand. Its every motion is calculated to avoid excessive force while achieving the task efficiently. In MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) and Laboratory for Information and Decisions Systems (LIDS) labs, these seemingly simple movements are the culmination of complex mathematics, careful engineering, and a vision for robots that can safely interact with humans and delicate objects.

Soft robots, with their deformable bodies, promise a future where machines move more seamlessly alongside people, assist in caregiving, or handle delicate items in industrial settings. Yet that very flexibility makes them difficult to control. Small bends or twists can produce unpredictable forces, raising the risk of damage or injury. This motivates the need for safe control strategies for soft robots. 

“Inspired by advances in safe control and formal methods for rigid robots, we aim to adapt these ideas to soft robotics — modeling their complex behavior and embracing, rather than avoiding, contact — to enable higher-performance designs (e.g., greater payload and precision) without sacrificing safety or embodied intelligence,” says lead senior author and MIT Assistant Professor Gioele Zardini, who is a principal investigator in LIDS and the Department of Civil and Environmental Engineering, and an affiliate faculty with the Institute for Data, Systems, and Society (IDSS). “This vision is shared by recent and parallel work from other groups.”

Safety first

The team developed a new framework that blends nonlinear control theory (controlling systems that involve highly complex dynamics) with advanced physical modeling techniques and efficient real-time optimization to produce what they call “contact-aware safety.” At the heart of the approach are high-order control barrier functions (HOCBFs) and high-order control Lyapunov functions (HOCLFs). HOCBFs define safe operating boundaries, ensuring the robot doesn’t exert unsafe forces. HOCLFs guide the robot efficiently toward its task objectives, balancing safety with performance.

“Essentially, we’re teaching the robot to know its own limits when interacting with the environment while still achieving its goals,” says MIT Department of Mechanical Engineering PhD student Kiwan Wong, the lead author of a new paper describing the framework. “The approach involves some complex derivation of soft robot dynamics, contact models, and control constraints, but the specification of control objectives and safety barriers is rather straightforward for the practitioner, and the outcomes are very tangible, as you see the robot moving smoothly, reacting to contact, and never causing unsafe situations.”

“Compared with traditional kinematic CBFs — where forward-invariant safe sets are hard to specify — the HOCBF framework simplifies barrier design, and its optimization formulation accounts for system dynamics (e.g., inertia), ensuring the soft robot stops early enough to avoid unsafe contact forces,” says Worcester Polytechnic Institute Assistant Professor and former CSAIL postdoc Wei Xiao.

“Since soft robots emerged, the field has highlighted their embodied intelligence and greater inherent safety relative to rigid robots, thanks to passive material and structural compliance. Yet their “cognitive” intelligence — especially safety systems — has lagged behind that of rigid serial-link manipulators,” says co-lead author Maximilian Stölzle, a research intern at Disney Research and formerly a Delft University of Technology PhD student and visiting researcher at MIT LIDS and CSAIL. “This work helps close that gap by adapting proven algorithms to soft robots and tailoring them for safe contact and soft-continuum dynamics.”

The LIDS and CSAIL team tested the system on a series of experiments designed to challenge the robot’s safety and adaptability. In one test, the arm pressed gently against a compliant surface, maintaining a precise force without overshooting. In another, it traced the contours of a curved object, adjusting its grip to avoid slippage. In yet another demonstration, the robot manipulated fragile items alongside a human operator, reacting in real time to unexpected nudges or shifts. “These experiments show that our framework is able to generalize to diverse tasks and objectives, and the robot can sense, adapt, and act in complex scenarios while always respecting clearly defined safety limits,” says Zardini.

Soft robots with contact-aware safety could be a real value-add in high-stakes places, of course. In health care, they could assist in surgeries, providing precise manipulation while reducing risk to patients. In industry, they might handle fragile goods without constant supervision. In domestic settings, robots could help with chores or caregiving tasks, interacting safely with children or the elderly — a key step toward making soft robots reliable partners in real-world environments. 

“Soft robots have incredible potential,” says co-lead senior author Daniela Rus, director of CSAIL and a professor in the Department of Electrical Engineering and Computer Science. “But ensuring safety and encoding motion tasks via relatively simple objectives has always been a central challenge. We wanted to create a system where the robot can remain flexible and responsive while mathematically guaranteeing it won’t exceed safe force limits.”

Combining soft robot models, differentiable simulation, and control theory

Underlying the control strategy is a differentiable implementation of something called the Piecewise Cosserat-Segment (PCS) dynamics model, which predicts how a soft robot deforms and where forces accumulate. This model allows the system to anticipate how the robot’s body will respond to actuation and complex interactions with the environment. “The aspect that I most like about this work is the blend of integration of new and old tools coming from different fields like advanced soft robot models, differentiable simulation, Lyapunov theory, convex optimization, and injury-severity–based safety constraints. All of this is nicely blended into a real-time controller fully grounded in first principles,” says co-author Cosimo Della Santina, who is an associate professor at Delft University of Technology. 

Complementing this is the Differentiable Conservative Separating Axis Theorem (DCSAT), which estimates distances between the soft robot and obstacles in the environment that can be approximated with a chain of convex polygons in a differentiable manner. “Earlier differentiable distance metrics for convex polygons either couldn’t compute penetration depth — essential for estimating contact forces — or yielded non-conservative estimates that could compromise safety,” says Wong. “Instead, the DCSAT metric returns strictly conservative, and therefore safe, estimates while simultaneously allowing for fast and differentiable computation.” Together, PCS and DCSAT give the robot a predictive sense of its environment for more proactive, safe interactions.

Looking ahead, the team plans to extend their methods to three-dimensional soft robots and explore integration with learning-based strategies. By combining contact-aware safety with adaptive learning, soft robots could handle even more complex, unpredictable environments. 

“This is what makes our work exciting,” says Rus. “You can see the robot behaving in a human-like, careful manner, but behind that grace is a rigorous control framework ensuring it never oversteps its bounds.”

“Soft robots are generally safer to interact with than rigid-bodied robots by design, due to the compliance and energy-absorbing properties of their bodies,” says University of Michigan Assistant Professor Daniel Bruder, who wasn’t involved in the research. “However, as soft robots become faster, stronger, and more capable, that may no longer be enough to ensure safety. This work takes a crucial step towards ensuring soft robots can operate safely by offering a method to limit contact forces across their entire bodies.”

The team’s work was supported, in part, by The Hong Kong Jockey Club Scholarships, the European Union’s Horizon Europe Program, Cultuurfonds Wetenschapsbeurzen, and the Rudge (1948) and Nancy Allen Chair. Their work was published earlier this month in the Institute of Electrical and Electronics Engineers’ Robotics and Automation Letters.

Researchers at MIT have demonstrated that wedge-shaped vortex generators attached to a ship’s hull can reduce drag by up to 7.5 percent, which reduces overall ship emissions and fuel expenses. The paper, “Net Drag Reduction in High Block Coefficient Ships and Vehicles Using Vortex Generators,” was presented at the Society of Naval Architects and Marine Engineers 2025 Maritime Convention in Norfolk, Virginia.

The work offers a promising path toward decarbonization, addressing the pressing need to meet the International Maritime Organization (IMO) goal to reduce carbon intensity of international shipping by at least 40 percent by 2030, compared to 2008 levels. Achieving such ambitious emissions reduction will require a coordinated approach, employing multiple methods, from redesigning ship hulls, propellers, and engines to using novel fuels and operational methods.

The researchers — José del Águila Ferrandis, Jack Kimmeth, and Michael Triantafyllou of MIT Sea Grant and the Department of Mechanical Engineering, along with Alfonso Parra Rubio and Neil Gershenfeld of the Center for Bits and Atoms — determined the optimized vortex generator shape and size using a combination of computational fluid dynamics (CFD) and experimental methods guided by AI optimization methods. 

The team first established parametric trends through extensive CFD analysis, and then tested multiple hulls through rapid prototyping to validate the results experimentally. Scale models of an axisymmetric hull with a bare tail, a tail with delta wing vortex generators, and a tail with wedge vortex generators were produced and tested. The team identified wedge-like vortex generators as the key shape that could achieve this level of drag reduction. 

Through flow visualization, the researchers could see that drag was reduced by delaying turbulent flow separation, helping water flow more smoothly along the ship’s hull, shrinking the wake behind the vessel. This also allows the propeller and rudder to work more efficiently in a uniform flow. “We document for the first time experimentally a reduction in fuel required by ships using vortex generators, relatively small structures in the shape of a wedge attached at a specific point of the ship’s hull,” explains Michael Triantafyllou, professor of mechanical engineering and director of MIT Sea Grant. 

Vortex generators have long been used in aircraft-wing design to maintain lift and delay stalling. This study is the first to show that the vortex generators can be applied for drag reduction in commercial ships.

The modular adaptability of the wedge vortex generators would allow integration into a broad range of hull forms, including bulk carriers and tankers, and the devices can synergize with, or even replace, existing technologies like pre-swirl stators (fixed fins mounted in front of propellers), improving overall system performance. As an example case, the researchers estimate that installing the vortex generators on a 300-meter Newcastlemax bulk carrier operating at 14.5 knots over a cross-Pacific route would result in significantly reduced emissions and approximately $750,000 in fuel savings per year.

The findings offer a practical, cost-effective solution that could be implemented efficiently across existing fleets. This study was supported through the CBA Consortium, working with Oldendorff Carriers, which operates about 700 bulk carriers around the world. An extension of this research is supported by the MIT Maritime Consortium, led by MIT professors Themis Sapsis and Fotini Christia. The Maritime Consortium was formed in 2025 to address critical gaps in the modernization of the commercial fleet through interdisciplinary research and collaboration across academia, industry, and regulatory agencies.

EFF intern Alexandra Halbeck contributed to this blog

When people talk to a chatbot, they often reveal highly personal information they wouldn’t share with anyone else. Chat logs are digital repositories of our most sensitive and revealing information. They are also tempting targets for law enforcement, to which the U.S. Constitution gives only one answer: get a warrant.

AI companies have a responsibility to their users to make sure the warrant requirement is strictly followed, to resist unlawful bulk surveillance requests, and to be transparent with their users about the number of government requests they receive.

Chat logs are deeply personal, just like your emails.

Tens of millions of people use chatbots to brainstorm, test ideas, and explore questions they might never post publicly or even admit to another person. Whether advisable or not, people also turn to consumer AI companies for medical information, financial advice, and even dating tips. These conversations reveal people’s most sensitive information.

Without privacy protections, users would be chilled in their use of AI systems.

Consider the sensitivity of the following prompts: “how to get abortion pills,” “how to protect myself at a protest,” or “how to escape an abusive relationship.” These exchanges can reveal everything from health status to political beliefs to private grief. A single chat thread can expose the kind of intimate detail once locked away in a handwritten diary.

Without privacy protections, users would be chilled in their use of AI systems for learning, expression, and seeking help.

Chat logs require a warrant.

Whether you draft an email, edit an online document, or ask a question to a chatbot, you have a reasonable expectation of privacy in that information. Chatbots may be a new technology, but the constitutional principle is old and clear. Before the government can rifle through your private thoughts stored on digital platforms, it must do what it has always been required to do: get a warrant.

For over a century, the Fourth Amendment has protected the content of private communications—such as letters, emails, and search engine prompts—from unreasonable government searches. AI prompts require the same constitutional protection.

This protection is not aspirational—it already exists. The Fourth Amendment draws a bright line around private communications: the government must show probable cause and obtain a particularized warrant before compelling a company to turn over your data. Companies like OpenAI acknowledge this warrant requirement explicitly, while others like Anthropic could stand to be more precise.

AI companies must resist bulk surveillance orders.

AI companies that create chatbots should commit to having your back and resisting unlawful bulk surveillance orders. A valid search warrant requires law enforcement to provide a judge with probable cause and to particularly describe the thing to be searched. This means that bulk surveillance orders often fail that test.

What do these overbroad orders look like? In the past decade or so, police have often sought “reverse” search warrants for user information held by technology companies. Rather than searching for one particular individual, police have demanded that companies rummage through their giant databases of personal data to help develop investigative leads. This has included “tower dumps” or “geofence warrants,” in which police order a company to search all users’ location data to identify anyone that’s been near a particular place at a particular time. It has also included “keyword” warrants, which seek to identify any person who typed a particular phrase into a search engine. This could include a chilling keyword search for a well-known politician’s name or busy street, or a geofence warrant near a protest or church.

Courts are beginning to rule that these broad demands are unconstitutional. And after years of complying, Google has finally made it technically difficult—if not impossible—to provide mass location data in response to a geofence warrant.

This is an old story: if a company stores a lot of data about its users, law enforcement (and private litigants) will eventually seek it out. Law enforcement is already demanding user data from AI chatbot companies, and it will only increase. These companies must be prepared for this onslaught, and they must commit to fighting to protect their users.

In addition to minimizing the amount of data accessible to law enforcement, they can start with three promises to their users. These aren’t radical ideas. They are basic transparency and accountability standards to preserve user trust and to ensure constitutional rights keep pace with technology:

1. commit to fighting bulk orders for user data in court,
2. commit to providing users with advanced notice before complying with a legal demand so that users can choose to fight on their own behalf, and 
3. commit to publishing periodic transparency reports, which tally up how many legal demands for user data the company receives (including the number of bulk orders specifically).

U.S. Customs and Border Protection (CBP), the Drug Enforcement Administration (DEA), and scores of state and local law enforcement agencies have installed a massive dragnet of automated license plate readers (ALPRs) in the US-Mexico borderlands. 

In many cases, the agencies have gone out of their way to disguise the cameras from public view. And the problem is only going to get worse: as recently as July 2025, CBP put out a solicitation to purchase 100 more covert trail cameras with license plate-capture ability. 

Last month, the Associated Press published an in-depth investigation into how agencies have deployed these systems and exploited this data to target drivers. But what do these cameras look like? Here's a guide to identifying ALPR systems when you're driving the open road along the border.

Special thanks to researcher Dugan Meyer and AZ Mirror's Jerod MacDonald-Evoy. All images by EFF and Meyer were taken within the last three years. 

ALPR at Checkpoints and Land Ports of Entry 

All land ports of entry have ALPR systems that collect all vehicles entering and exiting the country. They typically look like this: 

ALPR systems at the Eagle Pass International Bridge Port of Entry. Source: EFF

Most interior checkpoints, which are anywhere from a few miles to more than 60 from the border, are also equipped with ALPR systems operated by CBP. However, the DEA operates a parallel system at most interior checkpoints in southern border states. 

When it comes to checkpoints, here's the rule of thumb: If you're traveling away from the border, you are typically being captured by a CBP/Border Patrol system (Border Patrol is a sub-agency of CBP). If you're traveling toward the border, it is most likely a DEA system.

Here's a representative example of a CBP checkpoint camera system:

ALPR system at the Border Patrol checkpoint near Uvalde, Texas. Source: EFF

At a typical port of entry or checkpoint, each vehicle lane will have an ALPR system. We've even seen border patrol checkpoints that were temporarily closed continue to funnel people through these ALPR lanes, even though there was no one on hand to vet drivers face-to-face. According CBP's Privacy Impact Assessments (2017, 2020), CBP keeps this data for 15 years, but generally agents can only search the most recent five years worth of data. 

The scanners were previously made by a company called Perceptics which was infamously hacked, leading to a breach of driver data. The systems have since been "modernized" (i.e. replaced) by SAIC.

Here's a close up of the new systems:

Frontal ALPR camera at the checkpoint near Uvalde, Texas. Source: EFF

In 2024, the DEA announced plans to integrate port of entry ALPRs into its National License Plate Reader Program (NLPRP), which the agency says is a network of both DEA systems and external law enforcement ALPR systems that it uses to investigate crimes such as drug trafficking and bulk cash smuggling.

Again, if you're traveling towards the border and you pass a checkpoint, you're often captured by parallel DEA systems set up on the opposite side of the road. However, these systems have also been found to be installed on their own away from checkpoints. 

These are a major component of the DEA's NLPRP, which has a standard retention period of 90 days. This program dates back to at least 2010, according to records obtained by the ACLU. 

Here is a typical DEA system that you will find installed near existing Border Patrol checkpoints:

DEA ALPR set-up in southern Arizona. Source: EFF

These are typically made by a different vendor, Selex ES, which also includes the brands ELSAG and Leonardo. Here is a close-up:

Close-up of a DEA camera near the Tohono O'odham Nation in Arizona. Source: EFF

Covert ALPR

As you drive along border highways, law enforcement agencies have disguised cameras in order to capture your movements. 

The exact number of covert ALPRs at the border is unknown, but to date we have identified approximately 100 sites. We know CBP and DEA each operate covert ALPR systems, but it isn't always possible to know which agency operates any particular set-up. 

Another rule of thumb: if a covert ALPR has a Motorola Solutions camera (formerly Vigilant Solutions) inside, it's likely a CBP system. If it has a Selex ES camera inside, then it is likely a DEA camera. 

Here are examples of construction barrels with each kind of camera: 

A covert ALPR with a Motorola Solutions ALPR camera near Calexico, Calif. Source: EFF

These are typically seen along the roadside, often in sets of three, but almost always connected to some sort of solar panel. They are often placed behind existing barriers.

A covert ALPR with a Selex ES camera in southern Arizona. Source: EFF

The DEA models are also found by the roadside, but they also can be found inside or near checkpoints. 

If you're curious (as we were), here's what they look like inside, courtesy of the US Patent and Trademark Office:

Patent for portable covert license plate reader. Source: USPTO

In addition to orange construction barrels, agencies also conceal ALPRs in yellow sandbarrels. For example, these can be found throughout southern Arizona, especially in the southeastern part of the state.

A covert ALPR system in Arizona. Source: EFF

ALPR Trailers

Sometimes a speed trailer or signage trailer isn't designed so much for safety but to conceal ALPR systems. Sometimes ALPRs are attached to indistinct trailers with no discernible purpose that you'd hardly notice by the side of the road. 

It's important to note that its difficult to know who these belong to, since they aren't often marked. We know that all levels of government, even in the interior of the country, have purchased these set ups.  

Here are some of the different flavors of ALPR trailers:

An ALPR speed trailer in Texas. Source: EFF

ALPR trailer in Southern California. Source. EFF

ALPR trailer in Southern California. Source. EFF

An ALPR unit in southern Arizona. Source: EFF

ALPR unit in southern Arizona. Source: EFF

A Jenoptik Vector ALPR trailer in La Joya, Texas. Source: EFF

One particularly worrisome version of an ALPR trailer is the Jenoptik Vector: at least two jurisdictions along the border have equipped these trailers not only with ALPR, but with TraffiCatch technology that gathers Bluetooth and Wi-Fi identifiers. This means that in addition to gathering plates, these devices would also document mobile devices, such as phones, laptops, and even vehicle entertainment systems.

Stationary ALPR 

Stationary or fixed ALPR is one of the more traditional ways of installing these systems. The cameras are placed on existing utility poles or other infrastructure or on poles installed by the ALPR vendor. 

For example, here's a DEA system installed on a highway arch:

The lower set of ALPR cameras belong to the DEA. Source: Dugan Meyer CC BY

ALPR camera in Arizona. Source: Dugan Meyer CC BY

Flock Safety

At the local level, thousands of cities around the United States have adopted fixed ALPR, with the company Flock Safety grabbing a huge chunk of the market over the last few years. County sheriffs and municipal police along the border have also embraced the trend, with many using funds earmarked for border security to purchase these systems. Flock allows these agencies to share with one another and contribute their ALPR scans to a national pool of data. As part of a pilot program, Border Patrol had access to this ALPR data for most of 2025. 

A typical Flock Safety setup involves attaching cameras and solar panels to poles. For example:

Flock Safety ALPR poles installed just outside the Tohono O'odham Nation in Arizona. Source: EFF

A close-up of a Flock Safety camera in Douglas, Arizona. Source: EFF

We've also seen these camera poles placed outside the Santa Teresa Border Patrol station in New Mexico.

Flock may now be the most common provider nationwide, but it isn't the only player in the field. DHS recently released a market survey of 16 different vendors providing similar technology.  

Mobile ALPR 

ALPR cameras can also be found attached to patrol cars. Here's an example of a Motorola Solutions ALPR attached to a Hidalgo County Constable vehicle in South Texas:

Mobile ALPR on a Hidalgo County Constable vehicle. Source: Weslaco Police Department

These allow officers not only to capture ALPR data in real time as they are driving along, but they will also receive an in-car alert when a scan matches a vehicle on a "hot list," the term for a list of plates that law enforcement has flagged for further investigation. 

Here's another example: 

Mobile ALPR in La Mesa, Calif.. Source: La Mesa Police Department Facebook page

Identifying Other Technologies 

EFF has been documenting the wide variety of technologies deployed at the border, including surveillance towers, aerostats, and trail cameras. To learn more, download EFF's zine, "Surveillance Technology at the US-Mexico Border" and explore our map of border surveillance, which includes Google Streetview links so you can see exactly how each installation looks on the ground. Currently we have mapped out most DEA and CBP checkpoint ALPR setups, with covert cameras planned for addition in the near future.

In his 2020 book, “Future Politics,” British barrister Jamie Susskind wrote that the dominant question of the 20th century was “How much of our collective life should be determined by the state, and what should be left to the market and civil society?” But in the early decades of this century, Susskind suggested that we face a different question: “To what extent should our lives be directed and controlled by powerful digital systems—and on what terms?”

Artificial intelligence (AI) forces us to confront this question. It is a technology that in theory amplifies the power of its users: A manager, marketer, political campaigner, or opinionated internet user can utter a single instruction, and see their message—whatever it is—instantly written, personalized, and propagated via email, text, social, or other channels to thousands of people within their organization, or millions around the world. It also allows us to individualize solicitations for political donations, elaborate a grievance into a well-articulated policy position, or tailor a persuasive argument to an identity group, or even a single person...