Nature Climate Change, Published online: 20 June 2025; doi:10.1038/s41558-025-02369-z

Video games are a popular method for climate change communication, but current efforts undervalue the potential role of gaming communities. To empower gaming communities to take climate action, we suggest social strategies including fostering climate change conversations through games and in gaming social spaces, and organizing real-world gaming community events.

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Two articles crossed my path recently. First, a discussion of all the video Waymo has from outside its cars: in this case related to the LA protests. Second, a discussion of all the video Tesla has from inside its cars.

Lots of things are collecting lots of video of lots of other things. How and under what rules that video is used and reused will be a continuing source of debate.

When the Earth froze over, where did life shelter? MIT scientists say one refuge may have been pools of melted ice that dotted the planet’s icy surface.

In a study appearing today in Nature Communications, the researchers report that 635 million to 720 million years ago, during periods known as “Snowball Earth,” when much of the planet was covered in ice, some of our ancient cellular ancestors could have waited things out in meltwater ponds.

The scientists found that eukaryotes — complex cellular lifeforms that eventually evolved into the diverse multicellular life we see today — could have survived the global freeze by living in shallow pools of water. These small, watery oases may have persisted atop relatively shallow ice sheets present in equatorial regions. There, the ice surface could accumulate dark-colored dust and debris from below, which enhanced its ability to melt into pools. At temperatures hovering around 0 degrees Celsius, the resulting meltwater ponds could have served as habitable environments for certain forms of early complex life.

The team drew its conclusions based on an analysis of modern-day meltwater ponds. Today in Antarctica, small pools of melted ice can be found along the margins of ice sheets. The conditions along these polar ice sheets are similar to what likely existed along ice sheets near the equator during Snowball Earth.

The researchers analyzed samples from a variety of meltwater ponds located on the McMurdo Ice Shelf in an area that was first described by members of Robert Falcon Scott's 1903 expedition as “dirty ice.” The MIT researchers discovered clear signatures of eukaryotic life in every pond. The communities of eukaryotes varied from pond to pond, revealing a surprising diversity of life across the setting. The team also found that salinity plays a key role in the kind of life a pond can host: Ponds that were more brackish or salty had more similar eukaryotic communities, which differed from those in ponds with fresher waters.

“We’ve shown that meltwater ponds are valid candidates for where early eukaryotes could have sheltered during these planet-wide glaciation events,” says lead author Fatima Husain, a graduate student in MIT’s Department of Earth, Atmospheric and Planetary Sciences (EAPS). “This shows us that diversity is present and possible in these sorts of settings. It’s really a story of life’s resilience.”

The study’s MIT co-authors include Schlumberger Professor of Geobiology Roger Summons and former postdoc Thomas Evans, along with Jasmin Millar of Cardiff University, Anne Jungblut at the Natural History Museum in London, and Ian Hawes of the University of Waikato in New Zealand.

Polar plunge

“Snowball Earth” is the colloquial term for periods of time in Earth history during which the planet iced over. It is often used as a reference to the two consecutive, multi-million-year glaciation events which took place during the Cryogenian Period, which geologists refer to as the time between 635 and 720 million years ago. Whether the Earth was more of a hardened snowball or a softer “slushball” is still up for debate. But scientists are certain of one thing: Most of the planet was plunged into a deep freeze, with average global temperatures of minus 50 degrees Celsius. The question has been: How and where did life survive?

“We’re interested in understanding the foundations of complex life on Earth. We see evidence for eukaryotes before and after the Cryogenian in the fossil record, but we largely lack direct evidence of where they may have lived during,” Husain says. “The great part of this mystery is, we know life survived. We’re just trying to understand how and where.”

There are a number of ideas for where organisms could have sheltered during Snowball Earth, including in certain patches of the open ocean (if such environments existed), in and around deep-sea hydrothermal vents, and under ice sheets. In considering meltwater ponds, Husain and her colleagues pursued the hypothesis that surface ice meltwaters may also have been capable of supporting early eukaryotic life at the time.

“There are many hypotheses for where life could have survived and sheltered during the Cryogenian, but we don’t have excellent analogs for all of them,” Husain notes. “Above-ice meltwater ponds occur on Earth today and are accessible, giving us the opportunity to really focus in on the eukaryotes which live in these environments.”

Small pond, big life

For their new study, the researchers analyzed samples taken from meltwater ponds in Antarctica. In 2018, Summons and colleagues from New Zealand traveled to a region of the McMurdo Ice Shelf in East Antarctica, known to host small ponds of melted ice, each just a few feet deep and a few meters wide. There, water freezes all the way to the seafloor, in the process trapping dark-colored sediments and marine organisms. Wind-driven loss of ice from the surface creates a sort of conveyer belt that brings this trapped debris to the surface over time, where it absorbs the sun’s warmth, causing ice to melt, while surrounding debris-free ice reflects incoming sunlight, resulting in the formation of shallow meltwater ponds.

The bottom of each pond is lined with mats of microbes that have built up over years to form layers of sticky cellular communities.

“These mats can be a few centimeters thick, colorful, and they can be very clearly layered,” Husain says.

These microbial mats are made up of cyanobacteria, prokaryotic, single-celled photosynthetic organisms that lack a cell nucleus or other organelles. While these ancient microbes are known to survive within some of the the harshest environments on Earth including meltwater ponds, the researchers wanted to know whether eukaryotes — complex organisms that evolved a cell nucleus and other membrane bound organelles — could also weather similarly challenging circumstances. Answering this question would take more than a microscope, as the defining characteristics of the microscopic eukaryotes present among the microbial mats are too subtle to distinguish by eye.

To characterize the eukaryotes, the team analyzed the mats for specific lipids they make called sterols, as well as genetic components called ribosomal ribonucleic acid (rRNA), both of which can be used to identify organisms with varying degrees of specificity. These two independent sets of analyses provided complementary fingerprints for certain eukaryotic groups. As part of the team’s lipid research, they found many sterols and rRNA genes closely associated with specific types of algae, protists, and microscopic animals among the microbial mats. The researchers were able to assess the types and relative abundance of lipids and rRNA genes from pond to pond, and found the ponds hosted a surprising diversity of eukaryotic life.

“No two ponds were alike,” Husain says. “There are repeating casts of characters, but they’re present in different abundances. And we found diverse assemblages of eukaryotes from all the major groups in all the ponds studied. These eukaryotes are the descendants of the eukaryotes that survived the Snowball Earth. This really highlights that meltwater ponds during Snowball Earth could have served as above-ice oases that nurtured the eukaryotic life that enabled the diversification and proliferation of complex life — including us — later on.”

This research was supported, in part, by the NASA Exobiology Program, the Simons Collaboration on the Origins of Life, and a MISTI grant from MIT-New Zealand.

MIT has again been named the world’s top university by the QS World University Rankings, which were announced today. This is the 14th year in a row MIT has received this distinction.

The full 2026 edition of the rankings — published by Quacquarelli Symonds, an organization specializing in education and study abroad — can be found at TopUniversities.com. The QS rankings are based on factors including academic reputation, employer reputation, citations per faculty, student-to-faculty ratio, proportion of international faculty, and proportion of international students.

MIT was also ranked the world’s top university in 11 of the subject areas ranked by QS, as announced in March of this year.

The Institute received a No. 1 ranking in the following QS subject areas: Chemical Engineering; Civil and Structural Engineering; Computer Science and Information Systems; Data Science and Artificial Intelligence; Electrical and Electronic Engineering; Linguistics; Materials Science; Mechanical, Aeronautical, and Manufacturing Engineering; Mathematics; Physics and Astronomy; and Statistics and Operational Research.

MIT also placed second in seven subject areas: Accounting and Finance; Architecture/Built Environment; Biological Sciences; Business and Management Studies; Chemistry; Earth and Marine Sciences; and Economics and Econometrics.

Today's Supreme Court’s ruling in U.S. v. Skrmetti upholding bans on gender-affirming care for youth makes it clear: trans people are under attack. Threats to trans rights and healthcare are coming from legislatures, anti-trans bigots (both organized and not), apathetic bystanders, and more. Living under the most sophisticated surveillance apparatus in human history only makes things worse. While the dangers are very much tangible and immediate, the risks posed by technology can amplify them in insidious ways. Here is a non-exhaustive overview of concerns, a broad-sweeping threat model, and some recommended strategies that you can take to keep yourself and your loved ones safe.

Dangers for Trans Youth

Trans kids experience an inhumane amount of cruelty and assault. Much of today’s anti-trans legislation is aimed specifically at making life harder for transgender youth, across all aspects of life. For this reason, we have highlighted several of the unique threats facing transgender youth.

School Monitoring Software

Most school-issued devices are root-kitted with surveillance spyware known as student-monitoring software. The purveyors of these technologies have been widely criticized for posing significant risks to marginalized children, particularly LGBTQ+ students. We ran our own investigation on the dangers posed by these technologies with a project called Red Flag Machine. Our findings showed that a significant portion of the times students’ online behavior was flagged as “inappropriate” was when they were researching LGBTQ+ topics such as queer history, sexual education, psychology, and medicine. When a device with this software flags such activity it often leads to students being placed in direct contact with school administrators or even law enforcement. As I wrote 3 years ago, this creates a persistent and uniquely dangerous situation for students living in areas with regressive laws around LGBTQ+ life or unsafe home environments.

The risks posed by technology can amplify threats in insidious ways

Unfortunately, because of the invasive nature of these school-issued devices, we can’t recommend a safe way to research LGBTQ+ topics on them without risking school administrators finding out. If possible, consider compartmentalizing those searches to different devices, ones owned by you or a trusted friend, or devices found in an environment you trust, such as a public library.

Family Owned Devices

If you don’t own your phone, laptop, or other devices—such as if your parents or guardians are in control of them (e.g. they have access to unlock them or they exert control over the app stores you can access with them)— it’s safest to treat those devices as you would a school-issued device. This means you should not trust those devices for the most sensitive activities or searches that you want to keep especially private. While steps like deleting browser history and using hidden folders or photo albums can offer some safety, they aren’t sure-fire protections to prevent the adults in your life from accessing your sensitive information. When possible, try using a public library computer (outside of school) or borrow a trusted friend’s device with fewer restrictions. 

Dangers for Protestors

Pride demonstrations are once again returning to their roots as political protests. It’s important to treat them as such by locking down your devices and coming up with some safety plans in advance. We recommend reading our entire Surveillance Self-Defense guide on attending a protest, taking special care to implement strategies like disabling biometric unlock on your phone and documenting the protest without putting others at risk. If you’re attending the demonstration with others–which is strongly encouraged–consider setting up a Signal group chat and using strategies laid out in this blog post by Micah Lee.

Counter-protestors

There is a significant push from anti-trans bigots to make Pride month more dangerous for our community. An independent source has been tracking and mapping anti-trans organized groups who are specifically targeting Pride events. While the list is non-exhaustive, it does provide some insight into who these groups are and where they are active. If one of these groups is organizing in your area, it will be important to take extra precautions to keep yourself safe.

Data Brokers & Open-Source Intelligence

Data brokers pose a significant threat to everyone–and frankly, the entire industry deserves to be deleted out of existence. The dangers are even more pressing for people doing the vital work advocating for human rights of transgender people. If you’re a doctor, an activist, or a supportive family member of a transgender person, you are at risk of your own personal information being weaponized against you. Anti-trans bigots and their supporters online will routinely access open-source intelligence and data broker records to cause harm.

You can reduce some of these risks by opting out from data brokers. It’s not a cure-all (the entire dissolution of the data broker industry is the only solution), but it’s a meaningful step. The DIY method has been found most effective, though there are services to automate the process if you would rather save yourself the time and energy. For the DIY approach, we recommend using Yael Grauer’s Big Ass Data-Broker Opt Out List.

Legality is likely to continue to shift

It’s also important to look into other publicly accessible information that may be out there, including voter registration records, medical licensing information, property sales records, and more. Some of these can be obfuscated through mechanisms like “address confidentiality programs.” These protections vary state-by-state, so we recommend checking your local laws and protections.

Medical Data

In recent years, legislatures across the country have moved to restrict access to and ban transgender healthcare. Legality is likely to continue to shift, especially after the Supreme Court’s green light today in Skrmetti. Many of the concerns around criminalization of transgender healthcare overlap with those surrounding abortion access –issues that are deeply connected and not mutually exclusive. The Surveillance Self-Defense playlist for the abortion access movement is a great place to start when thinking through these risks, particularly the guides on mobile phone location tracking, making a security plan, and communicating with others. While some of this overlaps with the previously linked protest safety guides, that redundancy only underscores the importance.

Unfortunately, much of the data about your medical history and care is out of your hands. While some medical practitioners may have some flexibility over how your records reflect your trans identity, certain aspects like diagnostic codes and pharmaceutical data for hormone therapy or surgery are often more rigid and difficult to obscure. As a patient, it’s important to consult with your medical provider about this information. Consider opening up a dialogue with them about what information needs to be documented, versus what could be obfuscated, and how you can plan ahead in the event that this type of care is further outlawed or deemed criminal.

Account Safety Locking Down Social Media Accounts

It’s a good idea for everyone to review the privacy and security settings on their social media accounts. But given the extreme amount of anti-trans hate online (sometimes emboldened by the very platforms themselves), this is a necessary step for trans people online. To start, check out the Surveillance Self-Defense guide on social media account safety. 

We can’t let the threats posed by technology diminish our humanity and our liberation.

In addition to reviewing your account settings, you may want to think carefully about what information you choose to share online. While visibility of queerness and humanity is a powerful tool for destigmatizing our existence, only you can decide if the risk involved with sharing your face, your name, and your life outweigh the benefit of showing others that no matter what happens, trans people exist. There’s no single right answer—only what’s right for you.

Keep in mind also that LGBTQ expression is at significantly greater risk of censorship by these platforms. There is little individuals can do to fully evade or protect against this, underscoring the importance of advocacy and platform accountability.

Dating Apps

Dating apps also pose a unique set of risks for transgender people. Intimate partner violence for transgender people is at a staggeringly high rate compared to cisgender people–meaning we must take special care to protect ourselves. This guide on LGBTQ dating app safety is worth reading, but here’s the TLDR: always designate a friend as your safety contact before and after meeting anyone new, meet in public first, and be mindful of how you share photos with others on dating apps.

Safety and Liberation Are Collective Efforts

While bodily autonomy is under attack from multiple fronts, it’s crucial that we band together to share strategies of resistance. Digital privacy and security must be considered when it comes to holistic security and safety. Don’t let technology become the tool that enables violence or restricts the self-determination we all deserve.

Trans people have always existed. Trans people will continue to exist despite the state’s efforts to eradicate us. Digital privacy and security are just one aspect of our collective safety. We can’t let the threats posed by technology diminish our humanity and our liberation. Stay informed. Fight back. We keep each other safe.

Apple has released a scaremongering, self-serving warning aimed at the Australian government, claiming that Australians will be overrun by a parade of digital horribles if Australia follows the European Union’s lead and regulates Apple’s “walled garden.” 

The EU’s Digital Markets Act is a big, complex, ambitious law that takes aim squarely at the source of Big Tech’s power: lock-in. For users, the DMA offers interoperability rules that let Europeans escape US tech giants’ walled gardens without giving up their relationships and digital memories.  

For small businesses, the DMA offers something just as valuable: the right to process their own payments. That may sound boring, but here’s the thing: Apple takes 30 percent commission on most payments made through iPhone and iPad apps, and they ban app makers from including alternative payment methods or even mentioning that Apple customers can make their payments on the web. 

All this means that every euro a European Patreon user sends to a performer or artist takes a round-trip through Cupertino, California, and comes back 30 cents lighter. Same goes for other money sent to major newspapers, big games, or large service providers. Meanwhile, the actual cost of processing a payment in the EU is less than one percent, meaning that Apple is taking in a 3,000 percent margin on its EU payments. 

To make things worse, Apple uses “digital rights management” to lock iPhones and iPads to its official App Store. That means that Europeans can’t escape Apple’s 30 percent “app tax” by installing apps from a store with fairer payment policies.  

Here, too, the DMA offers relief, with a rule that requires Apple to permit “sideloading” of apps (that is, installing apps without using an app store). The same rule requires Apple to allow its customers to choose to use independent app stores. 

With the DMA, the EU is leading the world in smart, administrable tech policies that strike at the power of tech companies. This is a welcome break from the dominant approach to tech policy over the first two decades of this century, in which regulators focused on demanding that tech companies use their power wisely – by surveilling and controlling their users to prevent bad behavior – rather than taking that power away. 

Which is why Australia is so interested. A late 2024 report from the Australian Treasury took a serious look at transposing DMA-style rules to Australia. It’s a sound policy, as the European experience has shown. 

But you wouldn’t know it by listening to Apple. According to Apple, Australians aren’t competent to have the final say over which apps they use and how they pay for them, and only Apple can make those determinations safely. It’s true that Apple sometimes takes bold, admirable steps to protect its customers’ privacy – but it’s also true that sometimes Apple invades its customers’ privacy (and lies about it). It’s true that sometimes Apple defends its customers from government spying – but it’s also true that sometimes Apple serves its customers up on a platter to government spies, delivering population-scale surveillance for autocratic regimes (and Apple has even been known to change its apps to help autocrats cling to power). 

Apple sometimes has its customers’ backs, but often, it sides with its shareholders (or repressive governments) over those customers. There’s no such thing as a benevolent dictator: letting Apple veto your decisions about how you use your devices will not make you safer. 

Apple’s claims about the chaos and dangers that Europeans face thanks to the DMA are even more (grimly) funny when you consider that Apple has flouted EU law with breathtaking acts of malicious compliance. Apparently, the European iPhone carnage has been triggered by the words on the European law books, without Apple even having to follow those laws! 

The world is in the midst of a global anti-monopoly wave that keeps on growing. This decade has seen big, muscular antitrust action in the US, the UK, the EU, Canada, South Korea, Japan, Germany, Spain, France, and even China.  

It’s been a century since the last wave of trustbusting swept the globe, and while today’s monopolists are orders of magnitude larger than their early 20th-century forbears, they also have a unique vulnerability.  

Broadly speaking, today’s tech giants cheat in the same way everywhere. They do the same spying, the same price-gouging, and employ the same lock-in tactics in every country where they operate, which is practically every country. That means that when a large bloc like the EU makes a good tech regulation, it has the power to ripple out across the planet, benefiting all of us – like when the EU forced Apple to switch to standard USB-C cables to charge their devices, and we all got iPhones with USB-C ports. 

It makes perfect sense for Australia to import the DMA – after all, Apple and other American tech companies run the same scams on Australians as they do on Europeans. 

Around the world, antitrust enforcers have figured out that they can copy one another’s homework, to the benefit of the people they defend. For example, in 2022, the UK’s Digital Markets Unit published a landmark study on the abuses of the mobile duopoly. The EU Commission relied on the UK report when it crafted the DMA, as did an American Congressman who introduced a similar law that year. The same report’s findings became the basis for new enforcement efforts in Japan and South Korea. 

As Benjamin Franklin wrote, “He who receives an idea from me, receives instruction himself without lessening mine; as he who lights his taper at mine, receives light without darkening mine.” It’s wonderful to see Australian regulators picking up best practices from the EU, and we look forward to seeing what ideas Australia has for the rest of the world to copy. 

Social security numbers stolen. Public transport halted. Hospital systems frozen until ransoms are paid. These are some of the damaging consequences of unsecure memory in computer systems.

Over the past decade, public awareness of such cyberattacks has intensified, as their impacts have harmed individuals, corporations, and governments. Today, this awareness is coinciding with technologies that are finally mature enough to eliminate vulnerabilities in memory safety.  

"We are at a tipping point — now is the right time to move to memory-safe systems," says Hamed Okhravi, a cybersecurity expert in MIT Lincoln Laboratory’s Secure Resilient Systems and Technology Group.

In an op-ed earlier this year in Communications of the ACM, Okhravi joined 20 other luminaries in the field of computer security to lay out a plan for achieving universal memory safety. They argue for a standardized framework as an essential next step to adopting memory-safety technologies throughout all forms of computer systems, from fighter jets to cell phones.

Memory-safety vulnerabilities occur when a program performs unintended or erroneous operations in memory. Such operations are prevalent, accounting for an estimated 70 percent of software vulnerabilities. If attackers gain access to memory, they can potentially steal sensitive information, alter program execution, or even take control of the computer system.

These vulnerabilities exist largely because common software programming languages, such as C or C++, are inherently memory-insecure. A simple error by a software engineer, perhaps one line in a system’s multimillion lines of code, could be enough for an attacker to exploit. In recent years, new memory-safe languages, such as Rust, have been developed. But rewriting legacy systems in new, memory-safe languages can be costly and complicated.

Okhravi focuses on the national security implications of memory-safety vulnerabilities. For the U.S. Department of Defense (DoD), whose systems comprise billions of lines of legacy C or C++ code, memory safety has long been a known problem. The National Security Agency (NSA) and the federal government have recently urged technology developers to eliminate memory-safety vulnerabilities from their products. Security concerns extend beyond military systems to widespread consumer products.

"Cell phones, for example, are not immediately important for defense or war-fighting, but if we have 200 million vulnerable cell phones in the nation, that’s a serious matter of national security," Okhravi says.

Memory-safe technology

In recent years, several technologies have emerged to help patch memory vulnerabilities in legacy systems. As the guest editor for a special issue of IEEE Security and Privacy, Okhravi solicited articles from top contributors in the field to highlight these technologies and the ways they can build on one another.  

Some of these memory-safety technologies have been developed at Lincoln Laboratory, with sponsorship from DoD agencies. These technologies include TRACER and TASR, which are software products for Windows and Linux systems, respectively, that reshuffle the location of code in memory each time a program accesses it, making it very difficult for attackers to find exploits. These moving-target solutions have since been licensed by cybersecurity and cloud services companies.

"These technologies are quick wins, enabling us to make a lot of immediate impact without having to rebuild the whole system. But they are only a partial solution, a way of securing legacy systems while we are transitioning to safer languages," Okhravi says.

Innovative work is underway to make that transition easier. For example, the TRACTOR program at the U.S. Defense Advanced Research Projects Agency is developing artificial intelligence tools to automatically translate legacy C code to Rust. Lincoln Laboratory researchers will test and evaluate the translator for use in DoD systems.

Okhravi and his coauthors acknowledged in their op-ed that the timeline for full adoption of memory-safe systems is long — likely decades. It will require the deployment of a combination of new hardware, software, and techniques, each with their own adoption paths, costs, and disruptions. Organizations should prioritize mission-critical systems first.

"For example, the most important components in a fighter jet, such as the flight-control algorithm or the munition-handling logic, would be made memory-safe, say, within five years," Okhravi says. Subsystems less important to critical functions would have a longer time frame.

Use of memory-safe programming languages at Lincoln Laboratory

As Lincoln Laboratory continues its leadership in advancing memory-safety technologies, the Secure Resilient Systems and Technology Group has prioritized adopting memory-safe programming languages. "We’ve been investing in the group-wide use of Rust for the past six years as part of our broader strategy to prototype cyber-hardened mission systems and high-assurance cryptographic implementations for the DoD and intelligence community," says Roger Khazan, who leads the group. "Memory safety is fundamental to trustworthiness in these systems."

Rust’s strong guarantees around memory safety, along with its speed and ability to catch bugs early during development, make it especially well-suited for building secure and reliable systems. The laboratory has been using Rust to prototype and transition secure components for embedded, distributed, and cryptographic systems where resilience, performance, and correctness are mission-critical.

These efforts support both immediate U.S. government needs and a longer-term transformation of the national security software ecosystem. "They reflect Lincoln Laboratory’s broader mission of advancing technology in service to national security, grounded in technical excellence, innovation, and trust," Khazan adds.

A technology-agnostic framework

As new computer systems are designed, developers need a framework of memory-safety standards guiding them. Today, attempts to request memory safety in new systems are hampered by the lack of a clear set of definitions and practice.

Okhravi emphasizes that this standardized framework should be technology-agnostic and provide specific timelines with sets of requirements for different types of systems.

"In the acquisition process for the DoD, and even the commercial sector, when we are mandating memory safety, it shouldn’t be tied to a specific technology. It should be generic enough that different types of systems can apply different technologies to get there," he says.

Filling this gap not only requires building industrial consensus on technical approaches, but also collaborating with government and academia to bring this effort to fruition.

The need for collaboration was an impetus for the op-ed, and Okhravi says that the consortium of experts will push for standardization from their positions across industry, government, and academia. Contributors to the paper represent a wide range of institutes, from the University of Cambridge and SRI International to Microsoft and Google. Together, they are building momentum to finally root out memory vulnerabilities and the costly damages associated with them.

"We are seeing this cost-risk trade-off mindset shifting, partly because of the maturation of technology and partly because of such consequential incidents,” Okhravi says. "We hear all the time that such-and-such breach cost billions of dollars. Meanwhile, making the system secure might have cost 10 million dollars. Wouldn’t we have been better off making that effort?"

The MIT Press announces the acquisition of textbook publisher University Science Books from AIP Publishing, a subsidiary of the American Institute of Physics (AIP).

University Science Books was founded in 1978 to publish intermediate- and advanced-level science and reference books by respected authors, published with the highest design and production standards, and priced as affordably as possible. Over the years, USB’s authors have acquired international followings, and its textbooks in chemistry, physics, and astronomy have been recognized as the gold standard in their respective disciplines. USB was acquired by AIP Publishing in 2021.

Bestsellers include John Taylor’s “Classical Mechanics,” the No. 1 adopted text for undergrad mechanics courses in the United States and Canada, and his “Introduction to Error Analysis;” and Don McQuarrie’s “Physical Chemistry: A Molecular Approach” (commonly known as “Big Red”), the second-most adopted physical chemistry textbook in the U.S.

“We are so pleased to have found a new home for USB’s prestigious list of textbooks in the sciences,” says Alix Vance, CEO of AIP Publishing. “With its strong STEM focus, academic rigor, and high production standards, the MIT Press is the perfect partner to continue the publishing legacy of University Science Books.” 

“This acquisition is both a brand and content fit for the MIT Press,” says Amy Brand, director and publisher of the MIT Press. “USB’s respected science list will complement our long-established publishing history of publishing foundational texts in computer science, finance, and economics.”

The MIT Press will take over the USB list as of July 1, with inventory transferring to Penguin Random House Publishing Services, the MIT Press’ sales and distribution partner.

For details regarding University Science Books titles, inventory, and how to order, please contact the MIT Press. 

Established in 1962, The MIT Press is one of the largest and most distinguished university presses in the world and a leading publisher of books and journals at the intersection of science, technology, art, social science, and design.

AIP Publishing is a wholly owned not-for-profit subsidiary of the AIP and supports the charitable, scientific, and educational purposes of AIP through scholarly publishing activities on its behalf and on behalf of our publishing partners.

Researchers at MIT and the Scripps Research Institute have shown that they can generate a strong immune response to HIV with just one vaccine dose, by adding two powerful adjuvants — materials that help stimulate the immune system.

In a study of mice, the researchers showed that this approach produced a much wider diversity of antibodies against an HIV antigen, compared to the vaccine given on its own or with just one of the adjuvants. The dual-adjuvant vaccine accumulated in the lymph nodes and remained there for up to a month, allowing the immune system to build up a much greater number of antibodies against the HIV protein.

This strategy could lead to the development of vaccines that only need to be given once, for infectious diseases including HIV or SARS-CoV-2, the researchers say.

“This approach is compatible with many protein-based vaccines, so it offers the opportunity to engineer new formulations for these types of vaccines across a wide range of different diseases, such as influenza, SARS-CoV-2, or other pandemic outbreaks,” says J. Christopher Love, the Raymond A. and Helen E. St. Laurent Professor of Chemical Engineering at MIT, and a member of the Koch Institute for Integrative Cancer Research and the Ragon Institute of MGH, MIT, and Harvard.

Love and Darrell Irvine, a professor of immunology and microbiology at the Scripps Research Institute, are the senior authors of the study, which appears today in Science Translational Medicine. Kristen Rodrigues PhD ’23 and Yiming Zhang PhD ’25 are the lead authors of the paper.

More powerful vaccines

Most vaccines are delivered along with adjuvants, which help to stimulate a stronger immune response to the antigen. One adjuvant commonly used with protein-based vaccines, including those for hepatitis A and B, is aluminum hydroxide, also known as alum. This adjuvant works by activating the innate immune response, helping the body to form a stronger memory of the vaccine antigen.

Several years ago, Irvine developed another adjuvant based on saponin, an FDA-approved adjuvant derived from the bark of the Chilean soapbark tree. His work showed that nanoparticles containing both saponin and a molecule called MPLA, which promotes inflammation, worked better than saponin on its own. That nanoparticle, known as SMNP, is now being used as an adjuvant for an HIV vaccine that is currently in clinical trials.

Irvine and Love then tried combining alum and SMNP and showed that vaccines containing both of those adjuvants could generate even more powerful immune responses against either HIV or SARS-CoV-2.

In the new paper, the researchers wanted to explore why these two adjuvants work so well together to boost the immune response, specifically the B cell response. B cells produce antibodies that can circulate in the bloodstream and recognize a pathogen if the body is exposed to it again.

For this study, the researchers used an HIV protein called MD39 as their vaccine antigen, and anchored dozens of these proteins to each alum particle, along with SMNP.

After vaccinating mice with these particles, the researchers found that the vaccine accumulated in the lymph nodes — structures where B cells encounter antigens and undergo rapid mutations that generate antibodies with high affinity for a particular antigen. This process takes place within clusters of cells known as germinal centers.

The researchers showed that SMNP and alum helped the HIV antigen to penetrate through the protective layer of cells surrounding the lymph nodes without being broken down into fragments. The adjuvants also helped the antigens to remain intact in the lymph nodes for up to 28 days.

“As a result, the B cells that are cycling in the lymph nodes are constantly being exposed to the antigen over that time period, and they get the chance to refine their solution to the antigen,” Love says.

This approach may mimic what occurs during a natural infection, when antigens can remain in the lymph nodes for weeks, giving the body time to build up an immune response.

Antibody diversity

Single-cell RNA sequencing of B cells from the vaccinated mice revealed that the vaccine containing both adjuvants generated a much more diverse repertoire of B cells and antibodies. Mice that received the dual-adjuvant vaccine produced two to three times more unique B cells than mice that received just one of the adjuvants.

That increase in B cell number and diversity boosts the chances that the vaccine could generate broadly neutralizing antibodies — antibodies that can recognize a variety of strains of a given virus, such as HIV.

“When you think about the immune system sampling all of the possible solutions, the more chances we give it to identify an effective solution, the better,” Love says. “Generating broadly neutralizing antibodies is something that likely requires both the kind of approach that we showed here, to get that strong and diversified response, as well as antigen design to get the right part of the immunogen shown.”

Using these two adjuvants together could also contribute to the development of more potent vaccines against other infectious diseases, with just a single dose.

“What’s potentially powerful about this approach is that you can achieve long-term exposures based on a combination of adjuvants that are already reasonably well-understood, so it doesn’t require a different technology. It’s just combining features of these adjuvants to enable low-dose or potentially even single-dose treatments,” Love says.

The research was funded by the National Institutes of Health; the Koch Institute Support (core) Grant from the National Cancer Institute; the Ragon Institute of MGH, MIT, and Harvard; and the Howard Hughes Medical Institute.

This year, like almost all years before, LGBTQ+ Pride month is taking place at a time of burgeoning anti-LGBTQ+ violence, harassment, and criticism. Lawmakers and regulators are passing legislation restricting freedom of expression and privacy for LGBTQ+ individuals and fueling offline intolerance. Online platforms are also complicit in this pervasive ecosystem by censoring pro-LGBTQ+ speech, forcing LGBTQ+ individuals to self-censor or turn to VPNs to avoid being profiled, harassed, doxxed, or criminally prosecuted. Unfortunately, these risks look likely to continue, threatening LGBTQ+ individuals and the fight for queer liberation. 

This Pride, we’re here to help build an online space where you get to decide what aspects of yourself you share with others, how you present to the world, and what things you keep private.

We know that it feels overwhelming thinking about how to protect yourself online in the face of these issues—whether that's best practices for using gay dating apps like Grindr and Her, how to download a VPN to see and interact with banned LGBTQ+ content, methods for posting pictures from events and protests without outing your friends, or how to argue over your favorite queer musicians’ most recent problematic takes without being doxxed. 

That's why this LGBTQ+ Pride month, we’re launching an LGBT Q&A. Throughout Pride, we’ll be answering your most pressing digital rights questions on EFF’s Instagram and TikTok accounts. Comment your questions under these posts on Instagram and TikTok, and we’ll reply directly. Want to stay anonymous? Submit your questions via a secure link on our website and we’ll answer these in separate posts. 

Everyone needs guidance and protection from prying eyes. This is especially true for those of us who face consequences when intimate details around gender or sexual identities are revealed without consent. This Pride, we’re here to help build an online space where you get to decide what aspects of yourself you share with others, how you present to the world, and what things you keep private.

No question is too big or too small! But comments that discriminate against marginalized groups, including the LGBTQ+ community, will not be engaged with. 

The fight for the safety and rights of LGBTQ+ people is not just a fight for visibility online (and offline)—it’s a fight for survival. Now more than ever, it's essential to collectivize information sharing to not only make the digital world safer for LGBTQ+ individuals, but to make it a space where people can have fun, share memes, date, and build communities without facing repression and harm. Join us to make the internet private, safe, and full of gay pride.

Just in time for summer, EFFector is back—with a brand new look! If you're not signed up, now's a perfect time to subscribe and get the latest details on EFF's work defending your rights to privacy and free expression online.

EFFector 37.6 highlights an important role that EFF has to protecting you online: watching the watchers. In this issue, we're pushing back on invasive car-tracking technologies, and we share an update on our case challenging the illegal disclosure of government records to DOGE. You'll also find updates on issues like masking at protests, defending encryption in Europe, and the latest developments in the right to repair movement.

Speaking of right to repair: we're debuting a new audio companion to EFFector as well! This time, Hayley Tsukayama breaks down how Washington's new right to repair law fits into broader legislative trends. You can listen now on YouTube or the Internet Archive.

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Since 1990 EFF has published EFFector to help keep readers on the bleeding edge of their digital rights. We know that the intersection of technology, civil liberties, human rights, and the law can be complicated, so EFFector is a great way to stay on top of things. The newsletter is chock full of links to updates, announcements, blog posts, and other stories to help keep readers—and listeners—up to date on the movement to protect online privacy and free expression. 

Thank you to the supporters around the world who make our work possible! If you're not a member yet, join EFF today to help us fight for a brighter digital future.

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