"Never in a hundred years has the auto industry witnessed such explosive growth in exports from a single country,” one analyst said.

The insurer blames inflation and intense storms. Illinois officials say the company exploited lax regulations to raise prices 27 percent.

The president urged other countries to vote against a proposed worldwide fee on greenhouse gas emissions on the shipping industry on Friday.

The Trump administration has said it plans to revoke US Wind’s permit for the project, which aims to power more than 718,000 homes.

The former government health specialists urged Health Secretary Robert F. Kennedy Jr. to “intercede” in EPA’s effort to weaken regulations that reduce mercury and arsenic.

Climate change is out. Energy affordability is in.

State legislation would shield the crypto sector from regulations and establish a special judicial docket.

Funding gaps and infrastructure limits risk stalling cities’ ambitions when it comes to expanding bike services.

During a recent event in Bogotá, five presidential candidates held up “YES” signs when asked if they would authorize fracking in Colombia.

A new report found that without the efforts to curb emissions of heat-trapping gases that started 10 years ago with the Paris Agreement, Earth would instead be adding 114 superhot days a year by the end of the century.

Before cells can divide, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material. Until now, scientists had believed that as division occurs, the genome loses the distinctive 3D internal structure that it typically forms.

Once division is complete, it was thought, the genome gradually regains that complex, globular structure, which plays an essential role in controlling which genes are turned on in a given cell.

However, a new study from MIT shows that in fact, this picture is not fully accurate. Using a higher-resolution genome mapping technique, the research team discovered that small 3D loops connecting regulatory elements and genes persist in the genome during cell division, or mitosis.

“This study really helps to clarify how we should think about mitosis. In the past, mitosis was thought of as a blank slate, with no transcription and no structure related to gene activity. And we now know that that’s not quite the case,” says Anders Sejr Hansen, an associate professor of biological engineering at MIT. “What we see is that there’s always structure. It never goes away.”

The researchers also discovered that these regulatory loops appear to strengthen when chromosomes become more compact in preparation for cell division. This compaction brings genetic regulatory elements closer together and encourages them to stick together. This may help cells “remember” interactions present in one cell cycle and carry it to the next one.

“The findings help to bridge the structure of the genome to its function in managing how genes are turned on and off, which has been an outstanding challenge in the field for decades,” says Viraat Goel PhD ’25, the lead author of the study.

Hansen and Edward Banigan, a research scientist in MIT’s Institute for Medical Engineering and Science, are the senior authors of the paper, which appears today in Nature Structural and Molecular Biology. Leonid Mirny, a professor in MIT’s Institute for Medical Engineering and Science and the Department of Physics, and Gerd Blobel, a professor at the Perelman School of Medicine at the University of Pennsylvania, are also authors of the study.

A surprising finding

Over the past 20 years, scientists have discovered that inside the cell nucleus, DNA organizes itself into 3D loops. While many loops enable interactions between genes and regulatory regions that may be millions of base pairs away from each other, others are formed during cell division to compact chromosomes. Much of the mapping of these 3D structures has been done using a technique called Hi-C, originally developed by a team that included MIT researchers and was led by Job Dekker at the University of Massachusetts Chan Medical School. To perform Hi-C, researchers use enzymes to chop the genome into many small pieces and biochemically link pieces that are near each other in 3D space within the cell’s nucleus. They then determine the identities of the interacting pieces by sequencing them.

However, that technique doesn’t have high enough resolution to pick out all specific interactions between genes and regulatory elements such as enhancers. Enhancers are short sequences of DNA that can help to activate the transcription of a gene by binding to the gene’s promoter — the site where transcription begins.

In 2023, Hansen and others developed a new technique that allows them to analyze 3D genome structures with 100 to 1,000 times greater resolution than was previously possible. This technique, known as Region-Capture Micro-C (RC-MC), uses a different enzyme that cuts the genome into small fragments of similar size. It also focuses on a smaller segment of the genome, allowing for high-resolution 3-D mapping of a targeted genome region.

Using this technique, the researchers were able to identify a new kind of genome structure that hadn’t been seen before, which they called “microcompartments.” These are tiny highly connected loops that form when enhancers and promoters located near each other stick together.

In that paper, experiments revealed that these loops were not formed by the same mechanisms that form other genome structures, but the researchers were unable to determine exactly how they do form. In hopes of answering that question, the team set out to study cells as they undergo cell division. During mitosis, chromosomes become much more compact, so that they can be duplicated, sorted, and divvied up between two daughter cells. As this happens, larger genome structures called A/B compartments and topologically associating domains (TADs) disappear completely.

The researchers believed that the microcompartments they had discovered would also disappear during mitosis. By tracking cells through the entire cell division process, they hoped to learn how the microcompartments appear after mitosis is completed.

“During mitosis, it has been thought that almost all gene transcription is shut off. And before our paper, it was also thought that all 3D structure related to gene regulation was lost and replaced by compaction. It’s a complete reset every cell cycle,” Hansen says.

However, to their surprise, the researchers found that microcompartments could still be seen during mitosis, and in fact they become more prominent as the cell goes through cell division.

“We went into this study thinking, well, the one thing we know for sure is that there’s no regulatory structure in mitosis, and then we accidentally found structure in mitosis,” Hansen says.

Using their technique, the researchers also confirmed that larger structures such as A/B compartments and TADs do disappear during mitosis, as had been seen before.

“This study leverages the unprecedented genomic resolution of the RC-MC assay to reveal new and surprising aspects of mitotic chromatin organization, which we have overlooked in the past using traditional 3C-based assays. The authors reveal that, contrary to the well-described dramatic loss of TADs and compartmentalization during mitosis, fine-scale “microcompartments” — nested interactions between active regulatory elements — are maintained or even transiently strengthened,” says Effie Apostolou, an associate professor of molecular biology in medicine at Weill Cornell Medicine, who was not involved in the study.

A spike in transcription

The findings may offer an explanation for a spike in gene transcription that usually occurs near the end of mitosis, the researchers say. Since the 1960s, it had been thought that transcription ceased completely during mitosis, but in 2016 and 2017, a few studies showed that cells undergo a brief spike of transcription, which is quickly suppressed until the cell finishes dividing.

In their new study, the MIT team found that during mitosis, microcompartments are more likely to be found near the genes that spike during cell division. They also discovered that these loops appear to form as a result of the genome compaction that occurs during mitosis. This compaction brings enhancers and promoters closer together, allowing them to stick together to form microcompartments.

Once formed, the loops that constitute microcompartments may activate gene transcription somewhat by accident, which is then shut off by the cell. When the cell finishes dividing, entering a state known as G1, many of these small loops become weaker or disappear.

“It almost seems like this transcriptional spiking in mitosis is an undesirable accident that arises from generating a uniquely favorable environment for microcompartments to form during mitosis,” Hansen says. “Then, the cell quickly prunes and filters many of those loops out when it enters G1.”

Because chromosome compaction can also be influenced by a cell’s size and shape, the researchers are now exploring how variations in those features affect the structure of the genome and in turn, gene regulation.

“We are thinking about some natural biological settings where cells change shape and size, and whether we can perhaps explain some 3D genome changes that previously lack an explanation,” Hansen says. “Another key question is how does the cell then pick what are the microcompartments to keep and what are the microcompartments to remove when you enter G1, to ensure fidelity of gene expression?”

The research was funded in part by the National Institutes of Health, a National Science Foundation CAREER Award, the Gene Regulation Observatory of the Broad Institute, a Pew-Steward Scholar Award for Cancer Research, the Mathers Foundation, the MIT Westaway Fund, the Bridge Project of the Koch Institute and Dana-Farber/Harvard Cancer Center, and the Koch Institute Support (core) Grant from the National Cancer Institute.

Nature Climate Change, Published online: 17 October 2025; doi:10.1038/s41558-025-02466-z

The impacts of permafrost thaw are widespread across tundra landscapes. Now, research across a series of thermokarst landscapes on the Tibetan Plateau shows that abrupt permafrost thaw increases plant-available phosphorus, alters the vegetation community and tips the balance of belowground nutrient competition.

Nature Climate Change, Published online: 17 October 2025; doi:10.1038/s41558-025-02445-4

The response of the phosphorus (P) cycle to permafrost thaw is unknown, but has implications for carbon dynamics. This study assesses changes in the P cycle upon abrupt thaw and shows accelerated soil P cycling and increased plant uptake, which may boost primary production and partially offset soil carbon loss.

Nature Climate Change, Published online: 17 October 2025; doi:10.1038/s41558-025-02446-3

The Southern Ocean carbon sink is predicted to decline under climate change. This study explores why this is yet to be seen in observations, finding that recent surface freshening increases stratification and traps the CO2-rich water in the subsurface layer, which prevents atmospheric outgassing.

Nature Climate Change, Published online: 17 October 2025; doi:10.1038/s41558-025-02453-4

Damages such as crevasses or cracks can be early indicators of ice shelf weakening. Here, the authors quantify changes in damage structures in Antarctic ice sheets, which show sensitivity to warming

Two leading experts in the field of carbon capture and sequestration (CCS) — Howard J. Herzog, a senior research engineer in the MIT Energy Initiative, and Niall Mac Dowell, a professor in energy systems engineering at Imperial College London — explore methods for removing carbon dioxide already in the atmosphere in their new book, “Carbon Removal.” Published in October, the book is part of the Essential Knowledge series from the MIT Press, which consists of volumes “synthesizing specialized subject matter for nonspecialists” and includes Herzog’s 2018 book, “Carbon Capture.”

Burning fossil fuels, as well as other human activities, cause the release of carbon dioxide (CO2) into the atmosphere, where it acts like a blanket that warms the Earth, resulting in climate change. Much attention has focused on mitigation technologies that reduce emissions, but in their book, Herzog and Mac Dowell have turned their attention to “carbon dioxide removal” (CDR), an approach that removes carbon already present in the atmosphere.

In this new volume, the authors explain how CO2 naturally moves into and out of the atmosphere and present a brief history of carbon removal as a concept for dealing with climate change. They also describe the full range of “pathways” that have been proposed for removing CO2 from the atmosphere. Those pathways include engineered systems designed for “direct air capture” (DAC), as well as various “nature-based” approaches that call for planting trees or taking steps to enhance removal by biomass or the oceans. The book offers easily accessible explanations of the fundamental science and engineering behind each approach.

The authors compare the “quality” of the different pathways based on the following metrics:

Accounting. For public acceptance of any carbon-removal strategy, the authors note, the developers need to get the accounting right — and that’s not always easy. “If you’re going to spend money to get CO2 out of the atmosphere, you want to get paid for doing it,” notes Herzog. It can be tricky to measure how much you have removed, because there’s a lot of CO2 going in and out of the atmosphere all the time. Also, if your approach involves, say, burning fossil fuels, you must subtract the amount of CO2 that’s emitted from the total amount you claim to have removed. Then there’s the timing of the removal. With a DAC device, the removal happens right now, and the removed CO2 can be measured. “But if I plant a tree, it’s going to remove CO2 for decades. Is that equivalent to removing it right now?” Herzog queries. How to take that factor into account hasn’t yet been resolved.

Permanence. Different approaches keep the CO2 out of the atmosphere for different durations of time. How long is long enough? As the authors explain, this is one of the biggest issues, especially with nature-based solutions, where events such as wildfires or pestilence or land-use changes can release the stored CO2 back into the atmosphere. How do we deal with that?

Cost. Cost is another key factor. Using a DAC device to remove CO2 costs far more than planting trees, but it yields immediate removal of a measurable amount of CO2 that can then be locked away forever. How does one monetize that trade-off?

Additionality. “You’re doing this project, but would what you’re doing have been done anyway?” asks Herzog. “Is your effort additional to business as usual?” This question comes into play with many of the nature-based approaches involving trees, soils, and so on.

Permitting and governance. These issues are especially important — and complicated — with approaches that involve doing things in the ocean. In addition, Herzog points out that some CCS projects could also achieve carbon removal, but they would have a hard time getting permits to build the pipelines and other needed infrastructure.

The authors conclude that none of the CDR strategies now being proposed is a clear winner on all the metrics. However, they stress that carbon removal has the potential to play an important role in meeting our climate change goals — not by replacing our emissions-reduction efforts, but rather by supplementing them. However, as Herzog and Mac Dowell make clear in their book, many challenges must be addressed to move CDR from today’s speculation to deployment at scale, and the book supports the wider discussion about how to move forward. Indeed, the authors have fulfilled their stated goal: “to provide an objective analysis of the opportunities and challenges for CDR and to separate myth from reality.”

At an age when many kids prefer to play games on their phones, 11-year-old Vivan Mirchandani wanted to explore physics videos. Little did he know that MIT Open Learning’s free online resources would change the course of his life. 

Now, at 16, Mirchandani is well on his way to a career as a physics scholar — all because he forged his own unconventional educational journey.

Nontraditional education has granted Mirchandani the freedom to pursue topics he’s personally interested in. This year, he wrote a paper on cosmology that proposes a new framework for understanding Einstein’s general theory of relativity. Other projects include expanding on fluid dynamics laws for cats, training an AI model to resemble the consciousness of his late grandmother, and creating his own digital twin. That’s in addition to his regular studies, regional science fairs, Model United Nations delegation, and a TEDEd Talk.

Mirchandani started down this path between the ages of 10 and 12, when he decided to read books and find online content about physics during the early Covid-19 lockdown in India. He was shocked to find that MIT Open Learning offers free course videos, lecture notes, exams, and other resources from the Institute on sites like MIT OpenCourseWare and the newly launched MIT Learn.

“My first course was 8.01 (Classical Mechanics), and it completely changed how I saw physics,” Mirchandani says. “Physics sounded like elegance. It’s the closest we’ve ever come to have a theory of everything.”

Experiencing “real learning”

Mirchandani discovered MIT Open Learning through OpenCourseWare, which offers free, online, open educational resources from MIT undergraduate and graduate courses. He says MIT Open Learning’s “academically rigorous” content prepares learners to ask questions and think like a scientist.

“Instead of rote memorization, I finally experienced real learning,” Mirchandani says. “OpenCourseWare was a holy grail. Without it, I would still be stuck on the basic concepts.”

Wanting to follow in the footsteps of physicists like Sir Isaac Newton, Albert Einstein, and Stephen Hawking, Mirchandani decided at age 12 he would sacrifice his grade point average to pursue a nontraditional educational path that gave him hands-on experience in science.

“The education system doesn’t prepare you for actual scientific research, it prepares you for exams,” Mirchandani says. “What draws me to MIT Open Learning and OpenCourseWare is it breaks the old model of education. It’s not about sitting in a lecture hall, it’s about access and experimentation.”

With guidance from his physics teacher, Mirchandani built his own curriculum using educational materials on MIT OpenCourseWare to progress from classical physics to computer science to quantum physics. He has completed more than 27 online MIT courses to date.

“The best part of OpenCourseWare is you get to study from the greatest institution in the world, and you don’t have to pay for it,” he says.

Innovating in the real world

6.0001 (Introduction to Computer Science and Programming Using Python) and slides from 2.06 (Fluid Dynamics) gave Mirchandani the foundation to help with the family business, Dynamech Engineers, which sells machinery for commercial snack production. Some of the recent innovations he has assisted with include a zero-oil frying technology that cuts 300 calories per kilogram, a gas-based heat exchange system, and a simplified, singular machine combining the processes of two separate machines. Using the modeling techniques he learned through MIT OpenCourseWare, Mirchandani designed how these products would work without losing efficiency.

But when you ask Mirchandani which achievement he is most proud of, he’ll say it’s being one of 35 students accepted for the inaugural RSI-India cohort, an academic program for high school students modeled after the Research Science Institute program co-sponsored by MIT and the Center for Excellence in Education. Competing against other Indian students who had perfect scores on their board exams and SATs, he didn’t expect to get in, but the program valued the practical research experience he was able to pursue thanks to the knowledge he gained from his external studies.

“None of it would have happened without MIT OpenCourseWare,” he says. “It’s basically letting curiosity get the better of us. If everybody does that, we’d have a better scientific community.”

Should you have to think twice before posting a protest flyer to your Instagram story? Or feel pressure to delete that bald JD Vance meme that you shared? Now imagine that you could get kicked out of the country—potentially losing your job or education—based on the Trump administration’s dislike of your views on social media. 

That threat to free expression and dissent is happening now, but we won’t let it stand. 

"...they're not just targeting individuals—they're targeting the very idea of freedom itself."

The Electronic Frontier Foundation and co-counsel are representing the United Automobile Workers (UAW), Communications Workers of America (CWA), and American Federation of Teachers (AFT) in a lawsuit against the U.S. State Department and Department of Homeland Security for their viewpoint-based surveillance and suppression of noncitizens’ First Amendment-protected speech online.  The lawsuit asks a federal court to stop the government’s unconstitutional surveillance program, which has silenced citizens and noncitizens alike. It has even hindered unions’ ability to associate with their members. 

• Press Release
• Full Complaint in UAW v. State Department 

"When they spy on, silence, and fire union members for speaking out, they're not just targeting individuals—they're targeting the very idea of freedom itself,” said UAW President Shawn Fain. 

The Trump administration has built this mass surveillance program to monitor the constitutionally protected online speech of noncitizens who are lawfully present in the U.S. The program uses AI and automated technologies to scour social media and other online platforms to identify and punish individuals who express viewpoints the government considers "hostile" to "our culture" and "our civilization".  But make no mistake: no one should be forced to conform to the views of the state. 

The Foundation of Democracy 

Your free expression and privacy are fundamental human rights, and democracy crumbles without them. We have an opportunity to fight back, but we need you.  EFF’s team of lawyers, activists, researchers, and technologists have been on a mission to protect your freedom online since 1990, and we’re just getting started.

Donate and become a member of EFF today. Your support helps protect crucial rights, online and off, for everyone.

Give Today

Viewpoint-based Online Surveillance of Permanent Residents and Visa Holders Violates First Amendment, Lawsuit Argues

NEW YORK—The United Automobile Workers (UAW), Communications Workers of America (CWA), and American Federation of Teachers (AFT) filed a lawsuit today against the Departments of State and Homeland Security for their viewpoint-based surveillance and suppression of protected expression online. The complaint asks a federal court to stop this unconstitutional surveillance program, which has silenced and frightened both citizens and noncitizens, and hampered the ability of the unions to associate with their members and potential members. The case is titled UAW v. State Department.

Since taking power, the Trump administration has created a mass surveillance program to monitor constitutionally protected speech by noncitizens lawfully present in the U.S. Using AI and other automated technologies, the program surveils the social media accounts of visa holders with the goal of identifying and punishing those who express viewpoints the government doesn't like. This has been paired with a public intimidation campaign, silencing not just noncitizens with immigration status, but also the families, coworkers, and friends with whom their lives are integrated.

As detailed in the complaint, when asked in a survey if they had changed their social media activity as a result of the Trump administration's ideological online surveillance program, over 60 percent of responding UAW members and over 30 percent of responding CWA members who were aware of the program said they had. Among noncitizens, these numbers were even higher. Of respondents aware of the program, over 80 percent of UAW members who were not U.S. citizens and over 40 percent of CWA members who were not U.S. citizens said they had changed their activity online.

Individual union members reported refraining from posting, refraining from sharing union content, deleting posts, and deleting entire accounts in response to the ideological online surveillance program. Criticism of the Trump administration or its policies was the most common type of content respondents reported changing their social media activity around. Many members also reported altering their offline union activity in response to the program, including avoiding being publicly identified as part of the unions and reducing their participation in rallies and protests. One member even said they declined to report a wage theft claim due to fears arising from the surveillance program.

Represented by the Electronic Frontier Foundation (EFF), Muslim Advocates (MA), and the Media Freedom & Information Access Clinic (MFIA), the UAW, CWA, and AFT seek to halt the program that affects thousands of their members individually and has harmed the ability of the unions to organize, represent, and recruit members. The lawsuit argues that the viewpoint-based online surveillance program violates the First Amendment and the Administrative Procedure Act.

"The Trump administration's use of surveillance to track and intimidate UAW members is a direct assault on the First Amendment—and an attack on every working person in this country," said UAW President Shawn Fain. "When they spy on, silence, and fire union members for speaking out, they're not just targeting individuals—they're targeting the very idea of freedom itself. The right to protest, to organize, to speak without fear—that's the foundation of American democracy. If they can come for UAW members at our worksites, they can come for any one of us tomorrow. And we will not stand by and let that happen."

"Every worker should be alarmed by the Trump administration’s online surveillance program," said CWA President Claude Cummings Jr. "The labor movement is built on our freedoms under the First Amendment to speak and assemble without fear retaliation by the government. The unconstitutional Challenged Surveillance Program threatens those freedoms and explicitly targets those who are critical of the administration and its policies. This policy interferes with CWA members’ ability to express their points of view online and organize to improve their working conditions."

"Free speech is the foundation of democracy in America," said AFT President Randi Weingarten. "The Trump administration has rejected that core constitutional right and now says only speech it agrees with is permitted—and that it will silence those who disagree. This suit exposes the online surveillance tools and other cyber tactics never envisioned by the founders to enforce compliance with the administration’s views. It details the direct harms on both the target of these attacks and the chilling effect on all those we represent and teach."

"Using a variety of AI and automated tools, the government can now conduct viewpoint-based surveillance and analysis on a scale that was never possible with human review alone," said EFF Staff Attorney Lisa Femia. "The scale of this spying is matched by an equally massive chilling effect on free speech."

"The administration is hunting online for an ever-growing list of disfavored viewpoints," said Golnaz Fakhimi, Legal Director of Muslim Advocates. "Its goal is clear: consolidate authoritarian power by crushing dissent, starting with noncitizens, but certainly not ending there. This urgent lawsuit aims to put a stop to this power grab and defend First Amendment freedoms crucial to a pluralistic and democratic society."

"This case goes to the heart of the First Amendment," said Anthony Cosentino, a student in the Media Freedom & Information Access Clinic. "The government can’t go after people for saying things it doesn’t like. The current administration has ignored that principle, developing a vast surveillance apparatus to find and punish people for their constitutionally protected speech. It is an extraordinary abuse of power, creating a climate of fear not seen in this country since the McCarthy era, especially on college campuses. Our laws and Constitution will not allow it."

For the complaint: https://www.eff.org/document/uaw-v-dos-complaint

For more about the litigation: https://eff.org/cases/united-auto-workers-v-us-department-state

Contacts:
Electronic Frontier Foundation: press@eff.org
Muslim Advocates: golnaz@muslimadvocates.org

CNN has a great piece about how cryptocurrency ATMs are used to scam people out of their money. The fees are usurious, and they’re a common place for scammers to send victims to buy cryptocurrency for them. The companies behind the ATMs, at best, do not care about the harm they cause; the profits are just too good.